Chemical biology approaches to unraveling the histone code

Inhibitors of JmjC-Containing Histone Demethylases

Autori: Miranda Wright, Paul E. Brennan, Akane Kawamura
Pubblicato in: Chemical Epigenetics, Numero 33, 2020, Pagina/e 221-253, ISBN 978-3-030-42981-2
Editore: Springer International Publishing
DOI: 10.1007/7355_2019_75

Chemical Compounds Targeting DNA Methylation and Hydroxymethylation

Autori: Roman Belle, Akane Kawamura, Paola B. Arimondo
Pubblicato in: Chemical Epigenetics, Numero 33, 2020, Pagina/e 255-286, ISBN 978-3-030-42981-2
Editore: Springer International Publishing
DOI: 10.1007/7355_2019_76

CHAPTER 5. Cyclic Peptides as Chemical Probes

Autori: L. Serrano, G. Roper, A. Kawamura
Pubblicato in: The Discovery and Utility of Chemical Probes in Target Discovery, 2020, Pagina/e 100-123, ISBN 978-1-78801-589-9
Editore: Royal Society of Chemistry
DOI: 10.1039/9781839160745-00100

Epigenetic Drug Discovery

Autori: Christoffer Højrup, Oliver D. Coleman, John-Paul Bukowski, Rasmus P. Clausen, Akane Kawamura
Pubblicato in: Epigenetic Drug Discovery, 2019, ISBN 9783527809257
Editore: Wiley-VCH Verlag GmbH & Co. KGaA
DOI: 10.1002/9783527809257

Structural diversity in de novo cyclic peptide ligands from genetically encoded library technologies

Autori: Tom E. McAllister, Oliver D. Coleman, Grace Roper, Akane Kawamura
Pubblicato in: Peptide Science, Numero 113/1, 2021, ISSN 2475-8817
Editore: Wiley
DOI: 10.1002/pep2.24204

Non-competitive cyclic peptides for targeting enzyme–substrate complexes

Autori: T. E. McAllister, T.-L. Yeh, M. I. Abboud, I. K. H. Leung, E. S. Hookway, O. N. F. King, B. Bhushan, S. T. Williams, R. J. Hopkinson, M. Münzel, N. D. Loik, R. Chowdhury, U. Oppermann, T. D. W. Claridge, Y. Goto, H. Suga, C. J. Schofield, A. Kawamura
Pubblicato in: Chemical Science, Numero 9/20, 2018, Pagina/e 4569-4578, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c8sc00286j

Investigating d -lysine stereochemistry for epigenetic methylation, demethylation and recognition

Autori: Roman Belle, Abbas H. K. Al Temimi, Kiran Kumar, Bas J. G. E. Pieters, Anthony Tumber, James E. Dunford, Catrine Johansson, Udo Oppermann, Tom Brown, Christopher J. Schofield, Richard J. Hopkinson, Robert S. Paton, Akane Kawamura, Jasmin Mecinović
Pubblicato in: Chemical Communications, Numero 53/99, 2017, Pagina/e 13264-13267, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c7cc08028j

Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26

Autori: Louise J. Walport, Richard J. Hopkinson, Rasheduzzaman Chowdhury, Yijia Zhang, Joanna Bonnici, Rachel Schiller, Akane Kawamura, Christopher J. Schofield
Pubblicato in: FEBS Letters, Numero 592/19, 2018, Pagina/e 3264-3273, ISSN 0014-5793
Editore: Elsevier BV
DOI: 10.1002/1873-3468.13231

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases

Autori: Bhaskar Bhushan, Alexandre Erdmann, Yijia Zhang, Roman Belle, Catrine Johannson, Udo Oppermann, Richard J. Hopkinson, Christopher J. Schofield, Akane Kawamura
Pubblicato in: Bioorganic & Medicinal Chemistry, Numero 26/11, 2018, Pagina/e 2984-2991, ISSN 0968-0896
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2018.03.030

Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity

Autori: Kosuke Nishio, Roman Belle, Takayuki Katoh, Akane Kawamura, Toru Sengoku, Kazuharu Hanada, Noboru Ohsawa, Mikako Shirouzu, Shigeyuki Yokoyama, Hiroaki Suga
Pubblicato in: ChemBioChem, Numero 19/9, 2018, Pagina/e 979-985, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800047

Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A

Autori: Toby Passioura, Bhaskar Bhushan, Anthony Tumber, Akane Kawamura, Hiroaki Suga
Pubblicato in: Bioorganic & Medicinal Chemistry, Numero 26/6, 2018, Pagina/e 1225-1231, ISSN 0968-0896
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2018.01.013

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

Autori: Akane Kawamura, Martin Münzel, Tatsuya Kojima, Clarence Yapp, Bhaskar Bhushan, Yuki Goto, Anthony Tumber, Takayuki Katoh, Oliver N. F. King, Toby Passioura, Louise J. Walport, Stephanie B. Hatch, Sarah Madden, Susanne Müller, Paul E. Brennan, Rasheduzzaman Chowdhury, Richard J. Hopkinson, Hiroaki Suga, Christopher J. Schofield
Pubblicato in: Nature Communications, Numero 8, 2017, Pagina/e 14773, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms14773

Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2

Autori: Rasheduzzaman Chowdhury, Martine I. Abboud, Tom E. McAllister, Biswadip Banerji, Bhaskar Bhushan, John L. Sorensen, Akane Kawamura, Christopher J. Schofield
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-76307-8

Editorial overview: Epigenetics equals chemical biology

Autori: Akane Kawamura, A. Ganesan
Pubblicato in: Current Opinion in Chemical Biology, Numero 57, 2020, Pagina/e A1-A4, ISSN 1367-5931
Editore: Elsevier BV
DOI: 10.1016/j.cbpa.2020.07.001

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