Pubblicazioni Peer reviewed articles (55) Protease-Cleavable Linkers Modulate the Anticancer Activity of Noninternalizing Antibody–Drug Conjugates Autori: Alberto Dal Corso, Samuele Cazzamalli, Rémy Gébleux, Martin Mattarella, Dario Neri Pubblicato in: Bioconjugate Chemistry, Numero 28/7, 2017, Pagina/e 1826-1833, ISSN 1043-1802 Editore: American Chemical Society DOI: 10.1021/acs.bioconjchem.7b00304 A Specific and Covalent JNK-1 Ligand Selected from an Encoded Self-Assembling Chemical Library Autori: Gunther Zimmermann, Ulrike Rieder, Davor Bajic, Sara Vanetti, Apirat Chaikuad, Stefan Knapp, Jörg Scheuermann, Martin Mattarella, Dario Neri Pubblicato in: Chemistry - A European Journal, Numero 23/34, 2017, Pagina/e 8152-8155, ISSN 0947-6539 Editore: John Wiley & Sons Ltd. DOI: 10.1002/chem.201701644 DNA-Encoded Chemical Libraries: A Selection System Based On Endowing Organic Compounds with Amplifiable Information Autori: Dario Neri, Richard A. Lerner Pubblicato in: Annual Review of Biochemistry, Numero 87/1, 2018, ISSN 0066-4154 Editore: Annual Reviews, Inc. DOI: 10.1146/annurev-biochem-062917-012550 Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8 + T-cell Recognition of a Retroviral Antigen Autori: Philipp Probst, Janine Kopp, Annette Oxenius, Mario P. Colombo, Danilo Ritz, Tim Fugmann, Dario Neri Pubblicato in: Cancer Research, Numero 77/13, 2017, Pagina/e 3644-3654, ISSN 0008-5472 Editore: American Association for Cancer Research DOI: 10.1158/0008-5472.CAN-16-2946 A non-internalizing antibody-drug conjugate based on an anthracycline payload displays potent therapeutic activity in vivo Autori: Alberto Dal Corso, Rémy Gébleux, Patrizia Murer, Alex Soltermann, Dario Neri Pubblicato in: Journal of Controlled Release, Numero 264, 2017, Pagina/e 211-218, ISSN 0168-3659 Editore: Elsevier BV DOI: 10.1016/j.jconrel.2017.08.040 Intratumoral administration of IL2- and TNF-based fusion proteins cures cancer without establishing protective immunity Autori: Barbara Ziffels, Francesca Pretto, Dario Neri Pubblicato in: Immunotherapy, Numero 10/3, 2018, Pagina/e 177-188, ISSN 1750-743X Editore: Future Medicine Ltd. DOI: 10.2217/imt-2017-0119 Potency-matched Dual Cytokine–Antibody Fusion Proteins for Cancer Therapy Autori: Roberto De Luca, Alex Soltermann, Francesca Pretto, Catherine Pemberton-Ross, Giovanni Pellegrini, Sarah Wulhfard, Dario Neri Pubblicato in: Molecular Cancer Therapeutics, Numero 16/11, 2017, Pagina/e 2442-2451, ISSN 1535-7163 Editore: American Association for Cancer Research DOI: 10.1158/1535-7163.MCT-17-0211 Antibody-based targeted delivery of interleukin-4 synergizes with dexamethasone for the reduction of inflammation in arthritis Autori: Anja Sophie Schmid, Teresa Hemmerle, Francesca Pretto, Anja Kipar, Dario Neri Pubblicato in: Rheumatology, 2018, ISSN 1462-0324 Editore: Oxford University Press DOI: 10.1093/rheumatology/kex447 Data-Independent Acquisition of HLA Class I Peptidomes on the Q Exactive Mass Spectrometer Platform Autori: Danilo Ritz, Jonny Kinzi, Dario Neri, Tim Fugmann Pubblicato in: PROTEOMICS, Numero 17/19, 2017, Pagina/e 1700177, ISSN 1615-9853 Editore: John Wiley & Sons Ltd. DOI: 10.1002/pmic.201700177 