Programmable BioMolecular Circuits: Emulating Regulatory Functions in Living Cells Using a Bottom-Up Approach

Publicaciones

Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

Autores: Eva Magdalena Estirado, Bas J. H. M. Rosier, Tom F. A. de Greef and Luc Brunsveld
Publicado en: Chemical Communications, 2020, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d0cc02120b

Engineered Living Materials based on Adhesin-mediated Trapping of Programmable Cells

Autores: Maxime C.M. van den Oetelaar; Maarten Merkx; Pim L. Joostens; Tim van der Hek; Yahav Rave; Mick P.A. Verhagen; Kees Verduin; Laura S. van Hazendonk; Guido J.M. Oerlemans; Shuaiqi Guo; Mariska Brüls; Sander R. Keij; Weizhou Xing; Emilien Dubuc; Jetske Stalpers; Simone A.E. Twisk; Bruno V. Eijkens; Roy J. E. A. Boonen; M Marieke Gerth; Ilja K. Voets; Tom F. A. de Greef; Manoj Sharma; Martijn Nijs
Publicado en: ACS Synthetic Biology, 2020, ISSN 2161-5063
Editor: American Chemical Society
DOI: 10.1101/734350

Supramolecular interactions between catalytic species allow rational control over reaction kinetics

Autores: Abraham J. P. Teunissen, Tim F. E. Paffen, Ivo A. W. Filot, Menno D. Lanting, Roy J. C. van der Haas,Tom F. A. de Greef, E. W. Meijer
Publicado en: Chemical Science, 2019, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/c9sc02357g

Regulating Competing Supramolecular Interactions Using Ligand Concentration

Autores: Abraham J. P. Teunissen; Tim F. E. Paffen; Gianfranco Ercolani; Tom F. A. de Greef; E. W. Meijer
Publicado en: VOLUME=138;ISSUE=21;STARTPAGE=6852;ENDPAGE=6860;ISSN=0002-7863;TITLE=Journal of the American Chemical Society, Edición 3, 2016, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.6b03421

Determinants of Ligand-Functionalized DNA Nanostructure-Cell Interactions

Autores: Glenn A.O. Cremers; Bas J.H.M. Rosier; Ab Meijs; Ab Meijs; Nicholas B. Tito; Sander M.J. van Duijnhoven; Hans van Eenennaam; Lorenzo Albertazzi; Tom F. A. de Greef
Publicado en: Journal of the American Chemical Society, Edición 2, 2021, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.3929/ethz-b-000498818

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Autores: Ardjan J. van der Linden, Maaruthy Yelleswarapu, Pascal A. Pieters, Zoe Swank, Wilhelm T. S. Huck, Sebastian J. Maerkl, Tom F. A. de Greef
Publicado en: Journal of Visualized Experiments, 2019, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/59655

Designed Asymmetric Protein Assembly on a Symmetric Scaffold

Autores: Lenne J. M. Lemmens, Job A. L. Roodhuizen, Tom F. A. de Greef, Albert J. Markvoort, Luc Brunsveld
Publicado en: Angewandte Chemie, 2020, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202003626

Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome

Autores: Bas J. H. M. Rosier, Albert J. Markvoort, Berta Gumí Audenis, Job A. L. Roodhuizen, Anniek den Hamer, Luc Brunsveld, Tom F. A. de Greef
Publicado en: Nature Catalysis, Edición 3/3, 2020, Página(s) 295-306, ISSN 2520-1158
Editor: Nature Springer
DOI: 10.1038/s41929-019-0403-7

Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform

Autores: Jurgen Schill,Bas J. H. M. Rosier,Berta Gumí Audenis, Eva Magdalena Estirado,Tom F. A. de Greef, Luc Brunsveld
Publicado en: Angewandte Chemie, 2021, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202016244

Hierarchical control of enzymatic actuators using DNA-based switchable memories

Autores: Lenny H. H. Meijer, Alex Joesaar, Erik Steur, Wouter Engelen, Rutger A. van Santen, Maarten Merkx, Tom F. A. de Greef
Publicado en: Nature Communications, Edición 8/1, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-01127-w

DNA-Based Nanodevices Controlled by Purely Entropic Linker Domains

Autores: Davide Mariottini, Andrea Idili, Minke A. D. Nijenhuis, Tom F. A. de Greef, Francesco Ricci
Publicado en: Journal of the American Chemical Society, Edición 140/44, 2018, Página(s) 14725-14734, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.8b07640

Cell-free microcompartmentalised transcription–translation for the prototyping of synthetic communication networks

Autores: Emilien Dubuc, Pascal A Pieters, Ardjan J van der Linden, Jan CM van Hest, Wilhelm TS Huck, Tom FA de Greef
Publicado en: Current Opinion in Biotechnology, Edición 58, 2019, Página(s) 72-80, ISSN 0958-1669
Editor: Elsevier BV
DOI: 10.1016/j.copbio.2018.10.006

