Fulfilling Paul Ehrlich’s Dream: therapeutics with activity on demand

Informazioni relative al progetto

ZAUBERKUGEL

ID dell’accordo di sovvenzione: 670603

DOI

10.3030/670603

Progetto chiuso

Data della firma CE 29 Luglio 2015

Data di avvio 1 Settembre 2015

Data di completamento 31 Agosto 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (55)

Protease-Cleavable Linkers Modulate the Anticancer Activity of Noninternalizing Antibody–Drug Conjugates

Autori: Alberto Dal Corso, Samuele Cazzamalli, Rémy Gébleux, Martin Mattarella, Dario Neri
Pubblicato in: Bioconjugate Chemistry, Numero 28/7, 2017, Pagina/e 1826-1833, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.7b00304

A Specific and Covalent JNK-1 Ligand Selected from an Encoded Self-Assembling Chemical Library

Autori: Gunther Zimmermann, Ulrike Rieder, Davor Bajic, Sara Vanetti, Apirat Chaikuad, Stefan Knapp, Jörg Scheuermann, Martin Mattarella, Dario Neri
Pubblicato in: Chemistry - A European Journal, Numero 23/34, 2017, Pagina/e 8152-8155, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201701644

DNA-Encoded Chemical Libraries: A Selection System Based On Endowing Organic Compounds with Amplifiable Information

Autori: Dario Neri, Richard A. Lerner
Pubblicato in: Annual Review of Biochemistry, Numero 87/1, 2018, ISSN 0066-4154
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-062917-012550

Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8 + T-cell Recognition of a Retroviral Antigen

Autori: Philipp Probst, Janine Kopp, Annette Oxenius, Mario P. Colombo, Danilo Ritz, Tim Fugmann, Dario Neri
Pubblicato in: Cancer Research, Numero 77/13, 2017, Pagina/e 3644-3654, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-16-2946

A non-internalizing antibody-drug conjugate based on an anthracycline payload displays potent therapeutic activity in vivo

Autori: Alberto Dal Corso, Rémy Gébleux, Patrizia Murer, Alex Soltermann, Dario Neri
Pubblicato in: Journal of Controlled Release, Numero 264, 2017, Pagina/e 211-218, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2017.08.040

Intratumoral administration of IL2- and TNF-based fusion proteins cures cancer without establishing protective immunity

Autori: Barbara Ziffels, Francesca Pretto, Dario Neri
Pubblicato in: Immunotherapy, Numero 10/3, 2018, Pagina/e 177-188, ISSN 1750-743X
Editore: Future Medicine Ltd.
DOI: 10.2217/imt-2017-0119

Potency-matched Dual Cytokine–Antibody Fusion Proteins for Cancer Therapy

Autori: Roberto De Luca, Alex Soltermann, Francesca Pretto, Catherine Pemberton-Ross, Giovanni Pellegrini, Sarah Wulhfard, Dario Neri
Pubblicato in: Molecular Cancer Therapeutics, Numero 16/11, 2017, Pagina/e 2442-2451, ISSN 1535-7163
Editore: American Association for Cancer Research
DOI: 10.1158/1535-7163.MCT-17-0211

Antibody-based targeted delivery of interleukin-4 synergizes with dexamethasone for the reduction of inflammation in arthritis

Autori: Anja Sophie Schmid, Teresa Hemmerle, Francesca Pretto, Anja Kipar, Dario Neri
Pubblicato in: Rheumatology, 2018, ISSN 1462-0324
Editore: Oxford University Press
DOI: 10.1093/rheumatology/kex447

Data-Independent Acquisition of HLA Class I Peptidomes on the Q Exactive Mass Spectrometer Platform

Autori: Danilo Ritz, Jonny Kinzi, Dario Neri, Tim Fugmann
Pubblicato in: PROTEOMICS, Numero 17/19, 2017, Pagina/e 1700177, ISSN 1615-9853
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.201700177

Chemically Defined Antibody– and Small Molecule–Drug Conjugates for in Vivo Tumor Targeting Applications: A Comparative Analysis

Autori: Samuele Cazzamalli, Alberto Dal Corso, Fontaine Widmayer, Dario Neri
Pubblicato in: Journal of the American Chemical Society, Numero 140/5, 2018, Pagina/e 1617-1621, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b13361

