Chemical biology approaches to unraveling the histone code

Inhibitors of JmjC-Containing Histone Demethylases

Autores: Miranda Wright, Paul E. Brennan, Akane Kawamura
Publicado en: Chemical Epigenetics, Edición 33, 2020, Página(s) 221-253, ISBN 978-3-030-42981-2
Editor: Springer International Publishing
DOI: 10.1007/7355_2019_75

Chemical Compounds Targeting DNA Methylation and Hydroxymethylation

Autores: Roman Belle, Akane Kawamura, Paola B. Arimondo
Publicado en: Chemical Epigenetics, Edición 33, 2020, Página(s) 255-286, ISBN 978-3-030-42981-2
Editor: Springer International Publishing
DOI: 10.1007/7355_2019_76

CHAPTER 5. Cyclic Peptides as Chemical Probes

Autores: L. Serrano, G. Roper, A. Kawamura
Publicado en: The Discovery and Utility of Chemical Probes in Target Discovery, 2020, Página(s) 100-123, ISBN 978-1-78801-589-9
Editor: Royal Society of Chemistry
DOI: 10.1039/9781839160745-00100

Epigenetic Drug Discovery

Autores: Christoffer Højrup, Oliver D. Coleman, John-Paul Bukowski, Rasmus P. Clausen, Akane Kawamura
Publicado en: Epigenetic Drug Discovery, 2019, ISBN 9783527809257
Editor: Wiley-VCH Verlag GmbH & Co. KGaA
DOI: 10.1002/9783527809257

Structural diversity in de novo cyclic peptide ligands from genetically encoded library technologies

Autores: Tom E. McAllister, Oliver D. Coleman, Grace Roper, Akane Kawamura
Publicado en: Peptide Science, Edición 113/1, 2021, ISSN 2475-8817
Editor: Wiley
DOI: 10.1002/pep2.24204

Non-competitive cyclic peptides for targeting enzyme–substrate complexes

Autores: T. E. McAllister, T.-L. Yeh, M. I. Abboud, I. K. H. Leung, E. S. Hookway, O. N. F. King, B. Bhushan, S. T. Williams, R. J. Hopkinson, M. Münzel, N. D. Loik, R. Chowdhury, U. Oppermann, T. D. W. Claridge, Y. Goto, H. Suga, C. J. Schofield, A. Kawamura
Publicado en: Chemical Science, Edición 9/20, 2018, Página(s) 4569-4578, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/c8sc00286j

Investigating d -lysine stereochemistry for epigenetic methylation, demethylation and recognition

Autores: Roman Belle, Abbas H. K. Al Temimi, Kiran Kumar, Bas J. G. E. Pieters, Anthony Tumber, James E. Dunford, Catrine Johansson, Udo Oppermann, Tom Brown, Christopher J. Schofield, Richard J. Hopkinson, Robert S. Paton, Akane Kawamura, Jasmin Mecinović
Publicado en: Chemical Communications, Edición 53/99, 2017, Página(s) 13264-13267, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/c7cc08028j

Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26

Autores: Louise J. Walport, Richard J. Hopkinson, Rasheduzzaman Chowdhury, Yijia Zhang, Joanna Bonnici, Rachel Schiller, Akane Kawamura, Christopher J. Schofield
Publicado en: FEBS Letters, Edición 592/19, 2018, Página(s) 3264-3273, ISSN 0014-5793
Editor: Elsevier BV
DOI: 10.1002/1873-3468.13231

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases

Autores: Bhaskar Bhushan, Alexandre Erdmann, Yijia Zhang, Roman Belle, Catrine Johannson, Udo Oppermann, Richard J. Hopkinson, Christopher J. Schofield, Akane Kawamura
Publicado en: Bioorganic & Medicinal Chemistry, Edición 26/11, 2018, Página(s) 2984-2991, ISSN 0968-0896
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2018.03.030

Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity

Autores: Kosuke Nishio, Roman Belle, Takayuki Katoh, Akane Kawamura, Toru Sengoku, Kazuharu Hanada, Noboru Ohsawa, Mikako Shirouzu, Shigeyuki Yokoyama, Hiroaki Suga
Publicado en: ChemBioChem, Edición 19/9, 2018, Página(s) 979-985, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800047

Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A

Autores: Toby Passioura, Bhaskar Bhushan, Anthony Tumber, Akane Kawamura, Hiroaki Suga
Publicado en: Bioorganic & Medicinal Chemistry, Edición 26/6, 2018, Página(s) 1225-1231, ISSN 0968-0896
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2018.01.013

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

Autores: Akane Kawamura, Martin Münzel, Tatsuya Kojima, Clarence Yapp, Bhaskar Bhushan, Yuki Goto, Anthony Tumber, Takayuki Katoh, Oliver N. F. King, Toby Passioura, Louise J. Walport, Stephanie B. Hatch, Sarah Madden, Susanne Müller, Paul E. Brennan, Rasheduzzaman Chowdhury, Richard J. Hopkinson, Hiroaki Suga, Christopher J. Schofield
Publicado en: Nature Communications, Edición 8, 2017, Página(s) 14773, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms14773

Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2

Autores: Rasheduzzaman Chowdhury, Martine I. Abboud, Tom E. McAllister, Biswadip Banerji, Bhaskar Bhushan, John L. Sorensen, Akane Kawamura, Christopher J. Schofield
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-76307-8

Editorial overview: Epigenetics equals chemical biology

Autores: Akane Kawamura, A. Ganesan
Publicado en: Current Opinion in Chemical Biology, Edición 57, 2020, Página(s) A1-A4, ISSN 1367-5931
Editor: Elsevier BV
DOI: 10.1016/j.cbpa.2020.07.001

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