Children’s Liver Tumour European Research Network

Risultati finali

Indicates successful registration of the trial on a publically accessible database.

Project Management
Trial publication report

Trial Publication report report month 60 Report detailing the trial publications to date and and plan for future publications

Protocol finalisation and submission to EC.

Indicates successful development of key trial documents. Submission to EC in accordance with EC H2020 clinical trial requirements.

Project Data Management Plan
Dissemination and Communication Plan: and updated regularly

To document clearly how information about CHILTERN will be disseminated to all partners and participants during the project. This will also involve WP leads who will be responsible for providing information about their WP.

Protocols for standardised collection of clinical samples and sample analysis
Publication Policy

To document clearly how the results from all the work packages will made available to the appropriate audiences; including clinicians, researchers, patients and the public

Pubblicazioni

Hepatoblastoma and Paediatric Hepatocellular Carcinoma: An Update

Autori: Sarangarajan Ranganathan, Dolores Lopez-Terrada, Rita Alaggio
Pubblicato in: Pediatr Dev Pathol, Numero Mar-Apr 2020;23(2), 2020, Pagina/e 79-95, ISSN 1093-5266
Editore: Springer Verlag
DOI: 10.1177/1093526619875228

Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications

Autori: Carrillo-Reixach et al, J Hepatol,
Pubblicato in: Hepatol, Numero 2020, 2020, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2020.03.025

Bridging molecular basis, prognosis, and treatment of pediatric liver tumors

Autori: C Armengol, S Cairo, R Kappler.
Pubblicato in: Hepatoma Res, Numero 7:50, 2021, ISSN 2394-5079
Editore: OAE Publishing Inc

A combined clinical and biological risk score predicts outcome in hepatoblastoma patients.

Autori: Cairo S., Armengol C., Maibach R., Häberle B., Becker K., Carrillo-Reixach J., Guettier C., Vokuhl C., Schmid I., Buendia M.-A., Branchereau S., von Schweinitz D., Kappler R
Pubblicato in: Eur. J. Cancer, Numero 141, 2020, Pagina/e 30-39, ISSN 0959-8049
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2020.09.026

Focal Adhesion Kinase (FAK) Over-expression and Prognostic Implication in Paediatric Hepatocellular Carcinoma

Autori: Paola Francalanci, Isabella Giovannoni, Cristiano De Stefanis, Ilaria Romito, Chiara Grimaldi, Aurora Castellano, Rita Alaggio, Anna Alisi
Pubblicato in: J Mol Sci, Numero Aug 12;21(16):E5795, 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165795

SP8 Promotes an Aggressive Phenotype in Hepatoblastoma via FGF8 Activation

Autori: Wagner AE, Schwarzmayr T, Haberle B, Vokuhl C, Schmid I, Kaller M, Hermeking H, von Schweinitz D, Kappler R
Pubblicato in: Cancers, Numero 12 (8), 2020, Pagina/e 2294, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082294

A Summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the Optical into the Molecular Era.

Autori: Stefan M. Pfister, Miguel Reyes-Múgica, John K.C. Chan, Henrik Hasle, Alexander J. Lazar, Sabrina Rossi, Andrea Ferrari, Jason A. Jarzembowski, Kathy Pritchard-Jones, D. Ashley Hill, Thomas S. Jacques, Pieter Wesseling, Dolores H. López Terrada, Andreas von Deimling, Christian P. Kratz, Ian A. Cree and Rita Alaggio
Pubblicato in: Cancer Discov, Numero Dec 17, 2021, ISSN 2159-8274
Editore: American Association for Cancer Research Inc.

Identification of IGF2 as Genomic Driver and Actionable Therapeutic Target in Hepatoblastoma

Autori: Laura Torrens, Jordi Abril-Fornaguera, Juan Carrillo-Reixach, Alex Rialdi, Ugne Balaseviciute, Carla Montironi, Philipp Haber, Álvaro del Río-Álvarez, Montserrat Domingo-Sàbat, Laura Royo, Nicholas Akers, Catherine E. Willoughby, Miguel Torres-Martin, Marc Puigvehi, Roser Pinyol, Stefano Cairo, Margaret Childs, Rudolf Maibach, Rita Alaggio, Piotr Czauderna, Bruce Morland, Bojan Losic, Vincen
Pubblicato in: Cancer Research (under review), Numero 7/12/2021, 2021, ISSN 0008-5472
Editore: American Association for Cancer Research

A LIM Homeobox-2 Suppresses Hallmarks of Adult and Pediatric Liver Cancers by Inactivating MAPK/ ERK and Wnt/Beta-Catenin Pathways

Autori: Nicola Mosca, Fatma Zohra Khoubai, Sandrine Fedou, Juan Carrillo-Reixach, Stefano Caruso, Alvaro Del Rio-Alvarez, Emeric Dubois, Christophe Avignon,Nathalie Dugot-Senant, Catherine Guettier, Charlotte Mussini, Jessica Zucman-Rossi, Carolina Armengol, Pierre Thiébaud, Philippe Veschambre, Christophe François Grosset
Pubblicato in: Liver Cancer, Numero in press - already published online, 2021, ISSN 2235-1795
Editore: Karger

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