Risultati finali Documents, reports (10) D.3.3 Report on improvements of environmental risk assessment models and user guidance This report will contain the results from the model refinement for the environmental risk assessment methods identified in D3.2 so that they are suitable for the needs of decision holders and practical guidance to a.o. stakeholders on the use of (refined/improved) existing hazard/risk models along the stage gate Cooper innovation chain. Results from the demonstration of the Risk Governance framework The entire SoS Nano-Risk Framework will be demonstrated using comprehensive case studies collated in WP6. Document on quality criteria for data This deliverable will describe quality criteria for data. The data requirements defined in D 5.1 will form the basis of the methodology of quality labelling. Results of gap analysis This deliverable is a document containing a) a list of the available information collected from task 5.2, b) a list of the information needed for calibration of the selected risk assessment models (input from WP2-4), and c) a description of the gaps that exist and need to be filled. caLIBRAte summary report of annual dissemination and communication activities Annual updates foreseen. Each year, the project will compile an overview of all outreach activities conducted under the auspices of caLIBRAte. This will ensure the project is continuing to meet the dissemination objectives outlined at its commencement. In addition, it will provide the consortium with a clear view of what activities must still be conducted in the following years in order to meet project obligations. Inventory of existing value-chain case-studies This deliverable will map/catalogue existing cases studies for NM and NM-enabled products, their production, downstream use and waste handling, focusing on those where exposure/release is considered a possibility. Information will be collated from finished and ongoing EU projects and also from literature. Value-chain case studies will be categorized in different levels in line with the rest of the project (e.g., sector covered, environmental compartments affected, applicable existing Tools). Report addressing the compilation of omics data sets, network inference and benchmarks for gap identification This report will give the results of the evaluation of the evaluation of data sets and the applicability of innovative hazard methods in the hazard and risks assessment methods in each of the stages. Comprehensive analysis of available tools and methodologies for Horizon Scanning The deliverable is the outcome of the Task 1.2, and it will report a catalogue and mapping of available tools for horizon scanning together with a comprehensive analysis identifying gaps and overlaps of the past’s efforts. Plan for dissemination, implementation and exploitation Two versions of the plan will be produced. The first will be internal and will provide guidance to the partners on protection and exploitation of IPR and the project’s data management plan. The second will be external and will be used to communicate the measures of success or the project. The plan will be updated with dissemination activities and outcomes. Annual updates foreseen. Complete list of requirements for a nano-specific risk governance framework This deliverable will report the outcomes of the Task 8.1, and it will list the outcomes of surveys, literature reviews, and workshops for identifying key requirements and functionalities of the SoS Risk Governance approach. Other (2) Integrated HRA models, in the format of a suite of computational models and written guidance documentation This deliverable builds further upon D2.3 and D2.4. It extents the practical guidance drafted under deliverable D2.3 with possible improvements by inclusion of more innovative approaches. In addition, this deliverable may also consist of practical computational models, that are specific to certain stage-gates This deliverable is the ultimate product delivered by WP2, near the end of the project and involves the integration of existing and possibly novel innovative hazard, exposure and risk assessment approaches, as well as the practical guidance for use along the stage-gate model. caLIBRAte decision support tools The decision support tool (DSS) is the core of this deliverable and is further developed based on results from the SUN project. It will enable the end-user to make decisions based on the existing input of different stakeholders and enhance communication through the applicability to experts and non-experts alike. Websites, patent fillings, videos etc. (3) Review article with completed evaluation and guidance on prioritisation of innovative hazard exposure and risk assessment models towards applications in the stage-gate model This deliverable consists of a scientific review in