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CORDIS - Risultati della ricerca dell’UE
CORDIS

Ubiquitous Pharmacogenomics (U-PGx): Making actionable pharmacogenomic data and effective treatment optimization accessible to every European citizen

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Therapeutic recommendations in Dutch, Greek, German, Italian, Slovene and Spanish (si apre in una nuova finestra)

Therapeutic recommendations in Dutch Greek German Italian Slovene and Spanish

Report on ELSI education needs (si apre in una nuova finestra)
Report on design of future study employing one promising model (si apre in una nuova finestra)
Overall report on ELSI aspects of U-PGx (si apre in una nuova finestra)

Overall report on ELSI aspects of UPGx

Survey to evaluate the state of PGx knowledge in the 7 participating countries (si apre in una nuova finestra)
Report on ethical issues, guidelines, governance model and principals for patients included in U-PGx (si apre in una nuova finestra)

Report on ethical issues guidelines governance model and principals for patients included in UPGx

Establishment of PK models for prediction of DDI and genetic polymorphisms on drug exposure for candidate genes included in the U-PGx trial (si apre in una nuova finestra)

Establishment of PK models for prediction of DDI and genetic polymorphisms on drug exposure for candidate genes included in the UPGx trial

Detection, assessment and evaluation of clinically relevant DDI in the U-PGx trial (si apre in una nuova finestra)

Detection assessment and evaluation of clinically relevant DDI in the UPGx trial

Report on detailed analysis of existing information infrastructures and requirements of implementation sites (si apre in una nuova finestra)
Report on predictions from first model (si apre in una nuova finestra)
Analysis of European regulatory requirements (si apre in una nuova finestra)
Report on models identified to be developed (si apre in una nuova finestra)
Policy recommendations on the pre-emptive use of U-PGx testing in routine clinical practice and uptake by health care systems (si apre in una nuova finestra)

Policy recommendations on the preemptive use of UPGx testing in routine clinical practice and uptake by health care systems

Report on comparison of model predictions and observed data from WP4 (si apre in una nuova finestra)
Critical re-evaluation and first implementation of revised DPWG guidelines by consideration of relevant DDI (si apre in una nuova finestra)

Critical reevaluation and first implementation of revised DPWG guidelines by consideration of relevant DDI

Report on predictions from further models (si apre in una nuova finestra)
List of relevant genetic variants for pre-emptive PGx testing (si apre in una nuova finestra)

List of relevant genetic variants for preemptive PGx testing

Report on the association of novel genomic variants and extreme phenotypes (si apre in una nuova finestra)
Report on finalization endpoint data extraction from clinical database into NONMEM dataset (si apre in una nuova finestra)
Report on public events and societal activities in relation with U-PGx (si apre in una nuova finestra)

Report on public events and societal activities in relation with UPGx

PGx-guidelines therapeutic recommendations and risk-assessments in English (si apre in una nuova finestra)

PGxguidelines therapeutic recommendations and riskassessments in English

Published review paper based upon the current scientific and grey literature on ethics of PGx (si apre in una nuova finestra)
Midterm Review (si apre in una nuova finestra)
Report on interoperability and development of a shared semantic model (si apre in una nuova finestra)
Translated patient surveys for the web-based intensive monitoring system (si apre in una nuova finestra)

Translated patient surveys for the webbased intensive monitoring system

Final report on decision support solutions at implementation sites (si apre in una nuova finestra)
Organization of a U-PGx Personalized Medicine Day in France (si apre in una nuova finestra)

Organization of a UPGx Personalized Medicine Day in France

Organization of the 1st patient/general public oriented PGx information events (si apre in una nuova finestra)

Organization of the 1st patientgeneral public oriented PGx information events

Education programme for non-participants (si apre in una nuova finestra)

Education programme for nonparticipants

Organization of a U-PGx Personalized Medicine Day in Greece (si apre in una nuova finestra)

Organization of a UPGx Personalized Medicine Day in Greece

Organization of a U-PGx Personalized Medicine Day in the UK (si apre in una nuova finestra)

Organization of a UPGx Personalized Medicine Day in the UK

Organization of the 3rd patient/general public-oriented PGx information event (si apre in una nuova finestra)