Chemically Defined Antibody– and Small Molecule–Drug Conjugates for in Vivo Tumor Targeting Applications: A Comparative Analysis Autori: Samuele Cazzamalli, Alberto Dal Corso, Fontaine Widmayer, Dario Neri Pubblicato in: Journal of the American Chemical Society, Numero 140/5, 2018, Pagina/e 1617-1621, ISSN 0002-7863 Editore: American Chemical Society DOI: 10.1021/jacs.7b13361 Novel antibody-cytokine fusion proteins featuring granulocyte-colony stimulating factor, interleukin-3 and interleukin-4 as payloads Autori: Anja Sophie Schmid, Diana Tintor, Dario Neri Pubblicato in: Journal of Biotechnology, Numero 271, 2018, Pagina/e 29-36, ISSN 0168-1656 Editore: Elsevier BV DOI: 10.1016/j.jbiotec.2018.02.004 Membranal and blood-soluble HLA class II peptidome analyses using data-dependent and independent acquisition Autori: Danilo Ritz, Emiliano Sani, Hanna Debiec, Pierre Ronco, Dario Neri, Tim Fugmann Pubblicato in: PROTEOMICS, 2018, ISSN 1615-9853 Editore: John Wiley & Sons Ltd. DOI: 10.1002/pmic.201700246 Targeted Delivery of Cytotoxic Drugs: Challenges, Opportunities and New Developments Autori: Samuele Cazzamalli, Alberto Dal Corso, Dario Neri Pubblicato in: CHIMIA International Journal for Chemistry, Numero 71/10, 2017, Pagina/e 712-715, ISSN 0009-4293 Editore: Schweizerische Chemische Gedellschaft DOI: 10.2533/chimia.2017.712 Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold Autori: Yizhou Li, Roberto De Luca, Samuele Cazzamalli, Francesca Pretto, Davor Bajic, Jörg Scheuermann, Dario Neri Pubblicato in: Nature Chemistry, Numero 10/4, 2018, Pagina/e 441-448, ISSN 1755-4330 Editore: Nature Publishing Group DOI: 10.1038/s41557-018-0017-8 DNA-encoded chemical libraries - achievements and remaining challenges Autori: Nicholas Favalli, Gabriele Bassi, Jörg Scheuermann, Dario Neri Pubblicato in: FEBS Letters, Numero 592/12, 2018, Pagina/e 2168-2180, ISSN 0014-5793 Editore: Elsevier BV DOI: 10.1002/1873-3468.13068 A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition Autori: Nicholas Favalli, Stefan Biendl, Marco Hartmann, Jacopo Piazzi, Filippo Sladojevich, Susanne Gräslund, Peter J. Brown, Katja Näreoja, Herwig Schüler, Jörg Scheuermann, Raphael Franzini, Dario Neri Pubblicato in: ChemMedChem, Numero 13/13, 2018, Pagina/e 1303-1307, ISSN 1860-7179 Editore: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/cmdc.201800193 Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2 Autori: Samuele Cazzamalli, Barbara Ziffels, Fontaine Widmayer, Patrizia Murer, Giovanni Pellegrini, Francesca Pretto, Sarah Wulhfard, Dario Neri Pubblicato in: Clinical Cancer Research, Numero 24/15, 2018, Pagina/e 3656-3667, ISSN 1078-0432 Editore: American Association for Cancer Research DOI: 10.1158/1078-0432.CCR-17-3457 DNA-encoded chemical libraries: foundations and applications in lead discovery Autori: Gunther Zimmermann, Dario Neri Pubblicato in: Drug Discovery Today, Numero 21/11, 2016, Pagina/e 1828-1834, ISSN 1359-6446 Editore: Elsevier BV DOI: 10.1016/j.drudis.2016.07.013 Purification of soluble HLA class I complexes from human serum or plasma deliver high quality immuno peptidomes required for biomarker discovery Autori: Danilo Ritz, Andreas