Novel antibody-cytokine fusion proteins featuring granulocyte-colony stimulating factor, interleukin-3 and interleukin-4 as payloads

Autori: Anja Sophie Schmid, Diana Tintor, Dario Neri
Pubblicato in: Journal of Biotechnology, Numero 271, 2018, Pagina/e 29-36, ISSN 0168-1656
Editore: Elsevier BV
DOI: 10.1016/j.jbiotec.2018.02.004

Membranal and blood-soluble HLA class II peptidome analyses using data-dependent and independent acquisition

Autori: Danilo Ritz, Emiliano Sani, Hanna Debiec, Pierre Ronco, Dario Neri, Tim Fugmann
Pubblicato in: PROTEOMICS, 2018, ISSN 1615-9853
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.201700246

Targeted Delivery of Cytotoxic Drugs: Challenges, Opportunities and New Developments

Autori: Samuele Cazzamalli, Alberto Dal Corso, Dario Neri
Pubblicato in: CHIMIA International Journal for Chemistry, Numero 71/10, 2017, Pagina/e 712-715, ISSN 0009-4293
Editore: Schweizerische Chemische Gedellschaft
DOI: 10.2533/chimia.2017.712

Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold

Autori: Yizhou Li, Roberto De Luca, Samuele Cazzamalli, Francesca Pretto, Davor Bajic, Jörg Scheuermann, Dario Neri
Pubblicato in: Nature Chemistry, Numero 10/4, 2018, Pagina/e 441-448, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-018-0017-8

DNA-encoded chemical libraries - achievements and remaining challenges

Autori: Nicholas Favalli, Gabriele Bassi, Jörg Scheuermann, Dario Neri
Pubblicato in: FEBS Letters, Numero 592/12, 2018, Pagina/e 2168-2180, ISSN 0014-5793
Editore: Elsevier BV
DOI: 10.1002/1873-3468.13068

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition

Autori: Nicholas Favalli, Stefan Biendl, Marco Hartmann, Jacopo Piazzi, Filippo Sladojevich, Susanne Gräslund, Peter J. Brown, Katja Näreoja, Herwig Schüler, Jörg Scheuermann, Raphael Franzini, Dario Neri
Pubblicato in: ChemMedChem, Numero 13/13, 2018, Pagina/e 1303-1307, ISSN 1860-7179
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.201800193

Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2

Autori: Samuele Cazzamalli, Barbara Ziffels, Fontaine Widmayer, Patrizia Murer, Giovanni Pellegrini, Francesca Pretto, Sarah Wulhfard, Dario Neri
Pubblicato in: Clinical Cancer Research, Numero 24/15, 2018, Pagina/e 3656-3667, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-17-3457

DNA-encoded chemical libraries: foundations and applications in lead discovery

Autori: Gunther Zimmermann, Dario Neri
Pubblicato in: Drug Discovery Today, Numero 21/11, 2016, Pagina/e 1828-1834, ISSN 1359-6446
Editore: Elsevier BV
DOI: 10.1016/j.drudis.2016.07.013

Purification of soluble HLA class I complexes from human serum or plasma deliver high quality immuno peptidomes required for biomarker discovery

Autori: Danilo Ritz, Andreas Gloger, Dario Neri, Tim Fugmann
Pubblicato in: PROTEOMICS, Numero 17/1-2, 2017, Pagina/e 1600364, ISSN 1615-9853
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.201600364

Different tissue distribution properties for glycosylation variants of fusion proteins containing the p40 subunit of murine interleukin-12

Autori: F. Bootz, D. Venetz, B. Ziffels, D. Neri
Pubblicato in: Protein Engineering Design and Selection, Numero 29/10, 2016, Pagina/e 445-455, ISSN 1741-0126
Editore: Oxford University Press
DOI: 10.1093/protein/gzw038

Acetazolamide Serves as Selective Delivery Vehicle for Dipeptide-Linked Drugs to Renal Cell Carcinoma

Autori: Samuele Cazzamalli, Alberto Dal Corso, Dario Neri
Pubblicato in: Molecular Cancer Therapeutics, Numero 15/12, 2016, Pagina/e 2926-2935, ISSN 1535-7163
Editore: American Association for Cancer Research
DOI: 10.1158/1535-7163.MCT-16-0283

Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes

Autori: Andreas Gloger, Danilo Ritz, Tim Fugmann, Dario Neri
Pubblicato in: Cancer Immunology, Immunotherapy, Numero 65/11, 2016, Pagina/e 1377-1393, ISSN 0340-7004
Editore: Springer Verlag
DOI: 10.1007/s00262-016-1897-3

Targeted Reconstitution of Cytokine Activity upon Antigen Binding using Split Cytokine Antibody Fusion Proteins

Autori: Dario Venetz, Danil Koovely, Bruce Weder, Dario Neri
Pubblicato in: Journal of Biological Chemistry, Numero 291/35, 2016, Pagina/e 18139-18147, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M116.737734

Optimized Reaction Conditions for Amide Bond Formation in DNA-Encoded Combinatorial Libraries

Autori: Yizhou Li, Elena Gabriele, Florent Samain, Nicholas Favalli, Filippo Sladojevich, Jörg Scheuermann, Dario Neri
Pubblicato in: ACS Combinatorial Science, Numero 18/8, 2016, Pagina/e 438-443, ISSN 2156-8952
Editore: American Chemical Society
DOI: 10.1021/acscombsci.6b00058

Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma

Autori: Samuele Cazzamalli, Alberto Dal Corso, Dario Neri
Pubblicato in: Journal of Controlled Release, Numero 246, 2017, Pagina/e 39-45, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2016.11.023

Non-internalizing antibody-drug conjugates display potent anti-cancer activity upon proteolytic release of monomethyl auristatin E in the subendothelial extracellular matrix

Autori: Rémy Gébleux, Marco Stringhini, Ruben Casanova, Alex Soltermann, Dario Neri
Pubblicato in: International Journal of Cancer, Numero 140/7, 2017, Pagina/e 1670-1679, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.30569

The MHC Class II Immunopeptidome of Lymph Nodes in Health and in Chemically Induced Colitis

Autori: Tim Fugmann, Adriana Sofron, Danilo Ritz, Franziska Bootz, Dario Neri
Pubblicato in: The Journal of Immunology, Numero 198/3, 2017, Pagina/e 1357-1364, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1601157

Intralesional treatment of metastatic melanoma: a review of therapeutic options

Autori: Benjamin Weide, Dario Neri, Giuliano Elia
Pubblicato in: Cancer Immunology, Immunotherapy, 2017, ISSN 0340-7004
Editore: Springer Verlag
DOI: 10.1007/s00262-016-1952-0

Hit-Validation Methodologies for Ligands Isolated from DNA-Encoded Chemical Libraries

Autori: Gunther Zimmermann, Yizhou Li, Ulrike Rieder, Martin Mattarella, Dario Neri, Jörg Scheuermann
Pubblicato in: ChemBioChem, 2017, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201600637

Quantitative PCR is a Valuable Tool to Monitor the Performance of DNA-Encoded Chemical Library Selections

Autori: Yizhou Li, Gunther Zimmermann, Jörg Scheuermann, Dario Neri
Pubblicato in: ChemBioChem, 2017, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201600626

A novel dual-cytokine–antibody fusion protein for the treatment of CD38-positive malignancies

Autori: Roberto De Luca, Paul Kachel, Klara Kropivsek, Berend Snijder, Markus G Manz, Dario Neri
Pubblicato in: Protein Engineering, Design and Selection, Numero 31/5, 2018, Pagina/e 173-179, ISSN 1741-0126
Editore: Oxford University Press
DOI: 10.1093/protein/gzy015

Antibody-based Delivery of TNF to the Tumor Neovasculature Potentiates the Therapeutic Activity of a Peptide Anticancer Vaccine

Autori: Philipp Probst, Marco Stringhini, Danilo Ritz, Tim Fugmann, Dario Neri
Pubblicato in: Clinical Cancer Research, Numero 25/2, 2019, Pagina/e 698-709, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-18-1728

Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation

Autori: Simon Schwager, Silvana Renner, Teresa Hemmerle, Sinem Karaman, Steven T. Proulx, Roman Fetz, Alexandra Michaela Golding-Ochsenbein, Philipp Probst, Cornelia Halin, Dario Neri, Michael Detmar
Pubblicato in: JCI Insight, Numero 3/23, 2018, ISSN 2379-3708
Editore: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.124850

