Medical Genomics and Epigenomics Network

Información del proyecto

MEDGENET

Identificador del acuerdo de subvención: 692298

DOI

10.3030/692298

Proyecto cerrado

Fecha de la firma de la CE 2 Diciembre 2015

Fecha de inicio 1 Enero 2016

Fecha de finalización 31 Diciembre 2018

Financiado con arreglo a

• Twinning of research institutions

Coste total

€ 1 016 531,25

Aportación de la UE

€ 974 529,25

Coordinado por

Masarykova univerzita
Czechia

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (31)

Report on outreach activities II.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

1st on-line book of abstracts WP2

On-line book of abstracts from each workshop published on MEDGENET website on annual basis

Report on outreach activities VI.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

Report on WP2 coordination, networking and educational events III.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on WP1 coordination, networking and educational events I.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on outreach activities III.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

2nd on-line book of abstracts WP2

On-line book of abstracts from each workshop published on MEDGENET website on annual basis

1st on-line book of abstracts WP1

On-line book of abstracts from each workshop published on MEDGENET website

Report on WP1 coordination, networking and educational events IV.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project.

E-Newsletter II.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on CEITEC scientific excellence and MEDGENET impact assessment

Report on CEITEC scientific excellence and MEDGENET impact assessment – assessment on the number of high quality publications produced in CEITEC Molecular Medicine Program, impact of these publications, h-index of involved CEITEC researchers , number of outputs with high potential for clinical application, number of submitted collaborative international projects, income from successful projects with academia and industry. The report will be part of the Final project report and will also be available online on the project website

3rd on-line bok of abstracts WP1

On-line book of abstracts from each workshop published on MEDGENET website

Report after introducing the a tool for monitoring evolution of publishing activity
Report on WP1 coordination, networking and educational events VI.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on WP1 coordination, networking and educational events II.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project.

Report on outreach activities IV.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

Report on WP2 coordination, networking and educational events I.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter VI.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter I.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter III.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Network’s public engagement and outreach plan

Network’s public engagement and outreach plan – with the proposal and description of activities and events

Report on WP1 coordination, networking and educational events V.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project.

Report on WP2 coordination, networking and educational events II.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

2nd on-line book of abstracts WP1

On-line book of abstracts from each workshop published on MEDGENET website

Database of funding opportunities

Database of funding opportunities available in all 4 countries of MEDGENET partners. The database will provide information about the most suitable funding for each individual scientists and research group and will be accessible on the MEDGENET website

Report on outreach activities V.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

E-Newsletter V.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on WP1 coordination, networking and educational events III.

Report on WP1 coordination, networking and educational events – published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter IV.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on outreach activities I.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

Report on WP2 coordination, networking and educational events IV.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Websites, patent fillings, videos etc. (1)

MEDGENET web page

MEDGENET web page - will give information about project itself, its goals and activities with regular updates

Publicaciones

Peer reviewed articles (197)

MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma

Autores: Petra Vychytilova-Faltejskova, Igor Kiss, Sona Klusova, Jan Hlavsa, Vladimir Prochazka, Zdenek Kala, Jan Mazanec, Jitka Hausnerova, Leos Kren, Marketa Hermanova, Jiri Lenz, Petr Karasek, Rostislav Vyzula, Ondrej Slaby
Publicado en: Diagnostic Pathology, Edición 10/1, 2015, ISSN 1746-1596
Editor: BioMed Central
DOI: 10.1186/s13000-015-0272-6

The outcome of chronic lymphocytic leukemia patients who relapsed after fludarabine, cyclophosphamide, and rituximab

Autores: Anna Panovská, Lukáš Smolej, Daniel Lysák, Yvona Brychtová, Martin Šimkovič, Monika Motyčková, Pavel Vodárek, Michaela Lindtnerová, Martin Trbušek, Jitka Malčíková, Šárka Pospíšilová, Jiří Mayer, Michael Doubek
Publicado en: European Journal of Haematology, Edición 90/6, 2013, Página(s) 479-485, ISSN 0902-4441
Editor: Blackwell Publishing Inc.
DOI: 10.1111/ejh.12106

Hypergravity synthesis of graphitic carbon nanomaterial in glide arc plasma

Autores: Jiří Šperka, Pavel Souček, Jack J.W.A. Van Loon, Alan Dowson, Christian Schwarz, Jutta Krause, Yuriy Butenko, Gerrit Kroesen, Vít Kudrle
Publicado en: Materials Research Bulletin, Edición 54, 2014, Página(s) 61-65, ISSN 0025-5408
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.materresbull.2014.03.013

Treatment of chronic lymphocytic leukemia with monoclonal antibodies, where are we heading?

Autores: Michael Doubek, Michal Šmída
Publicado en: Expert Review of Hematology, Edición 8/6, 2015, Página(s) 743-764, ISSN 1747-4086
Editor: Expert Reviews
DOI: 10.1586/17474086.2015.1079123

TaqMan based real time PCR assay targeting EML4-ALK fusion transcripts in NSCLC

Autores: Blanka Robesova, Monika Bajerova, Kvetoslava Liskova, Jana Skrickova, Marcela Tomiskova, Sarka Pospisilova, Jiri Mayer, Dana Dvorakova
Publicado en: Lung Cancer, Edición 85/1, 2014, Página(s) 25-30, ISSN 0169-5002
Editor: Elsevier BV
DOI: 10.1016/j.lungcan.2014.04.002

Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma

Autores: Andrea Janikova, Andrea Mareckova, Aneta Baumeisterova, Marta Krejci, Jana Supikova, David Salek, Ondrej Horky, Boris Tichy, Ivo Hanke, Sarka Pospisilova, Mojmir Moulis, Jiri Mayer
Publicado en: Leukemia & Lymphoma, Edición 55/8, 2014, Página(s) 1935-1938, ISSN 1042-8194
Editor: Taylor & Francis
DOI: 10.3109/10428194.2013.858150

Contributions of the TEL-patch Amino Acid Cluster on TPP1 to Telomeric DNA Synthesis by Human Telomerase

Autores: Andrew B. Dalby, Ctirad Hofr, Thomas R. Cech
Publicado en: Journal of Molecular Biology, Edición 427/6, 2015, Página(s) 1291-1303, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2015.01.008

Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenström macroglobulinemia

Autores: Lenka Kubiczkova Besse, Lenka Sedlarikova, Fedor Kryukov, Jana Nekvindova, Lenka Radova, Martina Almasi, Jana Pelcova, Jiri Minarik, Tomas Pika, Zuzana Pikalova, Vlastimil Scudla, Marta Krejci, Zdenek Adam, Ludek Pour, Roman Hajek, Sabina Sevcikova
Publicado en: American Journal of Hematology, Edición 90/3, 2015, Página(s) E51-E52, ISSN 0361-8609
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ajh.23910

Forced aggregation and defined factors allow highly uniform-sized embryoid bodies and functional cardiomyocytes from human embryonic and induced pluripotent stem cells

Autores: Martin Pesl, Ivana Acimovic, Jan Pribyl, Renata Hezova, Aleksandra Vilotic, Jeremy Fauconnier, Jan Vrbsky, Peter Kruzliak, Petr Skladal, Tomas Kara, Vladimir Rotrekl, Alain Lacampagne, Petr Dvorak, Albano C. Meli
Publicado en: Heart and Vessels, Edición 29/6, 2014, Página(s) 834-846, ISSN 0910-8327
Editor: Springer Verlag
DOI: 10.1007/s00380-013-0436-9

IgG-Switched CLL Has a Distinct Immunogenetic Signature from the Common MD Variant: Ontogenetic Implications

Autores: A. Vardi, A. Agathangelidis, L.-A. Sutton, M. Chatzouli, L. Scarfo, L. Mansouri, V. Douka, A. Anagnostopoulos, N. Darzentas, R. Rosenquist, P. Ghia, C. Belessi, K. Stamatopoulos
Publicado en: Clinical Cancer Research, Edición 20/2, 2014, Página(s) 323-330, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-13-1993

Hepcidin levels in Diamond-Blackfan anemia reflect erythropoietic activity and transfusion dependency

Autores: D. Pospisilova, D. Holub, Z. Zidova, L. Sulovska, J. Houda, V. Mihal, I. Hadacova, L. Radova, P. Dzubak, M. Hajduch, V. Divoky, M. Horvathova
Publicado en: Haematologica, Edición 99/7, 2014, Página(s) e118-e121, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2014.104034

The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus

Autores: Marek Mraz, Katerina Stano Kozubik, Karla Plevova, Katerina Musilova, Boris Tichy, Marek Borsky, Petr Kuglik, Michael Doubek, Yvona Brychtova, Jiri Mayer, Sarka Pospisilova
Publicado en: Leukemia Research, Edición 37/7, 2013, Página(s) 802-808, ISSN 0145-2126
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.leukres.2013.03.018

Phylogenetic Reconstruction of the Calosphaeriales and Togniniales Using Five Genes and Predicted RNA Secondary Structures of ITS, and Flabellascus tenuirostris gen. et sp. nov.

Autores: Martina Réblová, Walter M. Jaklitsch, Kamila Réblová, Václav Štěpánek
Publicado en: PLOS ONE, Edición 10/12, 2015, Página(s) e0144616, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0144616

ARResT/AssignSubsets: a novel application for robust subclassification of chronic lymphocytic leukemia based on B cell receptor IG stereotypy

Autores: Vojtech Bystry, Andreas Agathangelidis, Vasilis Bikos, Lesley Ann Sutton, Panagiotis Baliakas, Anastasia Hadzidimitriou, Kostas Stamatopoulos, Nikos Darzentas
Publicado en: Bioinformatics, Edición 31/23, 2015, Página(s) btv456, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btv456

The Significance of Stereotyped B-Cell Receptors in Chronic Lymphocytic Leukemia

Autores: Nikos Darzentas, Kostas Stamatopoulos
Publicado en: Hematology/Oncology Clinics of North America, Edición 27/2, 2013, Página(s) 237-250, ISSN 0889-8588
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.hoc.2012.12.001

Extension of microRNA expression pattern associated with high-risk neuroblastoma

Autores: Julie Bienertova-Vasku, Pavel Mazanek, Renata Hezova, Anna Curdova, Jana Nekvindova, Leos Kren, Jaroslav Sterba, Ondrej Slaby
Publicado en: Tumor Biology, Edición 34/4, 2013, Página(s) 2315-2319, ISSN 1010-4283
Editor: Springer Verlag
DOI: 10.1007/s13277-013-0777-0

MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma

Autores: Martina Redova, Alexandr Poprach, Andrej Besse, Robert Iliev, Jana Nekvindova, Radek Lakomy, Lenka Radova, Marek Svoboda, Jan Dolezel, Rostislav Vyzula, Ondrej Slaby
Publicado en: Tumor Biology, Edición 34/1, 2013, Página(s) 481-491, ISSN 1010-4283
Editor: Springer Verlag
DOI: 10.1007/s13277-012-0573-2

Assessment of TP53 functionality in chronic lymphocytic leukaemia by different assays; an ERIC-wide approach

Autores: G. Doreen te Raa, Jitka Malčiková, Marek Mraz, Martin Trbusek, Magali Le Garff-Tavernier, Hélène Merle-Béral, Rudolf Greil, Olaf Merkel, Sarka Pospíšilová, Ke Lin, Andrew R. Pettitt, Tatjana Stankovic, Marinus H. van Oers, Eric Eldering, Stephan Stilgenbauer, Thorsten Zenz, Arnon P. Kater
Publicado en: British Journal of Haematology, Edición 167/4, 2014, Página(s) 565-569, ISSN 0007-1048
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bjh.13006

Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones

Autores: K. Plevova, H. S. Francova, K. Burckova, Y. Brychtova, M. Doubek, S. Pavlova, J. Malcikova, J. Mayer, B. Tichy, S. Pospisilova
Publicado en: Haematologica, Edición 99/2, 2014, Página(s) 329-338, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.087593

Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia

Autores: Jakub Trizuljak, Josef Srovnal, Karla Plevová, Yvona Brychtová, Lukáš Semerád, Denisa Bakešová, Eva Létalová, Andrea Benedíková, Jiří Mayer, Marián Hajdúch, Šárka Pospíšilová, Michael Doubek
Publicado en: Clinical Lymphoma Myeloma and Leukemia, Edición 15/7, 2015, Página(s) 439-442, ISSN 2152-2669
Editor: Cancer Media Group
DOI: 10.1016/j.clml.2015.02.003

Temporal Dynamics of Clonal Evolution in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-34/IGKV2-30 Antigen Receptors: Longitudinal Immunogenetic Evidence