Organization of a UPGx Personalized Medicine Day in Germany

Organization of a major 4-day U-PGx Personalized Medicine Symposium in Leiden, Netherlands (si apre in una nuova finestra)

Organization of a major 4day UPGx Personalized Medicine Symposium in Leiden Netherlands

Summer school including ELSI topics (prepared by WP8) for medical and pharmacy students (si apre in una nuova finestra)

Summer school including ELSI topics prepared by WP8 for medical and pharmacy students

Organization of the 2nd patient/general public oriented PGx information events (si apre in una nuova finestra)

Organization of the 2nd patientgeneral public oriented PGx information events

Organization of a U-PGx Personalized Medicine Day in Slovenia (si apre in una nuova finestra)

Organization of a UPGx Personalized Medicine Day in Slovenia

Organization of a U-PGx Personalized Medicine Day in Sweden (si apre in una nuova finestra)

Organization of a UPGx Personalized Medicine Day in Sweden

Organization of a U-PGx Personalized Medicine Day in Spain (si apre in una nuova finestra)

Organization of a UPGx Personalized Medicine Day in Spain

Promotional video will be produced that visualises and promotes the idea of the idea of personalised medicine and pre-emptive PGx testing (si apre in una nuova finestra)

Promotional video will be produced that visualises and promotes the idea of the idea of personalised medicine and preemptive PGx testing

Workshop for participating healthcare professionals (si apre in una nuova finestra)
Organization of a U-PGx Personalized Medicine Day in Austria (si apre in una nuova finestra)

Organization of a UPGx Personalized Medicine Day in Austria

1st version of the public-domain web-based U-PGx information portal (si apre in una nuova finestra)

1st version of the publicdomain webbased UPGx information portal

Delivery of decision support solutions including framework for digital infrastructure including secure cloud solutions (si apre in una nuova finestra)
Dedicated webpage with secured login access for investigators and study staff (si apre in una nuova finestra)
3rd version of the public-domain web-based PGx information portal (si apre in una nuova finestra)

3rd version of the publicdomain webbased PGx information portal

Standardized Electronic Case Record Form (eCRF) (si apre in una nuova finestra)

Standardized Electronic Case Record Form eCRF

A new model of cost-effectiveness analysis, taking into account the restriction of budget (si apre in una nuova finestra)

A new model of costeffectiveness analysis taking into account the restriction of budget

Validated bioinformatics tool (si apre in una nuova finestra)
2nd version of the public-domain web-based PGx information portal (si apre in una nuova finestra)

2nd version of the publicdomain webbased PGx information portal

A standard cost-effectiveness model to assess cost-effectiveness of PGx testing in each implementation site (si apre in una nuova finestra)

A standard costeffectiveness model to assess costeffectiveness of PGx testing in each implementation site

Release of open-source software artefacts for decision support solutions (si apre in una nuova finestra)

Release of opensource software artefacts for decision support solutions

eLearning program for the train the trainers concept (si apre in una nuova finestra)

Pubblicazioni

Population pharmacogenomics: an update on ethnogeographic differences and opportunities for precision public health. (si apre in una nuova finestra)

Autori: Zhou Y, Lauschke VM.
Pubblicato in: Human genetics, 2021, ISSN 0340-6717
Editore: Springer Verlag
DOI: 10.1007/s00439-021-02385-x

Tri-Allelic Haplotypes Determine and Differentiate Functionally Normal Allele CYP2D6*2 and Impaired Allele CYP2D6*41. (si apre in una nuova finestra)

Autori: Zanger UM, Momoi K, Hofmann U, Schwab M, Klein K.
Pubblicato in: Clinical pharmacology and therapeutics, 2021, ISSN 0009-9236
Editore: Nature Publishing Group
DOI: 10.1002/cpt.2078

Pharmacogenetics Guidelines: Overview and Comparison of the DPWG, CPIC, CPNDS, and RNPGx Guidelines. (si apre in una nuova finestra)

Autori: Abdullah-Koolmees H, van Keulen AM, Nijenhuis M, Deneer VHM.
Pubblicato in: Frontiers in pharmacology, 2020, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.595219

Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel: A Study by the International Clopidogrel Pharmacogenomics Consortium (si apre in una nuova finestra)

Autori: Shefali Setia Verma, Thomas O. Bergmeijer, Li Gong, Jean‐Luc Reny, Joshua P. Lewis, Braxton D. Mitchell, Dimitrios Alexopoulos, Daniel Aradi, Russ B. Altman, Kevin Bliden, Yuki Bradford, Gianluca Campo, Kiyuk Chang, John H. Cleator, Jean‐Pierre Déry, Nadia P. Dridi, Israel Fernandez‐Cadenas, Pierre Fontana, Meinrad Gawaz, Tobias Geisler, Gian Franco Gensini, Betti Giusti, Paul A. Gurbel, Wi
Pubblicato in: Clinical Pharmacology & Therapeutics, Numero 108/5, 2020, Pagina/e 1067-1077, ISSN 0009-9236
Editore: Nature Publishing Group
DOI: 10.1002/cpt.1911

Substrate specificity of CYP2D6 genetic variants. (si apre in una nuova finestra)

Autori: van der Lee M, Guchelaar HJ, Swen JJ.
Pubblicato in: Pharmacogenomics, 2021, ISSN 1462-2416
Editore: Ashley Publications Ltd.
DOI: 10.2217/pgs-2021-0093

Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes (si apre in una nuova finestra)

Autori: Delilah F.G. Hendriks, Sabine U. Vorrink, Tomas Smutny, Sarah C. Sim, Åsa Nordling, Shahid Ullah, Masaki Kumondai, Barry C. Jones, Inger Johansson, Tommy B. Andersson, Volker M. Lauschke, Magnus Ingelman‐Sundberg
Pubblicato in: Clinical Pharmacology & Therapeutics, Numero 108/4, 2020, Pagina/e 844-855, ISSN 0009-9236
Editore: Nature Publishing Group
DOI: 10.1002/cpt.1860

Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data (si apre in una nuova finestra)

Autori: Maaike van der Lee; William G. Allard; Rolf H. A. M. Vossen; Renee Baak-Pablo; Roberta Menafra; Birgit A. L. M. Deiman; Maarten J. Deenen; Patrick Neven; Inger Johansson; Stefano Gastaldello; Magnus Ingelman-Sundberg; Henk-Jan Guchelaar; Jesse J. Swen; Seyed Yahya Anvar
Pubblicato in: VOLUME=13;ISSUE=603;TITLE=Science Translational Medicine, Numero 6, 2021, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abf3637

Can CYP Inhibition Overcome Chemotherapy Resistance? (si apre in una nuova finestra)

Autori: Magnus Ingelman-Sundberg, Volker M. Lauschke
Pubblicato in: Trends in Pharmacological Sciences, Numero 41/8, 2020, Pagina/e 503-506, ISSN 0165-6147
Editore: Elsevier BV
DOI: 10.1016/j.tips.2020.05.007

Economic evaluation in psychiatric pharmacogenomics: a systematic review. (si apre in una nuova finestra)

Autori: Karamperis K, Koromina M, Papantoniou P, Skokou M, Kanellakis F, Mitropoulos K, Vozikis A, Müller DJ, Patrinos GP, Mitropoulou C.
Pubblicato in: The pharmacogenomics journal, 2021, ISSN 1470-269X
Editore: Nature Publishing Group
DOI: 10.1038/s41397-021-00249-1

IL15RA and SMAD3 Genetic Variants Predict Overall Survival in Metastatic Colorectal Cancer Patients Treated with FOLFIRI Therapy: A New Paradigm. (si apre in una nuova finestra)

Autori: De Mattia E, Polesel J, Roncato R, Labriet A, Bignucolo A, Gagno S, Buonadonna A, D'Andrea M, Lévesque E, Jonker D, Couture F, Guillemette C, Cecchin E, Toffoli G.
Pubblicato in: Cancers, 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13071705

Impact of antipsychotic polypharmacy on nonadherence of oral antipsychotic drugs – A study based on blood sample analyses from 24,239 patients (si apre in una nuova finestra)

