A Unified Approach to Redox-Neutral C-C Couplings: Exploiting Vinyl Cation Rearrangements

Informacje na temat projektu

VINCAT

Identyfikator umowy o grant: 682002

DOI

10.3030/682002

Projekt został zamknięty

Data podpisania przez KE 14 Września 2016

Data rozpoczęcia 1 Stycznia 2017

Data zakończenia 30 Czerwca 2022

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 1 940 025,00

Wkład UE

€ 1 940 025,00

Koordynowany przez

UNIVERSITAT WIEN
Austria

Periodic Reporting for period 4 - VINCAT (A Unified Approach to Redox-Neutral C-C Couplings: Exploiting Vinyl Cation Rearrangements)

Okres sprawozdawczy: 2021-07-01 do 2022-06-30

Podsumowanie kontekstu i ogólnych celów projektu

In this project, we aim to develop chemical reactions that create important new bonds between atoms without generating wasteful by-products.
We do this by proposing a new paradigm for chemical synthesis, which we term VINCAT.
The pressing demands of a growing world population and the need to develop environmentally friendly chemistry to power the needs of society render this project important.

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

We have, among several other achievements, devised a new way to prepare a family of compounds that had been essentially unreachable by chemical synthesis.
These are so-called 1,4-dicarbonyl compounds, molecules of great importance as e.g. potential treatments for cancer.
The work done on these classes of substances within the scope of this project has opened broad perspectives for biology and pharmacology which we are keen to explore.
Other highlights of the work done within VINCAT include alpha-fluorination of carbonyls employing fluoride but also olefinations deploying sulfonium ylides.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

We have been able to break ground on the synthesis of 1,4-dicarbonyls and the transfer of chirality from a sulfur atom to a carbon atom. This has very important consequences in asymmetric synthesis, the discipline of organic synthesis that aims to prepare molecules of a single "handedness", such as the ones that exist in Nature.

1,4-dicarbonyl synthesis made possible by VINCAT