Gloger, Dario Neri, Tim Fugmann Pubblicato in: PROTEOMICS, Numero 17/1-2, 2017, Pagina/e 1600364, ISSN 1615-9853 Editore: John Wiley & Sons Ltd. DOI: 10.1002/pmic.201600364 Different tissue distribution properties for glycosylation variants of fusion proteins containing the p40 subunit of murine interleukin-12 Autori: F. Bootz, D. Venetz, B. Ziffels, D. Neri Pubblicato in: Protein Engineering Design and Selection, Numero 29/10, 2016, Pagina/e 445-455, ISSN 1741-0126 Editore: Oxford University Press DOI: 10.1093/protein/gzw038 Acetazolamide Serves as Selective Delivery Vehicle for Dipeptide-Linked Drugs to Renal Cell Carcinoma Autori: Samuele Cazzamalli, Alberto Dal Corso, Dario Neri Pubblicato in: Molecular Cancer Therapeutics, Numero 15/12, 2016, Pagina/e 2926-2935, ISSN 1535-7163 Editore: American Association for Cancer Research DOI: 10.1158/1535-7163.MCT-16-0283 Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes Autori: Andreas Gloger, Danilo Ritz, Tim Fugmann, Dario Neri Pubblicato in: Cancer Immunology, Immunotherapy, Numero 65/11, 2016, Pagina/e 1377-1393, ISSN 0340-7004 Editore: Springer Verlag DOI: 10.1007/s00262-016-1897-3 Targeted Reconstitution of Cytokine Activity upon Antigen Binding using Split Cytokine Antibody Fusion Proteins Autori: Dario Venetz, Danil Koovely, Bruce Weder, Dario Neri Pubblicato in: Journal of Biological Chemistry, Numero 291/35, 2016, Pagina/e 18139-18147, ISSN 0021-9258 Editore: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/jbc.M116.737734 Optimized Reaction Conditions for Amide Bond Formation in DNA-Encoded Combinatorial Libraries Autori: Yizhou Li, Elena Gabriele, Florent Samain, Nicholas Favalli, Filippo Sladojevich, Jörg Scheuermann, Dario Neri Pubblicato in: ACS Combinatorial Science, Numero 18/8, 2016, Pagina/e 438-443, ISSN 2156-8952 Editore: American Chemical Society DOI: 10.1021/acscombsci.6b00058 Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma Autori: Samuele Cazzamalli, Alberto Dal Corso, Dario Neri Pubblicato in: Journal of Controlled Release, Numero 246, 2017, Pagina/e 39-45, ISSN 0168-3659 Editore: Elsevier BV DOI: 10.1016/j.jconrel.2016.11.023 Non-internalizing antibody-drug conjugates display potent anti-cancer activity upon proteolytic release of monomethyl auristatin E in the subendothelial extracellular matrix Autori: Rémy Gébleux, Marco Stringhini, Ruben Casanova, Alex Soltermann, Dario Neri Pubblicato in: International Journal of Cancer, Numero 140/7, 2017, Pagina/e 1670-1679, ISSN 0020-7136 Editore: John Wiley & Sons Inc. DOI: 10.1002/ijc.30569 The MHC Class II Immunopeptidome of Lymph Nodes in Health and in Chemically Induced Colitis Autori: Tim Fugmann, Adriana Sofron, Danilo Ritz, Franziska Bootz, Dario Neri Pubblicato in: The Journal of Immunology, Numero 198/3, 2017, Pagina/e 1357-1364, ISSN 0022-1767 Editore: American Association of Immunologists DOI: 10.4049/jimmunol.1601157 Intralesional treatment of metastatic melanoma: a review of therapeutic options Autori: Benjamin Weide, Dario Neri, Giuliano Elia Pubblicato in: Cancer Immunology, Immunotherapy, 2017, ISSN 0340-7004 Editore: Springer Verlag DOI: 10.1007/s00262-016-1952-0 Hit-Validation Methodologies