A Unified Approach to Redox-Neutral C-C Couplings: Exploiting Vinyl Cation Rearrangements

Informazioni relative al progetto

VINCAT

ID dell’accordo di sovvenzione: 682002

DOI

10.3030/682002

Progetto chiuso

Data della firma CE 14 Settembre 2016

Data di avvio 1 Gennaio 2017

Data di completamento 30 Giugno 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 940 025,00

Contributo UE

€ 1 940 025,00

Coordinato da

UNIVERSITAT WIEN
Austria

Periodic Reporting for period 4 - VINCAT (A Unified Approach to Redox-Neutral C-C Couplings: Exploiting Vinyl Cation Rearrangements)

Periodo di rendicontazione: 2021-07-01 al 2022-06-30

Sintesi del contesto e degli obiettivi generali del progetto

In this project, we aim to develop chemical reactions that create important new bonds between atoms without generating wasteful by-products.
We do this by proposing a new paradigm for chemical synthesis, which we term VINCAT.
The pressing demands of a growing world population and the need to develop environmentally friendly chemistry to power the needs of society render this project important.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

We have, among several other achievements, devised a new way to prepare a family of compounds that had been essentially unreachable by chemical synthesis.
These are so-called 1,4-dicarbonyl compounds, molecules of great importance as e.g. potential treatments for cancer.
The work done on these classes of substances within the scope of this project has opened broad perspectives for biology and pharmacology which we are keen to explore.
Other highlights of the work done within VINCAT include alpha-fluorination of carbonyls employing fluoride but also olefinations deploying sulfonium ylides.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

We have been able to break ground on the synthesis of 1,4-dicarbonyls and the transfer of chirality from a sulfur atom to a carbon atom. This has very important consequences in asymmetric synthesis, the discipline of organic synthesis that aims to prepare molecules of a single "handedness", such as the ones that exist in Nature.

1,4-dicarbonyl synthesis made possible by VINCAT