Medical Genomics and Epigenomics Network

Informations projet

MEDGENET

N° de convention de subvention: 692298

DOI

10.3030/692298

Projet clôturé

Date de signature de la CE 2 Decembre 2015

Date de début 1 Janvier 2016

Date de fin 31 Decembre 2018

Financé au titre de

• Twinning of research institutions

Coût total

€ 1 016 531,25

Contribution de l’UE

€ 974 529,25

Coordonné par

Masarykova univerzita
Czechia

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (31)

Report on outreach activities II.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

1st on-line book of abstracts WP2

On-line book of abstracts from each workshop published on MEDGENET website on annual basis

Report on outreach activities VI.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

Report on WP2 coordination, networking and educational events III.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on WP1 coordination, networking and educational events I.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on outreach activities III.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

2nd on-line book of abstracts WP2

On-line book of abstracts from each workshop published on MEDGENET website on annual basis

1st on-line book of abstracts WP1

On-line book of abstracts from each workshop published on MEDGENET website

Report on WP1 coordination, networking and educational events IV.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project.

E-Newsletter II.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on CEITEC scientific excellence and MEDGENET impact assessment

Report on CEITEC scientific excellence and MEDGENET impact assessment – assessment on the number of high quality publications produced in CEITEC Molecular Medicine Program, impact of these publications, h-index of involved CEITEC researchers , number of outputs with high potential for clinical application, number of submitted collaborative international projects, income from successful projects with academia and industry. The report will be part of the Final project report and will also be available online on the project website

3rd on-line bok of abstracts WP1

On-line book of abstracts from each workshop published on MEDGENET website

Report after introducing the a tool for monitoring evolution of publishing activity
Report on WP1 coordination, networking and educational events VI.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on WP1 coordination, networking and educational events II.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project.

Report on outreach activities IV.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

Report on WP2 coordination, networking and educational events I.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter VI.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter I.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter III.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Network’s public engagement and outreach plan

Network’s public engagement and outreach plan – with the proposal and description of activities and events

Report on WP1 coordination, networking and educational events V.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project.

Report on WP2 coordination, networking and educational events II.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

2nd on-line book of abstracts WP1

On-line book of abstracts from each workshop published on MEDGENET website

Database of funding opportunities

Database of funding opportunities available in all 4 countries of MEDGENET partners. The database will provide information about the most suitable funding for each individual scientists and research group and will be accessible on the MEDGENET website

Report on outreach activities V.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

E-Newsletter V.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on WP1 coordination, networking and educational events III.

Report on WP1 coordination, networking and educational events – published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter IV.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on outreach activities I.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

Report on WP2 coordination, networking and educational events IV.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Websites, patent fillings, videos etc. (1)

MEDGENET web page

MEDGENET web page - will give information about project itself, its goals and activities with regular updates

Publications

Peer reviewed articles (197)

MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma

Auteurs: Petra Vychytilova-Faltejskova, Igor Kiss, Sona Klusova, Jan Hlavsa, Vladimir Prochazka, Zdenek Kala, Jan Mazanec, Jitka Hausnerova, Leos Kren, Marketa Hermanova, Jiri Lenz, Petr Karasek, Rostislav Vyzula, Ondrej Slaby
Publié dans: Diagnostic Pathology, Numéro 10/1, 2015, ISSN 1746-1596
Éditeur: BioMed Central
DOI: 10.1186/s13000-015-0272-6

The outcome of chronic lymphocytic leukemia patients who relapsed after fludarabine, cyclophosphamide, and rituximab

Auteurs: Anna Panovská, Lukáš Smolej, Daniel Lysák, Yvona Brychtová, Martin Šimkovič, Monika Motyčková, Pavel Vodárek, Michaela Lindtnerová, Martin Trbušek, Jitka Malčíková, Šárka Pospíšilová, Jiří Mayer, Michael Doubek
Publié dans: European Journal of Haematology, Numéro 90/6, 2013, Page(s) 479-485, ISSN 0902-4441
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/ejh.12106

Hypergravity synthesis of graphitic carbon nanomaterial in glide arc plasma

Auteurs: Jiří Šperka, Pavel Souček, Jack J.W.A. Van Loon, Alan Dowson, Christian Schwarz, Jutta Krause, Yuriy Butenko, Gerrit Kroesen, Vít Kudrle
Publié dans: Materials Research Bulletin, Numéro 54, 2014, Page(s) 61-65, ISSN 0025-5408
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.materresbull.2014.03.013

Treatment of chronic lymphocytic leukemia with monoclonal antibodies, where are we heading?