Autores: Lesley Sutton, Efterpi Kostareli
Publicado en: Molecular Medicine, Edición 19/1, 2013, Página(s) 1, ISSN 1076-1551
Editor: North Shore - Long Jewish Research Institute
DOI: 10.2119/molmed.2013.00042

Identification of novel sequence variations in microRNAs in chronic lymphocytic leukemia

Autores: J. Kminkova, M. Mraz, K. Zaprazna, V. Navrkalova, B. Tichy, K. Plevova, J. Malcikova, K. Cerna, T. Rausch, V. Benes, Y. Brychtova, M. Doubek, J. Mayer, S. Pospisilova
Publicado en: Carcinogenesis, Edición 35/5, 2014, Página(s) 992-1002, ISSN 0143-3334
Editor: Oxford University Press
DOI: 10.1093/carcin/bgt396

MicroRNA Profiling of Activated and Tolerogenic Human Dendritic Cells

Autores: Zuzana Stumpfova, Renata Hezova, Albano Carlo Meli, Ondrej Slaby, Jaroslav Michalek
Publicado en: Mediators of Inflammation, Edición 2014, 2014, Página(s) 1-10, ISSN 0962-9351
Editor: Hindawi Publishing Corporation
DOI: 10.1155/2014/259689

The structure and substrate specificity of human Cdk12/Cyclin K

Autores: Christian A. Bösken, Lucas Farnung, Corinna Hintermair, Miriam Merzel Schachter, Karin Vogel-Bachmayr, Dalibor Blazek, Kanchan Anand, Robert P. Fisher, Dirk Eick, Matthias Geyer
Publicado en: Nature Communications, Edición 5, 2014, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms4505

The impact of SF3B1 mutations in CLL on the DNA-damage response

Autores: G D te Raa, I A M Derks, V Navrkalova, A Skowronska, P D Moerland, J van Laar, C Oldreive, H Monsuur, M Trbusek, J Malcikova, M Lodén, C H Geisler, J Hüllein, A Jethwa, T Zenz, S Pospisilova, T Stankovic, M H J van Oers, A P Kater, E Eldering
Publicado en: Leukemia, Edición 29/5, 2014, Página(s) 1133-1142, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2014.318

The role of microRNAs in mitochondria in cancer

Autores: Julie Bienertova-Vasku, Jiri Sana, Ondrej Slaby
Publicado en: Cancer Letters, Edición 336/1, 2013, Página(s) 1-7, ISSN 0304-3835
Editor: Elsevier BV
DOI: 10.1016/j.canlet.2013.05.001

Identification of MicroRNAs Regulated by Isothiocyanates and Association of Polymorphisms Inside Their Target Sites with Risk of Sporadic Colorectal Cancer

Autores: Ondrej Slaby, Milana Sachlova, Veronika Brezkova, Renata Hezova, Alena Kovarikova, Svatava Bischofová, Sabina Sevcikova, Julie Bienertova-Vasku, Anna Vasku, Marek Svoboda, Rostislav Vyzula
Publicado en: Nutrition and Cancer, Edición 65/2, 2013, Página(s) 247-254, ISSN 0163-5581
Editor: Lawrence Erlbaum Associates Inc.
DOI: 10.1080/01635581.2013.756530

ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin

Autores: V. Navrkalova, L. Sebejova, J. Zemanova, J. Kminkova, B. Kubesova, J. Malcikova, M. Mraz, J. Smardova, S. Pavlova, M. Doubek, Y. Brychtova, D. Potesil, V. Nemethova, J. Mayer, S. Pospisilova, M. Trbusek
Publicado en: Haematologica, Edición 98/7, 2013, Página(s) 1124-1131, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2012.081620

Splenic marginal-zone lymphoma: ontogeny and genetics

Autores: Panagiotis Baliakas, Jonathan C. Strefford, Vasilis Bikos, Marina Parry, Kostas Stamatopoulos, David Oscier
Publicado en: Leukemia & Lymphoma, Edición 56/2, 2014, Página(s) 301-310, ISSN 1042-8194
Editor: Taylor & Francis
DOI: 10.3109/10428194.2014.919636

Role of S-turn2 in the Structure, Dynamics, and Function of Mitochondrial Ribosomal A-Site. A Bioinformatics and Molecular Dynamics Simulation Study

Autores: Joanna Panecka, Marek Havrila, Kamila Réblová, Jiří Šponer, Joanna Trylska
Publicado en: The Journal of Physical Chemistry B, Edición 118/24, 2014, Página(s) 6687-6701, ISSN 1520-6106
Editor: American Chemical Society
DOI: 10.1021/jp5030685

The Epitranscriptome and Innate Immunity

Autores: Mary A. O’Connell, Niamh M. Mannion, Liam P. Keegan
Publicado en: PLOS Genetics, Edición 11/12, 2015, Página(s) e1005687, ISSN 1553-7404
Editor: Public Library ScienceUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1005687

Urine microRNAs as potential noninvasive biomarkers in urologic cancers

Autores: Hana Mlcochova, Renata Hezova, Michal Stanik, Ondrej Slaby
Publicado en: Urologic Oncology: Seminars and Original Investigations, Edición 32/1, 2014, Página(s) 41.e1-41.e9, ISSN 1078-1439
Editor: Elsevier BV
DOI: 10.1016/j.urolonc.2013.04.011

"Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2"

Autores: J C Strefford, L-A Sutton, P Baliakas, A Agathangelidis, J Malčíková, K Plevova, L Scarfó, Z Davis, E Stalika, D Cortese, N Cahill, L B Pedersen, P F di Celle, T Tzenou, C Geisler, P Panagiotidis, A W Langerak, N Chiorazzi, S Pospisilova, D Oscier, F Davi, C Belessi, L Mansouri, P Ghia, K Stamatopoulos, R Rosenquist
Publicado en: Leukemia, Edición 27/11, 2013, Página(s) 2196-2199, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2013.98

Novel Evolutionary Lineages Revealed in the Chaetothyriales (Fungi) Based on Multigene Phylogenetic Analyses and Comparison of ITS Secondary Structure

Autores: Martina Réblová, Wendy A. Untereiner, Kamila Réblová
Publicado en: PLoS ONE, Edición 8/5, 2013, Página(s) e63547, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0063547

Towards error-free profiling of immune repertoires

Autores: Mikhail Shugay, Olga V Britanova, Ekaterina M Merzlyak, Maria A Turchaninova, Ilgar Z Mamedov, Timur R Tuganbaev, Dmitriy A Bolotin, Dmitry B Staroverov, Ekaterina V Putintseva, Karla Plevova, Carsten Linnemann, Dmitriy Shagin, Sarka Pospisilova, Sergey Lukyanov, Ton N Schumacher, Dmitriy M Chudakov
Publicado en: Nature Methods, Edición 11/6, 2014, Página(s) 653-655, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/NMETH.2960

Human Rap1 modulates TRF2 attraction to telomeric DNA

Autores: E. Janou kova, I. Ne asova, J. Pavlou kova, M. Zimmermann, M. Hluchy, V. Marini, M. Novakova, C. Hofr
Publicado en: Nucleic Acids Research, Edición 43/5, 2015, Página(s) 2691-2700, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkv097

Clonal evolution in chronic lymphocytic leukemia detected by fluorescence in situ hybridization and conventional cytogenetics after stimulation with CpG oligonucleotides and interleukin-2: A prospective analysis

Autores: Martin Brejcha, Martina Stoklasová, Yvona Brychtová, Anna Panovská, Kristina Štěpanovská, Gabriela Vaňková, Karla Plevová, Alexandra Oltová, Kateřina Horká, Šárka Pospíšilová, Jiří Mayer, Michael Doubek
Publicado en: Leukemia Research, Edición 38/2, 2014, Página(s) 170-175, ISSN 0145-2126
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.leukres.2013.10.019

Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data

Autores: Panagiotis Baliakas, Michalis Iskas, Anne Gardiner, Zadie Davis, Karla Plevova, Florence Nguyen-Khac, Jitka Malcikova, Achilles Anagnostopoulos, Sharron Glide, Sarah Mould, Kristina Stepanovska, Martin Brejcha, Chrysoula Belessi, Frederic Davi, Sarka Pospisilova, Anastasia Athanasiadou, Kostas Stamatopoulos, David Oscier
Publicado en: American Journal of Hematology, Edición 89/3, 2014, Página(s) 249-255, ISSN 0361-8609
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ajh.23618

Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

Autores: P. Baliakas, A. Agathangelidis, A. Hadzidimitriou, L.-A. Sutton, E. Minga, A. Tsanousa, L. Scarfo, Z. Davis, X.-J. Yan, T. Shanafelt, K. Plevova, Y. Sandberg, F. J. Vojdeman, M. Boudjogra, T. Tzenou, M. Chatzouli, C. C. Chu, S. Veronese, A. Gardiner, L. Mansouri, K. E. Smedby, L. B. Pedersen, D. Moreno, K. Van Lom, V. Giudicelli, H. S. Francova, F. Nguyen-Khac, P. Panagiotidis, G. Juliusson, L. Angelis, A. Anagnostopoulos, M.-P. Lefranc, M. Facco, L. Trentin, M. Catherwood, M. Montillo, C. H. Geisler, A. W. Langerak, S. Pospisilova, N. Chiorazzi, D. Oscier, D. F. Jelinek, N. Darzentas, C. Belessi, F. Davi, P. Ghia, R. Rosenquist, K. Stamatopoulos
Publicado en: Blood, Edición 125/5, 2015, Página(s) 856-859, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2014-09-600874

MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis

Autores: A. Benner, L. Mansouri, D. Rossi, A. Majid, K. Willander, A. Parker, G. Bond, S. Pavlova, H. Nuckel, O. Merkel, P. Ghia, E. Montserrat, M. A. Kaderi, R. Rosenquist, G. Gaidano, M. J. S. Dyer, P. Soderkvist, M. Linderholm, D. Oscier, Z. Tvaruzkova, S. Pospisilova, U. Duhrsen, R. Greil, H. Dohner, S. Stilgenbauer, T. Zenz
Publicado en: Haematologica, Edición 99/8, 2014, Página(s) 1285-1291, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.101170

Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice

Autores: O. Stehlíková, J. Chovancová, B. Tichý, M. Krejčí, Y. Brychtová, A. Panovská, H. Francová Skuhrová, K. Burčková, M. Borský, T. Loja, J. Mayer, Š. Pospíšilová, M. Doubek
Publicado en: International Journal of Laboratory Hematology, Edición 36/2, 2014, Página(s) 165-171, ISSN 1751-5521
Editor: Blackwell Science
DOI: 10.1111/ijlh.12149

MicroRNA-206: a Promising Theranostic Marker

Autores: Jan Novák, Peter Kružliak, Julie Bienertová-Vašků, Ondřej Slabý, Miroslav Novák
Publicado en: Theranostics, Edición 4/2, 2014, Página(s) 119-133, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.7552

Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting

Autores: L.-A. Sutton, V. Ljungstrom, L. Mansouri, E. Young, D. Cortese, V. Navrkalova, J. Malcikova, A. F. Muggen, M. Trbusek, P. Panagiotidis, F. Davi, C. Belessi, A. W. Langerak, P. Ghia, S. Pospisilova, K. Stamatopoulos, R. Rosenquist
Publicado en: Haematologica, Edición 100/3, 2015, Página(s) 370-376, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2014.109777

Prognostic relevance of MYD88 mutations in CLL: the jury is still out

Autores: P. Baliakas, A. Hadzidimitriou, A. Agathangelidis, D. Rossi, L.-A. Sutton, J. Kminkova, L. Scarfo, S. Pospisilova, G. Gaidano, K. Stamatopoulos, P. Ghia, R. Rosenquist
Publicado en: Blood, Edición 126/8, 2015, Página(s) 1043-1044, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2015-05-648634

Molecular systematics of <I>Barbatosphaeria</I> (<I>Sordariomycetes</I>): multigene phylogeny and secondary ITS structure

Autores: M. Réblová, K. Réblová, V. Štěpánek
Publicado en: Persoonia - Molecular Phylogeny and Evolution of Fungi, Edición 35/1, 2015, Página(s) 21-38, ISSN 0031-5850
Editor: National Herbarium Nederland/Leiden Branch
DOI: 10.3767/003158515X687434

Immunogenomic analysis of insect bite hypersensitivity in a model horse population

Autores: Leona Vychodilova, Jan Matiasovic, Olga Bobrova, Jan Futas, Marie Klumplerova, Karla Stejskalova, Michaela Cvanova, Eva Janova, Jarmila Osickova, Mirko Vyskocil, Marketa Sedlinska, Ladislav Dusek, Eliane Marti, Petr Horin
Publicado en: Veterinary Immunology and Immunopathology, Edición 152/3-4, 2013, Página(s) 260-268, ISSN 0165-2427
Editor: Elsevier BV
DOI: 10.1016/j.vetimm.2012.12.013

