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BIOengineered grafts for Cartilage Healing In Patients (BIO-CHIP)

Objective

Spontaneous healing of articular cartilage injuries is poor and untreated defects predispose to osteoarthritis. Current therapies, including innovative autologous cell-based treatments, cannot predictably and reproducibly restore cartilage structure and function.
BIOCHIP will carry out a multicenter, prospective phase II clinical trial to treat knee cartilage injuries using engineered grafts based on autologous nasal chondrocytes (NC). As compared to typically employed articular chondrocytes, NC have a higher and more reproducible capacity to generate mature cartilage tissues. Importantly, molecular/mechanical characterization, large size animal studies and a phase I trial carried out by BIOCHIP partners have already shown the compatibility of NC upon implantation in a joint, with promising preliminary clinical results.
BIO-CHIP’s specific objectives are:
(1) To test the hypothesis that the maturation of NC-based cartilage grafts improves the clinical efficacy in the treatment of cartilage lesions (108 patients will be recruited to reach statistical significance)
(2) To extend the range of clinical indications of NC-based grafts to so far untreatable pre-osteoarthritic lesions (‘kissing’ cartilage lesions in a sheep model)
BIO-CHIP capitalizes on clinical experience of 4 reference centers for cartilage surgery, on established GMP manufacturing capacity and on preparation for commercial exploitation by a strong orthopedic device company. Demonstration of therapeutic efficacy of the new treatment will address a large clinical need (over 2 million cartilage defects/year worldwide), improve quality of life (reduce pain & disability in the young, delay prosthetic implants in the elderly), exploit a commercial opportunity (prospected revenues of up to 130 million €/year) and reduce healthcare costs (estimated 12,000€ healthcare savings/procedure). BIO-CHIP will consolidate the currently leading role of Europe in the development of cell-based cartilage regeneration strate

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2015-single-stage_RTD

Coordinator

UNIVERSITAT BASEL
Net EU contribution
€ 0,00
Address
Petersplatz 1
4051 Basel
Switzerland

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 20 000,00

Participants (12)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITATSSPITAL BASEL
Switzerland
Net EU contribution
€ 0,00
Address
Hebelstrasse 32
4031 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 1 490 187,50
UNIVERSITAETSKLINIKUM FREIBURG
Germany
Net EU contribution
€ 446 931,25
Address
Hugstetter Strasse 49
79106 Freiburg

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Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
SVEUCILISTE U ZAGREBU MEDICINSKI FAKULTET
Croatia
Net EU contribution
€ 435 670,00
Address
Salata 3
10 000 Zagreb

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Region
Hrvatska Grad Zagreb Grad Zagreb
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FACULTY OF SCIENCE UNIVERSITY OF ZAGREB
Croatia
Net EU contribution
€ 201 958,75
Address
Horvatovac 102/a
10000 Zagreb

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Region
Hrvatska Grad Zagreb Grad Zagreb
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

KLINICKA BOLNICA SVETI DUH
Croatia
Net EU contribution
€ 122 912,50
Address
Sveti Duh 64
10000 Zagreb

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Region
Hrvatska Grad Zagreb Grad Zagreb
Activity type
Other
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITY OF ZAGREB-FACULTY OF VETERINARY MEDICINE
Croatia
Net EU contribution
€ 206 458,75
Address
Heinzelova 55
10000 Zagreb

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Region
Hrvatska Grad Zagreb Grad Zagreb
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ISTITUTO ORTOPEDICO GALEAZZI SPA
Italy
Net EU contribution
€ 272 451,25
Address
Via Riccardo Galeazzi 4
20161 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITA DEGLI STUDI DI MILANO
Italy
Net EU contribution
€ 68 750,00
Address
Via Festa Del Perdono 7
20122 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 1 204 593,75
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00
MEDACTA INTERNATIONAL SA
Switzerland
Net EU contribution
€ 0,00
Address
Strada Regina
6874 Castel San Pietro

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Region
Schweiz/Suisse/Svizzera Ticino Ticino
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 546 250,00
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
Net EU contribution
€ 53 056,25
Address
5 Rue Watt
75013 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany
Net EU contribution
€ 39 053,75
Address
Sanderring 2
97070 Wuerzburg

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Region
Bayern Unterfranken Würzburg, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00