Individualised medicine in chronic inflammatory skin diseases

Informazioni relative al progetto

IMCIS

ID dell’accordo di sovvenzione: 676858

DOI 10.3030/676858

Progetto chiuso

Data della firma CE 7 Giugno 2016

Data di avvio 1 Luglio 2016

Data di completamento 31 Ottobre 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 495 906,00

Contributo UE € 1 495 906,00

Coordinato da

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany

Pubblicazioni

Peer reviewed articles (29)

Addictions in patients with atopic dermatitis: a cross-sectional pilot study in Germany.

Autori: Pilz AC, Durner V, Schielein MC, Schuster B, Beckmann J, Biedermann T, Eyerich K, Zink A
Pubblicato in: J Eur Acad Dermatol Venereol, 2022, ISSN 0926-9959
Editore: Elsevier BV
DOI: 10.1111/jdv.17708

Mechanisms of skin autoimmunity: Cellular and soluble immune components of the skin

Autori: Johann E. Gudjonsson, Kenji Kabashima, Kilian Eyerich
Pubblicato in: Journal of Allergy and Clinical Immunology, Numero 146/1, 2020, Pagina/e 8-16, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2020.05.009

CD23 Levels on B Cells Determine Long-Term Therapeutic Response in Patients with Atopic Eczema Treated with Selective IgE Immune Apheresis.

Autori: Thomas J, Wang R, Batra R, Böhner A, Garzorz-Stark N, Eberlein B, Theis F, Biedermann T, Schmidt-Weber C, Zink A, Eyerich K, Eyerich S.
Pubblicato in: J Invest Dermatol, 2021, ISSN 0022-202X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2020.05.122

Tofacitinib in Hypertrophic Lichen Planus.

Autori: Seiringer P, Lauffer F, Pilz AC, Boehmer D, Biedermann T, Eyerich K.
Pubblicato in: Acta Derm Venereol, 2020, ISSN 0001-5555
Editore: Taylor & Francis
DOI: 10.2340/00015555-3585

Bisphosphonates for the Treatment of Calcinosis Cutis-A Retrospective Single-Center Study.

Autori: Rauch L, Hein R, Biedermann T, Eyerich K, Lauffer F
Pubblicato in: Biomedicines, 2021, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines9111698

New biological treatments for asthma and skin allergies

Autori: Stefanie Eyerich, Martin Metz, Apostolos Bossios, Kilian Eyerich
Pubblicato in: Allergy, Numero 75/3, 2020, Pagina/e 546-560, ISSN 0105-4538
Editore: Blackwell Publishing Inc.
DOI: 10.1111/all.14027

So close, and yet so far away: The dichotomy of the specific immune response and inflammation in psoriasis and atopic dermatitis.

Autori: A Schäbitz; K Eyerich; K Eyerich; K Eyerich; N Garzorz-Stark; N Garzorz-Stark
Pubblicato in: J Intern Med, Numero 1, 2021, ISSN 1365-2796
Editore: Wiley
DOI: 10.1111/joim.13235

STAT1 gain of function and STAT3 loss of function mutations impair IL-17 and IL-22 immunity associated with CMC

Autori: Julia Hiller, Beate Hagl, Renate Effner, Anne Puel, Martin Schaller, Birgit Mascher, Stefanie Eyerich, Kilian Eyerich, Annette F. Jansson, Johannes Ring, Jean-Laurent Casanova, Ellen D. Renner, Claudia Traidl-Hoffmann
Pubblicato in: Journal of Investigative Dermatology, 2017, ISSN 0022-202X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2017.09.035

Sebocytes contribute to skin inflammation by promoting the differentiation of Th17 cells

Autori: M. Mattii, M. Lovászi, N. Garzorz, A. Atenhan, M. Quaranta, F. Lauffer, A. Konstantinow, M. Küpper, C. C. Zouboulis, L. Kemeny, K. Eyerich, C. B. Schmidt-Weber, D. Törőcsik, S. Eyerich
Pubblicato in: British Journal of Dermatology, 2017, ISSN 0007-0963
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bjd.15879

Sebum lipids influence macrophage polarization and activation

Autori: M. Lovászi, M. Mattii, K. Eyerich, A. Gácsi, E. Csányi, D. Kovács, R. Rühl, A. Szegedi, L. Kemény, M. Ståhle, C.C. Zouboulis, S. Eyerich, D. Törőcsik
Pubblicato in: British Journal of Dermatology, 2017, ISSN 0007-0963
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bjd.15754

