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Chemical biology approaches to unraveling the histone code

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Publications

Non-competitive cyclic peptides for targeting enzyme–substrate complexes

Author(s): T. E. McAllister, T.-L. Yeh, M. I. Abboud, I. K. H. Leung, E. S. Hookway, O. N. F. King, B. Bhushan, S. T. Williams, R. J. Hopkinson, M. Münzel, N. D. Loik, R. Chowdhury, U. Oppermann, T. D. W. Claridge, Y. Goto, H. Suga, C. J. Schofield, A. Kawamura
Published in: Chemical Science, Issue 9/20, 2018, Page(s) 4569-4578, ISSN 2041-6520
DOI: 10.1039/c8sc00286j

Investigating d -lysine stereochemistry for epigenetic methylation, demethylation and recognition

Author(s): Roman Belle, Abbas H. K. Al Temimi, Kiran Kumar, Bas J. G. E. Pieters, Anthony Tumber, James E. Dunford, Catrine Johansson, Udo Oppermann, Tom Brown, Christopher J. Schofield, Richard J. Hopkinson, Robert S. Paton, Akane Kawamura, Jasmin Mecinović
Published in: Chemical Communications, Issue 53/99, 2017, Page(s) 13264-13267, ISSN 1359-7345
DOI: 10.1039/c7cc08028j

Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26

Author(s): Louise J. Walport, Richard J. Hopkinson, Rasheduzzaman Chowdhury, Yijia Zhang, Joanna Bonnici, Rachel Schiller, Akane Kawamura, Christopher J. Schofield
Published in: FEBS Letters, Issue 592/19, 2018, Page(s) 3264-3273, ISSN 0014-5793
DOI: 10.1002/1873-3468.13231

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

Author(s): Akane Kawamura, Martin Münzel, Tatsuya Kojima, Clarence Yapp, Bhaskar Bhushan, Yuki Goto, Anthony Tumber, Takayuki Katoh, Oliver N. F. King, Toby Passioura, Louise J. Walport, Stephanie B. Hatch, Sarah Madden, Susanne Müller, Paul E. Brennan, Rasheduzzaman Chowdhury, Richard J. Hopkinson, Hiroaki Suga, Christopher J. Schofield
Published in: Nature Communications, Issue 8, 2017, Page(s) 14773, ISSN 2041-1723
DOI: 10.1038/ncomms14773