Auteurs: Michael Doubek, Michal Šmída
Publié dans: Expert Review of Hematology, Numéro 8/6, 2015, Page(s) 743-764, ISSN 1747-4086
Éditeur: Expert Reviews
DOI: 10.1586/17474086.2015.1079123

TaqMan based real time PCR assay targeting EML4-ALK fusion transcripts in NSCLC

Auteurs: Blanka Robesova, Monika Bajerova, Kvetoslava Liskova, Jana Skrickova, Marcela Tomiskova, Sarka Pospisilova, Jiri Mayer, Dana Dvorakova
Publié dans: Lung Cancer, Numéro 85/1, 2014, Page(s) 25-30, ISSN 0169-5002
Éditeur: Elsevier BV
DOI: 10.1016/j.lungcan.2014.04.002

Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma

Auteurs: Andrea Janikova, Andrea Mareckova, Aneta Baumeisterova, Marta Krejci, Jana Supikova, David Salek, Ondrej Horky, Boris Tichy, Ivo Hanke, Sarka Pospisilova, Mojmir Moulis, Jiri Mayer
Publié dans: Leukemia & Lymphoma, Numéro 55/8, 2014, Page(s) 1935-1938, ISSN 1042-8194
Éditeur: Taylor & Francis
DOI: 10.3109/10428194.2013.858150

Contributions of the TEL-patch Amino Acid Cluster on TPP1 to Telomeric DNA Synthesis by Human Telomerase

Auteurs: Andrew B. Dalby, Ctirad Hofr, Thomas R. Cech
Publié dans: Journal of Molecular Biology, Numéro 427/6, 2015, Page(s) 1291-1303, ISSN 0022-2836
Éditeur: Academic Press
DOI: 10.1016/j.jmb.2015.01.008

Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenström macroglobulinemia

Auteurs: Lenka Kubiczkova Besse, Lenka Sedlarikova, Fedor Kryukov, Jana Nekvindova, Lenka Radova, Martina Almasi, Jana Pelcova, Jiri Minarik, Tomas Pika, Zuzana Pikalova, Vlastimil Scudla, Marta Krejci, Zdenek Adam, Ludek Pour, Roman Hajek, Sabina Sevcikova
Publié dans: American Journal of Hematology, Numéro 90/3, 2015, Page(s) E51-E52, ISSN 0361-8609
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ajh.23910

Forced aggregation and defined factors allow highly uniform-sized embryoid bodies and functional cardiomyocytes from human embryonic and induced pluripotent stem cells

Auteurs: Martin Pesl, Ivana Acimovic, Jan Pribyl, Renata Hezova, Aleksandra Vilotic, Jeremy Fauconnier, Jan Vrbsky, Peter Kruzliak, Petr Skladal, Tomas Kara, Vladimir Rotrekl, Alain Lacampagne, Petr Dvorak, Albano C. Meli
Publié dans: Heart and Vessels, Numéro 29/6, 2014, Page(s) 834-846, ISSN 0910-8327
Éditeur: Springer Verlag
DOI: 10.1007/s00380-013-0436-9

IgG-Switched CLL Has a Distinct Immunogenetic Signature from the Common MD Variant: Ontogenetic Implications

Auteurs: A. Vardi, A. Agathangelidis, L.-A. Sutton, M. Chatzouli, L. Scarfo, L. Mansouri, V. Douka, A. Anagnostopoulos, N. Darzentas, R. Rosenquist, P. Ghia, C. Belessi, K. Stamatopoulos
Publié dans: Clinical Cancer Research, Numéro 20/2, 2014, Page(s) 323-330, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-13-1993

Hepcidin levels in Diamond-Blackfan anemia reflect erythropoietic activity and transfusion dependency

Auteurs: D. Pospisilova, D. Holub, Z. Zidova, L. Sulovska, J. Houda, V. Mihal, I. Hadacova, L. Radova, P. Dzubak, M. Hajduch, V. Divoky, M. Horvathova
Publié dans: Haematologica, Numéro 99/7, 2014, Page(s) e118-e121, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2014.104034

The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus

Auteurs: Marek Mraz, Katerina Stano Kozubik, Karla Plevova, Katerina Musilova, Boris Tichy, Marek Borsky, Petr Kuglik, Michael Doubek, Yvona Brychtova, Jiri Mayer, Sarka Pospisilova
Publié dans: Leukemia Research, Numéro 37/7, 2013, Page(s) 802-808, ISSN 0145-2126
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.leukres.2013.03.018

Phylogenetic Reconstruction of the Calosphaeriales and Togniniales Using Five Genes and Predicted RNA Secondary Structures of ITS, and Flabellascus tenuirostris gen. et sp. nov.

