Study of the interplay between CRISPR interference and DNA repair pathways towards the development of novel CRISPR tools

Publicaciones

The impact of genetic diversity on gene essentiality within the Escherichia coli species

Autores: François Rousset, Jose Cabezas-Caballero, Florence Piastra-Facon, Jesús Fernández-Rodríguez, Olivier Clermont, Erick Denamur, Eduardo P. C. Rocha, David Bikard
Publicado en: Nature Microbiology, Edición 20585276, 2021, ISSN 2058-5276
Editor: Nature Microbiology
DOI: 10.1038/s41564-020-00839-y

CRISPR Tools To Control Gene Expression in Bacteria

Autores: Antoine Vigouroux, David Bikard
Publicado en: Microbiology and Molecular Biology Reviews, Edición 84/2, 2020, ISSN 1092-2172
Editor: American Society for Microbiology
DOI: 10.1128/mmbr.00077-19

Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects

Autores: Antoine Vigouroux, Baptiste Cordier, Andrey Aristov, Laura Alvarez, Gizem Özbaykal, Thibault Chaze, Enno Rainer Oldewurtel, Mariette Matondo, Felipe Cava, David Bikard, Sven van Teeffelen
Publicado en: eLife, Edición 9, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/eLife.51998

Lipoprotein DolP supports proper folding of BamA in the bacterial outer membrane, promoting fitness upon envelope stress.

Autores: David Ranava; Yiying Yang; Luis Orenday-Tapia; François Rousset; Catherine Turlan; Violette Morales; Lun Cui; Cyril Moulin; Carine Froment; Gladys Munoz; Jérôme Rech; Julien Marcoux; Anne Caumont-Sarcos; Cécile Albenne; David Bikard; Raffaele Ieva
Publicado en: Elife, Edición 2050084X, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.67817

Gene silencing with CRISPRi in bacteria and optimization of dCas9 expression levels

Autores: Florence Depardieu, David Bikard
Publicado en: Methods, Edición 172, 2020, Página(s) 61-75, ISSN 1046-2023
Editor: Academic Press
DOI: 10.1016/j.ymeth.2019.07.024

A CRISPRi screen in E. coli reveals sequence-specific toxicity of dCas9

Autores: Lun Cui, Antoine Vigouroux, François Rousset, Hugo Varet, Varun Khanna, David Bikard
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-04209-5

Tuning dCas9's ability to block transcription enables robust, noiseless knockdown of bacterial genes

Autores: Antoine Vigouroux, Enno Oldewurtel, Lun Cui, David Bikard, Sven van Teeffelen
Publicado en: Molecular Systems Biology, Edición 14/3, 2018, Página(s) e7899, ISSN 1744-4292
Editor: Nature Publishing Group
DOI: 10.15252/msb.20177899

Inhibition of NHEJ repair by type II-A CRISPR-Cas systems in bacteria

Autores: Aude Bernheim, Alicia Calvo-Villamañán, Clovis Basier, Lun Cui, Eduardo P. C. Rocha, Marie Touchon, David Bikard
Publicado en: Nature Communications, Edición 8/1, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-02350-1

Using CRISPR-Cas systems as antimicrobials

Autores: David Bikard, Rodolphe Barrangou
Publicado en: Current Opinion in Microbiology, Edición 37, 2017, Página(s) 155-160, ISSN 1369-5274
Editor: Elsevier BV
DOI: 10.1016/j.mib.2017.08.005

Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors

Autores: François Rousset, Lun Cui, Elise Siouve, Christophe Becavin, Florence Depardieu, David Bikard
Publicado en: PLOS Genetics, Edición 14/11, 2018, Página(s) e1007749, ISSN 1553-7404
Editor: PLOS
DOI: 10.1371/journal.pgen.1007749

Editing the microbiome the CRISPR way

Autores: Gayetri Ramachandran, David Bikard
Publicado en: Philosophical Transactions of the Royal Society B: Biological Sciences, Edición 374/1772, 2019, Página(s) 20180103, ISSN 0962-8436
Editor: Royal Society of London
DOI: 10.1098/rstb.2018.0103

A matter of background: DNA repair pathways as a possible cause for the sparse distribution of CRISPR-Cas systems in bacteria

Autores: Aude Bernheim, David Bikard, Marie Touchon, Eduardo P. C. Rocha
Publicado en: Philosophical Transactions of the Royal Society B: Biological Sciences, Edición 374/1772, 2019, Página(s) 20180088, ISSN 0962-8436
Editor: Royal Society of London
DOI: 10.1098/rstb.2018.0088

CRISPR screens in the era of microbiomes

Autores: François Rousset, David Bikard
Publicado en: Current Opinion in Microbiology, Edición 57, 2020, Página(s) 70-77, ISSN 1369-5274
Editor: Elsevier BV
DOI: 10.1016/j.mib.2020.07.009

On-target activity predictions enable improved CRISPR–dCas9 screens in bacteria

Autores: Alicia Calvo-Villamañán, Jérome Wong Ng, Rémi Planel, Hervé Ménager, Arthur Chen, Lun Cui, David Bikard
Publicado en: Nucleic Acids Research, Edición 48/11, 2020, Página(s) e64-e64, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa294

Atypical organizations and epistatic interactions of CRISPRs and cas clusters in genomes and their mobile genetic elements

Autores: Aude Bernheim, David Bikard, Marie Touchon, Eduardo P C Rocha
Publicado en: Nucleic Acids Research, 2019, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkz1091

Phages and their satellites encode hotspots of antiviral systems

Autores: Rousset F., Depardieu F., Miele S., Dowding J., Laval A.-L., Lieberman E., Garry D., Rocha E.P.C., Bernheim A., Bikard D.
Publicado en: Cell Host & Microbe, Edición 19313128, 2022, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2022.02.018

Derechos de propiedad intelectual

IMPROVING SEQUENCE-SPECIFIC ANTIMICROBIALS BY BLOCKING DNA REPAIR

Número de solicitud/publicación: EP 16741899
Fecha: 2016-07-13

IMPROVING SEQUENCE-SPECIFIC ANTIMICROBIALS BY BLOCKING DNA REPAIR

Número de solicitud/publicación: EP 16741899
Fecha: 2016-07-13

IMPROVING SEQUENCE-SPECIFIC ANTIMICROBIALS BY BLOCKING DNA REPAIR

Número de solicitud/publicación: EP 16741899
Fecha: 2016-07-13
Solicitante(s): INSTITUT PASTEUR

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Publicaciones

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