Intra Erythrocyte Dexamethasone in the treatment of Ataxia Telangiectasia

Informazioni relative al progetto

IEDAT

ID dell’accordo di sovvenzione: 667946

DOI 10.3030/667946

Progetto chiuso

Data della firma CE 9 Dicembre 2015

Data di avvio 1 Gennaio 2016

Data di completamento 31 Agosto 2021

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale € 5 871 825,00

Contributo UE € 5 871 825,00

Coordinato da

ERYDEL SPA
Italy

Risultati finali

Documents, reports (5)

First evaluation workshop
Report on AT NEST definition, guidelines and SOPs
Registration number of clinical study in approved registry

Registration number of clinical study in approved registry Informed Consents Forms and/or Data Protection Forms (in their final version) will be included here. The authorisation for the use of personal data for specified purposes for a specified duration, and if applicable data transfers to third countries will be part of the content of these forms. Mandatory deliverable

Statistical report of comparison
Final evaluation workshop

Websites, patent fillings, videos etc. (2)

Project website (IEDAT)
Dissemination materials

Other (1)

Registry database

Pubblicazioni

Peer reviewed articles (7)

DDIT4 gene expression is switched on by a new HDAC4 function in ataxia telangiectasia

Autori: Anastasia Ricci, Luca Galluzzi, Mauro Magnani, Michele Menotta
Pubblicato in: The FASEB Journal, Numero 34/1, 2020, Pagina/e 1802-1818, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201902039r

The nucleoplasmic interactions among Lamin A/C-pRB-LAP2α-E2F1 are modulated by dexamethasone

Autori: Anastasia Ricci, Sara Orazi, Federica Biancucci, Mauro Magnani, Michele Menotta
Pubblicato in: Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-89608-3

Proteomics and transcriptomics analyses of ataxia telangiectasia cells treated with Dexamethasone

Autori: Michele Menotta, Sara Orazi, Anna Maria Gioacchini, Chiara Spapperi, Anastasia Ricci, Luciana Chessa, Mauro Magnani
Pubblicato in: PLOS ONE, Numero 13/4, 2018, Pagina/e e0195388, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0195388

ATM splicing variants as biomarkers for low dose dexamethasone treatment of A-T

Autori: Michele Menotta, Sara Biagiotti, Chiara Spapperi, Sara Orazi, Luigia Rossi, Luciana Chessa, Vincenzo Leuzzi, Daniela D’Agnano, Annarosa Soresina, Roberto Micheli, Mauro Magnani
Pubblicato in: Orphanet Journal of Rare Diseases, Numero 12/1, 2017, ISSN 1750-1172
Editore: BioMed Central
DOI: 10.1186/s13023-017-0669-2

Ex vivo encapsulation of dexamethasone sodium phosphate into human autologous erythrocytes using fully automated biomedical equipment

Autori: Giovanni Mambrini, Marco Mandolini, Luigia Rossi, Francesca Pierigè, Giovanni Capogrossi, Patricia Salvati, Sonja Serafini, Luca Benatti, Mauro Magnani
Pubblicato in: International Journal of Pharmaceutics, Numero 517/1-2, 2017, Pagina/e 175-184, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2016.12.011

In vivo effects of dexamethasone on blood gene expression in ataxia telangiectasia

Autori: Michele Menotta, Sara Biagiotti, Sara Orazi, Luigia Rossi, Luciana Chessa, Vincenzo Leuzzi, Daniela D’Agnano, Alessandro Plebani, Annarosa Soresina, Mauro Magnani
Pubblicato in: Molecular and Cellular Biochemistry, Numero 438/1-2, 2018, Pagina/e 153-166, ISSN 0300-8177
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11010-017-3122-x

Transcriptomic profile of ataxia telangiectasia cells treated for 30 days with a low dose of dexamethasone

Autori: Anastasia Ricci, Federica Biancucci, Mauro Magnani, Michele Menotta
Pubblicato in: All Life, Numero 14/1, 2021, Pagina/e 277-286, ISSN 2689-5293
Editore: all life
DOI: 10.1080/26895293.2021.1911863