Auteurs: Martina Réblová, Walter M. Jaklitsch, Kamila Réblová, Václav Štěpánek
Publié dans: PLOS ONE, Numéro 10/12, 2015, Page(s) e0144616, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0144616

ARResT/AssignSubsets: a novel application for robust subclassification of chronic lymphocytic leukemia based on B cell receptor IG stereotypy

Auteurs: Vojtech Bystry, Andreas Agathangelidis, Vasilis Bikos, Lesley Ann Sutton, Panagiotis Baliakas, Anastasia Hadzidimitriou, Kostas Stamatopoulos, Nikos Darzentas
Publié dans: Bioinformatics, Numéro 31/23, 2015, Page(s) btv456, ISSN 1367-4803
Éditeur: Oxford University Press
DOI: 10.1093/bioinformatics/btv456

The Significance of Stereotyped B-Cell Receptors in Chronic Lymphocytic Leukemia

Auteurs: Nikos Darzentas, Kostas Stamatopoulos
Publié dans: Hematology/Oncology Clinics of North America, Numéro 27/2, 2013, Page(s) 237-250, ISSN 0889-8588
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.hoc.2012.12.001

Extension of microRNA expression pattern associated with high-risk neuroblastoma

Auteurs: Julie Bienertova-Vasku, Pavel Mazanek, Renata Hezova, Anna Curdova, Jana Nekvindova, Leos Kren, Jaroslav Sterba, Ondrej Slaby
Publié dans: Tumor Biology, Numéro 34/4, 2013, Page(s) 2315-2319, ISSN 1010-4283
Éditeur: Springer Verlag
DOI: 10.1007/s13277-013-0777-0

MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma

Auteurs: Martina Redova, Alexandr Poprach, Andrej Besse, Robert Iliev, Jana Nekvindova, Radek Lakomy, Lenka Radova, Marek Svoboda, Jan Dolezel, Rostislav Vyzula, Ondrej Slaby
Publié dans: Tumor Biology, Numéro 34/1, 2013, Page(s) 481-491, ISSN 1010-4283
Éditeur: Springer Verlag
DOI: 10.1007/s13277-012-0573-2

Assessment of TP53 functionality in chronic lymphocytic leukaemia by different assays; an ERIC-wide approach

Auteurs: G. Doreen te Raa, Jitka Malčiková, Marek Mraz, Martin Trbusek, Magali Le Garff-Tavernier, Hélène Merle-Béral, Rudolf Greil, Olaf Merkel, Sarka Pospíšilová, Ke Lin, Andrew R. Pettitt, Tatjana Stankovic, Marinus H. van Oers, Eric Eldering, Stephan Stilgenbauer, Thorsten Zenz, Arnon P. Kater
Publié dans: British Journal of Haematology, Numéro 167/4, 2014, Page(s) 565-569, ISSN 0007-1048
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/bjh.13006

Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones

Auteurs: K. Plevova, H. S. Francova, K. Burckova, Y. Brychtova, M. Doubek, S. Pavlova, J. Malcikova, J. Mayer, B. Tichy, S. Pospisilova
Publié dans: Haematologica, Numéro 99/2, 2014, Page(s) 329-338, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.087593

Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia

Auteurs: Jakub Trizuljak, Josef Srovnal, Karla Plevová, Yvona Brychtová, Lukáš Semerád, Denisa Bakešová, Eva Létalová, Andrea Benedíková, Jiří Mayer, Marián Hajdúch, Šárka Pospíšilová, Michael Doubek
Publié dans: Clinical Lymphoma Myeloma and Leukemia, Numéro 15/7, 2015, Page(s) 439-442, ISSN 2152-2669
Éditeur: Cancer Media Group
DOI: 10.1016/j.clml.2015.02.003

Temporal Dynamics of Clonal Evolution in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-34/IGKV2-30 Antigen Receptors: Longitudinal Immunogenetic Evidence

