Folate-Target Nanodevices To Activated Macrophages For Rheumatoid Arthritis

Informacje na temat projektu

FOLSMART

Identyfikator umowy o grant: 683356

DOI

10.3030/683356

Projekt został zamknięty

Data podpisania przez KE 25 Listopada 2015

Data rozpoczęcia 1 Stycznia 2016

Data zakończenia 31 Grudnia 2020

Finansowanie w ramach

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Koszt całkowity

€ 4 993 833,75

Wkład UE

€ 4 993 833,75

Koordynowany przez

ASSOCIACAO UNIVERSIDADE EMPRESA PARA DESENVOLVIMENTO TECMINHO
Portugal

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (6)

Design of the logo, Launch of website, Twitter, Facebook, LinkedIn, Google Plus
Plan and formal distribution of essential internal procedures and tools
Exploitation activity - yearly report 1 in knowledge subjected of protection
Individualized press release for every partner
Exploitation activity - yearly report 3 in knowledge subjected of protection
Exploitation activity - yearly report 2 in knowledge subjected of protection

Websites, patent fillings, videos etc. (1)

Dissemination plan revised

Publikacje

Conference proceedings (5)

The role of phagocytic cells in acute respiratory distress syndrome

Autorzy: Petre, A., A. Ohradanova-Repic, K. Krenn, R. Ullrich, K. Markstaller, and H. Stockinger
Opublikowane w: 5th European congress of immunology Amsterdam 2018 : September 2 - 5 : Abstract Book, 2018, Strona(/y) 151
Wydawca: European Congress of Immunology

The purinergic pathway activated by the proinflammatory stimuli endows M-CSF-dependent folate receptor ß (FRß)+ macrophages with potent immunosuppressive capacity

Autorzy: Ohradanova-Repic, A., C. Machacek, C. Charvet, F. Lager, D. Le Roux, R. Platzer, V. Leksa, G. Mitulovic, T. R. Burkard, G. J. Zlabinger, M. B. Fischer, G. Renault, S. Blüml, A. Cavaco-Paulo, J. B. Huppa, G. Bismuth, and H. Stockinger
Opublikowane w: Meeting Book of the Annual Meeting of the Austrian Society for Allergology and Immunology 2018, 2018, Strona(/y) 26
Wydawca: Annual Meeting of the Austrian Society for Allergology and Immunology 2018

Folate-targeted liposomes for rheumatoid arthritis therapy

Autorzy: Nogueira, Eugénia Sofia Costa; Cavaco-Paulo, Artur
Opublikowane w: Abstract Book of the XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients’ needs, 2018, Strona(/y) 43
Wydawca: The Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS)

Effect of sucrose in freeze-dried liposomes encapsulating drugs

Autorzy: Diana Guimarães, Eugénia Nogueira, Artur Cavaco-Paulo
Opublikowane w: Abstract Book of the XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients’ needs, 2018, Strona(/y) 80
Wydawca: The Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS)

Folic acid-tagged protein nanoemulsions with controllable size for cancer therapy

Autorzy: Loureiro, Ana Isabel Sá; Cavaco-Paulo, Artur
Opublikowane w: Abstract Book of the XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients’ needs, Numer 2, 2018, Strona(/y) 105
Wydawca: The Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS)

Monographic books (1)

Role of Metabolism in Regulating Immune Cell Fate Decisions

Autorzy: Anna Ohradanova-Repic, Marianne Boes, Hannes Stockinger (Eds.)
Opublikowane w: Role of Metabolism in Regulating Immune Cell Fate Decisions, 2020, ISBN 9782889637218
Wydawca: Frontiers Media
DOI: 10.3389/978-2-88963-721-8

Peer reviewed articles (17)

Quantification of drugs encapsulated in liposomes by 1H NMR

Autorzy: Diana Guimarães, Jennifer Noro, Ana Loureiro, Artur Cavaco-Paulo, Eugénia Nogueira
Opublikowane w: Colloids and Surfaces B: Biointerfaces, Numer 179, 2019, Strona(/y) 414-420, ISSN 0927-7765
Wydawca: Elsevier BV
DOI: 10.1016/j.colsurfb.2019.03.039

PTS micelles for the delivery of hydrophobic methotrexate

Autorzy: Patrícia Cerqueira, Jennifer Noro, Sofia Moura, Diana Guimarães, Carla Silva, Artur Cavaco-Paulo, Ana Loureiro
Opublikowane w: International Journal of Pharmaceutics, Numer 566, 2019, Strona(/y) 282-290, ISSN 0378-5173
Wydawca: Elsevier BV
DOI: 10.1016/j.ijpharm.2019.05.049