for Ligands Isolated from DNA-Encoded Chemical Libraries Autori: Gunther Zimmermann, Yizhou Li, Ulrike Rieder, Martin Mattarella, Dario Neri, Jörg Scheuermann Pubblicato in: ChemBioChem, 2017, ISSN 1439-4227 Editore: John Wiley & Sons Ltd. DOI: 10.1002/cbic.201600637 Quantitative PCR is a Valuable Tool to Monitor the Performance of DNA-Encoded Chemical Library Selections Autori: Yizhou Li, Gunther Zimmermann, Jörg Scheuermann, Dario Neri Pubblicato in: ChemBioChem, 2017, ISSN 1439-4227 Editore: John Wiley & Sons Ltd. DOI: 10.1002/cbic.201600626 A novel dual-cytokine–antibody fusion protein for the treatment of CD38-positive malignancies Autori: Roberto De Luca, Paul Kachel, Klara Kropivsek, Berend Snijder, Markus G Manz, Dario Neri Pubblicato in: Protein Engineering, Design and Selection, Numero 31/5, 2018, Pagina/e 173-179, ISSN 1741-0126 Editore: Oxford University Press DOI: 10.1093/protein/gzy015 Antibody-based Delivery of TNF to the Tumor Neovasculature Potentiates the Therapeutic Activity of a Peptide Anticancer Vaccine Autori: Philipp Probst, Marco Stringhini, Danilo Ritz, Tim Fugmann, Dario Neri Pubblicato in: Clinical Cancer Research, Numero 25/2, 2019, Pagina/e 698-709, ISSN 1078-0432 Editore: American Association for Cancer Research DOI: 10.1158/1078-0432.CCR-18-1728 Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation Autori: Simon Schwager, Silvana Renner, Teresa Hemmerle, Sinem Karaman, Steven T. Proulx, Roman Fetz, Alexandra Michaela Golding-Ochsenbein, Philipp Probst, Cornelia Halin, Dario Neri, Michael Detmar Pubblicato in: JCI Insight, Numero 3/23, 2018, ISSN 2379-3708 Editore: The American Society for Clinical Investigation DOI: 10.1172/jci.insight.124850 A Novel Fully-Human Potency-Matched Dual Cytokine-Antibody Fusion Protein Targets Carbonic Anhydrase IX in Renal Cell Carcinomas Autori: Roberto De Luca, Baptiste Gouyou, Tiziano Ongaro, Alessandra Villa, Barbara Ziffels, Alessandro Sannino, Gianluca Buttinoni, Simone Galeazzi, Mirko Mazzacuva, Dario Neri Pubblicato in: Frontiers in Oncology, Numero 9, 2019, ISSN 2234-943X Editore: Frontiers Media S. A. DOI: 10.3389/fonc.2019.01228 Development of a novel fully-human anti-CD123 antibody to target acute myeloid leukemia Autori: Cornelia Hutmacher, Laura Volta, Francesco Rinaldi, Patrizia Murer, Renier Myburgh, Markus G. Manz, Dario Neri Pubblicato in: Leukemia Research, Numero 84, 2019, Pagina/e 106178, ISSN 0145-2126 Editore: Pergamon Press Ltd. DOI: 10.1016/j.leukres.2019.106178 Targeted Delivery of TNF Potentiates the Antibody-Dependent Cell-Mediated Cytotoxicity of an Anti-Melanoma Immunoglobulin Autori: Patrizia Murer, Jonathan D. Kiefer, Louis Plüss, Mattia Matasci, Sandra L. Blümich, Marco Stringhini, Dario Neri Pubblicato in: Journal of Investigative Dermatology, Numero 139/6, 2019, Pagina/e 1339-1348, ISSN 0022-202X Editore: Blackwell Publishing Inc. DOI: 10.1016/j.jid.2018.11.028 Antibody-cytokine fusion proteins: A novel class of biopharmaceuticals for the therapy of cancer and of chronic inflammation Autori: Patrizia Murer, Dario Neri Pubblicato in: New Biotechnology, Numero 52, 2019, Pagina/e 42-53, ISSN 1871-6784 Editore: Elsevier BV DOI: 