Auteurs: Lesley Sutton, Efterpi Kostareli
Publié dans: Molecular Medicine, Numéro 19/1, 2013, Page(s) 1, ISSN 1076-1551
Éditeur: North Shore - Long Jewish Research Institute
DOI: 10.2119/molmed.2013.00042

Identification of novel sequence variations in microRNAs in chronic lymphocytic leukemia

Auteurs: J. Kminkova, M. Mraz, K. Zaprazna, V. Navrkalova, B. Tichy, K. Plevova, J. Malcikova, K. Cerna, T. Rausch, V. Benes, Y. Brychtova, M. Doubek, J. Mayer, S. Pospisilova
Publié dans: Carcinogenesis, Numéro 35/5, 2014, Page(s) 992-1002, ISSN 0143-3334
Éditeur: Oxford University Press
DOI: 10.1093/carcin/bgt396

MicroRNA Profiling of Activated and Tolerogenic Human Dendritic Cells

Auteurs: Zuzana Stumpfova, Renata Hezova, Albano Carlo Meli, Ondrej Slaby, Jaroslav Michalek
Publié dans: Mediators of Inflammation, Numéro 2014, 2014, Page(s) 1-10, ISSN 0962-9351
Éditeur: Hindawi Publishing Corporation
DOI: 10.1155/2014/259689

The structure and substrate specificity of human Cdk12/Cyclin K

Auteurs: Christian A. Bösken, Lucas Farnung, Corinna Hintermair, Miriam Merzel Schachter, Karin Vogel-Bachmayr, Dalibor Blazek, Kanchan Anand, Robert P. Fisher, Dirk Eick, Matthias Geyer
Publié dans: Nature Communications, Numéro 5, 2014, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/ncomms4505

The impact of SF3B1 mutations in CLL on the DNA-damage response

Auteurs: G D te Raa, I A M Derks, V Navrkalova, A Skowronska, P D Moerland, J van Laar, C Oldreive, H Monsuur, M Trbusek, J Malcikova, M Lodén, C H Geisler, J Hüllein, A Jethwa, T Zenz, S Pospisilova, T Stankovic, M H J van Oers, A P Kater, E Eldering
Publié dans: Leukemia, Numéro 29/5, 2014, Page(s) 1133-1142, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/leu.2014.318

The role of microRNAs in mitochondria in cancer

Auteurs: Julie Bienertova-Vasku, Jiri Sana, Ondrej Slaby
Publié dans: Cancer Letters, Numéro 336/1, 2013, Page(s) 1-7, ISSN 0304-3835
Éditeur: Elsevier BV
DOI: 10.1016/j.canlet.2013.05.001

Identification of MicroRNAs Regulated by Isothiocyanates and Association of Polymorphisms Inside Their Target Sites with Risk of Sporadic Colorectal Cancer

Auteurs: Ondrej Slaby, Milana Sachlova, Veronika Brezkova, Renata Hezova, Alena Kovarikova, Svatava Bischofová, Sabina Sevcikova, Julie Bienertova-Vasku, Anna Vasku, Marek Svoboda, Rostislav Vyzula
Publié dans: Nutrition and Cancer, Numéro 65/2, 2013, Page(s) 247-254, ISSN 0163-5581
Éditeur: Lawrence Erlbaum Associates Inc.
DOI: 10.1080/01635581.2013.756530

ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin

Auteurs: V. Navrkalova, L. Sebejova, J. Zemanova, J. Kminkova, B. Kubesova, J. Malcikova, M. Mraz, J. Smardova, S. Pavlova, M. Doubek, Y. Brychtova, D. Potesil, V. Nemethova, J. Mayer, S. Pospisilova, M. Trbusek
Publié dans: Haematologica, Numéro 98/7, 2013, Page(s) 1124-1131, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2012.081620

Splenic marginal-zone lymphoma: ontogeny and genetics

Auteurs: Panagiotis Baliakas, Jonathan C. Strefford, Vasilis Bikos, Marina Parry, Kostas Stamatopoulos, David Oscier
Publié dans: Leukemia & Lymphoma, Numéro 56/2, 2014, Page(s) 301-310, ISSN 1042-8194
Éditeur: Taylor & Francis
DOI: 10.3109/10428194.2014.919636