Distinct in vitro sensitivity of p53-mutated and ATM-mutated chronic lymphocytic leukemia cells to ofatumumab and rituximab

Autores: Ludmila Sebejova, Marek Borsky, Zuzana Jaskova, David Potesil, Veronika Navrkalova, Jitka Malcikova, Martin Sramek, Michael Doubek, Tomas Loja, Sarka Pospisilova, Jiri Mayer, Martin Trbusek
Publicado en: Experimental Hematology, Edición 42/10, 2014, Página(s) 867-874.e1, ISSN 0301-472X
Editor: Elsevier BV
DOI: 10.1016/j.exphem.2014.06.003

MicroRNAs involved in chemo- and radioresistance of high-grade gliomas

Autores: Andrej Besse, Jiri Sana, Pavel Fadrus, Ondrej Slaby
Publicado en: Tumor Biology, Edición 34/4, 2013, Página(s) 1969-1978, ISSN 1010-4283
Editor: Springer Verlag
DOI: 10.1007/s13277-013-0772-5

The BCR–ABL1 T315I mutation and additional genomic aberrations are dominant genetic lesions associated with disease progression in patients with chronic myelogenous leukemia resistant to tyrosine kinase inhibitor therapy

Autores: Jitka Malcikova, Filip Razga, Tomas Jurcek, Dana Dvorakova, Daniela Zackova, Martina Toskova, Ludmila Sebejova, Jana Smardova, Alexandra Oltova, Gabriela Vankova, Lenka Jurackova, Martin Trbusek, Sarka Pospisilova, Jiri Mayer, Zdenek Racil
Publicado en: Leukemia & Lymphoma, Edición 54/9, 2013, Página(s) 2083-2087, ISSN 1042-8194
Editor: Taylor & Francis
DOI: 10.3109/10428194.2012.762649

Diagnostic and prognostic potential of miR-21, miR-29c, miR-148 and miR-203 in adenocarcinoma and squamous cell carcinoma of esophagus

Autores: Renata Hezova, Alena Kovarikova, Josef Srovnal, Milada Zemanova, Tomas Harustiak, Jiri Ehrmann, Marian Hajduch, Marek Svoboda, Milana Sachlova, Ondrej Slaby
Publicado en: Diagnostic Pathology, Edición 10/1, 2015, ISSN 1746-1596
Editor: BioMed Central
DOI: 10.1186/s13000-015-0280-6

TP53 mutation analysis in chronic lymphocytic leukemia: comparison of different detection methods

Autores: Barbara Kantorova, Jitka Malcikova, Jana Smardova, Sarka Pavlova, Martin Trbusek, Nikola Tom, Karla Plevova, Boris Tichy, Sim Truong, Eva Diviskova, Jana Kotaskova, Alexandra Oltova, Nancy Patten, Yvona Brychtova, Michael Doubek, Jiri Mayer, Sarka Pospisilova
Publicado en: Tumor Biology, Edición 36/5, 2015, Página(s) 3371-3380, ISSN 1010-4283
Editor: Springer Verlag
DOI: 10.1007/s13277-014-2971-0

Combination of MiR-378 and MiR-210 Serum Levels Enables Sensitive Detection of Renal Cell Carcinoma

Autores: Michal Fedorko, Michal Stanik, Robert Iliev, Martina Redova-Lojova, Tana Machackova, Marek Svoboda, Dalibor Pacik, Jan Dolezel, Ondrej Slaby
Publicado en: International Journal of Molecular Sciences, Edición 16/10, 2015, Página(s) 23382-23389, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms161023382

Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia

Autores: Aliki Xochelli, Andreas Agathangelidis, Ioannis Kavakiotis, Evangelia Minga, Lesley Ann Sutton, Panagiotis Baliakas, Ioanna Chouvarda, Véronique Giudicelli, Ioannis Vlahavas, Nikos Maglaveras, Lisa Bonello, Livio Trentin, Alessandra Tedeschi, Panagiotis Panagiotidis, Christian Geisler, Anton W. Langerak, Sarka Pospisilova, Diane F. Jelinek, David Oscier, Nicholas Chiorazzi, Nikos Darzentas, Fred Davi, Paolo Ghia, Richard Rosenquist, Anastasia Hadzidimitriou, Chrysoula Belessi, Marie-Paule Lefranc, Kostas Stamatopoulos
Publicado en: Immunogenetics, Edición 67/1, 2015, Página(s) 61-66, ISSN 0093-7711
Editor: Springer Verlag
DOI: 10.1007/s00251-014-0812-3

Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway

Autores: L.  merdova, J. Svobodova, M. Kabatkova, J. Kohoutek, D. Bla ek, M. Machala, J. Vondra ek
Publicado en: Carcinogenesis, Edición 35/11, 2014, Página(s) 2534-2543, ISSN 0143-3334
Editor: Oxford University Press
DOI: 10.1093/carcin/bgu190

miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1

Autores: M. Mraz, L. Chen, L. Z. Rassenti, E. M. Ghia, H. Li, K. Jepsen, E. N. Smith, K. Messer, K. A. Frazer, T. J. Kipps
Publicado en: Blood, Edición 124/1, 2014, Página(s) 84-95, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2013-09-527234

ToTem: a tool for variant calling pipeline optimization

Autores: Nikola Tom, Ondrej Tom, Jitka Malcikova, Sarka Pavlova, Blanka Kubesova, Tobias Rausch, Miroslav Kolarik, Vladimir Benes, Vojtech Bystry, Sarka Pospisilova
Publicado en: BMC Bioinformatics, Edición 19/1, 2018, ISSN 1471-2105
Editor: BioMed Central
DOI: 10.1186/s12859-018-2227-x

Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements

Autores: A Vardi, E Vlachonikola, M Karypidou, E Stalika, V Bikos, K Gemenetzi, C Maramis, A Siorenta, A Anagnostopoulos, S Pospisilova, N Maglaveras, I Chouvarda, K Stamatopoulos, A Hadzidimitriou
Publicado en: Leukemia, Edición 31/7, 2016, Página(s) 1555-1561, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2016.362

A novel <i>ex vivo</i> high-throughput assay reveals antiproliferative effects of idelalisib and ibrutinib in chronic lymphocytic leukemia

Autores: Daniel Primo, Lydia Scarfò, Aliki Xochelli, Mattias Mattsson, Pamela Ranghetti, Ana Belén Espinosa, Alicia Robles, Julian Gorrochategui, Joaquín Martínez-López, Javier de la Serna, Marcos González, Alberto Chaparro Gil, Eduardo Anguita, Sandra Iraheta, Veerendra Munugalavadla, Christophe Quéva, Stacey Tannheimer, Richard Rosenquist, Kostas Stamatopoulos, Joan Ballesteros, Paolo Ghia
Publicado en: Oncotarget, Edición 9/40, 2018, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.25419

GLASS: assisted and standardized assessment of gene variations from Sanger sequence trace data

Autores: Karol Pal, Vojtech Bystry, Tomas Reigl, Martin Demko, Adam Krejci, Tasoula Touloumenidou, Evangelia Stalika, Boris Tichy, Paolo Ghia, Kostas Stamatopoulos, Sarka Pospisilova, Jitka Malcikova, Nikos Darzentas
Publicado en: Bioinformatics, Edición 33/23, 2017, Página(s) 3802-3804, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btx423

Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Autores: Aliki Xochelli, Panagiotis Baliakas, Ioannis Kavakiotis, Andreas Agathangelidis, Lesley-Ann Sutton, Eva Minga, Stavroula Ntoufa, Eugen Tausch, Xiao-Jie Yan, Tait Shanafelt, Karla Plevova, Myriam Boudjogra, Davide Rossi, Zadie Davis, Alba Navarro, Yorick Sandberg, Fie Juhl Vojdeman, Lydia Scarfo, Niki Stavroyianni, Andrey Sudarikov, Silvio Veronese, Tatiana Tzenou, Teodora Karan-Djurasevic, Mark Ca
Publicado en: Clinical Cancer Research, Edición 23/17, 2017, Página(s) 5292-5301, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-16-3100

Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia

Autores: Panagiotis Baliakas, Theodoros Moysiadis, Anastasia Hadzidimitriou, Aliki Xochelli, Sabine Jeromin, Andreas Agathangelidis, Mattias Mattsson, Lesley-Ann Sutton, Eva Minga, Lydia Scarfò, Davide Rossi, Zadie Davis, Neus Villamor, Helen Parker, Jana Kotaskova, Evangelia Stalika, Karla Plevova, Larry Mansouri, Diego Cortese, Alba Navarro, Julio Delgado, Marta Larrayoz, Emma Young, Achilles Anagnostop
Publicado en: Haematologica, Edición 104/2, 2019, Página(s) 360-369, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.195032

ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—update on methodological approaches and results interpretation

Autores: J. Malcikova, E. Tausch, D. Rossi, L. A. Sutton, T. Soussi, T. Zenz, A. P. Kater, C. U. Niemann, D. Gonzalez, F. Davi, M. Gonzalez Diaz, C. Moreno, G. Gaidano, K. Stamatopoulos, R. Rosenquist, S. Stilgenbauer, P. Ghia, S. Pospisilova
Publicado en: Leukemia, Edición 32/5, 2018, Página(s) 1070-1080, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-017-0007-7

Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations

Autores: Aliki Xochelli, Vasilis Bikos, Eleftheria Polychronidou, Chrysi Galigalidou, Andreas Agathangelidis, Frédéric Charlotte, Panagiotis Moschonas, Zadie Davis, Monica Colombo, Maria Roumelioti, Lesley-Ann Sutton, Patricia Groenen, Michiel van den Brand, Myriam Boudjoghra, Patricia Algara, Alexandra Traverse-Glehen, Ana Ferrer, Evangelia Stalika, Maria Karypidou, George Kanellis, Christina Kalpadakis
Publicado en: The Journal of Pathology, 2018, ISSN 0022-3417
Editor: John Wiley & Sons Inc.
DOI: 10.1002/path.5209

Integrated epigenomic and transcriptomic analysis reveals TP63 as a novel player in clinically aggressive chronic lymphocytic leukemia

Autores: Nikos Papakonstantinou, Stavroula Ntoufa, Maria Tsagiopoulou, Theodoros Moysiadis, Sujata Bhoi, Andigoni Malousi, Fotis Psomopoulos, Larry Mansouri, Stamatia Laidou, Despoina Papazoglou, Maria Gounari, Konstantinos Pasentsis, Karla Plevova, Venera Kuci-Emruli, Marti Duran-Ferrer, Zadie Davis, Sara Ek, Davide Rossi, Gianluca Gaidano, Matthias Ritgen, David Oscier, Niki Stavroyianni, Sarka Pospisilo
Publicado en: International Journal of Cancer, 2018, ISSN 0020-7136
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ijc.31999

Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations

Autores: R Rosenquist, P Ghia, A Hadzidimitriou, L-A Sutton, A Agathangelidis, P Baliakas, N Darzentas, V Giudicelli, M-P Lefranc, A W Langerak, C Belessi, F Davi, K Stamatopoulos
Publicado en: Leukemia, Edición 31/7, 2017, Página(s) 1477-1481, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2017.125

Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it

Autores: Ivona Nečasová, Eliška Janoušková, Tomáš Klumpler, Ctirad Hofr
Publicado en: Nucleic Acids Research, Edición 45/21, 2017, Página(s) 12170-12180, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkx812

Multiple productive IGH rearrangements denote oligoclonality even in immunophenotypically monoclonal CLL

Autores: K Brazdilova, K Plevova, H Skuhrova Francova, H Kockova, M Borsky, V Bikos, J Malcikova, A Oltova, J Kotaskova, B Tichy, Y Brychtova, J Mayer, M Doubek, S Pospisilova
Publicado en: Leukemia, Edición 32/1, 2017, Página(s) 234-236, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2017.274

"ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres"

Autores: V. Navrkalova, E. Young, P. Baliakas, L. Radova, L.-A. Sutton, K. Plevova, L. Mansouri, V. Ljungstrom, S. Ntoufa, Z. Davis, G. Juliusson, K. E. Smedby, C. Belessi, P. Panagiotidis, T. Touloumenidou, F. Davi, A. W. Langerak, P. Ghia, J. C. Strefford, D. Oscier, J. Mayer, K. Stamatopoulos, S. Pospisilova, R. Rosenquist, M. Trbusek
Publicado en: Haematologica, Edición 101/9, 2016, Página(s) e369-e373, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.142968

Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference

Autores: P. Baliakas, A. Puiggros, A. Xochelli, L.-A. Sutton, F. Nguyen-Khac, A. Gardiner, K. Plevova, E. Minga, A. Hadzidimitriou, R. Walewska, H. McCarthy, M. Ortega, R. Collado, T. Gonzalez, I. Granada, E. Luno, J. Kota kova, T. Moysiadis, Z. Davis, N. Stavroyianni, A. Anagnostopoulos, J. C. Strefford, S. Pospisilova, F. Davi, A. Athanasiadou, R. Rosenquist, D. Oscier, B. Espinet, K. Stamatopoulos
Publicado en: Haematologica, Edición 101/7, 2016, Página(s) e299-e302, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.140202

Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond

Autores: R. Rosenquist, A. Rosenwald, M.-Q. Du, G. Gaidano, P. Groenen, A. Wotherspoon, P. Ghia, P. Gaulard, E. Campo, K. Stamatopoulos
Publicado en: Haematologica, Edición 101/9, 2016, Página(s) 1002-1009, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.134510

The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia

Autores: Nikos Papakonstantinou, Stavroula Ntoufa, Elisavet Chartomatsidou, Konstantia Kotta, Andreas Agathangelidis, Lefki Giassafaki, Tzeni Karamanli, Panagiota Bele, Theodoros Moysiadis, Panagiotis Baliakas, Lesley Ann Sutton, Niki Stavroyianni, Achilles Anagnostopoulos, Antonios M. Makris, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos
Publicado en: Oncotarget, 2016, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.9371

Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors

Autores: L.-A. Sutton, E. Young, P. Baliakas, A. Hadzidimitriou, T. Moysiadis, K. Plevova, D. Rossi, J. Kminkova, E. Stalika, L. B. Pedersen, J. Malcikova, A. Agathangelidis, Z. Davis, L. Mansouri, L. Scarfo, M. Boudjoghra, A. Navarro, A. F. Muggen, X.-J. Yan, F. Nguyen-Khac, M. Larrayoz, P. Panagiotidis, N. Chiorazzi, C. U. Niemann, C. Belessi, E. Campo, J. C. Strefford, A. W. Langerak, D. Oscier, G. Gaid
Publicado en: Haematologica, Edición 101/8, 2016, Página(s) 959-967, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.141812

Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

Autores: P. Baliakas, A. Agathangelidis, A. Hadzidimitriou, L.-A. Sutton, E. Minga, A. Tsanousa, L. Scarfo, Z. Davis, X.-J. Yan, T. Shanafelt, K. Plevova, Y. Sandberg, F. J. Vojdeman, M. Boudjogra, T. Tzenou, M. Chatzouli, C. C. Chu, S. Veronese, A. Gardiner, L. Mansouri, K. E. Smedby, L. B. Pedersen, D. Moreno, K. Van Lom, V. Giudicelli, H. S. Francova, F. Nguyen-Khac, P. Panagiotidis, G. Juliusson, L. Angelis, A. Anagnostopoulos, M.-P. Lefranc, M. Facco, L. Trentin, M. Catherwood, M. Montillo, C. H. Geisler, A. W. Langerak, S. Pospisilova, N. Chiorazzi, D. Oscier, D. F. Jelinek, N. Darzentas, C. Belessi, F. Davi, P. Ghia, R. Rosenquist, K. Stamatopoulos
Publicado en: Blood, Edición 00064971, 2015, Página(s) 856-859, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2014-09-600874

Recurrent mutations refine prognosis in chronic lymphocytic leukemia

Autores: P Baliakas, A Hadzidimitriou, L-A Sutton, D Rossi, E Minga, N Villamor, M Larrayoz, J Kminkova, A Agathangelidis, Z Davis, E Tausch, E Stalika, B Kantorova, L Mansouri, L Scarfò, D Cortese, V Navrkalova, M J J Rose-Zerilli, K E Smedby, G Juliusson, A Anagnostopoulos, A M Makris, A Navarro, J Delgado, D Oscier, C Belessi, S Stilgenbauer, P Ghia, S Pospisilova, G Gaidano, E Campo, J C Strefford, K Stamatopoulos, R Rosenquist
Publicado en: Leukemia, Edición 08876924, 2014, Página(s) 329-336, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2014.196

Prognostic relevance of MYD88 mutations in CLL: the jury is still out

Autores: P. Baliakas, A. Hadzidimitriou, A. Agathangelidis, D. Rossi, L.-A. Sutton, J. Kminkova, L. Scarfo, S. Pospisilova, G. Gaidano, K. Stamatopoulos, P. Ghia, R. Rosenquist
Publicado en: Blood, Edición 00064971, 2015, Página(s) 1043-1044, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2015-05-648634

Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data

Autores: Panagiotis Baliakas, Michalis Iskas, Anne Gardiner, Zadie Davis, Karla Plevova, Florence Nguyen-Khac, Jitka Malcikova, Achilles Anagnostopoulos, Sharron Glide, Sarah Mould, Kristina Stepanovska, Martin Brejcha, Chrysoula Belessi, Frederic Davi, Sarka Pospisilova, Anastasia Athanasiadou, Kostas Stamatopoulos, David Oscier
Publicado en: American Journal of Hematology, Edición 03618609, 2014, Página(s) 249-255, ISSN 0361-8609
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ajh.23618

Human Rap1 modulates TRF2 attraction to telomeric DNA

Autores: E. Janou kova, I. Ne asova, J. Pavlou kova, M. Zimmermann, M. Hluchy, V. Marini, M. Novakova, C. Hofr
Publicado en: Nucleic Acids Research, Edición 03051048, 2015, Página(s) 2691-2700, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkv097

Treatment of chronic lymphocytic leukemia with monoclonal antibodies, where are we heading?

Autores: Michael Doubek, Michal Šmída
Publicado en: Expert Review of Hematology, Edición 17474086, 2015, Página(s) 743-764, ISSN 1747-4086
Editor: Expert Reviews
DOI: 10.1586/17474086.2015.1079123

Molecular systematics of <I>Barbatosphaeria</I> (<I>Sordariomycetes</I>): multigene phylogeny and secondary ITS structure

Autores: M. Réblová, K. Réblová, V. Štěpánek
Publicado en: Persoonia - Molecular Phylogeny and Evolution of Fungi, Edición 00315850, 2015, Página(s) 21-38, ISSN 0031-5850
Editor: National Herbarium Nederland/Leiden Branch
DOI: 10.3767/003158515X687434

MicroRNAs in B-cell lymphomas: how a complex biology gets more complex

Autores: K Musilova, M Mraz
Publicado en: Leukemia, Edición 08876924, 2014, Página(s) 1004-1017, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2014.351

Clonal evolution in chronic lymphocytic leukemia detected by fluorescence in situ hybridization and conventional cytogenetics after stimulation with CpG oligonucleotides and interleukin-2: A prospective analysis

Autores: Martin Brejcha, Martina Stoklasová, Yvona Brychtová, Anna Panovská, Kristina Štěpanovská, Gabriela Vaňková, Karla Plevová, Alexandra Oltová, Kateřina Horká, Šárka Pospíšilová, Jiří Mayer, Michael Doubek
Publicado en: Leukemia Research, Edición 01452126, 2014, Página(s) 170-175, ISSN 0145-2126
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.leukres.2013.10.019

Forced aggregation and defined factors allow highly uniform-sized embryoid bodies and functional cardiomyocytes from human embryonic and induced pluripotent stem cells

Autores: Martin Pesl, Ivana Acimovic, Jan Pribyl, Renata Hezova, Aleksandra Vilotic, Jeremy Fauconnier, Jan Vrbsky, Peter Kruzliak, Petr Skladal, Tomas Kara, Vladimir Rotrekl, Alain Lacampagne, Petr Dvorak, Albano C. Meli
Publicado en: Heart and Vessels, Edición 09108327, 2014, Página(s) 834-846, ISSN 0910-8327
Editor: Springer Verlag
DOI: 10.1007/s00380-013-0436-9

MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia

Autores: Marek Mraz, Thomas J. Kipps
Publicado en: Leukemia & Lymphoma, Edición 10428194, 2013, Página(s) 1836-1839, ISSN 1042-8194
Editor: Taylor & Francis
DOI: 10.3109/10428194.2013.796055

Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1

Autores: Vineeta Khare, Alex Lyakhovich, Kyle Dammann, Michaela Lang, Melanie Borgmann, Boris Tichy, Sarka Pospisilova, Gloria Luciani, Christoph Campregher, Rayko Evstatiev, Maren Pflueger, Harald Hundsberger, Christoph Gasche
Publicado en: Biochemical Pharmacology, Edición 00062952, 2013, Página(s) 234-244, ISSN 0006-2952
Editor: Elsevier BV
DOI: 10.1016/j.bcp.2012.10.026

The role of microRNAs in mitochondria in cancer

Autores: Julie Bienertova-Vasku, Jiri Sana, Ondrej Slaby
Publicado en: Cancer Letters, Edición 03043835, 2013, Página(s) 1-7, ISSN 0304-3835
Editor: Elsevier BV
DOI: 10.1016/j.canlet.2013.05.001

TP53 Mutation Analysis in Clinical Practice: Lessons From Chronic Lymphocytic Leukemia

Autores: Jitka Malcikova, Sarka Pavlova, Katerina Stano Kozubik, Sarka Pospisilova
Publicado en: Human Mutation, Edición 10597794, 2014, Página(s) 663-671, ISSN 1059-7794
Editor: John Wiley & Sons Inc.
DOI: 10.1002/humu.22508

The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors

Autores: Jitka Malcikova, Evangelia Stalika, Zadie Davis, Karla Plevova, Martin Trbusek, Larry Mansouri, Lydia Scarfò, Panagiotis Baliakas, Anne Gardiner, Lesley-Ann Sutton, Hana Skuhrova Francova, Andreas Agathangelidis, Achilles Anagnostopoulos, Ian Tracy, Antonis Makris, Jana Smardova, Paolo Ghia, Chrysoula Belessi, David Gonzalez, Richard Rosenquist, David Oscier, Sarka Pospisilova, Kostas Stamatopoulos
Publicado en: British Journal of Haematology, Edición 00071048, 2014, Página(s) 621-625, ISSN 0007-1048
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bjh.12893

MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma

Autores: Petra Vychytilova-Faltejskova, Igor Kiss, Sona Klusova, Jan Hlavsa, Vladimir Prochazka, Zdenek Kala, Jan Mazanec, Jitka Hausnerova, Leos Kren, Marketa Hermanova, Jiri Lenz, Petr Karasek, Rostislav Vyzula, Ondrej Slaby
Publicado en: Diagnostic Pathology, Edición 17461596, 2015, ISSN 1746-1596
Editor: BioMed Central
DOI: 10.1186/s13000-015-0272-6

Identification of novel sequence variations in microRNAs in chronic lymphocytic leukemia

Autores: J. Kminkova, M. Mraz, K. Zaprazna, V. Navrkalova, B. Tichy, K. Plevova, J. Malcikova, K. Cerna, T. Rausch, V. Benes, Y. Brychtova, M. Doubek, J. Mayer, S. Pospisilova
Publicado en: Carcinogenesis, Edición 01433334, 2014, Página(s) 992-1002, ISSN 0143-3334
Editor: Oxford University Press
DOI: 10.1093/carcin/bgt396

Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients

Autores: J. Sana, L. Radova, R. Lakomy, L. Kren, P. Fadrus, M. Smrcka, A. Besse, J. Nekvindova, M. Hermanova, R. Jancalek, M. Svoboda, M. Hajduch, P. Slampa, R. Vyzula, O. Slaby
Publicado en: Carcinogenesis, Edición 01433334, 2014, Página(s) 2756-2762, ISSN 0143-3334
Editor: Oxford University Press
DOI: 10.1093/carcin/bgu212

The BCR–ABL1 T315I mutation and additional genomic aberrations are dominant genetic lesions associated with disease progression in patients with chronic myelogenous leukemia resistant to tyrosine kinase inhibitor therapy

Autores: Jitka Malcikova, Filip Razga, Tomas Jurcek, Dana Dvorakova, Daniela Zackova, Martina Toskova, Ludmila Sebejova, Jana Smardova, Alexandra Oltova, Gabriela Vankova, Lenka Jurackova, Martin Trbusek, Sarka Pospisilova, Jiri Mayer, Zdenek Racil
Publicado en: Leukemia & Lymphoma, Edición 10428194, 2013, Página(s) 2083-2087, ISSN 1042-8194
Editor: Taylor & Francis
DOI: 10.3109/10428194.2012.762649