Immune response patterns in non-communicable inflammatory skin diseases

Autori: Kilian Eyerich, Stefanie Eyerich
Pubblicato in: Journal of the European Academy of Dermatology and Venereology, 2017, ISSN 0926-9959
Editore: Elsevier BV
DOI: 10.1111/jdv.14673

Newly acquired kiwi fruit allergy after bone marrow transplantation from a kiwi-allergic donor

Autori: N. Garzorz, J. Thomas, B. Eberlein, C. Haferlach, J. Ring, T. Biedermann, C. Schmidt-Weber, K. Eyerich, F. Seifert, S. Eyerich
Pubblicato in: Journal of the European Academy of Dermatology and Venereology, Numero 30/7, 2016, Pagina/e 1136-1139, ISSN 0926-9959
Editore: Elsevier BV
DOI: 10.1111/jdv.13617

Motion correction in optoacoustic mesoscopy

Autori: Mathias Schwarz, Natalie Garzorz-Stark, Kilian Eyerich, Juan Aguirre, Vasilis Ntziachristos
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-11277-y

Interleukin-22 Promotes Wound Repair in Diabetes by Improving Keratinocyte Pro-Healing Functions

Autori: Simona Avitabile, Teresa Odorisio, Stefania Madonna, Stefanie Eyerich, Liliana Guerra, Kilian Eyerich, Giovanna Zambruno, Andrea Cavani, Francesca Cianfarani
Pubblicato in: Journal of Investigative Dermatology, Numero 135/11, 2015, Pagina/e 2862-2870, ISSN 0022-202X
Editore: Blackwell Publishing Inc.
DOI: 10.1038/jid.2015.278

Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement

Autori: A.M. Drucker, K. Eyerich, M.S. de Bruin-Weller, J.P. Thyssen, P.I. Spuls, A.D. Irvine, G. Girolomoni, S. Dhar, C. Flohr, D.F. Murrell, A.S. Paller, E. Guttman-Yassky
Pubblicato in: British Journal of Dermatology, 2017, ISSN 0007-0963
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bjd.15928

Toll-like receptor 7/8 agonists stimulate plasmacytoid dendritic cells to initiate T H 17-deviated acute contact dermatitis in human subjects

Autori: Natalie Garzorz-Stark, Felix Lauffer, Linda Krause, Jenny Thomas, Anne Atenhan, Regina Franz, Sophie Roenneberg, Alexander Boehner, Manja Jargosch, Richa Batra, Nikola S. Mueller, Stefan Haak, Christina Groß, Olaf Groß, Claudia Traidl-Hoffmann, Fabian J. Theis, Carsten B. Schmidt-Weber, Tilo Biedermann, Stefanie Eyerich, Kilian Eyerich
Pubblicato in: Journal of Allergy and Clinical Immunology, 2017, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2017.07.045

IL-17 and IL-22 in immunity: Driving protection and pathology

Autori: Kilian Eyerich, Valentina Dimartino, Andrea Cavani
Pubblicato in: European Journal of Immunology, Numero 47/4, 2017, Pagina/e 607-614, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201646723

Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy

Autori: J. Aguirre, B. Hindelang, Andrei Berezhnoi, U. Darsow, F. Lauffer, K. Eyerich, T. Biedermann, V. Ntziachristos
Pubblicato in: Photoacoustics, Numero 10, 2018, Pagina/e 31-37, ISSN 2213-5979
Editore: Elsevier GmbH
DOI: 10.1016/j.pacs.2018.02.002

Ixekizumab for acrodermatitis continua

Autori: Anna Caroline Pilz, Sophie Roenneberg, Tilo Biedermann, Kilian Eyerich
Pubblicato in: JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Numero 16/7, 2018, Pagina/e 907-910, ISSN 1610-0379
Editore: Blackwell Publishing Inc.
DOI: 10.1111/ddg.13568

Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council

Autori: Kilian Eyerich, Sara J. Brown, Bethany E. Perez White, Reiko J. Tanaka, Robert Bissonette, Sandipan Dhar, Thomas Bieber, Dirk J. Hijnen, Emma Guttman-Yassky, Alan Irvine, Jacob P. Thyssen, Christian Vestergaard, Thomas Werfel, Andreas Wollenberg, Amy S. Paller, Nick J. Reynolds
Pubblicato in: Journal of Allergy and Clinical Immunology, Numero 143/1, 2019, Pagina/e 36-45, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2018.10.033

Non-invasive imaging in dermatology and the unique potential of Raster-Scan Optoacoustic Mesoscopy (RSOM)