A Novel Fully-Human Potency-Matched Dual Cytokine-Antibody Fusion Protein Targets Carbonic Anhydrase IX in Renal Cell Carcinomas

Autori: Roberto De Luca, Baptiste Gouyou, Tiziano Ongaro, Alessandra Villa, Barbara Ziffels, Alessandro Sannino, Gianluca Buttinoni, Simone Galeazzi, Mirko Mazzacuva, Dario Neri
Pubblicato in: Frontiers in Oncology, Numero 9, 2019, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2019.01228

Development of a novel fully-human anti-CD123 antibody to target acute myeloid leukemia

Autori: Cornelia Hutmacher, Laura Volta, Francesco Rinaldi, Patrizia Murer, Renier Myburgh, Markus G. Manz, Dario Neri
Pubblicato in: Leukemia Research, Numero 84, 2019, Pagina/e 106178, ISSN 0145-2126
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.leukres.2019.106178

Targeted Delivery of TNF Potentiates the Antibody-Dependent Cell-Mediated Cytotoxicity of an Anti-Melanoma Immunoglobulin

Autori: Patrizia Murer, Jonathan D. Kiefer, Louis Plüss, Mattia Matasci, Sandra L. Blümich, Marco Stringhini, Dario Neri
Pubblicato in: Journal of Investigative Dermatology, Numero 139/6, 2019, Pagina/e 1339-1348, ISSN 0022-202X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2018.11.028

Antibody-cytokine fusion proteins: A novel class of biopharmaceuticals for the therapy of cancer and of chronic inflammation

Autori: Patrizia Murer, Dario Neri
Pubblicato in: New Biotechnology, Numero 52, 2019, Pagina/e 42-53, ISSN 1871-6784
Editore: Elsevier BV
DOI: 10.1016/j.nbt.2019.04.002

Antibody-Based Delivery of Cytokine Payloads to Carbonic Anhydrase IX Leads to Cancer Cures in Immunocompetent Tumor-Bearing Mice

Autori: Barbara Ziffels, Marco Stringhini, Philipp Probst, Tim Fugmann, Theo Sturm, Dario Neri
Pubblicato in: Molecular Cancer Therapeutics, Numero 18/9, 2019, Pagina/e 1544-1554, ISSN 1535-7163
Editore: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-18-1301

In Vivo Antitumor Activity of a Novel Acetazolamide–Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas

Autori: Cazzamalli, Samuele; Figueras, Eduard; Pethő, Lilla; Borbély, Adina; Steinkühler, Christian; Neri, Dario; Sewald, Norbert
Pubblicato in: ACS Omega, 3 (11), Numero 1, 2018, Pagina/e 14726-14731, ISSN 2470-1343
Editore: American Chemistry Society
DOI: 10.3929/ethz-b-000304161

Potentiation of PD-L1 blockade with a potency-matched dual cytokine–antibody fusion protein leads to cancer eradication in BALB/c-derived tumors but not in other mouse strains

Autori: Roberto De Luca, Dario Neri
Pubblicato in: Cancer Immunology, Immunotherapy, Numero 67/9, 2018, Pagina/e 1381-1391, ISSN 0340-7004
Editore: Springer Verlag
DOI: 10.1007/s00262-018-2194-0

Design and characterisation of a novel interleukin-15 receptor alpha fusion protein and analysis of interleukin-15 complexation

Autori: Anja Sophie Schmid, Dario Neri
Pubblicato in: PLOS ONE, Numero 14/7, 2019, Pagina/e e0219313, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0219313

DNA-Compatible Diazo-Transfer Reaction in Aqueous Media Suitable for DNA-Encoded Chemical Library Synthesis

Autori: Adrián Gironda-Martínez, Dario Neri, Florent Samain, Etienne J. Donckele
Pubblicato in: Organic Letters, Numero 21/23, 2019, Pagina/e 9555-9558, ISSN 1523-7060
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.9b03726

Comparative evaluation of bolus and fractionated administration modalities for two antibody-cytokine fusions in immunocompetent tumor-bearing mice

Autori: Emanuele Puca, Roberto De Luca, Frauke Seehusen, Josep Maria Monné Rodriguez, Dario Neri
Pubblicato in: Journal of Controlled Release, 2019, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2019.11.036