MicroRNA-206: a Promising Theranostic Marker

Autores: Jan Novák, Peter Kružliak, Julie Bienertová-Vašků, Ondřej Slabý, Miroslav Novák
Publicado en: Theranostics, Edición 18387640, 2014, Página(s) 119-133, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.7552

miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib

Autores: Jana Merhautova, Renata Hezova, Alexandr Poprach, Alena Kovarikova, Lenka Radova, Marek Svoboda, Rostislav Vyzula, Regina Demlova, Ondrej Slaby
Publicado en: BioMed Research International, Edición 23146133, 2015, Página(s) 1-5, ISSN 2314-6133
Editor: Hindawi Publishing Corporation
DOI: 10.1155/2015/941980

Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting

Autores: L.-A. Sutton, V. Ljungstrom, L. Mansouri, E. Young, D. Cortese, V. Navrkalova, J. Malcikova, A. F. Muggen, M. Trbusek, P. Panagiotidis, F. Davi, C. Belessi, A. W. Langerak, P. Ghia, S. Pospisilova, K. Stamatopoulos, R. Rosenquist
Publicado en: Haematologica, Edición 03906078, 2015, Página(s) 370-376, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2014.109777

Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia

Autores: J Malcikova, K Stano-Kozubik, B Tichy, B Kantorova, S Pavlova, N Tom, L Radova, J Smardova, F Pardy, M Doubek, Y Brychtova, M Mraz, K Plevova, E Diviskova, A Oltova, J Mayer, S Pospisilova, M Trbusek
Publicado en: Leukemia, Edición 08876924, 2014, Página(s) 877-885, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2014.297

MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia

Autores: B. Cui, L. Chen, S. Zhang, M. Mraz, J.-F. Fecteau, J. Yu, E. M. Ghia, L. Zhang, L. Bao, L. Z. Rassenti, K. Messer, G. A. Calin, C. M. Croce, T. J. Kipps
Publicado en: Blood, Edición 00064971, 2014, Página(s) 546-554, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2014-03-559690

The outcome of chronic lymphocytic leukemia patients who relapsed after fludarabine, cyclophosphamide, and rituximab

Autores: Anna Panovská, Lukáš Smolej, Daniel Lysák, Yvona Brychtová, Martin Šimkovič, Monika Motyčková, Pavel Vodárek, Michaela Lindtnerová, Martin Trbušek, Jitka Malčíková, Šárka Pospíšilová, Jiří Mayer, Michael Doubek
Publicado en: European Journal of Haematology, Edición 09024441, 2013, Página(s) 479-485, ISSN 0902-4441
Editor: Blackwell Publishing Inc.
DOI: 10.1111/ejh.12106

TP53 mutation analysis in chronic lymphocytic leukemia: comparison of different detection methods

Autores: Barbara Kantorova, Jitka Malcikova, Jana Smardova, Sarka Pavlova, Martin Trbusek, Nikola Tom, Karla Plevova, Boris Tichy, Sim Truong, Eva Diviskova, Jana Kotaskova, Alexandra Oltova, Nancy Patten, Yvona Brychtova, Michael Doubek, Jiri Mayer, Sarka Pospisilova
Publicado en: Tumor Biology, Edición 10104283, 2015, Página(s) 3371-3380, ISSN 1010-4283
Editor: Springer Verlag
DOI: 10.1007/s13277-014-2971-0

Identification of MicroRNAs Regulated by Isothiocyanates and Association of Polymorphisms Inside Their Target Sites with Risk of Sporadic Colorectal Cancer

Autores: Ondrej Slaby, Milana Sachlova, Veronika Brezkova, Renata Hezova, Alena Kovarikova, Svatava Bischofová, Sabina Sevcikova, Julie Bienertova-Vasku, Anna Vasku, Marek Svoboda, Rostislav Vyzula
Publicado en: Nutrition and Cancer, Edición 01635581, 2013, Página(s) 247-254, ISSN 0163-5581
Editor: Lawrence Erlbaum Associates Inc.
DOI: 10.1080/01635581.2013.756530

MicroRNA Profiling of Activated and Tolerogenic Human Dendritic Cells

Autores: Zuzana Stumpfova, Renata Hezova, Albano Carlo Meli, Ondrej Slaby, Jaroslav Michalek
Publicado en: Mediators of Inflammation, Edición 09629351, 2014, Página(s) 1-10, ISSN 0962-9351
Editor: Hindawi Publishing Corporation
DOI: 10.1155/2014/259689

Extension of microRNA expression pattern associated with high-risk neuroblastoma

Autores: Julie Bienertova-Vasku, Pavel Mazanek, Renata Hezova, Anna Curdova, Jana Nekvindova, Leos Kren, Jaroslav Sterba, Ondrej Slaby
Publicado en: Tumor Biology, Edición 10104283, 2013, Página(s) 2315-2319, ISSN 1010-4283
Editor: Springer Verlag
DOI: 10.1007/s13277-013-0777-0

B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells

Autores: Vaclav Seda, Marek Mraz
Publicado en: European Journal of Haematology, Edición 09024441, 2015, Página(s) 193-205, ISSN 0902-4441
Editor: Blackwell Publishing Inc.
DOI: 10.1111/ejh.12427

Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

Autores: Larry Mansouri, Lesley-Ann Sutton, Viktor Ljungström, Sina Bondza, Linda Arngården, Sujata Bhoi, Jimmy Larsson, Diego Cortese, Antonia Kalushkova, Karla Plevova, Emma Young, Rebeqa Gunnarsson, Elin Falk-Sörqvist, Peter Lönn, Alice F. Muggen, Xiao-Jie Yan, Birgitta Sander, Gunilla Enblad, Karin E. Smedby, Gunnar Juliusson, Chrysoula Belessi, Johan Rung, Nicholas Chiorazzi, Jonathan C. Strefford, Anton W. Langerak, Sarka Pospisilova, Frederic Davi, Mats Hellström, Helena Jernberg-Wiklund, Paolo Ghia, Ola Söderberg, Kostas Stamatopoulos, Mats Nilsson, Richard Rosenquist
Publicado en: The Journal of Experimental Medicine, Edición 00221007, 2015, Página(s) 833-843, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20142009

The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration

Autores: M. Kaucka, K. Plevova, S. Pavlova, P. Janovska, A. Mishra, J. Verner, J. Prochazkova, P. Krejci, J. Kotaskova, P. Ovesna, B. Tichy, Y. Brychtova, M. Doubek, A. Kozubik, J. Mayer, S. Pospisilova, V. Bryja
Publicado en: Cancer Research, Edición 00085472, 2013, Página(s) 1491-1501, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-12-1752

miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1

Autores: M. Mraz, L. Chen, L. Z. Rassenti, E. M. Ghia, H. Li, K. Jepsen, E. N. Smith, K. Messer, K. A. Frazer, T. J. Kipps
Publicado en: Blood, Edición 00064971, 2014, Página(s) 84-95, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2013-09-527234

Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones

Autores: K. Plevova, H. S. Francova, K. Burckova, Y. Brychtova, M. Doubek, S. Pavlova, J. Malcikova, J. Mayer, B. Tichy, S. Pospisilova
Publicado en: Haematologica, Edición 03906078, 2014, Página(s) 329-338, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.087593

RNA secondary structure, an important bioinformatics tool to enhance multiple sequence alignment: a case study (Sordariomycetes, Fungi)

Autores: Martina Réblová, Kamila Réblová
Publicado en: Mycological Progress, Edición 1617416X, 2013, Página(s) 305-319, ISSN 1617-416X
Editor: IHW-Verl
DOI: 10.1007/s11557-012-0836-8

The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus

Autores: Marek Mraz, Katerina Stano Kozubik, Karla Plevova, Katerina Musilova, Boris Tichy, Marek Borsky, Petr Kuglik, Michael Doubek, Yvona Brychtova, Jiri Mayer, Sarka Pospisilova
Publicado en: Leukemia Research, Edición 01452126, 2013, Página(s) 802-808, ISSN 0145-2126
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.leukres.2013.03.018

Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenström macroglobulinemia

Autores: Lenka Kubiczkova Besse, Lenka Sedlarikova, Fedor Kryukov, Jana Nekvindova, Lenka Radova, Martina Almasi, Jana Pelcova, Jiri Minarik, Tomas Pika, Zuzana Pikalova, Vlastimil Scudla, Marta Krejci, Zdenek Adam, Ludek Pour, Roman Hajek, Sabina Sevcikova
Publicado en: American Journal of Hematology, Edición 03618609, 2015, Página(s) E51-E52, ISSN 0361-8609
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ajh.23910

Histone H1 Differentially Inhibits DNA Bending by Reduced and Oxidized HMGB1 Protein

Autores: Michal Štros, Eva Polanská, Martin Kučírek, Šárka Pospíšilová
Publicado en: PLOS ONE, Edición 19326203, 2015, Página(s) e0138774, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0138774

Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma

Autores: Lenka Besse, Lenka Sedlarikova, Fedor Kryukov, Jana Nekvindova, Lenka Radova, Ondrej Slaby, Petr Kuglik, Martina Almasi, Miroslav Penka, Marta Krejci, Zdenek Adam, Ludek Pour, Sabina Sevcikova, Roman Hajek
Publicado en: PLOS ONE, Edición 19326203, 2015, Página(s) e0137294, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0137294

ARResT/AssignSubsets: a novel application for robust subclassification of chronic lymphocytic leukemia based on B cell receptor IG stereotypy

Autores: Vojtech Bystry, Andreas Agathangelidis, Vasilis Bikos, Lesley Ann Sutton, Panagiotis Baliakas, Anastasia Hadzidimitriou, Kostas Stamatopoulos, Nikos Darzentas
Publicado en: Bioinformatics, Edición 13674803, 2015, Página(s) btv456, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btv456

The impact of SF3B1 mutations in CLL on the DNA-damage response

Autores: G D te Raa, I A M Derks, V Navrkalova, A Skowronska, P D Moerland, J van Laar, C Oldreive, H Monsuur, M Trbusek, J Malcikova, M Lodén, C H Geisler, J Hüllein, A Jethwa, T Zenz, S Pospisilova, T Stankovic, M H J van Oers, A P Kater, E Eldering
Publicado en: Leukemia, Edición 08876924, 2014, Página(s) 1133-1142, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2014.318

"Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2"

Autores: J C Strefford, L-A Sutton, P Baliakas, A Agathangelidis, J Malčíková, K Plevova, L Scarfó, Z Davis, E Stalika, D Cortese, N Cahill, L B Pedersen, P F di Celle, T Tzenou, C Geisler, P Panagiotidis, A W Langerak, N Chiorazzi, S Pospisilova, D Oscier, F Davi, C Belessi, L Mansouri, P Ghia, K Stamatopoulos, R Rosenquist
Publicado en: Leukemia, Edición 08876924, 2013, Página(s) 2196-2199, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2013.98

CLCN1 Mutations in Czech Patients with Myotonia Congenita, In Silico Analysis of Novel and Known Mutations in the Human Dimeric Skeletal Muscle Chloride Channel

Autores: Daniela Skálová, Jana Zídková, Stanislav Voháňka, Radim Mazanec, Zuzana Mušová, Petr Vondráček, Lenka Mrázová, Josef Kraus, Kamila Réblová, Lenka Fajkusová
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e82549, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0082549

The Significance of Stereotyped B-Cell Receptors in Chronic Lymphocytic Leukemia

Autores: Nikos Darzentas, Kostas Stamatopoulos
Publicado en: Hematology/Oncology Clinics of North America, Edición 08898588, 2013, Página(s) 237-250, ISSN 0889-8588
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.hoc.2012.12.001

Hepcidin levels in Diamond-Blackfan anemia reflect erythropoietic activity and transfusion dependency

Autores: D. Pospisilova, D. Holub, Z. Zidova, L. Sulovska, J. Houda, V. Mihal, I. Hadacova, L. Radova, P. Dzubak, M. Hajduch, V. Divoky, M. Horvathova
Publicado en: Haematologica, Edición 03906078, 2014, Página(s) e118-e121, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2014.104034

The structure and substrate specificity of human Cdk12/Cyclin K

Autores: Christian A. Bösken, Lucas Farnung, Corinna Hintermair, Miriam Merzel Schachter, Karin Vogel-Bachmayr, Dalibor Blazek, Kanchan Anand, Robert P. Fisher, Dirk Eick, Matthias Geyer
Publicado en: Nature Communications, Edición 20411723, 2014, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms4505

Phylogenetic Reconstruction of the Calosphaeriales and Togniniales Using Five Genes and Predicted RNA Secondary Structures of ITS, and Flabellascus tenuirostris gen. et sp. nov.