Editorial: Role of Metabolism in Regulating Immune Cell Fate Decisions

Autorzy: Anna Ohradanova-Repic; Marianne Boes; Hannes Stockinger
Opublikowane w: Frontiers in Immunology, Numer 1, 2019, ISSN 1664-3224
Wydawca: Frontiers Media
DOI: 10.3389/fimmu.2020.00527

Protective Effect of Saccharides on Freeze-Dried Liposomes Encapsulating Drugs

Autorzy: Diana Guimarães, Jennifer Noro, Carla Silva, Artur Cavaco-Paulo, Eugénia Nogueira
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 7, 2019, ISSN 2296-4185
Wydawca: Frontiers Media
DOI: 10.3389/fbioe.2019.00424

Glutathione from recovered glucose as ingredient in antioxidant nanocapsules for triggered flavor delivery

Autorzy: Claudia Tallian, Vanessa Rumpler, Lukas Skopek, Hannes Russmayer, Matthias G. Steiger, Robert Vielnascher, Simone Weinberger, Alessandro Pellis, Sara Vecchiato, Georg M. Guebitz
Opublikowane w: Journal of Materials Chemistry B, Numer 7/25, 2019, Strona(/y) 3958-3969, ISSN 2050-7518
Wydawca: Royal Society of Chemistry
DOI: 10.1039/c9tb00473d

Increased Encapsulation Efficiency of Methotrexate in Liposomes for Rheumatoid Arthritis Therapy

Autorzy: Diana Guimarães, Jennifer Noro, Ana Loureiro, Franck Lager, Gilles Renault, Artur Cavaco-Paulo and Eugénia Nogueira
Opublikowane w: Biomedicines, 2020, ISSN 2227-9059
Wydawca: MDPI
DOI: 10.3390/biomedicines8120630

Internalization of Methotrexate Conjugates by Folate Receptor-α

Autorzy: Eugénia Nogueira, Marisa P. Sárria, Nuno G. Azoia, Egipto Antunes, Ana Loureiro, Diana Guimarães, Jennifer Noro, Alexandra Rollett, Georg Guebitz, Artur Cavaco-Paulo
Opublikowane w: Biochemistry, Numer 57/49, 2018, Strona(/y) 6780-6786, ISSN 0006-2960
Wydawca: American Chemical Society
DOI: 10.1021/acs.biochem.8b00607

Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances

Autorzy: Anna Ohradanova-Repic, Christian Machacek, Celine Charvet, Franck Lager, Delphine Le Roux, René Platzer, Vladimir Leksa, Goran Mitulovic, Thomas R. Burkard, Gerhard J. Zlabinger, Michael B. Fischer, Vincent Feuillet, Gilles Renault, Stephan Blüml, Miroslav Benko, Miloslav Suchanek, Johannes B. Huppa, Takami Matsuyama, Artur Cavaco-Paulo, Georges Bismuth, Hannes Stockinger
Opublikowane w: Frontiers in Immunology, Numer 9, 2018, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2018.00852

Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis

Autorzy: Johannes J. Kovarik, Elisabeth Kernbauer, Markus A. Hölzl, Johannes Hofer, Guido A. Gualdoni, Klaus G. Schmetterer, Fitore Miftari, Yury Sobanov, Anastasia Meshcheryakova, Diana Mechtcheriakova, Nadine Witzeneder, Georg Greiner, Anna Ohradanova-Repic, Petra Waidhofer-Söllner, Marcus D. Säemann, Thomas Decker, Gerhard J. Zlabinger
Opublikowane w: PLOS ONE, Numer 12/7, 2017, Strona(/y) e0180900, ISSN 1932-6203
Wydawca: Public Library of Science
DOI: 10.1371/journal.pone.0180900

Fab antibody fragment-functionalized liposomes for specific targeting of antigen-positive cells

Autorzy: Anna Ohradanova-Repic, Eugénia Nogueira, Ingrid Hartl, Andreia C. Gomes, Ana Preto, Eva Steinhuber, Vanessa Mühlgrabner, Marko Repic, Mario Kuttke, Alexander Zwirzitz, Marek Prouza, Miloslav Suchanek, Gordana Wozniak-Knopp, Vaclav Horejsi, Gernot Schabbauer, Artur Cavaco-Paulo, Hannes Stockinger
Opublikowane w: Nanomedicine: Nanotechnology, Biology and Medicine, Numer 14/1, 2018, Strona(/y) 123-130, ISSN 1549-9634
Wydawca: Elsevier BV
DOI: 10.1016/j.nano.2017.09.003