Autori: B. Hindelang, J. Aguirre, M. Schwarz, A. Berezhnoi, K. Eyerich, V. Ntziachristos, T. Biedermann, U. Darsow
Pubblicato in: Journal of the European Academy of Dermatology and Venereology, 2018, ISSN 0926-9959
Editore: Elsevier BV
DOI: 10.1111/jdv.15342

Type I Immune Response Induces Keratinocyte Necroptosis and Is Associated with Interface Dermatitis

Autori: Felix Lauffer, Manja Jargosch, Linda Krause, Natalie Garzorz-Stark, Regina Franz, Sophie Roenneberg, Alexander Böhner, Nikola S. Mueller, Fabian J. Theis, Carsten B. Schmidt-Weber, Tilo Biedermann, Stefanie Eyerich, Kilian Eyerich
Pubblicato in: Journal of Investigative Dermatology, Numero 138/8, 2018, Pagina/e 1785-1794, ISSN 0022-202X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2018.02.034

Cellular and molecular immunologic mechanisms in patients with atopic dermatitis

Autori: Thomas Werfel, Jean-Pierre Allam, Tilo Biedermann, Kilian Eyerich, Stefanie Gilles, Emma Guttman-Yassky, Wolfram Hoetzenecker, Edward Knol, Hans-Uwe Simon, Andreas Wollenberg, Thomas Bieber, Roger Lauener, Peter Schmid-Grendelmeier, Claudia Traidl-Hoffmann, Cezmi A. Akdis
Pubblicato in: Journal of Allergy and Clinical Immunology, Numero 138/2, 2016, Pagina/e 336-349, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2016.06.010

Relations between epidermal barrier dysregulation and Staphylococcus species–dominated microbiome dysbiosis in patients with atopic dermatitis

Autori: Can Altunbulakli, Matthias Reiger, Avidan U. Neumann, Natalie Garzorz-Stark, Megan Fleming, Claudia Huelpuesch, Francesc Castro-Giner, Kilian Eyerich, Cezmi A. Akdis, Claudia Traidl-Hoffmann
Pubblicato in: Journal of Allergy and Clinical Immunology, Numero 142/5, 2018, Pagina/e 1643-1647.e12, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2018.07.005

Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis

Autori: Nick Vandeghinste, Jürgen Klattig, Catherine Jagerschmidt, Stéphanie Lavazais, Florence Marsais, Jan D. Haas, Marielle Auberval, Felix Lauffer, Tara Moran, Mate Ongenaert, Maarten Van Balen, Sonia Dupont, Liên Lepescheux, Teresa Garcia, Stefan Härtle, Kilian Eyerich, Padraic G. Fallon, Reginald Brys, Stefan Steidl
Pubblicato in: Journal of Investigative Dermatology, Numero 138/7, 2018, Pagina/e 1555-1563, ISSN 0022-202X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2018.01.036

Generalized pustular psoriasis - a model disease for specific targeted immunotherapy, systematic review

Autori: Alexander Boehner, Alexander A. Navarini, Kilian Eyerich
Pubblicato in: Experimental Dermatology, Numero 27/10, 2018, Pagina/e 1067-1077, ISSN 0906-6705
Editore: Blackwell Publishing Inc.
DOI: 10.1111/exd.13699

De novo pathway-based biomarker identification

Autori: Nicolas Alcaraz, Markus List, Richa Batra, Fabio Vandin, Henrik J. Ditzel, Jan Baumbach
Pubblicato in: Nucleic Acids Research, Numero 45/16, 2017, Pagina/e e151-e151, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkx642

Predicting persistence of atopic dermatitis in children using clinical attributes and serum proteins

Autori: Felix Lauffer, Veronika Baghin, Marie Standl, Sebastian P. Stark, Manja Jargosch, Julius Wehrle, Jenny Thomas, Carsten B. Schmidt‐Weber, Tilo Biedermann, Stefanie Eyerich, Kilian Eyerich, Natalie Garzorz‐Stark
Pubblicato in: Allergy, 2020, ISSN 0105-4538
Editore: Blackwell Publishing Inc.
DOI: 10.1111/all.14557

Keratinocytes Regulate the Threshold of Inflammation by Inhibiting T Cell Effector Functions.

Autori: Seiringer P, Eyerich S, Eyerich K, Dittlein D, Pilz AC, Scala E, Ring J, Behrendt H, Cavani A, Traidl-Hoffmann C.
Pubblicato in: Cells, 2021, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10071606