Autores: Martina Réblová, Walter M. Jaklitsch, Kamila Réblová, Václav Štěpánek
Publicado en: PLOS ONE, Edición 19326203, 2015, Página(s) e0144616, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0144616

Diagnostic and prognostic potential of miR-21, miR-29c, miR-148 and miR-203 in adenocarcinoma and squamous cell carcinoma of esophagus

Autores: Renata Hezova, Alena Kovarikova, Josef Srovnal, Milada Zemanova, Tomas Harustiak, Jiri Ehrmann, Marian Hajduch, Marek Svoboda, Milana Sachlova, Ondrej Slaby
Publicado en: Diagnostic Pathology, Edición 17461596, 2015, ISSN 1746-1596
Editor: BioMed Central
DOI: 10.1186/s13000-015-0280-6

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

Autores: K. M. Ekumi, H. Paculova, T. Lenasi, V. Pospichalova, C. A. Bosken, J. Rybarikova, V. Bryja, M. Geyer, D. Blazek, M. Barboric
Publicado en: Nucleic Acids Research, Edición 03051048, 2015, Página(s) 2575-2589, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkv101

MicroRNAs targeting EGFR signalling pathway in colorectal cancer

Autores: Jitka Mlcochova, Petra Faltejskova, Radim Nemecek, Marek Svoboda, Ondrej Slaby
Publicado en: Journal of Cancer Research and Clinical Oncology, Edición 01715216, 2013, Página(s) 1615-1624, ISSN 0171-5216
Editor: Springer Verlag
DOI: 10.1007/s00432-013-1470-9

Combination of fludarabine, amsacrine, and cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with high-risk acute myeloid leukemia

Autores: Marta Krejci, Michael Doubek, Jaroslav Dusek, Yvona Brychtova, Zdenek Racil, Milan Navratil, Miroslav Tomiska, Ondrej Horky, Sarka Pospisilova, Jiri Mayer
Publicado en: Annals of Hematology, Edición 09395555, 2013, Página(s) 1397-1403, ISSN 0939-5555
Editor: Springer Verlag
DOI: 10.1007/s00277-013-1790-5

Immunogenomic analysis of insect bite hypersensitivity in a model horse population

Autores: Leona Vychodilova, Jan Matiasovic, Olga Bobrova, Jan Futas, Marie Klumplerova, Karla Stejskalova, Michaela Cvanova, Eva Janova, Jarmila Osickova, Mirko Vyskocil, Marketa Sedlinska, Ladislav Dusek, Eliane Marti, Petr Horin
Publicado en: Veterinary Immunology and Immunopathology, Edición 01652427, 2013, Página(s) 260-268, ISSN 0165-2427
Editor: Elsevier BV
DOI: 10.1016/j.vetimm.2012.12.013

Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice

Autores: O. Stehlíková, J. Chovancová, B. Tichý, M. Krejčí, Y. Brychtová, A. Panovská, H. Francová Skuhrová, K. Burčková, M. Borský, T. Loja, J. Mayer, Š. Pospíšilová, M. Doubek
Publicado en: International Journal of Laboratory Hematology, Edición 17515521, 2014, Página(s) 165-171, ISSN 1751-5521
Editor: Blackwell Science
DOI: 10.1111/ijlh.12149

Ofatumumab added to dexamethasone in patients with relapsed or refractory chronic lymphocytic leukemia: Results from a phase II study

Autores: Michael Doubek, Yvona Brychtova, Anna Panovska, Ludmila Sebejova, Olga Stehlikova, Jana Chovancova, Jitka Malcikova, Jana Smardova, Karla Plevova, Pavlina Volfova, Martin Trbusek, Marek Mraz, Denisa Bakesova, Jakub Trizuljak, Marketa Hadrabova, Petra Obrtlikova, Josef Karban, Lukas Smolej, Alexandra Oltova, Eva Jelinkova, Sarka Pospisilova, Jiri Mayer
Publicado en: American Journal of Hematology, Edición 03618609, 2015, Página(s) 417-421, ISSN 0361-8609
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ajh.23964

Contributions of the TEL-patch Amino Acid Cluster on TPP1 to Telomeric DNA Synthesis by Human Telomerase

Autores: Andrew B. Dalby, Ctirad Hofr, Thomas R. Cech
Publicado en: Journal of Molecular Biology, Edición 00222836, 2015, Página(s) 1291-1303, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2015.01.008

NOD/SCID IL2Rγ-null mouse xenograft model of human p53-mutated chronic lymphocytic leukemia and ATM-mutated mantle cell lymphoma using permanent cell lines

Autores: Jan Verner, Martin Trbusek, Jana Chovancova, Zuzana Jaskova, Mojmir Moulis, Frantisek Folber, Roman Halouzka, Jiri Mayer, Sarka Pospisilova, Michael Doubek
Publicado en: Leukemia & Lymphoma, Edición 10428194, 2015, Página(s) 3198-3206, ISSN 1042-8194
Editor: Taylor & Francis
DOI: 10.3109/10428194.2015.1034701

Fludarabine with cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with poor-risk chronic lymphocytic leukemia

Autores: Marta Krejci, Michael Doubek, Yvona Brychtova, Olga Stehlikova, Jana Chovancova, Boris Tichy, Hana Skuhrova Francova, Milan Navratil, Miroslav Tomiska, Ondrej Horky, Sarka Pospisilova, Jiri Mayer
Publicado en: Annals of Hematology, Edición 09395555, 2013, Página(s) 249-254, ISSN 0939-5555
Editor: Springer Verlag
DOI: 10.1007/s00277-012-1579-y

Combination of MiR-378 and MiR-210 Serum Levels Enables Sensitive Detection of Renal Cell Carcinoma

Autores: Michal Fedorko, Michal Stanik, Robert Iliev, Martina Redova-Lojova, Tana Machackova, Marek Svoboda, Dalibor Pacik, Jan Dolezel, Ondrej Slaby
Publicado en: International Journal of Molecular Sciences, Edición 14220067, 2015, Página(s) 23382-23389, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms161023382

Binding of Histone H1 to DNA Is Differentially Modulated by Redox State of HMGB1

Autores: Eva Polanská, Šárka Pospíšilová, Michal Štros
Publicado en: PLoS ONE, Edición 19326203, 2014, Página(s) e89070, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0089070

Novel Evolutionary Lineages Revealed in the Chaetothyriales (Fungi) Based on Multigene Phylogenetic Analyses and Comparison of ITS Secondary Structure

Autores: Martina Réblová, Wendy A. Untereiner, Kamila Réblová
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e63547, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0063547

Distinct in vitro sensitivity of p53-mutated and ATM-mutated chronic lymphocytic leukemia cells to ofatumumab and rituximab

Autores: Ludmila Sebejova, Marek Borsky, Zuzana Jaskova, David Potesil, Veronika Navrkalova, Jitka Malcikova, Martin Sramek, Michael Doubek, Tomas Loja, Sarka Pospisilova, Jiri Mayer, Martin Trbusek
Publicado en: Experimental Hematology, Edición 0301472X, 2014, Página(s) 867-874.e1, ISSN 0301-472X
Editor: Elsevier BV
DOI: 10.1016/j.exphem.2014.06.003

ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin

Autores: V. Navrkalova, L. Sebejova, J. Zemanova, J. Kminkova, B. Kubesova, J. Malcikova, M. Mraz, J. Smardova, S. Pavlova, M. Doubek, Y. Brychtova, D. Potesil, V. Nemethova, J. Mayer, S. Pospisilova, M. Trbusek
Publicado en: Haematologica, Edición 03906078, 2013, Página(s) 1124-1131, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2012.081620

Towards error-free profiling of immune repertoires

Autores: Mikhail Shugay, Olga V Britanova, Ekaterina M Merzlyak, Maria A Turchaninova, Ilgar Z Mamedov, Timur R Tuganbaev, Dmitriy A Bolotin, Dmitry B Staroverov, Ekaterina V Putintseva, Karla Plevova, Carsten Linnemann, Dmitriy Shagin, Sarka Pospisilova, Sergey Lukyanov, Ton N Schumacher, Dmitriy M Chudakov
Publicado en: Nature Methods, Edición 15487091, 2014, Página(s) 653-655, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/NMETH.2960

Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia

Autores: Aliki Xochelli, Andreas Agathangelidis, Ioannis Kavakiotis, Evangelia Minga, Lesley Ann Sutton, Panagiotis Baliakas, Ioanna Chouvarda, Véronique Giudicelli, Ioannis Vlahavas, Nikos Maglaveras, Lisa Bonello, Livio Trentin, Alessandra Tedeschi, Panagiotis Panagiotidis, Christian Geisler, Anton W. Langerak, Sarka Pospisilova, Diane F. Jelinek, David Oscier, Nicholas Chiorazzi, Nikos Darzentas, Fred Davi, Paolo Ghia, Richard Rosenquist, Anastasia Hadzidimitriou, Chrysoula Belessi, Marie-Paule Lefranc, Kostas Stamatopoulos
Publicado en: Immunogenetics, Edición 00937711, 2015, Página(s) 61-66, ISSN 0093-7711
Editor: Springer Verlag
DOI: 10.1007/s00251-014-0812-3

Urine microRNAs as potential noninvasive biomarkers in urologic cancers

Autores: Hana Mlcochova, Renata Hezova, Michal Stanik, Ondrej Slaby
Publicado en: Urologic Oncology: Seminars and Original Investigations, Edición 10781439, 2014, Página(s) 41.e1-41.e9, ISSN 1078-1439
Editor: Elsevier BV
DOI: 10.1016/j.urolonc.2013.04.011

MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma

Autores: Martina Redova, Alexandr Poprach, Andrej Besse, Robert Iliev, Jana Nekvindova, Radek Lakomy, Lenka Radova, Marek Svoboda, Jan Dolezel, Rostislav Vyzula, Ondrej Slaby
Publicado en: Tumor Biology, Edición 10104283, 2013, Página(s) 481-491, ISSN 1010-4283
Editor: Springer Verlag
DOI: 10.1007/s13277-012-0573-2

Temporal Dynamics of Clonal Evolution in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-34/IGKV2-30 Antigen Receptors: Longitudinal Immunogenetic Evidence

Autores: Lesley Sutton, Efterpi Kostareli
Publicado en: Molecular Medicine, Edición 10761551, 2013, Página(s) 1, ISSN 1076-1551
Editor: North Shore - Long Jewish Research Institute
DOI: 10.2119/molmed.2013.00042

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins

Autores: Niamh Mannion, Fabiana Arieti, Angela Gallo, Liam Keegan, Mary O'Connell
Publicado en: Biomolecules, Edición 2218273X, 2015, Página(s) 2338-2362, ISSN 2218-273X
Editor: MDPI AG
DOI: 10.3390/biom5042338

IgG-Switched CLL Has a Distinct Immunogenetic Signature from the Common MD Variant: Ontogenetic Implications

Autores: A. Vardi, A. Agathangelidis, L.-A. Sutton, M. Chatzouli, L. Scarfo, L. Mansouri, V. Douka, A. Anagnostopoulos, N. Darzentas, R. Rosenquist, P. Ghia, C. Belessi, K. Stamatopoulos
Publicado en: Clinical Cancer Research, Edición 10780432, 2014, Página(s) 323-330, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-13-1993

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

Autores: Jan Machal, Jan Novak, Renata Hezova, Filip Zlamal, Anna Vasku, Ondrej Slaby, Julie Bienertova-Vasku
Publicado en: Genes & Nutrition, Edición 15558932, 2015, ISSN 1555-8932
Editor: New Century Health Publishers
DOI: 10.1007/s12263-015-0488-9

Hypergravity effects on glide arc plasma

Autores: Jiří Šperka, Pavel Souček, Jack J. W. A. Van Loon, Alan Dowson, Christian Schwarz, Jutta Krause, Gerrit Kroesen, Vít Kudrle
Publicado en: The European Physical Journal D, Edición 14346060, 2013, ISSN 1434-6060
Editor: Springer Verlag
DOI: 10.1140/epjd/e2013-40408-7

Splenic marginal-zone lymphoma: ontogeny and genetics

Autores: Panagiotis Baliakas, Jonathan C. Strefford, Vasilis Bikos, Marina Parry, Kostas Stamatopoulos, David Oscier
Publicado en: Leukemia & Lymphoma, Edición 10428194, 2014, Página(s) 301-310, ISSN 1042-8194
Editor: Taylor & Francis
DOI: 10.3109/10428194.2014.919636

Isosteric and Nonisosteric Base Pairs in RNA Motifs: Molecular Dynamics and Bioinformatics Study of the Sarcin–Ricin Internal Loop

Autores: Marek Havrila, Kamila Réblová, Craig L. Zirbel, Neocles B. Leontis, Jiří Šponer
Publicado en: The Journal of Physical Chemistry B, Edición 15206106, 2013, Página(s) 14302-14319, ISSN 1520-6106
Editor: American Chemical Society
DOI: 10.1021/jp408530w

Assessment of TP53 functionality in chronic lymphocytic leukaemia by different assays; an ERIC-wide approach