10.1016/j.nbt.2019.04.002 Antibody-Based Delivery of Cytokine Payloads to Carbonic Anhydrase IX Leads to Cancer Cures in Immunocompetent Tumor-Bearing Mice Autori: Barbara Ziffels, Marco Stringhini, Philipp Probst, Tim Fugmann, Theo Sturm, Dario Neri Pubblicato in: Molecular Cancer Therapeutics, Numero 18/9, 2019, Pagina/e 1544-1554, ISSN 1535-7163 Editore: American Association for Cancer Research DOI: 10.1158/1535-7163.mct-18-1301 In Vivo Antitumor Activity of a Novel Acetazolamide–Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas Autori: Cazzamalli, Samuele; Figueras, Eduard; Pethő, Lilla; Borbély, Adina; Steinkühler, Christian; Neri, Dario; Sewald, Norbert Pubblicato in: ACS Omega, 3 (11), Numero 1, 2018, Pagina/e 14726-14731, ISSN 2470-1343 Editore: American Chemistry Society DOI: 10.3929/ethz-b-000304161 Potentiation of PD-L1 blockade with a potency-matched dual cytokine–antibody fusion protein leads to cancer eradication in BALB/c-derived tumors but not in other mouse strains Autori: Roberto De Luca, Dario Neri Pubblicato in: Cancer Immunology, Immunotherapy, Numero 67/9, 2018, Pagina/e 1381-1391, ISSN 0340-7004 Editore: Springer Verlag DOI: 10.1007/s00262-018-2194-0 Design and characterisation of a novel interleukin-15 receptor alpha fusion protein and analysis of interleukin-15 complexation Autori: Anja Sophie Schmid, Dario Neri Pubblicato in: PLOS ONE, Numero 14/7, 2019, Pagina/e e0219313, ISSN 1932-6203 Editore: Public Library of Science DOI: 10.1371/journal.pone.0219313 DNA-Compatible Diazo-Transfer Reaction in Aqueous Media Suitable for DNA-Encoded Chemical Library Synthesis Autori: Adrián Gironda-Martínez, Dario Neri, Florent Samain, Etienne J. Donckele Pubblicato in: Organic Letters, Numero 21/23, 2019, Pagina/e 9555-9558, ISSN 1523-7060 Editore: American Chemical Society DOI: 10.1021/acs.orglett.9b03726 Comparative evaluation of bolus and fractionated administration modalities for two antibody-cytokine fusions in immunocompetent tumor-bearing mice Autori: Emanuele Puca, Roberto De Luca, Frauke Seehusen, Josep Maria Monné Rodriguez, Dario Neri Pubblicato in: Journal of Controlled Release, 2019, ISSN 0168-3659 Editore: Elsevier BV DOI: 10.1016/j.jconrel.2019.11.036 The antibody‐based delivery of interleukin‐12 to solid tumors boosts NK and CD8 + T cell activity and synergizes with immune checkpoint inhibitors Autori: Emanuele Puca, Philipp Probst, Marco Stringhini, Patrizia Murer, Giovanni Pellegrini, Samuele Cazzamalli, Cornelia Hutmacher, Baptiste Gouyou, Sarah Wulhfard, Mattia Matasci, Alessandra Villa, Dario Neri Pubblicato in: International Journal of Cancer, 2019, ISSN 0020-7136 Editore: John Wiley & Sons Inc. DOI: 10.1002/ijc.32603 Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade Autori: Sheila Dakhel, Tiziano Ongaro, Baptiste Gouyou, Mattia Matasci, Alessandra Villa, Dario Neri, Samuele Cazzamalli Pubblicato in: Oncotarget, Numero 10/62, 2019, ISSN 1949-2553 Editore: Impact Journals DOI: 10.18632/oncotarget.27320 Targeted Delivery of IL2 to the Tumor Stroma Potentiates the Action of Immune Checkpoint Inhibitors by Preferential Activation of NK and CD8 + T Cells Autori: Cornelia Hutmacher, Nicolás Gonzalo Núñez, Anna