Role of S-turn2 in the Structure, Dynamics, and Function of Mitochondrial Ribosomal A-Site. A Bioinformatics and Molecular Dynamics Simulation Study

Auteurs: Joanna Panecka, Marek Havrila, Kamila Réblová, Jiří Šponer, Joanna Trylska
Publié dans: The Journal of Physical Chemistry B, Numéro 118/24, 2014, Page(s) 6687-6701, ISSN 1520-6106
Éditeur: American Chemical Society
DOI: 10.1021/jp5030685

The Epitranscriptome and Innate Immunity

Auteurs: Mary A. O’Connell, Niamh M. Mannion, Liam P. Keegan
Publié dans: PLOS Genetics, Numéro 11/12, 2015, Page(s) e1005687, ISSN 1553-7404
Éditeur: Public Library ScienceUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1005687

Urine microRNAs as potential noninvasive biomarkers in urologic cancers

Auteurs: Hana Mlcochova, Renata Hezova, Michal Stanik, Ondrej Slaby
Publié dans: Urologic Oncology: Seminars and Original Investigations, Numéro 32/1, 2014, Page(s) 41.e1-41.e9, ISSN 1078-1439
Éditeur: Elsevier BV
DOI: 10.1016/j.urolonc.2013.04.011

"Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2"

Auteurs: J C Strefford, L-A Sutton, P Baliakas, A Agathangelidis, J Malčíková, K Plevova, L Scarfó, Z Davis, E Stalika, D Cortese, N Cahill, L B Pedersen, P F di Celle, T Tzenou, C Geisler, P Panagiotidis, A W Langerak, N Chiorazzi, S Pospisilova, D Oscier, F Davi, C Belessi, L Mansouri, P Ghia, K Stamatopoulos, R Rosenquist
Publié dans: Leukemia, Numéro 27/11, 2013, Page(s) 2196-2199, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/leu.2013.98

Novel Evolutionary Lineages Revealed in the Chaetothyriales (Fungi) Based on Multigene Phylogenetic Analyses and Comparison of ITS Secondary Structure

Auteurs: Martina Réblová, Wendy A. Untereiner, Kamila Réblová
Publié dans: PLoS ONE, Numéro 8/5, 2013, Page(s) e63547, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0063547

Towards error-free profiling of immune repertoires

Auteurs: Mikhail Shugay, Olga V Britanova, Ekaterina M Merzlyak, Maria A Turchaninova, Ilgar Z Mamedov, Timur R Tuganbaev, Dmitriy A Bolotin, Dmitry B Staroverov, Ekaterina V Putintseva, Karla Plevova, Carsten Linnemann, Dmitriy Shagin, Sarka Pospisilova, Sergey Lukyanov, Ton N Schumacher, Dmitriy M Chudakov
Publié dans: Nature Methods, Numéro 11/6, 2014, Page(s) 653-655, ISSN 1548-7091
Éditeur: Nature Publishing Group
DOI: 10.1038/NMETH.2960

Human Rap1 modulates TRF2 attraction to telomeric DNA

Auteurs: E. Janou kova, I. Ne asova, J. Pavlou kova, M. Zimmermann, M. Hluchy, V. Marini, M. Novakova, C. Hofr
Publié dans: Nucleic Acids Research, Numéro 43/5, 2015, Page(s) 2691-2700, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkv097

Clonal evolution in chronic lymphocytic leukemia detected by fluorescence in situ hybridization and conventional cytogenetics after stimulation with CpG oligonucleotides and interleukin-2: A prospective analysis

Auteurs: Martin Brejcha, Martina Stoklasová, Yvona Brychtová, Anna Panovská, Kristina Štěpanovská, Gabriela Vaňková, Karla Plevová, Alexandra Oltová, Kateřina Horká, Šárka Pospíšilová, Jiří Mayer, Michael Doubek
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Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data

Auteurs: Panagiotis Baliakas, Michalis Iskas, Anne Gardiner, Zadie Davis, Karla Plevova, Florence Nguyen-Khac, Jitka Malcikova, Achilles Anagnostopoulos, Sharron Glide, Sarah Mould, Kristina Stepanovska, Martin Brejcha, Chrysoula Belessi, Frederic Davi, Sarka Pospisilova, Anastasia Athanasiadou, Kostas Stamatopoulos, David Oscier
Publié dans: American Journal of Hematology, Numéro 89/3, 2014, Page(s) 249-255, ISSN 0361-8609
Éditeur: John Wiley & Sons Inc.
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Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

