Function and malfunction of the prion protein

Información del proyecto

PRION2020

Identificador del acuerdo de subvención: 670958

DOI

10.3030/670958

Proyecto cerrado

Fecha de la firma de la CE 5 Octubre 2015

Fecha de inicio 1 Noviembre 2015

Fecha de finalización 31 Octubre 2020

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 500 000,00

Aportación de la UE

€ 2 500 000,00

Coordinado por

UNIVERSITAT ZURICH
Switzerland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (31)

Prion infection, transmission, and cytopathology modeled in a low-biohazard human cell line

Autores: Merve Avar, Daniel Heinzer, Nicolas Steinke, Berre Doğançay, Rita Moos, Severine Lugan, Claudia Cosenza, Simone Hornemann, Olivier Andréoletti, Adriano Aguzzi
Publicado en: Life Science Alliance, Edición 3/8, 2020, Página(s) e202000814, ISSN 2575-1077
Editor: Life Science Alliance
DOI: 10.26508/lsa.202000814

Loss of PIKfyve drives the spongiform degeneration in prion diseases

Autores: Asvin K K Lakkaraju, Karl Frontzek, Emina Lemes, Uli Herrmann, Marco Losa, Rajlakshmi Marpakwar, Adriano Aguzzi
Publicado en: EMBO Molecular Medicine, Edición 13/9, 2021, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202114714

The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis

Autores: Bei Li, Meiling Chen, Adriano Aguzzi, Caihong Zhu
Publicado en: Journal of Molecular Medicine, Edición 99/6, 2021, Página(s) 877-887, ISSN 0946-2716
Editor: Springer Verlag
DOI: 10.1007/s00109-021-02061-7

LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies

Autores: Marc Emmenegger, Elena De Cecco, Marian Hruska‐Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa‐Vergniory, Andrès Gonzalez‐Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin Luk, Ronald Melki, Philipp
Publicado en: EMBO Molecular Medicine, Edición 13/9, 2021, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202114745

Protective anti‐prion antibodies in human immunoglobulin repertoires

Autores: Assunta Senatore, Karl Frontzek, Marc Emmenegger, Andra Chincisan, Marco Losa, Regina Reimann, Geraldine Horny, Jingjing Guo, Sylvie Fels, Silvia Sorce, Caihong Zhu, Nathalie George, Stefan Ewert, Thomas Pietzonka, Simone Hornemann, Adriano Aguzzi
Publicado en: EMBO Molecular Medicine, Edición e12739, 2020, Página(s) 1-19, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012739

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein

Autores: Eleanna Kara, Alessandro Crimi, Anne Wiedmer, Marc Emmenegger, Claudia Manzoni, Sara Bandres-Ciga, Karishma D’Sa, Regina H. Reynolds, Juan A. Botía, Marco Losa, Veronika Lysenko, Manfredi Carta, Daniel Heinzer, Merve Avar, Andra Chincisan, Cornelis Blauwendraat, Sonia García-Ruiz, Daniel Pease, Lorene Mottier, Alessandra Carrella, Dezirae Beck-Schneider, Andreia D. Magalhães, Caroline Aemiseg
Publicado en: Cell Reports, Edición 35/10, 2021, Página(s) 109189, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109189

Toward Therapy of Human Prion Diseases

Autores: Adriano Aguzzi, Asvin K.K. Lakkaraju, Karl Frontzek
Publicado en: Annual Review of Pharmacology and Toxicology, Edición 58/1, 2018, Página(s) 331-351, ISSN 0362-1642
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-pharmtox-010617-052745

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

Autores: Despoina Goniotaki, Asvin K. K. Lakkaraju, Amulya N. Shrivastava, Pamela Bakirci, Silvia Sorce, Assunta Senatore, Rajlakshmi Marpakwar, Simone Hornemann, Fabrizio Gasparini, Antoine Triller, Adriano Aguzzi
Publicado en: PLOS Pathogens, Edición 13/11, 2017, Página(s) e1006733, ISSN 1553-7374
Editor: PLOS Pathogens
DOI: 10.1371/journal.ppat.1006733

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

Autores: Küffer, Alexander; Lakkaraju, Asvin K. K.; Mogha, Amit; Petersen, Sarah C.; Airich, Kristina; Doucerain, Cédric; Marpakwar, Rajlakshmi; Bakirci, Pamela; Senatore, Assunta; Monnard, Arnaud; Schiavi, Carmen; Nuvolone, Mario; Grosshans, Bianka; Hornemann, Simone; Bassilana, Frederic; Monk, Kelly R.; Aguzzi, Adriano
Publicado en: Nature, Edición 4, 2016, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.5167/uzh-125485

Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay

Autores: Ballmer, Boris A.; Moos, Rita; Liberali, Prisca; Pelkmans, Lucas; Hornemann, Simone; Aguzzi, Adriano
Publicado en: Journal of Biological Chemistry, Edición 292(20), 2017, Página(s) 8356-8368., ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.5167/uzh-136555

Absolute Quantification of Amyloid Propagons by Digital Microfluidics

Autores: Pfammatter, Manuela; Andreasen, Maria; Meisl, Georg; Taylor, Christopher G; Adamcik, Jozef; Bolisetty, Sreenath; Sanchez-Ferrer, Antoni; Klenerman, David; Dobson, Christopher M; Mezzenga, Raffaele; Knowles, Tuomas P J; Aguzzi, Adriano A; Hornemann, Simone
Publicado en: Analytical Chemistry, Edición 89(22), 2017, Página(s) 12306-12313, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.5167/uzh-141180

Prions, prionoids and protein misfolding disorders

Autores: Claudia Scheckel, Adriano Aguzzi
Publicado en: Nature Reviews Genetics, Edición 19/7, 2018, Página(s) 405-418, ISSN 1471-0056
Editor: Nature Publishing Group
DOI: 10.1038/s41576-018-0011-4

Intrinsic Toxicity of Antibodies to the Globular Domain of the Prion Protein

Autores: Reimann, Regina R; Aguzzi, Adriano
Publicado en: Biological Psychiatry, Edición 12 April 2018, 2018, ISSN 0006-3223
Editor: Elsevier BV
DOI: 10.5167/uzh-151650

A neuroprotective role for microglia in prion diseases

Autores: Caihong Zhu, Uli S. Herrmann, Jeppe Falsig, Irina Abakumova, Mario Nuvolone, Petra Schwarz, Katrin Frauenknecht, Elisabeth J. Rushing, Adriano Aguzzi
Publicado en: The Journal of Experimental Medicine, Edición 213/6, 2016, Página(s) 1047-1059, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20151000

Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein

Autores: Henning Leske, Simone Hornemann, Uli Simon Herrmann, Caihong Zhu, Paolo Dametto, Bei Li, Florent Laferriere, Magdalini Polymenidou, Pawel Pelczar, Regina Rose Reimann, Petra Schwarz, Elisabeth Jane Rushing, Kurt Wüthrich, Adriano Aguzzi
Publicado en: PLOS ONE, Edición 12/2, 2017, Página(s) e0170503, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0170503

Cell Biology of Prions and Prionoids: A Status Report

Autores: Adriano Aguzzi, Asvin K.K. Lakkaraju
Publicado en: Trends in Cell Biology, Edición 26/1, 2016, Página(s) 40-51, ISSN 0962-8924
Editor: Elsevier BV
DOI: 10.1016/j.tcb.2015.08.007

Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication

Autores: Karl Frontzek, Manuela Pfammatter, Silvia Sorce, Assunta Senatore, Petra Schwarz, Rita Moos, Katrin Frauenknecht, Simone Hornemann, Adriano Aguzzi
Publicado en: PLOS ONE, Edición 11/9, 2016, Página(s) e0163601, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0163601

The biological function of the cellular prion protein: an update

Autores: Marie-Angela Wulf, Assunta Senatore, Adriano Aguzzi
Publicado en: BMC Biology, Edición 15/1, 2017, ISSN 1741-7007
Editor: BioMed Central
DOI: 10.1186/s12915-017-0375-5

Strictly co-isogenic C57BL/6J- Prnp −/− mice: A rigorous resource for prion science

Autores: Mario Nuvolone, Mario Hermann, Silvia Sorce, Giancarlo Russo, Cinzia Tiberi, Petra Schwarz, Eric Minikel, Despina Sanoudou, Pawel Pelczar, Adriano Aguzzi
Publicado en: The Journal of Experimental Medicine, Edición 213/3, 2016, Página(s) 313-327, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20151610

Differential Toxicity of Antibodies to the Prion Protein

Autores: Regina R. Reimann, Tiziana Sonati, Simone Hornemann, Uli S. Herrmann, Michael Arand, Simon Hawke, Adriano Aguzzi
Publicado en: PLOS Pathogens, Edición 12/1, 2016, Página(s) e1005401, ISSN 1553-7374
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1005401

Genome-Wide Identification of microRNAs Regulating the Human Prion Protein

Autores: Pease, Daniel; Scheckel, Claudia; Schaper, Elke; Eckhardt, Valeria; Emmenegger, Marc; Xenarios, Ioannis; Aguzzi, Adriano
Publicado en: Pease, Daniel; Scheckel, Claudia; Schaper, Elke; Eckhardt, Valeria; Emmenegger, Marc; Xenarios, Ioannis; Aguzzi, Adriano (2019). Genome-Wide Identification of microRNAs Regulating the Human Prion Protein. Brain Pathology, 29(2):232-244., Edición 1, 2019, ISSN 1015-6305
Editor: International Society of Neuropathology
DOI: 10.5167/uzh-158645