which novel approaches (that are e.g. not contained in existing methods listed under D2.2 for which practical guidance is provided in D2.3) are described, discussed and prioritized towards (future) application in the stage-gate model. caLIBRAte logo and website This deliverable will provide branded resources for use by the project and its partners. The website will be used as a tool to provide information to interested stakeholders and to build engagement with them. The website will eb delivered by month 6. Project webinars on project website and social media Update foreseen month 36. The project webinars will be delivered under Task 9.4 and used as a means of disseminating the project outcomes through social media. The webinars will be especially useful for non-experts. They will feature experts drawn from within the project partners to highlight and show the work that they are delivering. Pubblicazioni Peer reviewed articles (23) INfORM: Inference of NetwOrk Response Modules Autori: Veer Singh Marwah, Pia Anneli Sofia Kinaret, Angela Serra, Giovanni Scala, Antti Lauerma, Vittorio Fortino, Dario Greco Pubblicato in: Bioinformatics, 2018, ISSN 1367-4803 Editore: Oxford University Press DOI: 10.1093/bioinformatics/bty063 Directions in QPPR development to complement the predictive models used in risk assessment of nanomaterials Autori: Joris T.K. Quik, Martine Bakker, Dik van de Meent, Mikko Poikkimäki, Miikka Dal Maso, Willie Peijnenburg Pubblicato in: NanoImpact, Issue 11, 2018, Page(s) 58-66, ISSN 2452-0748 Editore: Elsevier DOI: 10.1016/j.impact.2018.02.003 Toxic and Genomic Influences of Inhaled Nanomaterials as a Basis for Predicting Adverse Outcome Autori: Penny Nymark, Pekka Kohonen, Vesa Hongisto, Roland C. Grafström Pubblicato in: Annals of the American Thoracic Society, Issue 15/Supplement_2, 2018, Page(s) S91-S97, ISSN 2325-6621 Editore: American Thoracic Society DOI: 10.1513/AnnalsATS.201706-478MG Network Analysis Reveals Similar Transcriptomic Responses to Intrinsic Properties of Carbon Nanomaterials in Vitro and in Vivo Autori: Pia Kinaret, Veer Marwah, Vittorio Fortino, Marit Ilves, Henrik Wolff, Lasse Ruokolainen, Petri Auvinen, Kai Savolainen, Harri Alenius, Dario Greco Pubblicato in: ACS Nano, Issue 11/4, 2017, Page(s) 3786-3796, ISSN 1936-0851 Editore: American Chemical Society DOI: 10.1021/acsnano.6b08650 Dip coating of air purifier ceramic honeycombs with photocatalytic TiO 2 nanoparticles: A case study for occupational exposure Autori: Antti Joonas Koivisto, Kirsten Inga Kling, Ana Sofia Fonseca, Anders Brostrøm Bluhme, Marcel Moreman, Mingzhou Yu, Anna Luisa Costa, Baldi Giovanni, Simona Ortelli, Wouter Fransman, Ulla Vogel, Keld Alstrup Jensen Pubblicato in: Science of The Total Environment, Issue 630, 2018, Page(s) 1283-1291, ISSN 0048-9697 Editore: Elsevier BV DOI: 10.1016/j.scitotenv.2018.02.316 Testing the performance of one and two box models as tools for risk assessment of particle exposure during packing of inorganic fertilizer Autori: Carla Ribalta, Antti J. Koivisto, Ana López-Lilao, Sara Estupiñá, María C. Minguillón, Eliseo Monfort, Mar Viana Pubblicato in: Science of The Total Environment, Issue 650, 2019, Page(s) 2423-2436, ISSN 0048-9697 Editore: Elsevier BV DOI: 10.1016/j.scitotenv.2018.09.379 Material-specific properties applied to an environmental risk assessment of engineered nanomaterials – implications on grouping and read-across concepts Autori: Henning Wigger, Bernd Nowack Pubblicato in: Nanotoxicology, Issue 10, 2019, Page(s) 1-21, ISSN 1743-5390 Editore: Informa Healthcare DOI: 10.1080/17435390.2019.1568604 Value of information analysis for assessing risks and benefits of nanotechnology innovation Autori: Alex Zabeo, Jeffrey M. Keisler, Danail Hristozov, Antonio Marcomini, Igor Linkov Pubblicato in: Environmental Sciences Europe, Issue 31/1, 2019, Page(s) 11, ISSN 2190-4707 Editore: Springer Verlag DOI: 10.1186/s12302-019-0194-0 Evaluating environmental risk assessment models for nanomaterials according to requirements along the product innovation Stage-Gate process Autori: Sara Nørgaard Sørensen, Anders Baun, Michael Burkard, Miikka Dal Maso, Steffen Foss Hansen, Samuel Harrison, Rune Hjorth, Stephen Lofts, Marianne Matzke, Bernd Nowack, Willie Peijnenburg, Mikko Poikkimäki, Joris T. K. Quik, Kristin Schirmer, Anja Verschoor, Henning Wigger, David J. Spurgeon Pubblicato in: Environmental Science: Nano, Issue 6/2, 2019, Page(s) 505-518, ISSN 2051-8153 Editore: Royal Society of Chemistry DOI: 10.1039/c8en00933c Risk associated with engineered nanomaterials: Different tools for different ways to govern Autori: Benjamin D. Trump, Danail Hristozov, Timothy Malloy, Igor Linkov Pubblicato in: Nano Today, Issue 21, 2018, Page(s) 9-13, ISSN 1748-0132 Editore: Elsevier BV DOI: 10.1016/j.nantod.2018.03.002 A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury