Chemical biology approaches to unraveling the histone code

Project Information

EPITOOLS

Grant agreement ID: 679479

DOI 10.3030/679479

Project closed

EC signature date 15 February 2016

Start date 1 April 2016

End date 30 September 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 758 846,00

EU contribution € 1 758 846,00

Coordinated by

UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom

Publications

Book chapters (4)

Inhibitors of JmjC-Containing Histone Demethylases

Author(s): Miranda Wright, Paul E. Brennan, Akane Kawamura
Published in: Chemical Epigenetics, Issue 33, 2020, Page(s) 221-253, ISBN 978-3-030-42981-2
Publisher: Springer International Publishing
DOI: 10.1007/7355_2019_75

Chemical Compounds Targeting DNA Methylation and Hydroxymethylation

Author(s): Roman Belle, Akane Kawamura, Paola B. Arimondo
Published in: Chemical Epigenetics, Issue 33, 2020, Page(s) 255-286, ISBN 978-3-030-42981-2
Publisher: Springer International Publishing
DOI: 10.1007/7355_2019_76

CHAPTER 5. Cyclic Peptides as Chemical Probes

Author(s): L. Serrano, G. Roper, A. Kawamura
Published in: The Discovery and Utility of Chemical Probes in Target Discovery, 2020, Page(s) 100-123, ISBN 978-1-78801-589-9
Publisher: Royal Society of Chemistry
DOI: 10.1039/9781839160745-00100

Epigenetic Drug Discovery

Author(s): Christoffer Højrup, Oliver D. Coleman, John-Paul Bukowski, Rasmus P. Clausen, Akane Kawamura
Published in: Epigenetic Drug Discovery, 2019, ISBN 9783527809257
Publisher: Wiley-VCH Verlag GmbH & Co. KGaA
DOI: 10.1002/9783527809257

Peer reviewed articles (9)

Structural diversity in de novo cyclic peptide ligands from genetically encoded library technologies

Author(s): Tom E. McAllister, Oliver D. Coleman, Grace Roper, Akane Kawamura
Published in: Peptide Science, Issue 113/1, 2021, ISSN 2475-8817
Publisher: Wiley
DOI: 10.1002/pep2.24204

Non-competitive cyclic peptides for targeting enzyme–substrate complexes

Author(s): T. E. McAllister, T.-L. Yeh, M. I. Abboud, I. K. H. Leung, E. S. Hookway, O. N. F. King, B. Bhushan, S. T. Williams, R. J. Hopkinson, M. Münzel, N. D. Loik, R. Chowdhury, U. Oppermann, T. D. W. Claridge, Y. Goto, H. Suga, C. J. Schofield, A. Kawamura
Published in: Chemical Science, Issue 9/20, 2018, Page(s) 4569-4578, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sc00286j

Investigating d -lysine stereochemistry for epigenetic methylation, demethylation and recognition

Author(s): Roman Belle, Abbas H. K. Al Temimi, Kiran Kumar, Bas J. G. E. Pieters, Anthony Tumber, James E. Dunford, Catrine Johansson, Udo Oppermann, Tom Brown, Christopher J. Schofield, Richard J. Hopkinson, Robert S. Paton, Akane Kawamura, Jasmin Mecinović
Published in: Chemical Communications, Issue 53/99, 2017, Page(s) 13264-13267, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7cc08028j

Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26

Author(s): Louise J. Walport, Richard J. Hopkinson, Rasheduzzaman Chowdhury, Yijia Zhang, Joanna Bonnici, Rachel Schiller, Akane Kawamura, Christopher J. Schofield
Published in: FEBS Letters, Issue 592/19, 2018, Page(s) 3264-3273, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.13231

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases

Author(s): Bhaskar Bhushan, Alexandre Erdmann, Yijia Zhang, Roman Belle, Catrine Johannson, Udo Oppermann, Richard J. Hopkinson, Christopher J. Schofield, Akane Kawamura
Published in: Bioorganic & Medicinal Chemistry, Issue 26/11, 2018, Page(s) 2984-2991, ISSN 0968-0896
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2018.03.030

Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity

Author(s): Kosuke Nishio, Roman Belle, Takayuki Katoh, Akane Kawamura, Toru Sengoku, Kazuharu Hanada, Noboru Ohsawa, Mikako Shirouzu, Shigeyuki Yokoyama, Hiroaki Suga
Published in: ChemBioChem, Issue 19/9, 2018, Page(s) 979-985, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800047

Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A

Author(s): Toby Passioura, Bhaskar Bhushan, Anthony Tumber, Akane Kawamura, Hiroaki Suga
Published in: Bioorganic & Medicinal Chemistry, Issue 26/6, 2018, Page(s) 1225-1231, ISSN 0968-0896
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2018.01.013

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

Author(s): Akane Kawamura, Martin Münzel, Tatsuya Kojima, Clarence Yapp, Bhaskar Bhushan, Yuki Goto, Anthony Tumber, Takayuki Katoh, Oliver N. F. King, Toby Passioura, Louise J. Walport, Stephanie B. Hatch, Sarah Madden, Susanne Müller, Paul E. Brennan, Rasheduzzaman Chowdhury, Richard J. Hopkinson, Hiroaki Suga, Christopher J. Schofield
Published in: Nature Communications, Issue 8, 2017, Page(s) 14773, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms14773

Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2

Author(s): Rasheduzzaman Chowdhury, Martine I. Abboud, Tom E. McAllister, Biswadip Banerji, Bhaskar Bhushan, John L. Sorensen, Akane Kawamura, Christopher J. Schofield
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-76307-8

Non-peer reviewed articles (1)

Editorial overview: Epigenetics equals chemical biology

Author(s): Akane Kawamura, A. Ganesan
Published in: Current Opinion in Chemical Biology, Issue 57, 2020, Page(s) A1-A4, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2020.07.001