Rita Liuzzi, Burkhard Becher, Dario Neri Pubblicato in: Cancer Immunology Research, Numero 7/4, 2019, Pagina/e 572-583, ISSN 2326-6066 Editore: American Association for Cancer Research Inc. DOI: 10.1158/2326-6066.cir-18-0566 Antibody–Cytokine Fusions: Versatile Products for the Modulation of Anticancer Immunity Autori: Dario Neri Pubblicato in: Cancer Immunology Research, Numero 7/3, 2019, Pagina/e 348-354, ISSN 2326-6066 Editore: American Association for Cancer Research Inc. DOI: 10.1158/2326-6066.cir-18-0622 A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia Autori: Padma Akkapeddi, Rita Fragoso, Julie A. Hixon, Ana Sofia Ramalho, Mariana L. Oliveira, Tânia Carvalho, Andreas Gloger, Mattia Matasci, Francisco Corzana, Scott K. Durum, Dario Neri, Gonçalo J. L. Bernardes, João T. Barata Pubblicato in: Leukemia, Numero 33/9, 2019, Pagina/e 2155-2168, ISSN 0887-6924 Editore: Nature Publishing Group DOI: 10.1038/s41375-019-0434-8 Immunocytokines and bispecific antibodies: two complementary strategies for the selective activation of immune cells at the tumor site Autori: Jonathan D. Kiefer, Dario Neri Pubblicato in: Immunological Reviews, Numero 270/1, 2016, Pagina/e 178-192, ISSN 0105-2896 Editore: Blackwell Publishing Inc. DOI: 10.1111/imr.12391 Antibody Format and Drug Release Rate Determine the Therapeutic Activity of Noninternalizing Antibody-Drug Conjugates Autori: R. Gebleux, S. Wulhfard, G. Casi, D. Neri Pubblicato in: Molecular Cancer Therapeutics, Numero 14/11, 2015, Pagina/e 2606-2612, ISSN 1535-7163 Editore: American Association for Cancer Research DOI: 10.1158/1535-7163.MCT-15-0480 Immunocytokines: a novel class of products for the treatment of chronic inflammation and autoimmune conditions Autori: Franziska Bootz, Dario Neri Pubblicato in: Drug Discovery Today, Numero 21/1, 2016, Pagina/e 180-189, ISSN 1359-6446 Editore: Elsevier BV DOI: 10.1016/j.drudis.2015.10.012 High-sensitivity HLA class I peptidome analysis enables a precise definition of peptide motifs and the identification of peptides from cell lines and patients’ sera Autori: Danilo Ritz, Andreas Gloger, Benjamin Weide, Claus Garbe, Dario Neri, Tim Fugmann Pubblicato in: PROTEOMICS, 2016, Pagina/e n/a-n/a, ISSN 1615-9853 Editore: John Wiley & Sons Ltd. DOI: 10.1002/pmic.201500445 Immunocytokines for cancer treatment: past, present and future Autori: Dario Neri, Paul M Sondel Pubblicato in: Current Opinion in Immunology, Numero 40, 2016, Pagina/e 96-102, ISSN 0952-7915 Editore: Elsevier BV DOI: 10.1016/j.coi.2016.03.006 A universal reporter cell line for bioactivity evaluation of engineered cytokine products Autori: Jacqueline Mock, Christian Pellegrino, Dario Neri Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322 Editore: Nature Publishing Group DOI: 10.1038/s41598-020-60182-4 A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasis Autori: Patrizia Murer, Louis Plüss, Dario Neri Pubblicato in: mAbs, Numero 12/1, 2020, Pagina/e 1714371, ISSN 1942-0870 Editore: Landes Bioscience DOI: 10.1080/19420862.2020.1714371 È in corso la ricerca di dati su OpenAIRE... Si è verificato un errore durante la ricerca dei dati su OpenAIRE Nessun risultato disponibile