The antibody‐based delivery of interleukin‐12 to solid tumors boosts NK and CD8 + T cell activity and synergizes with immune checkpoint inhibitors

Autori: Emanuele Puca, Philipp Probst, Marco Stringhini, Patrizia Murer, Giovanni Pellegrini, Samuele Cazzamalli, Cornelia Hutmacher, Baptiste Gouyou, Sarah Wulhfard, Mattia Matasci, Alessandra Villa, Dario Neri
Pubblicato in: International Journal of Cancer, 2019, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.32603

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade

Autori: Sheila Dakhel, Tiziano Ongaro, Baptiste Gouyou, Mattia Matasci, Alessandra Villa, Dario Neri, Samuele Cazzamalli
Pubblicato in: Oncotarget, Numero 10/62, 2019, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.27320

Targeted Delivery of IL2 to the Tumor Stroma Potentiates the Action of Immune Checkpoint Inhibitors by Preferential Activation of NK and CD8 + T Cells

Autori: Cornelia Hutmacher, Nicolás Gonzalo Núñez, Anna Rita Liuzzi, Burkhard Becher, Dario Neri
Pubblicato in: Cancer Immunology Research, Numero 7/4, 2019, Pagina/e 572-583, ISSN 2326-6066
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-18-0566

Antibody–Cytokine Fusions: Versatile Products for the Modulation of Anticancer Immunity

Autori: Dario Neri
Pubblicato in: Cancer Immunology Research, Numero 7/3, 2019, Pagina/e 348-354, ISSN 2326-6066
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.cir-18-0622

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia

Autori: Padma Akkapeddi, Rita Fragoso, Julie A. Hixon, Ana Sofia Ramalho, Mariana L. Oliveira, Tânia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K. Durum, Dario Neri, Gonçalo J. L. Bernardes, João T. Barata
Pubblicato in: Leukemia, Numero 33/9, 2019, Pagina/e 2155-2168, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-019-0434-8

Immunocytokines and bispecific antibodies: two complementary strategies for the selective activation of immune cells at the tumor site

Autori: Jonathan D. Kiefer, Dario Neri
Pubblicato in: Immunological Reviews, Numero 270/1, 2016, Pagina/e 178-192, ISSN 0105-2896
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imr.12391

Antibody Format and Drug Release Rate Determine the Therapeutic Activity of Noninternalizing Antibody-Drug Conjugates

Autori: R. Gebleux, S. Wulhfard, G. Casi, D. Neri
Pubblicato in: Molecular Cancer Therapeutics, Numero 14/11, 2015, Pagina/e 2606-2612, ISSN 1535-7163
Editore: American Association for Cancer Research
DOI: 10.1158/1535-7163.MCT-15-0480

Immunocytokines: a novel class of products for the treatment of chronic inflammation and autoimmune conditions

Autori: Franziska Bootz, Dario Neri
Pubblicato in: Drug Discovery Today, Numero 21/1, 2016, Pagina/e 180-189, ISSN 1359-6446
Editore: Elsevier BV
DOI: 10.1016/j.drudis.2015.10.012

High-sensitivity HLA class I peptidome analysis enables a precise definition of peptide motifs and the identification of peptides from cell lines and patients’ sera

Autori: Danilo Ritz, Andreas Gloger, Benjamin Weide, Claus Garbe, Dario Neri, Tim Fugmann
Pubblicato in: PROTEOMICS, 2016, Pagina/e n/a-n/a, ISSN 1615-9853
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.201500445

Immunocytokines for cancer treatment: past, present and future

Autori: Dario Neri, Paul M Sondel
Pubblicato in: Current Opinion in Immunology, Numero 40, 2016, Pagina/e 96-102, ISSN 0952-7915
Editore: Elsevier BV
DOI: 10.1016/j.coi.2016.03.006

A universal reporter cell line for bioactivity evaluation of engineered cytokine products

Autori: Jacqueline Mock, Christian Pellegrino, Dario Neri
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-60182-4

A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasis

Autori: Patrizia Murer, Louis Plüss, Dario Neri
Pubblicato in: mAbs, Numero 12/1, 2020, Pagina/e 1714371, ISSN 1942-0870
Editore: Landes Bioscience
DOI: 10.1080/19420862.2020.1714371