A Unified Approach to Redox-Neutral C-C Couplings: Exploiting Vinyl Cation Rearrangements

Projektinformationen

VINCAT

ID Finanzhilfevereinbarung: 682002

DOI

10.3030/682002

Projekt abgeschlossen

EK-Unterschriftsdatum 14 September 2016

Startdatum 1 Januar 2017

Enddatum 30 Juni 2022

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten

€ 1 940 025,00

EU-Beitrag

€ 1 940 025,00

Koordiniert durch

UNIVERSITAT WIEN
Austria

Periodic Reporting for period 4 - VINCAT (A Unified Approach to Redox-Neutral C-C Couplings: Exploiting Vinyl Cation Rearrangements)

Berichtszeitraum: 2021-07-01 bis 2022-06-30

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

In this project, we aim to develop chemical reactions that create important new bonds between atoms without generating wasteful by-products.
We do this by proposing a new paradigm for chemical synthesis, which we term VINCAT.
The pressing demands of a growing world population and the need to develop environmentally friendly chemistry to power the needs of society render this project important.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

We have, among several other achievements, devised a new way to prepare a family of compounds that had been essentially unreachable by chemical synthesis.
These are so-called 1,4-dicarbonyl compounds, molecules of great importance as e.g. potential treatments for cancer.
The work done on these classes of substances within the scope of this project has opened broad perspectives for biology and pharmacology which we are keen to explore.
Other highlights of the work done within VINCAT include alpha-fluorination of carbonyls employing fluoride but also olefinations deploying sulfonium ylides.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

We have been able to break ground on the synthesis of 1,4-dicarbonyls and the transfer of chirality from a sulfur atom to a carbon atom. This has very important consequences in asymmetric synthesis, the discipline of organic synthesis that aims to prepare molecules of a single "handedness", such as the ones that exist in Nature.

1,4-dicarbonyl synthesis made possible by VINCAT