NG2 glia are required for maintaining microglia homeostatic state

Autores: Yingjun Liu, Adriano Aguzzi
Publicado en: Glia, Edición 68/2, 2019, Página(s) 345-355, ISSN 0894-1491
Editor: John Wiley & Sons Inc.
DOI: 10.1002/glia.23721

GPR56/ADGRG1 regulates development and maintenance of peripheral myelin

Autores: Ackerman, Sarah D.; Luo, Rong; Poitelon, Yannick; Mogha, Amit; Harty, Breanne L.; D’Rozario, Mitchell; Sanchez, Nicholas E.; Lakkaraju, Asvin K.K.; Gamble, Paul; Li, Jun; Qu, Jun; MacEwan, Matthew R.; Ray, Wilson Zachary; Aguzzi, Adriano; Feltri, M. Laura; Piao, Xianhua; Monk, Kelly R.
Publicado en: Journal of Experimental Medicine, Edición 1, 2018, Página(s) 215(3):941-961., ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.5167/uzh-150267

Toxic Protein Spread in Neurodegeneration: Reality versus Fantasy

Autores: Eleanna Kara, Jordan D. Marks, Adriano Aguzzi
Publicado en: Trends in Molecular Medicine, Edición 24/12, 2018, Página(s) 1007-1020, ISSN 1471-4914
Editor: Elsevier BV
DOI: 10.1016/j.molmed.2018.09.004

Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency

Autores: Alexandre P. A. Theocharides, Pontus Lundberg, Asvin K. K. Lakkaraju, Veronika Lysenko, Renier Myburgh, Adriano Aguzzi, Radek C. Skoda, Markus G. Manz
Publicado en: Blood, Edición 127/25, 2016, Página(s) 3253-3259, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2016-02-696310

Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads

Autores: Hornemann, Simone; Schwarz, Petra; Rushing, Elisabeth J.; Connolly, Michael D.; Zuckermann, Ronald N.; Yam, Alice Y.; Aguzzi, Adriano
Publicado en: PLoS ONE, Vol 14, Iss 9, p e0216013 (2019), Edición 2, 2019, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.5167/uzh-177400

Immunotherapy for neurodegeneration?

Autores: Liu, Yingjun; Aguzzi, Adriano
Publicado en: Liu, Yingjun; Aguzzi, Adriano (2019). Immunotherapy for neurodegeneration? Science, 364(6436):130-131., Edición 1, 2019, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aaw0685

Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons

Autores: Claudia Scheckel; Marigona Imeri; Petra Schwarz; Adriano Aguzzi
Publicado en: eLife, Edición 1, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.5167/uzh-190429

Autoantibodies against the prion protein in individuals with PRNP mutations

Autores: Karl Frontzek, Manfredi Carta, Marco Losa, Mirka Epskamp, Georg Meisl, Alice Anane, Jean-Philippe Brandel, Ulrike Camenisch, Joaquín Castilla, Stéphane Haïk, Tuomas Knowles, Ewald Lindner, Andreas Lutterotti, Eric Vallabh Minikel, Ignazio Roiter, Jiri G. Safar, Raquel Sanchez-Valle, Dana Žáková, Simone Hornemann, Adriano Aguzzi
Publicado en: Neurology, 2020, Página(s) 10.1212/WNL.0000000000009183, ISSN 0028-3878
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000009183

Genome-wide transcriptomics identifies an early preclinical signature of prion infection

Autores: Silvia Sorce, Mario Nuvolone, Giancarlo Russo, Andra Chincisan, Daniel Heinzer, Merve Avar, Manuela Pfammatter, Petra Schwarz, Mirzet Delic, Micha Müller, Simone Hornemann, Despina Sanoudou, Claudia Scheckel, Adriano Aguzzi
Publicado en: PLOS Pathogens, Edición 16/6, 2020, Página(s) e1008653, ISSN 1553-7374
Editor: Public Library of Science (PLoS)
DOI: 10.1371/journal.ppat.1008653

Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins.

Autores: Marc Emmenegger; Sreedhar S. Kumar; Vishalini Emmenegger; Tomas Malinauskas; Thomas Buettner; Laura Rose; Peter Schierack; Martin F. Sprinzl; Clemens Sommer; Karl J. Lackner; Adriano Aguzzi; Dirk Roggenbuck; Katrin Frauenknecht
Publicado en: PLoS Pathogens, Edición 2, 2021, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.5167/uzh-211255