Periodic Reporting for period 4 - MODEM (Multipoint Optical DEvices for Minimally invasive neural circuits interface)
Berichtszeitraum: 2021-04-01 bis 2022-03-31
MODEM has developed a set of innovative technologies for multipoint optical neural interfacing with the mammalian brain in vivo. These are approaches to based on modal multiplexing and de-multiplexing of light into a single, thin, minimally invasive tapered optical fiber serving as a carrier for multipoint signals to and from the brain. This has been achieved through nano- and micro-structuring of the taper edge, capitalizing on the photonic properties of the tapered waveguide to precisely control light delivery and collection in vivo.
The overall objectives achieved by the MODEM project are: 1) Development of minimally invasive technologies for versatile, user-defined optogenetic control over deep brain regions; 2) Development of fully integrated high signal-to- noise-ratio optrodes; 3) Development of minimally invasive technologies for multi-point in vivo all-optical “electrophysiology” through a single waveguide; 4) Development of new optical methodologies for dissecting brain circuitry at small and large scales.