Chromosomal Common Fragile Sites: Unravelling their biological functions and the basis of their instability

Informazioni relative al progetto

CFS modelling

ID dell’accordo di sovvenzione: 679068

DOI 10.3030/679068

Progetto chiuso

Data della firma CE 13 Gennaio 2016

Data di avvio 1 Maggio 2016

Data di completamento 31 Luglio 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 499 711,00

Contributo UE € 1 499 711,00

Coordinato da

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

Pubblicazioni

Peer reviewed articles (7)

Supraphysiological protection from replication stress does not extend mammalian lifespan.

Autori: Eliene Albers; Alexandra Avram; Mauro Sbroggiò; Oscar Fernandez-Capetillo; Andrés J. López-Contreras
Pubblicato in: Aging (Albany NY), Numero 2, 2020, ISSN 1945-4589
Editore: Impact Journals
DOI: 10.18632/aging.103039

Genetic insights into biological mechanisms governing human ovarian ageing

Autori: Katherine S. Ruth, Felix R. Day, Jazib Hussain, Ana Martínez-Marchal, Catherine E. Aiken, Ajuna Azad, Deborah J. Thompson, Lucie Knoblochova, Hironori Abe, Jane L. Tarry-Adkins, Javier Martin Gonzalez, Pierre Fontanillas, Annique Claringbould, Olivier B. Bakker, Patrick Sulem, Robin G. Walters, Chikashi Terao, Sandra Turon, Momoko Horikoshi, Kuang Lin, N. Charlotte Onland-Moret, Aditya Sankar, Em
Pubblicato in: Nature, 2021, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03779-7

Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress

Autori: Stephanie Munk, Jón Otti Sigurðsson, Zhenyu Xiao, Tanveer Singh Batth, Giulia Franciosa, Louise von Stechow, Andres Joaquin Lopez-Contreras, Alfred Cornelis Otto Vertegaal, Jesper Velgaard Olsen
Pubblicato in: Cell Reports, Numero 21/2, 2017, Pagina/e 546-558, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2017.09.059

Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality

Autori: Eliene Albers, Mauro Sbroggiò, David Pladevall-Morera, Anna H. Bizard, Alexandra Avram, Patricia Gonzalez, Javier Martin-Gonzalez, Ian D. Hickson, Andres J. Lopez-Contreras
Pubblicato in: Cell Reports, Numero 24/12, 2018, Pagina/e 3274-3284, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.08.071

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability

Autori: David Pladevall-Morera, Stephanie Munk, Andreas Ingham, Lorenza Garribba, Eliene Albers, Ying Liu, Jesper V Olsen, Andres J Lopez-Contreras
Pubblicato in: Nucleic Acids Research, 2019, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkz510

ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors

Autori: David Pladevall-Morera,María Castejón-Griñán,Paula Aguilera,Karina Gaardahl,Andreas Ingham ,Jacqueline A. Brosnan-Cashman, Alan K. Meeker and Andres J. Lopez-Contreras
Pubblicato in: Cancers, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14071790

ATR expands embryonic stem cell fate potential in response to replication stress

Autori: Sina Atashpaz; Sara Samadi Shams; Javier Martin Gonzalez; Endre Sebestyén; Negar Arghavanifard; Andrea Gnocchi; Eliene Albers; Simone Minardi; Giovanni Faga; Paolo Soffientini; Elisa Allievi; Valeria Cancila; Angela Bachi; Oscar Fernandez-Capetillo; Claudio Tripodo; Francesco Ferrari; Andrés J. López-Contreras; Vincenzo Costanzo
Pubblicato in: eLife, Numero 2, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.1101/2020.01.01.888354