Autori: Pekka Kohonen, Juuso A. Parkkinen, Egon L. Willighagen, Rebecca Ceder, Krister Wennerberg, Samuel Kaski, Roland C. Grafström Pubblicato in: Nature Communications, Issue 8, 2017, Page(s) 15932, ISSN 2041-1723 Editore: Nature Publishing Group DOI: 10.1038/ncomms15932 Health risk assessment from exposure to particles during packing in working environments Autori: C. Ribalta, A. López-Lilao, S. Estupiñá, A.S. Fonseca, A. Tobías, A. García-Cobos, M.C. Minguillón, E. Monfort, M. Viana Pubblicato in: Science of The Total Environment, Issue 671, 2019, Page(s) 474-487, ISSN 0048-9697 Editore: Elsevier BV DOI: 10.1016/j.scitotenv.2019.03.347 Risk Governance of Nanomaterials: Review of Criteria and Tools for Risk Communication, Evaluation, and Mitigation Autori: Panagiotis Isigonis, Danail Hristozov, Christina Benighaus, Elisa Giubilato, Khara Grieger, Lisa Pizzol, Elena Semenzin, Igor Linkov, Alex Zabeo, Antonio Marcomini Pubblicato in: Nanomaterials, Issue 9/5, 2019, Page(s) 696, ISSN 2079-4991 Editore: MDPI AG DOI: 10.3390/nano9050696 Redefining environmental nanomaterial flows: consequences of the regulatory nanomaterial definition on the results of environmental exposure models Autori: Henning Wigger, Wendel Wohlleben, Bernd Nowack Pubblicato in: Environmental Science: Nano, Issue 5/6, 2018, Page(s) 1372-1385, ISSN 2051-8153 Editore: Royal Society of Chemistry DOI: 10.1039/c8en00137e Systematic consideration of parameter uncertainty and variability in probabilistic species sensitivity distributions Autori: Henning Wigger, Delphine Kawecki, Bernd Nowack, Véronique Adam Pubblicato in: Integrated Environmental Assessment and Management, 2019, ISSN 1551-3777 Editore: Society of Environmental Toxicology and Chemistry DOI: 10.1002/ieam.4214 Powder Intrinsic Properties as Dustiness Predictor for an Efficient Exposure Assessment? Autori: Neeraj Shandilya, Eelco Kuijpers, Ilse Tuinman, Wouter Fransman Pubblicato in: Annals of Work Exposures and Health, Issue 63/9, 2019, Page(s) 1029-1045, ISSN 2398-7308 Editore: Oxford University Press DOI: 10.1093/annweh/wxz065 Identifying ecotoxicological descriptors to enable predictive hazard assessments of nano-TiO2 from a meta-analysis of ecotoxicological data Autori: Yaping Cai, Bernd Nowack, Henning Wigger Pubblicato in: NanoImpact, Issue 15, 2019, Page(s) 100180, ISSN 2452-0748 Editore: Elsevier DOI: 10.1016/j.impact.2019.100180 From risk perception to risk governance in nanotechnology: a multi-stakeholder study Autori: Andrea Porcari, Elisabetta Borsella, Christina Benighaus, Khara Grieger, Panagiotis Isigonis, Somik Chakravarty, Pete Kines & Keld Alstrup Jensen Pubblicato in: Journal of Nanoparticle Research, Issue 2019, 21: 245, 2019, ISSN 1388-0764 Editore: Kluwer Academic Publishers Best practices from nano-risk analysis relevant for other emerging technologies Autori: Khara Grieger, Jacob L. Jones, Steffen Foss Hansen, Christine Ogilvie Hendren, Keld Alstrup Jensen, Jennifer Kuzma, Anders Baun Pubblicato in: Nature Nanotechnology, Issue 14/11, 2019, Page(s) 998-1001, ISSN 1748-3387 Editore: Nature Publishing Group DOI: 10.1038/s41565-019-0572-1 Common gene expression patterns in environmental model organisms exposed to engineered nanomaterials: a meta-analysis Autori: Michael Burkard, Alexander Betz, Kristin Schirmer, Anze Zupanic Pubblicato in: Environmental Science & Technology, 2019, ISSN 0013-936X Editore: American Chemical Society DOI: 10.1021/acs.est.9b05170 A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions Autori: Penny Nymark, Linda Rieswijk, Friederike Ehrhart, Nina Jeliazkova, Georgia Tsiliki, Haralambos Sarimveis, Chris T Evelo, Vesa Hongisto, Pekka Kohonen, Egon Willighagen, Roland C Grafström Pubblicato in: Toxicological Sciences, Issue 162/1, 2017, Page(s) 264-275, ISSN 1096-6080 Editore: Oxford University Press DOI: 10.1093/toxsci/kfx252 Particle release and control of worker exposure during laboratory-scale synthesis, handling and simulated spills of manufactured nanomaterials in fume hoods Autori: Ana S. Fonseca, Eelco Kuijpers, Kirsten I. Kling, Marcus Levin, Antti J. Koivisto, Signe H. Nielsen, W. Fransman, Yijri Fedutik, Keld A. Jensen, Ismo K. Koponen Pubblicato in: Journal of Nanoparticle Research, Issue 20/2, 2018, ISSN 1388-0764 Editore: Kluwer Academic Publishers DOI: 10.1007/s11051-018-4136-3 Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials Autori: Marvin Martens, Tim Verbruggen, Penny Nymark, Roland Grafström, Lyle D. Burgoon, Hristo Aladjov, Fernando Torres Andón, Chris T. Evelo, Egon L. Willighagen Pubblicato in: Frontiers in Genetics, Issue 9, 2018, ISSN 1664-8021 Editore: Frontiers Media DOI: 10.3389/fgene.2018.00661 È in corso la ricerca di dati su OpenAIRE... Si è verificato un errore durante la ricerca dei dati su OpenAIRE Nessun risultato disponibile