Autores: G. Doreen te Raa, Jitka Malčiková, Marek Mraz, Martin Trbusek, Magali Le Garff-Tavernier, Hélène Merle-Béral, Rudolf Greil, Olaf Merkel, Sarka Pospíšilová, Ke Lin, Andrew R. Pettitt, Tatjana Stankovic, Marinus H. van Oers, Eric Eldering, Stephan Stilgenbauer, Thorsten Zenz, Arnon P. Kater
Publicado en: British Journal of Haematology, Edición 00071048, 2014, Página(s) 565-569, ISSN 0007-1048
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bjh.13006

Molecular Evidence for Antigen Drive in the Natural History of Mantle Cell Lymphoma

Autores: Aliki Xochelli, Lesley-Ann Sutton, Andreas Agathangelidis, Evangelia Stalika, Maria Karypidou, Fotini Marantidou, Alba Navarro Lopez, Giorgos Papadopoulos, Jana Supikova, Patricia Groenen, Myriam Boudjogra, Christer Sundstrom, Maurilio Ponzoni, Hana Skuhrova Francova, Achilles Anagnostopoulos, Sarka Pospisilova, Theodora Papadaki, Dimitris Tzovaras, Paolo Ghia, Christiane Pott, Frederic Davi, Elias Campo, Richard Rosenquist, Anastasia Hadzidimitriou, Chrysoula Belessi, Kostas Stamatopoulos
Publicado en: The American Journal of Pathology, Edición 00029440, 2015, Página(s) 1740-1748, ISSN 0002-9440
Editor: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2015.02.006

The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex

Autores: Lucie Kozakova, Lucie Vondrova, Karel Stejskal, Panagoula Charalabous, Peter Kolesar, Alan R Lehmann, Stjepan Uldrijan, Christopher M Sanderson, Zbynek Zdrahal, Jan J Palecek
Publicado en: Cell Cycle, Edición 15384101, 2015, Página(s) 920-930, ISSN 1538-4101
Editor: Landes Bioscience
DOI: 10.1080/15384101.2014.1000112

Role of S-turn2 in the Structure, Dynamics, and Function of Mitochondrial Ribosomal A-Site. A Bioinformatics and Molecular Dynamics Simulation Study

Autores: Joanna Panecka, Marek Havrila, Kamila Réblová, Jiří Šponer, Joanna Trylska
Publicado en: The Journal of Physical Chemistry B, Edición 15206106, 2014, Página(s) 6687-6701, ISSN 1520-6106
Editor: American Chemical Society
DOI: 10.1021/jp5030685

Dynamic changes in microRNA expression profiles reflect progression of Barrett's esophagus to esophageal adenocarcinoma

Autores: O. Slaby, J. Srovnal, L. Radova, J. Gregar, J. Juracek, P. Luzna, M. Svoboda, M. Hajduch, J. Ehrmann
Publicado en: Carcinogenesis, Edición 01433334, 2015, Página(s) 521-527, ISSN 0143-3334
Editor: Oxford University Press
DOI: 10.1093/carcin/bgv023

Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma

Autores: Andrea Janikova, Andrea Mareckova, Aneta Baumeisterova, Marta Krejci, Jana Supikova, David Salek, Ondrej Horky, Boris Tichy, Ivo Hanke, Sarka Pospisilova, Mojmir Moulis, Jiri Mayer
Publicado en: Leukemia & Lymphoma, Edición 10428194, 2014, Página(s) 1935-1938, ISSN 1042-8194
Editor: Taylor & Francis
DOI: 10.3109/10428194.2013.858150

Small nucleolar RNAs functioning and potential roles in cancer

Autores: Nithyananda Thorenoor, Ondrej Slaby
Publicado en: Tumor Biology, Edición 10104283, 2015, Página(s) 41-53, ISSN 1010-4283
Editor: Springer Verlag
DOI: 10.1007/s13277-014-2818-8

Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia

Autores: Jakub Trizuljak, Josef Srovnal, Karla Plevová, Yvona Brychtová, Lukáš Semerád, Denisa Bakešová, Eva Létalová, Andrea Benedíková, Jiří Mayer, Marián Hajdúch, Šárka Pospíšilová, Michael Doubek
Publicado en: Clinical Lymphoma Myeloma and Leukemia, Edición 21522669, 2015, Página(s) 439-442, ISSN 2152-2669
Editor: Cancer Media Group
DOI: 10.1016/j.clml.2015.02.003

The Epitranscriptome and Innate Immunity

Autores: Mary A. O’Connell, Niamh M. Mannion, Liam P. Keegan
Publicado en: PLOS Genetics, Edición 15537404, 2015, Página(s) e1005687, ISSN 1553-7404
Editor: Public Library ScienceUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1005687

MicroRNAs involved in chemo- and radioresistance of high-grade gliomas

Autores: Andrej Besse, Jiri Sana, Pavel Fadrus, Ondrej Slaby
Publicado en: Tumor Biology, Edición 10104283, 2013, Página(s) 1969-1978, ISSN 1010-4283
Editor: Springer Verlag
DOI: 10.1007/s13277-013-0772-5

MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis

Autores: A. Benner, L. Mansouri, D. Rossi, A. Majid, K. Willander, A. Parker, G. Bond, S. Pavlova, H. Nuckel, O. Merkel, P. Ghia, E. Montserrat, M. A. Kaderi, R. Rosenquist, G. Gaidano, M. J. S. Dyer, P. Soderkvist, M. Linderholm, D. Oscier, Z. Tvaruzkova, S. Pospisilova, U. Duhrsen, R. Greil, H. Dohner, S. Stilgenbauer, T. Zenz
Publicado en: Haematologica, Edición 03906078, 2014, Página(s) 1285-1291, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.101170

Circulating miRNAs as new blood-based biomarkers for solid cancers

Autores: Martina Redova, Jiri Sana, Ondrej Slaby
Publicado en: Future Oncology, Edición 14796694, 2013, Página(s) 387-402, ISSN 1479-6694
Editor: Future Medicine Ltd.
DOI: 10.2217/FON.12.192

Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway

Autores: L.  merdova, J. Svobodova, M. Kabatkova, J. Kohoutek, D. Bla ek, M. Machala, J. Vondra ek
Publicado en: Carcinogenesis, Edición 01433334, 2014, Página(s) 2534-2543, ISSN 0143-3334
Editor: Oxford University Press
DOI: 10.1093/carcin/bgu190

Hypergravity synthesis of graphitic carbon nanomaterial in glide arc plasma

Autores: Jiří Šperka, Pavel Souček, Jack J.W.A. Van Loon, Alan Dowson, Christian Schwarz, Jutta Krause, Yuriy Butenko, Gerrit Kroesen, Vít Kudrle
Publicado en: Materials Research Bulletin, Edición 00255408, 2014, Página(s) 61-65, ISSN 0025-5408
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.materresbull.2014.03.013

Computational study of missense mutations in phenylalanine hydroxylase

Autores: Kamila Réblová, Petr Kulhánek, Lenka Fajkusová
Publicado en: Journal of Molecular Modeling, Edición 16102940, 2015, ISSN 1610-2940
Editor: Springer Verlag
DOI: 10.1007/s00894-015-2620-6

Hyperphenylalaninemia in the Czech Republic: Genotype–phenotype correlations and in silico analysis of novel missense mutations

Autores: Kamila Réblová, Zuzana Hrubá, Dagmar Procházková, Renata Pazdírková, Slávka Pouchlá, Lenka Fajkusová
Publicado en: Clinica Chimica Acta, Edición 00098981, 2013, Página(s) 1-10, ISSN 0009-8981
Editor: Elsevier BV
DOI: 10.1016/j.cca.2013.01.006

TaqMan based real time PCR assay targeting EML4-ALK fusion transcripts in NSCLC

Autores: Blanka Robesova, Monika Bajerova, Kvetoslava Liskova, Jana Skrickova, Marcela Tomiskova, Sarka Pospisilova, Jiri Mayer, Dana Dvorakova
Publicado en: Lung Cancer, Edición 01695002, 2014, Página(s) 25-30, ISSN 0169-5002
Editor: Elsevier BV
DOI: 10.1016/j.lungcan.2014.04.002

MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia

Autores: Marek Mraz, Thomas J. Kipps
Publicado en: Leukemia & Lymphoma, Edición 54/8, 2013, Página(s) 1836-1839, ISSN 1042-8194
Editor: Taylor & Francis
DOI: 10.3109/10428194.2013.796055

Histone H1 Differentially Inhibits DNA Bending by Reduced and Oxidized HMGB1 Protein

Autores: Michal Štros, Eva Polanská, Martin Kučírek, Šárka Pospíšilová
Publicado en: PLOS ONE, Edición 10/9, 2015, Página(s) e0138774, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0138774

CLCN1 Mutations in Czech Patients with Myotonia Congenita, In Silico Analysis of Novel and Known Mutations in the Human Dimeric Skeletal Muscle Chloride Channel

Autores: Daniela Skálová, Jana Zídková, Stanislav Voháňka, Radim Mazanec, Zuzana Mušová, Petr Vondráček, Lenka Mrázová, Josef Kraus, Kamila Réblová, Lenka Fajkusová
Publicado en: PLoS ONE, Edición 8/12, 2013, Página(s) e82549, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0082549

Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia

Autores: J Malcikova, K Stano-Kozubik, B Tichy, B Kantorova, S Pavlova, N Tom, L Radova, J Smardova, F Pardy, M Doubek, Y Brychtova, M Mraz, K Plevova, E Diviskova, A Oltova, J Mayer, S Pospisilova, M Trbusek
Publicado en: Leukemia, Edición 29/4, 2014, Página(s) 877-885, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2014.297

MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia

Autores: B. Cui, L. Chen, S. Zhang, M. Mraz, J.-F. Fecteau, J. Yu, E. M. Ghia, L. Zhang, L. Bao, L. Z. Rassenti, K. Messer, G. A. Calin, C. M. Croce, T. J. Kipps
Publicado en: Blood, Edición 124/4, 2014, Página(s) 546-554, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2014-03-559690

The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex

Autores: Lucie Kozakova, Lucie Vondrova, Karel Stejskal, Panagoula Charalabous, Peter Kolesar, Alan R Lehmann, Stjepan Uldrijan, Christopher M Sanderson, Zbynek Zdrahal, Jan J Palecek
Publicado en: Cell Cycle, Edición 14/6, 2015, Página(s) 920-930, ISSN 1538-4101
Editor: Landes Bioscience
DOI: 10.1080/15384101.2014.1000112

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins

Autores: Niamh Mannion, Fabiana Arieti, Angela Gallo, Liam Keegan, Mary O'Connell
Publicado en: Biomolecules, Edición 5/4, 2015, Página(s) 2338-2362, ISSN 2218-273X
Editor: MDPI AG
DOI: 10.3390/biom5042338

miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib

Autores: Jana Merhautova, Renata Hezova, Alexandr Poprach, Alena Kovarikova, Lenka Radova, Marek Svoboda, Rostislav Vyzula, Regina Demlova, Ondrej Slaby
Publicado en: BioMed Research International, Edición 2015, 2015, Página(s) 1-5, ISSN 2314-6133
Editor: Hindawi Publishing Corporation
DOI: 10.1155/2015/941980

The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors

Autores: Jitka Malcikova, Evangelia Stalika, Zadie Davis, Karla Plevova, Martin Trbusek, Larry Mansouri, Lydia Scarfò, Panagiotis Baliakas, Anne Gardiner, Lesley-Ann Sutton, Hana Skuhrova Francova, Andreas Agathangelidis, Achilles Anagnostopoulos, Ian Tracy, Antonis Makris, Jana Smardova, Paolo Ghia, Chrysoula Belessi, David Gonzalez, Richard Rosenquist, David Oscier, Sarka Pospisilova, Kostas Stamatopoulos
Publicado en: British Journal of Haematology, Edición 166/4, 2014, Página(s) 621-625, ISSN 0007-1048
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bjh.12893

Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

Autores: Larry Mansouri, Lesley-Ann Sutton, Viktor Ljungström, Sina Bondza, Linda Arngården, Sujata Bhoi, Jimmy Larsson, Diego Cortese, Antonia Kalushkova, Karla Plevova, Emma Young, Rebeqa Gunnarsson, Elin Falk-Sörqvist, Peter Lönn, Alice F. Muggen, Xiao-Jie Yan, Birgitta Sander, Gunilla Enblad, Karin E. Smedby, Gunnar Juliusson, Chrysoula Belessi, Johan Rung, Nicholas Chiorazzi, Jonathan C. Strefford, Anton W. Langerak, Sarka Pospisilova, Frederic Davi, Mats Hellström, Helena Jernberg-Wiklund, Paolo Ghia, Ola Söderberg, Kostas Stamatopoulos, Mats Nilsson, Richard Rosenquist
Publicado en: The Journal of Experimental Medicine, Edición 212/6, 2015, Página(s) 833-843, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20142009