Sigma Factor-Mediated Tuning of Bacterial Cell-Free Synthetic Genetic Oscillators

Autores: Maaruthy Yelleswarapu, Ardjan J. van der Linden, Bob van Sluijs, Pascal A. Pieters, Emilien Dubuc, Tom F. A. de Greef, Wilhelm T. S. Huck
Publicado en: ACS Synthetic Biology, Edición 7/12, 2018, Página(s) 2879-2887, ISSN 2161-5063
Editor: American Chemical Society
DOI: 10.1021/acssynbio.8b00300

DNA-based communication in populations of synthetic protocells

Autores: Alex Joesaar, Shuo Yang, Bas Bögels, Ardjan van der Linden, Pascal Pieters, B. V. V. S. Pavan Kumar, Neil Dalchau, Andrew Phillips, Stephen Mann, Tom F. A. de Greef
Publicado en: Nature Nanotechnology, Edición 14/4, 2019, Página(s) 369-378, ISSN 1748-3387
Editor: Nature Publishing Group
DOI: 10.1038/s41565-019-0399-9

Pathway Control in Cooperative vs. Anti-Cooperative Supramolecular Polymers

Autores: Lorena Herkert, Jörn Droste, Kalathil K. Kartha, Peter A. Korevaar, Tom F. A. de Greef, Michael Ryan Hansen, Gustavo Fernández
Publicado en: Angewandte Chemie International Edition, 2019, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201905064

Counterion-Dependent Mechanisms of DNA Origami Nanostructure Stabilization Revealed by Atomistic Molecular Simulation

Autores: Job A. L. Roodhuizen, Philip J. T. M. Hendrikx, Peter A. J. Hilbers, Tom F. A. de Greef, Albert J. Markvoort
Publicado en: ACS Nano, 2019, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.9b05650

Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy

Autores: Bas J. H. M. Rosier, Glenn A. O. Cremers, Wouter Engelen, Maarten Merkx, Luc Brunsveld, Tom F. A. de Greef
Publicado en: Chem. Commun., Edición 53/53, 2017, Página(s) 7393-7396, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/C7CC04178K

Small-Molecule-Induced and Cooperative Enzyme Assembly on a 14-3-3 Scaffold

Autores: Anniek den Hamer, Lenne J. M. Lemmens, Minke A. D. Nijenhuis, Christian Ottmann, Maarten Merkx, Tom F. A. de Greef, Luc Brunsveld
Publicado en: ChemBioChem, Edición 18/3, 2017, Página(s) 331-335, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201600631

Antibody-controlled actuation of DNA-based molecular circuits

Autores: Wouter Engelen, Lenny H. H. Meijer, Bram Somers, Tom F. A. de Greef, Maarten Merkx
Publicado en: Nature Communications, Edición 8, 2017, Página(s) 14473, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms14473

Non-equilibrium supramolecular polymerization

Autores: Alessandro Sorrenti, Jorge Leira-Iglesias, Albert J. Markvoort, Tom F. A. de Greef, Thomas M. Hermans
Publicado en: Chem. Soc. Rev., 2017, ISSN 0306-0012
Editor: Royal Society of Chemistry
DOI: 10.1039/C7CS00121E

A plug-and-play platform of ratiometric bioluminescent sensors for homogeneous immunoassays

Autores: Yan Ni, Bas J. H. M. Rosier, Eva A. van Aalen, Eva T. L. Hanckmann, Lieuwe Biewenga, Anna-Maria Makri Pistikou, Bart Timmermans, Chris Vu, Sophie Roos, Remco Arts, Wentao Li, Tom F. A. de Greef, Marcel M. G. J. van Borren, Frank J. M. van Kuppeveld, Berend-Jan Bosch & Maarten Merkx
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-24874-3

Efficient Small-Scale Conjugation of DNA to Primary Antibodies for Multiplexed Cellular Targeting

Autores: Glenn A. O. Cremers, Bas J. H. M. Rosier, Roger Riera Brillas, Lorenzo Albertazzi, and Tom F. A. de Greef
Publicado en: Bioconjugate Chem., 2019, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00490

Cell-Free Characterization of Coherent Feed-Forward Loop-Based Synthetic Genetic Circuits

Autores: Pascal A. Pieters, Bryan L. Nathalia, Ardjan J. van der Linden, Peng Yin, Jongmin Kim, Wilhelm T. S. Huck, and Tom F. A. de Greef
Publicado en: ACS Synthetic Biology, 2021, ISSN 2161-5063
Editor: American Chemical Society
DOI: 10.1101/2021.01.11.426179

Light-Activated Signaling in DNA-Encoded Sender–Receiver Architectures

Autores: Shuo Yang, Pascal A. Pieters, Alex Joesaar, Bas W. A. Bögels, Rens Brouwers, Iuliia Myrgorodska, Stephen Mann, Tom F. A. de Greef
Publicado en: ACS Nano, Edición 14/11, 2020, Página(s) 15992-16002, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.0c07537

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