Autori: Robert L Smith, Marit Tveito, Lennart Kyllesø, Marin M Jukic, Magnus Ingelman-Sundberg, Ole A Andreassen, Espen Molden
Pubblicato in: European Neuropsychopharmacology, Numero 37, 2020, Pagina/e 64-69, ISSN 0924-977X
Editore: Elsevier BV
DOI: 10.1016/j.euroneuro.2020.06.007

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6 and opioids (codeine, tramadol and oxycodone). (si apre in una nuova finestra)

Autori: Matic M, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Houwink EJF, Mulder H, Rongen GAPJM, Weide JV, Wilffert B, Swen JJ, Guchelaar HJ, Deneer VHM, van Schaik RHN.
Pubblicato in: European journal of human genetics : EJHG, 2021, ISSN 1018-4813
Editore: Natue Publishing Group
DOI: 10.1038/s41431-021-00920-y

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine. (si apre in una nuova finestra)

Autori: Zhou Y, Arribas GH, Turku A, Jürgenson T, Mkrtchian S, Krebs K, Wang Y, Svobodova B, Milani L, Schulte G, Korabecny J, Gastaldello S, Lauschke VM.
Pubblicato in: Science advances, 2021, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abi6856

Global Frequencies of Clinically Important HLA Alleles and Their Implications For the Cost‐Effectiveness of Preemptive Pharmacogenetic Testing (si apre in una nuova finestra)

Autori: Yitian Zhou, Kristi Krebs, Lili Milani, Volker M. Lauschke
Pubblicato in: Clinical Pharmacology & Therapeutics, 2020, ISSN 0009-9236
Editore: Nature Publishing Group
DOI: 10.1002/cpt.1944

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing. (si apre in una nuova finestra)

Autori: Lima JJ, Thomas CD, Barbarino J, Desta Z, Van Driest SL, El Rouby N, Johnson JA, Cavallari LH, Shakhnovich V, Thacker DL, Scott SA, Schwab M, Uppugunduri CRS, Formea CM, Franciosi JP, Sangkuhl K, Gaedigk A, Klein TE, Gammal RS, Furuta T.
Pubblicato in: Clinical pharmacology and therapeutics, 2021, ISSN 0009-9236
Editore: Nature Publishing Group
DOI: 10.1002/cpt.2015

CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations-Implication for Drug Safety, Dosing, and Individualized Therapy. (si apre in una nuova finestra)

Autori: Langmia IM, Just KS, Yamoune S, Brockmöller J, Masimirembwa C, Stingl JC.
Pubblicato in: Frontiers in genetics, 2021, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2021.692234

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs. (si apre in una nuova finestra)

Autori: Brouwer JMJL, Nijenhuis M, Soree B, Guchelaar HJ, Swen JJ, van Schaik RHN, Weide JV, Rongen GAPJM, Buunk AM, de Boer-Veger NJ, Houwink EJF, van Westrhenen R, Wilffert B, Deneer VHM, Mulder H.
Pubblicato in: European journal of human genetics : EJHG, 2021, ISSN 1018-4813
Editore: Natue Publishing Group
DOI: 10.1038/s41431-021-01004-7

Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier (si apre in una nuova finestra)

Autori: Yitian Zhou, Carolina Dagli Hernandez, Volker M. Lauschke
Pubblicato in: British Journal of Cancer, 2020, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-020-01084-0

CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System-Results From the ADRED Study. (si apre in una nuova finestra)

Autori: Katja S. Just; Harald Dormann; Mathias Freitag; Marlen Schurig; Miriam Böhme; Michael Steffens; Catharina Scholl; Thomas Seufferlein; Ingo Graeff; Matthias Schwab; Matthias Schwab; Matthias Schwab; Julia C. Stingl
Pubblicato in: Frontiers in Pharmacology, Numero 9, 2021, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2021.624104

Application of long-read sequencing to elucidate complex pharmacogenomic regions: a proof of principle. (si apre in una nuova finestra)

