Reversing the epigenetic state of oligodendrocyte precursors cells in multiple sclerosis

Informazioni relative al progetto

EPIScOPE

ID dell’accordo di sovvenzione: 681893

DOI 10.3030/681893

Progetto chiuso

Data della firma CE 22 Agosto 2016

Data di avvio 1 Settembre 2016

Data di completamento 31 Agosto 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 895 155,00

Contributo UE € 1 895 155,00

Coordinato da

KAROLINSKA INSTITUTET
Sweden

Pubblicazioni

Peer reviewed articles (10)

RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions

Autori: Alessandro Bonetti, Federico Agostini, Ana Maria Suzuki, Kosuke Hashimoto, Giovanni Pascarella, Juliette Gimenez, Leonie Roos, Alex J. Nash, Marco Ghilotti, Christopher J.  F. Cameron, Matthew Valentine, Yulia A. Medvedeva, Shuhei Noguchi, Eneritz Agirre, Kaori Kashi, Samudyata, Joachim Luginbühl, Riccardo Cazzoli, Saumya Agrawal, Nicholas M. Luscombe, Mathieu Blanchette, Takeya Kasukawa, Mich
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-14337-6

Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation

Autori: Roberta Marisca, Tobias Hoche, Eneritz Agirre, Laura Jane Hoodless, Wenke Barkey, Franziska Auer, Gonçalo Castelo-Branco, Tim Czopka
Pubblicato in: Nature Neuroscience, Numero 23/3, 2020, Pagina/e 363-374, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-019-0581-2

Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

Autori: Elisa M. Floriddia, Tânia Lourenço, Shupei Zhang, David van Bruggen, Markus M. Hilscher, Petra Kukanja, João P. Gonçalves dos Santos, Müge Altınkök, Chika Yokota, Enric Llorens-Bobadilla, Sara B. Mulinyawe, Mário Grãos, Lu O. Sun, Jonas Frisén, Mats Nilsson, Gonçalo Castelo-Branco
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-19453-x

Single-cell transcriptomic analysis of oligodendrocyte lineage cells

Autori: David van Bruggen, Eneritz Agirre, Gonçalo Castelo-Branco
Pubblicato in: Current Opinion in Neurobiology, Numero 47, 2017, Pagina/e 168-175, ISSN 0959-4388
Editore: Elsevier BV
DOI: 10.1016/j.conb.2017.10.005

Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development

Autori: Sueli Marques, David van Bruggen, Darya Pavlovna Vanichkina, Elisa Mariagrazia Floriddia, Hermany Munguba, Leif Väremo, Stefania Giacomello, Ana Mendanha Falcão, Mandy Meijer, Åsa Kristina Björklund, Jens Hjerling-Leffler, Ryan James Taft, Gonçalo Castelo-Branco
Pubblicato in: Developmental Cell, Numero 46/4, 2018, Pagina/e 504-517.e7, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2018.07.005

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

Autori: Ana Mendanha Falcão, David van Bruggen, Sueli Marques, Mandy Meijer, Sarah Jäkel, Eneritz Agirre, Samudyata, Elisa M. Floriddia, Darya P. Vanichkina, Charles ffrench-Constant, Anna Williams, André Ortlieb Guerreiro-Cacais, Gonçalo Castelo-Branco
Pubblicato in: Nature Medicine, Numero 24/12, 2018, Pagina/e 1837-1844, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-018-0236-y

RNA velocity of single cells

Autori: Gioele La Manno, Ruslan Soldatov, Amit Zeisel, Emelie Braun, Hannah Hochgerner, Viktor Petukhov, Katja Lidschreiber, Maria E. Kastriti, Peter Lönnerberg, Alessandro Furlan, Jean Fan, Lars E. Borm, Zehua Liu, David van Bruggen, Jimin Guo, Xiaoling He, Roger Barker, Erik Sundström, Gonçalo Castelo-Branco, Patrick Cramer, Igor Adameyko, Sten Linnarsson, Peter V. Kharchenko
Pubblicato in: Nature, Numero 560/7719, 2018, Pagina/e 494-498, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-018-0414-6

Altered human oligodendrocyte heterogeneity in multiple sclerosis

Autori: Sarah Jäkel, Eneritz Agirre, Ana Mendanha Falcão, David van Bruggen, Ka Wai Lee, Irene Knuesel, Dheeraj Malhotra, Charles ffrench-Constant, Anna Williams, Gonçalo Castelo-Branco
Pubblicato in: Nature, Numero 566/7745, 2019, Pagina/e 543-547, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-0903-2

Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

Autori: Karl E. Carlström, Keying Zhu, Ewoud Ewing, Inge E. Krabbendam, Robert A. Harris, Ana Mendanha Falcão, Maja Jagodic, Gonçalo Castelo-Branco, Fredrik Piehl
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-17871-5

Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues

Autori: Marek Bartosovic, Mukund Kabbe, Gonçalo Castelo-Branco
Pubblicato in: Nature Biotechnology, 2021, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-021-00869-9

Other (4)

Single-cell transcriptomic profiling of progenitors of the oligodendrocyte lineage reveals transcriptional convergence during development

Autori: Sueli Marques, Darya Vanichkina, David van Bruggen, Elisa Floriddia, Hermany Munguba, Leif Varemo, Stefania Giacomello, Ana Mendanha Falcao, Mandy Meijer, S Samudyata, Simone Codeluppi, Asa Bjorklund, Sten Linnarsson, Jens Hjerling-Leffler, Ryan Taft, Goncalo Castelo-Branco
Pubblicato in: BioRxiv, 2017
Editore: BioRxiv
DOI: 10.1101/186445

Developmental landscape of human forebrain at a single-cell level unveils early waves of oligodendrogenesis

Autori: David van Bruggen, Fabio Pohl, Christoffer Mattsson Langseth, Petra Kukanja, Hower Lee, Mukund Kabbe, Mandy Meijer, Markus M. Hilscher, Mats Nilsson, Erik Sundström, Gonçalo Castelo-Branco
Pubblicato in: BioRxiv, 2021
Editore: BioRxiv
DOI: 10.1101/2021.07.22.453317

A primed immune transcriptional program is activated in oligodendroglia in multiple sclerosis

Autori: Mandy Meijer, Eneritz Agirre, Mukund Kabbe, Cassandra A. van Tuijn, Abeer Heskol, Ana Mendanha Falcão, M. Ryan Corces, Thomas J. Montine, Xingqi Chen, Howard Y. Chang, Gonçalo Castelo-Branco
Pubblicato in: BioRxiv, 2020
Editore: BioRxiv
DOI: 10.1101/2020.07.21.213876

Cell-type specialization in the brain is encoded by specific long-range chromatin topologies

Autori: Warren Winick-Ng, Alexander Kukalev, Izabela Harabula, Luna Zea Redondo, Dominik Szabo, Mandy Meijer, Leonid Serebreni, Yingnan Zhang, Simona Bianco, Andrea M. Chiariello, Ibai Irastorza-Azcarate, Luca Fiorillo, Francesco Musella, Christoph J. Thieme, Ehsan Irani, Elena Torlai Triglia, Aleksandra A. Kolodziejczyk, Andreas Abentung, Galina Apostolova, Eleanor J. Paul, Vedran Franke, Rieke Kempfer,
Pubblicato in: BioRxiv, 2020
Editore: BioRxiv
DOI: 10.1101/2020.04.02.020990