Starved viable but non-culturable (VBNC) Legionella strains can infect and replicate in amoebae and human macrophages

Autorzy: Elisabeth Dietersdorfer, Alexander Kirschner, Barbara Schrammel, Anna Ohradanova-Repic, Hannes Stockinger, Regina Sommer, Julia Walochnik, Sílvia Cervero-Aragó
Opublikowane w: Water Research, Numer 141, 2018, Strona(/y) 428-438, ISSN 0043-1354
Wydawca: Elsevier BV
DOI: 10.1016/j.watres.2018.01.058

Lactoferrin is a natural inhibitor of plasminogen activation

Autorzy: Alexander Zwirzitz, Michael Reiter, Rostislav Skrabana, Anna Ohradanova-Repic, Otto Majdic, Marianna Gutekova, Ondrej Cehlar, Eva Petrovčíková, Eva Kutejova, Gerold Stanek, Hannes Stockinger, Vladimir Leksa
Opublikowane w: Journal of Biological Chemistry, Numer 293/22, 2018, Strona(/y) 8600-8613, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.003145

Absence of Albumin Improves in Vitro Cellular Uptake and Disruption of Poloxamer 407-Based Nanoparticles inside Cancer Cells

Autorzy: Ana Loureiro, Jennifer Noro, Ana S. Abreu, Eugénia Nogueira, Diana Soares da Costa, Carla Silva, Artur Cavaco-Paulo
Opublikowane w: Molecular Pharmaceutics, Numer 15/2, 2018, Strona(/y) 527-535, ISSN 1543-8384
Wydawca: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.7b00893

Structural insights into pH-responsive drug release of self-assembling human serum albumin-silk fibroin nanocapsules

Autorzy: Claudia Tallian, Alexandra Herrero-Rollett, Karina Stadler, Robert Vielnascher, Karin Wieland, Anna M. Weihs, Alessandro Pellis, Andreas H. Teuschl, Bernhard Lendl, Heinz Amenitsch, Georg M. Guebitz
Opublikowane w: European Journal of Pharmaceutics and Biopharmaceutics, Numer 133, 2018, Strona(/y) 176-187, ISSN 0939-6411
Wydawca: Elsevier BV
DOI: 10.1016/j.ejpb.2018.10.002

Dynamic Interaction- and Phospho-Proteomics Reveal Lck as a Major Signaling Hub of CD147 in T Cells

Autorzy: Verena Supper, Ingrid Hartl, Cyril Boulègue, Anna Ohradanova-Repic, Hannes Stockinger
Opublikowane w: The Journal of Immunology, Numer 198/6, 2017, Strona(/y) 2468-2478, ISSN 0022-1767
Wydawca: American Association of Immunologists
DOI: 10.4049/jimmunol.1600355

The mannose 6‐phosphate/insulin‐like growth factor 2 receptor mediates plasminogen‐induced efferocytosis

Autorzy: Ohradanova‐Repic, Anna; Machacek, Christian; Donner, Clemens; Mühlgrabner, Vanessa; Petrovčíková, Eva; Zahradníková, Alexandra; Vičíková, Kristína; Hořejší, Václav; Stockinger, Hannes; Leksa, Vladimir
Opublikowane w: Journal of Leukocyte Biology, Numer 1, 2019, ISSN 0165-2478
Wydawca: Elsevier BV
DOI: 10.1002/jlb.1ab0417-160rr

Poloxamer 407 based-nanoparticles for controlled release of methotrexate

Autorzy: Sofia Moura, Jennifer Noro, Patrícia Cerqueira, Carla Silva, Artur Cavaco-Paulo, Ana Loureiro
Opublikowane w: International Journal of Pharmaceutics, Numer 575, 2020, Strona(/y) 118924, ISSN 0378-5173
Wydawca: Elsevier BV
DOI: 10.1016/j.ijpharm.2019.118924

Prawa własności intelektualnej

Patent (1)

METHOD FOR PRODUCTION OF LIPOSOMES

Numer wniosku/publikacji: 20 20054346
Data: 2020-05-07
Wnioskodawca/wnioskodawcy: SOLFARCOS - SOLUÇÕES FARMACÊUTICAS E COSMÉTICAS LDA