Recurrent mutations refine prognosis in chronic lymphocytic leukemia

Autores: P Baliakas, A Hadzidimitriou, L-A Sutton, D Rossi, E Minga, N Villamor, M Larrayoz, J Kminkova, A Agathangelidis, Z Davis, E Tausch, E Stalika, B Kantorova, L Mansouri, L Scarfò, D Cortese, V Navrkalova, M J J Rose-Zerilli, K E Smedby, G Juliusson, A Anagnostopoulos, A M Makris, A Navarro, J Delgado, D Oscier, C Belessi, S Stilgenbauer, P Ghia, S Pospisilova, G Gaidano, E Campo, J C Strefford, K Stamatopoulos, R Rosenquist
Publicado en: Leukemia, Edición 29/2, 2014, Página(s) 329-336, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2014.196

Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1

Autores: Vineeta Khare, Alex Lyakhovich, Kyle Dammann, Michaela Lang, Melanie Borgmann, Boris Tichy, Sarka Pospisilova, Gloria Luciani, Christoph Campregher, Rayko Evstatiev, Maren Pflueger, Harald Hundsberger, Christoph Gasche
Publicado en: Biochemical Pharmacology, Edición 85/2, 2013, Página(s) 234-244, ISSN 0006-2952
Editor: Elsevier BV
DOI: 10.1016/j.bcp.2012.10.026

TP53 Mutation Analysis in Clinical Practice: Lessons From Chronic Lymphocytic Leukemia

Autores: Jitka Malcikova, Sarka Pavlova, Katerina Stano Kozubik, Sarka Pospisilova
Publicado en: Human Mutation, Edición 35/6, 2014, Página(s) 663-671, ISSN 1059-7794
Editor: John Wiley & Sons Inc.
DOI: 10.1002/humu.22508

Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients

Autores: J. Sana, L. Radova, R. Lakomy, L. Kren, P. Fadrus, M. Smrcka, A. Besse, J. Nekvindova, M. Hermanova, R. Jancalek, M. Svoboda, M. Hajduch, P. Slampa, R. Vyzula, O. Slaby
Publicado en: Carcinogenesis, Edición 35/12, 2014, Página(s) 2756-2762, ISSN 0143-3334
Editor: Oxford University Press
DOI: 10.1093/carcin/bgu212

The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration

Autores: M. Kaucka, K. Plevova, S. Pavlova, P. Janovska, A. Mishra, J. Verner, J. Prochazkova, P. Krejci, J. Kotaskova, P. Ovesna, B. Tichy, Y. Brychtova, M. Doubek, A. Kozubik, J. Mayer, S. Pospisilova, V. Bryja
Publicado en: Cancer Research, Edición 73/5, 2013, Página(s) 1491-1501, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-12-1752

Combination of fludarabine, amsacrine, and cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with high-risk acute myeloid leukemia

Autores: Marta Krejci, Michael Doubek, Jaroslav Dusek, Yvona Brychtova, Zdenek Racil, Milan Navratil, Miroslav Tomiska, Ondrej Horky, Sarka Pospisilova, Jiri Mayer
Publicado en: Annals of Hematology, Edición 92/10, 2013, Página(s) 1397-1403, ISSN 0939-5555
Editor: Springer Verlag
DOI: 10.1007/s00277-013-1790-5

Hyperphenylalaninemia in the Czech Republic: Genotype–phenotype correlations and in silico analysis of novel missense mutations

Autores: Kamila Réblová, Zuzana Hrubá, Dagmar Procházková, Renata Pazdírková, Slávka Pouchlá, Lenka Fajkusová
Publicado en: Clinica Chimica Acta, Edición 419, 2013, Página(s) 1-10, ISSN 0009-8981
Editor: Elsevier BV
DOI: 10.1016/j.cca.2013.01.006

B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells

Autores: Vaclav Seda, Marek Mraz
Publicado en: European Journal of Haematology, Edición 94/3, 2015, Página(s) 193-205, ISSN 0902-4441
Editor: Blackwell Publishing Inc.
DOI: 10.1111/ejh.12427

Isosteric and Nonisosteric Base Pairs in RNA Motifs: Molecular Dynamics and Bioinformatics Study of the Sarcin–Ricin Internal Loop

Autores: Marek Havrila, Kamila Réblová, Craig L. Zirbel, Neocles B. Leontis, Jiří Šponer
Publicado en: The Journal of Physical Chemistry B, Edición 117/46, 2013, Página(s) 14302-14319, ISSN 1520-6106
Editor: American Chemical Society
DOI: 10.1021/jp408530w

Small nucleolar RNAs functioning and potential roles in cancer

Autores: Nithyananda Thorenoor, Ondrej Slaby
Publicado en: Tumor Biology, Edición 36/1, 2015, Página(s) 41-53, ISSN 1010-4283
Editor: Springer Verlag
DOI: 10.1007/s13277-014-2818-8

Binding of Histone H1 to DNA Is Differentially Modulated by Redox State of HMGB1

Autores: Eva Polanská, Šárka Pospíšilová, Michal Štros
Publicado en: PLoS ONE, Edición 9/2, 2014, Página(s) e89070, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0089070

RNA secondary structure, an important bioinformatics tool to enhance multiple sequence alignment: a case study (Sordariomycetes, Fungi)

Autores: Martina Réblová, Kamila Réblová
Publicado en: Mycological Progress, Edición 12/2, 2013, Página(s) 305-319, ISSN 1617-416X
Editor: IHW-Verl
DOI: 10.1007/s11557-012-0836-8

Circulating miRNAs as new blood-based biomarkers for solid cancers

Autores: Martina Redova, Jiri Sana, Ondrej Slaby
Publicado en: Future Oncology, Edición 9/3, 2013, Página(s) 387-402, ISSN 1479-6694
Editor: Future Medicine Ltd.
DOI: 10.2217/FON.12.192

Hypergravity effects on glide arc plasma

Autores: Jiří Šperka, Pavel Souček, Jack J. W. A. Van Loon, Alan Dowson, Christian Schwarz, Jutta Krause, Gerrit Kroesen, Vít Kudrle
Publicado en: The European Physical Journal D, Edición 67/12, 2013, ISSN 1434-6060
Editor: Springer Verlag
DOI: 10.1140/epjd/e2013-40408-7

Ofatumumab added to dexamethasone in patients with relapsed or refractory chronic lymphocytic leukemia: Results from a phase II study

Autores: Michael Doubek, Yvona Brychtova, Anna Panovska, Ludmila Sebejova, Olga Stehlikova, Jana Chovancova, Jitka Malcikova, Jana Smardova, Karla Plevova, Pavlina Volfova, Martin Trbusek, Marek Mraz, Denisa Bakesova, Jakub Trizuljak, Marketa Hadrabova, Petra Obrtlikova, Josef Karban, Lukas Smolej, Alexandra Oltova, Eva Jelinkova, Sarka Pospisilova, Jiri Mayer
Publicado en: American Journal of Hematology, Edición 90/5, 2015, Página(s) 417-421, ISSN 0361-8609
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ajh.23964

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

Autores: K. M. Ekumi, H. Paculova, T. Lenasi, V. Pospichalova, C. A. Bosken, J. Rybarikova, V. Bryja, M. Geyer, D. Blazek, M. Barboric
Publicado en: Nucleic Acids Research, Edición 43/5, 2015, Página(s) 2575-2589, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkv101

Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma

Autores: Lenka Besse, Lenka Sedlarikova, Fedor Kryukov, Jana Nekvindova, Lenka Radova, Ondrej Slaby, Petr Kuglik, Martina Almasi, Miroslav Penka, Marta Krejci, Zdenek Adam, Ludek Pour, Sabina Sevcikova, Roman Hajek
Publicado en: PLOS ONE, Edición 10/9, 2015, Página(s) e0137294, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0137294

MicroRNAs targeting EGFR signalling pathway in colorectal cancer

Autores: Jitka Mlcochova, Petra Faltejskova, Radim Nemecek, Marek Svoboda, Ondrej Slaby
Publicado en: Journal of Cancer Research and Clinical Oncology, Edición 139/10, 2013, Página(s) 1615-1624, ISSN 0171-5216
Editor: Springer Verlag
DOI: 10.1007/s00432-013-1470-9

Molecular Evidence for Antigen Drive in the Natural History of Mantle Cell Lymphoma

Autores: Aliki Xochelli, Lesley-Ann Sutton, Andreas Agathangelidis, Evangelia Stalika, Maria Karypidou, Fotini Marantidou, Alba Navarro Lopez, Giorgos Papadopoulos, Jana Supikova, Patricia Groenen, Myriam Boudjogra, Christer Sundstrom, Maurilio Ponzoni, Hana Skuhrova Francova, Achilles Anagnostopoulos, Sarka Pospisilova, Theodora Papadaki, Dimitris Tzovaras, Paolo Ghia, Christiane Pott, Frederic Davi, Elias Campo, Richard Rosenquist, Anastasia Hadzidimitriou, Chrysoula Belessi, Kostas Stamatopoulos
Publicado en: The American Journal of Pathology, Edición 185/6, 2015, Página(s) 1740-1748, ISSN 0002-9440
Editor: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2015.02.006

Computational study of missense mutations in phenylalanine hydroxylase

Autores: Kamila Réblová, Petr Kulhánek, Lenka Fajkusová
Publicado en: Journal of Molecular Modeling, Edición 21/4, 2015, ISSN 1610-2940
Editor: Springer Verlag
DOI: 10.1007/s00894-015-2620-6

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

Autores: Jan Machal, Jan Novak, Renata Hezova, Filip Zlamal, Anna Vasku, Ondrej Slaby, Julie Bienertova-Vasku
Publicado en: Genes & Nutrition, Edición 10/5, 2015, ISSN 1555-8932
Editor: New Century Health Publishers
DOI: 10.1007/s12263-015-0488-9

NOD/SCID IL2Rγ-null mouse xenograft model of human p53-mutated chronic lymphocytic leukemia and ATM-mutated mantle cell lymphoma using permanent cell lines

Autores: Jan Verner, Martin Trbusek, Jana Chovancova, Zuzana Jaskova, Mojmir Moulis, Frantisek Folber, Roman Halouzka, Jiri Mayer, Sarka Pospisilova, Michael Doubek
Publicado en: Leukemia & Lymphoma, Edición 56/11, 2015, Página(s) 3198-3206, ISSN 1042-8194
Editor: Taylor & Francis
DOI: 10.3109/10428194.2015.1034701

Fludarabine with cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with poor-risk chronic lymphocytic leukemia

Autores: Marta Krejci, Michael Doubek, Yvona Brychtova, Olga Stehlikova, Jana Chovancova, Boris Tichy, Hana Skuhrova Francova, Milan Navratil, Miroslav Tomiska, Ondrej Horky, Sarka Pospisilova, Jiri Mayer
Publicado en: Annals of Hematology, Edición 92/2, 2013, Página(s) 249-254, ISSN 0939-5555
Editor: Springer Verlag
DOI: 10.1007/s00277-012-1579-y

MicroRNAs in B-cell lymphomas: how a complex biology gets more complex

Autores: K Musilova, M Mraz
Publicado en: Leukemia, Edición 29/5, 2014, Página(s) 1004-1017, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2014.351

Dynamic changes in microRNA expression profiles reflect progression of Barrett's esophagus to esophageal adenocarcinoma

Autores: O. Slaby, J. Srovnal, L. Radova, J. Gregar, J. Juracek, P. Luzna, M. Svoboda, M. Hajduch, J. Ehrmann
Publicado en: Carcinogenesis, Edición 36/5, 2015, Página(s) 521-527, ISSN 0143-3334
Editor: Oxford University Press
DOI: 10.1093/carcin/bgv023

Book chapters (2)

TP53 Aberrations in Chronic Lymphocytic Leukemia

Autores: Martin Trbusek, Jitka Malcikova
Publicado en: Advances in Chronic Lymphocytic Leukemia, Edición 792, 2013, Página(s) 109-131, ISBN 978-1-4614-8051-8
Editor: Springer New York
DOI: 10.1007/978-1-4614-8051-8_5

TP53 Aberrations in Chronic Lymphocytic Leukemia

Autores: Martin Trbusek, Jitka Malcikova
Publicado en: Advances in Chronic Lymphocytic Leukemia, 2013, Página(s) 109-131, ISBN 978-1-4614-8051-8
Editor: Springer New York
DOI: 10.1007/978-1-4614-8051-8_5