Autori: van der Lee M, Rowell WJ, Menafra R, Guchelaar HJ, Swen JJ, Anvar SY.
Pubblicato in: The pharmacogenomics journal, 2022, ISSN 1470-269X
Editore: Nature Publishing Group
DOI: 10.1038/s41397-021-00259-z

Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study (si apre in una nuova finestra)

Autori: Cathelijne H. van der Wouden, Stefan Böhringer, Erika Cecchin, Ka-Chun Cheung, Cristina Lucía Dávila-Fajardo, Vera H.M. Deneer, Vita Dolžan, Magnus Ingelman-Sundberg, Siv Jönsson, Mats O. Karlsson, Marjolein Kriek, Christina Mitropoulou, George P. Patrinos, Munir Pirmohamed, Emmanuelle Rial-Sebbag, Matthias Samwald, Matthias Schwab, Daniela Steinberger, Julia Stingl, Gere Sunder-Plassmann, Gi
Pubblicato in: Pharmacogenetics and Genomics, Numero 30/6, 2020, Pagina/e 131-144, ISSN 1744-6872
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/fpc.0000000000000405

Evaluation of the CYP2D6 Haplotype Activity Scores Based on Metabolic Ratios of 4,700 Patients Treated With Three Different CYP2D6 Substrates. (si apre in una nuova finestra)

Autori: Jukić MM, Smith RL, Molden E, Ingelman-Sundberg M.
Pubblicato in: Clinical pharmacology and therapeutics, 2021, ISSN 0009-9236
Editore: Nature Publishing Group
DOI: 10.1002/cpt.2246

Pharmacogenomics in the UK National Health Service: opportunities and challenges. (si apre in una nuova finestra)

Autori: Turner RM, Newman WG, Bramon E, McNamee CJ, Wong WL, Misbah S, Hill S, Caulfield M, Pirmohamed M.
Pubblicato in: Pharmacogenomics, 2020, ISSN 1462-2416
Editore: Ashley Publications Ltd.
DOI: 10.2217/pgs-2020-0091

Pharmacogenomics for Primary Care: An Overview. (si apre in una nuova finestra)

Autori: Rollinson V, Turner R, Pirmohamed M.
Pubblicato in: Genes, 2020, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11111337

The ethnogeographic variability of genetic factors underlying G6PD deficiency (si apre in una nuova finestra)

Autori: iamoglou S, Koromina M, Hishinuma E, Yamazaki S, Tsermpini EE, Kordou Z, Fukunaga K, Chantratita W, Zhou Y, Lauschke VM, Mushiroda T, Hiratsuka M, Patrinos GP.
Pubblicato in: Pharmacological research, 2021, ISSN 1043-6618
Editore: Academic Press
DOI: 10.1016/j.phrs.2021.105904

Diagnostic Test Criteria for HLA Genotyping to Prevent Drug Hypersensitivity Reactions: A Systematic Review of Actionable HLA Recommendations in CPIC and DPWG Guidelines (si apre in una nuova finestra)

Autori: Lisanne E. N. Manson, Jesse J. Swen, Henk-Jan Guchelaar
Pubblicato in: Frontiers in Pharmacology, Numero 11, 2020, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2020.567048

Characterization of Genetic Heterogeneity in Recurrent Metastases of Renal Cell Carcinoma. (si apre in una nuova finestra)

Autori: Sauter-Meyerhoff C, Bohnert R, Mazzola P, Stühler V, Kandabarau S, Büttner FA, Winter S, Herrmann L, Rausch S, Hennenlotter J, Fend F, Scharpf M, Stenzl A, Ossowski S, Bedke J, Schwab M, Schaeffeler E.
Pubblicato in: Cancers, 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13246221

A Novel CYP2C-Haplotype Associated With Ultrarapid Metabolism of Escitalopram. (si apre in una nuova finestra)

Autori: Line Skute Bråten; Tore Haslemo; Marin M. Jukic; Marin M. Jukic; Maxim Ivanov; Magnus Ingelman-Sundberg; Espen Molden; Marianne Kristiansen Kringen
Pubblicato in: Clinical Pharmacology & Therapeutics, Numero 13, 2021, ISSN 0009-9236
Editore: Nature Publishing Group
DOI: 10.1002/cpt.2233

A Review of the Important Role of CYP2D6 in Pharmacogenomics. (si apre in una nuova finestra)

Autori: Taylor C, Crosby I, Yip V, Maguire P, Pirmohamed M, Turner RM.
Pubblicato in: Genes, 2020, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11111295

Data-driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment. (si apre in una nuova finestra)

Autori: Fendt R, Hofmann U, Schneider ARP, Schaeffeler E, Burghaus R, Yilmaz A, Blank LM, Kerb R, Lippert J, Schlender JF, Schwab M, Kuepfer L.
Pubblicato in: CPT: pharmacometrics & systems pharmacology, 2021, ISSN 2163-8306
Editore: Nature Publishing Group
DOI: 10.1002/psp4.12646

Association of CYP2C19 and CYP2D6 Poor and Intermediate Metabolizer Status With Antidepressant and Antipsychotic Exposure: A Systematic Review and Meta-analysis. (si apre in una nuova finestra)

Autori: Milosavljevic F, Bukvic N, Pavlovic Z, Miljevic C, Pešic V, Molden E, Ingelman-Sundberg M, Leucht S, Jukic MM.
Pubblicato in: JAMA psychiatry, 2021, ISSN 2168-622X
Editore: American Medical Association
DOI: 10.1001/jamapsychiatry.2020.3643

Individualized versus Standardized Risk Assessment in Patients at High Risk for Adverse Drug Reactions (The IDrug Randomized Controlled Trial)-Never Change a Running System? (si apre in una nuova finestra)

Autori: Just KS, Scholl C, Boehme M, Kastenmüller K, Just JM, Bleckwenn M, Holdenrieder S, Meier F, Weckbecker K, Stingl JC.
Pubblicato in: Pharmaceuticals (Basel, Switzerland), 2021, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14101056

OpenBioLink: a benchmarking framework for large-scale biomedical link prediction (si apre in una nuova finestra)

Autori: Anna Breit, Simon Ott, Asan Agibetov, Matthias Samwald
Pubblicato in: Bioinformatics, Numero 36/13, 2020, Pagina/e 4097-4098, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btaa274

Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety. (si apre in una nuova finestra)

Autori: Minichmayr IK, Karlsson MO, Jönsson S.
Pubblicato in: Pharmaceutical research, 2021, ISSN 0724-8741
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-021-03024-w

Rates of complete nonadherence among atypical antipsychotic drugs: A study using blood samples from 13,217 outpatients with psychotic disorders. (si apre in una nuova finestra)

Autori: Smith RL, Tveito M, Kyllesø L, Jukic MM, Ingelman-Sundberg M, Andreassen OA, Molden E.
Pubblicato in: Schizophrenia research, 2021, ISSN 0920-9964
Editore: Elsevier BV
DOI: 10.1016/j.schres.2020.11.025

Genotyping for HLA Risk Alleles to Prevent Drug Hypersensitivity Reactions: Impact Analysis. (si apre in una nuova finestra)

Autori: Manson LEN, van den Hout WB, Guchelaar HJ.
Pubblicato in: Pharmaceuticals (Basel, Switzerland), 2021, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15010004

Pharmacogenomics of anticancer drugs: Personalising the choice and dose to manage drug response. (si apre in una nuova finestra)

Autori: Carr DF, Turner RM, Pirmohamed M.
Pubblicato in: British journal of clinical pharmacology, 2021, ISSN 0306-5251
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bcp.14407

Technologies for Pharmacogenomics: A Review. (si apre in una nuova finestra)

Autori: van der Lee M, Kriek M, Guchelaar HJ, Swen JJ.
Pubblicato in: Genes, 2020, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11121456

Physiologically Based Precision Dosing Approach for Drug-Drug-Gene Interactions: A Simvastatin Network Analysis. (si apre in una nuova finestra)

Autori: Wojtyniak JG, Selzer D, Schwab M, Lehr T.
Pubblicato in: Clinical pharmacology and therapeutics, 2021, ISSN 0009-9236
Editore: Nature Publishing Group
DOI: 10.1002/cpt.2111

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