Auteurs: P. Baliakas, A. Agathangelidis, A. Hadzidimitriou, L.-A. Sutton, E. Minga, A. Tsanousa, L. Scarfo, Z. Davis, X.-J. Yan, T. Shanafelt, K. Plevova, Y. Sandberg, F. J. Vojdeman, M. Boudjogra, T. Tzenou, M. Chatzouli, C. C. Chu, S. Veronese, A. Gardiner, L. Mansouri, K. E. Smedby, L. B. Pedersen, D. Moreno, K. Van Lom, V. Giudicelli, H. S. Francova, F. Nguyen-Khac, P. Panagiotidis, G. Juliusson, L. Angelis, A. Anagnostopoulos, M.-P. Lefranc, M. Facco, L. Trentin, M. Catherwood, M. Montillo, C. H. Geisler, A. W. Langerak, S. Pospisilova, N. Chiorazzi, D. Oscier, D. F. Jelinek, N. Darzentas, C. Belessi, F. Davi, P. Ghia, R. Rosenquist, K. Stamatopoulos
Publié dans: Blood, Numéro 125/5, 2015, Page(s) 856-859, ISSN 0006-4971
Éditeur: American Society of Hematology
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MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis

Auteurs: A. Benner, L. Mansouri, D. Rossi, A. Majid, K. Willander, A. Parker, G. Bond, S. Pavlova, H. Nuckel, O. Merkel, P. Ghia, E. Montserrat, M. A. Kaderi, R. Rosenquist, G. Gaidano, M. J. S. Dyer, P. Soderkvist, M. Linderholm, D. Oscier, Z. Tvaruzkova, S. Pospisilova, U. Duhrsen, R. Greil, H. Dohner, S. Stilgenbauer, T. Zenz
Publié dans: Haematologica, Numéro 99/8, 2014, Page(s) 1285-1291, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
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Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice

Auteurs: O. Stehlíková, J. Chovancová, B. Tichý, M. Krejčí, Y. Brychtová, A. Panovská, H. Francová Skuhrová, K. Burčková, M. Borský, T. Loja, J. Mayer, Š. Pospíšilová, M. Doubek
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Éditeur: Blackwell Science
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MicroRNA-206: a Promising Theranostic Marker

Auteurs: Jan Novák, Peter Kružliak, Julie Bienertová-Vašků, Ondřej Slabý, Miroslav Novák
Publié dans: Theranostics, Numéro 4/2, 2014, Page(s) 119-133, ISSN 1838-7640
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Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting

Auteurs: L.-A. Sutton, V. Ljungstrom, L. Mansouri, E. Young, D. Cortese, V. Navrkalova, J. Malcikova, A. F. Muggen, M. Trbusek, P. Panagiotidis, F. Davi, C. Belessi, A. W. Langerak, P. Ghia, S. Pospisilova, K. Stamatopoulos, R. Rosenquist
Publié dans: Haematologica, Numéro 100/3, 2015, Page(s) 370-376, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
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Prognostic relevance of MYD88 mutations in CLL: the jury is still out

Auteurs: P. Baliakas, A. Hadzidimitriou, A. Agathangelidis, D. Rossi, L.-A. Sutton, J. Kminkova, L. Scarfo, S. Pospisilova, G. Gaidano, K. Stamatopoulos, P. Ghia, R. Rosenquist
Publié dans: Blood, Numéro 126/8, 2015, Page(s) 1043-1044, ISSN 0006-4971
Éditeur: American Society of Hematology
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Molecular systematics of <I>Barbatosphaeria</I> (<I>Sordariomycetes</I>): multigene phylogeny and secondary ITS structure

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Publié dans: Persoonia - Molecular Phylogeny and Evolution of Fungi, Numéro 35/1, 2015, Page(s) 21-38, ISSN 0031-5850
Éditeur: National Herbarium Nederland/Leiden Branch
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Immunogenomic analysis of insect bite hypersensitivity in a model horse population

Auteurs: Leona Vychodilova, Jan Matiasovic, Olga Bobrova, Jan Futas, Marie Klumplerova, Karla Stejskalova, Michaela Cvanova, Eva Janova, Jarmila Osickova, Mirko Vyskocil, Marketa Sedlinska, Ladislav Dusek, Eliane Marti, Petr Horin
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Éditeur: Elsevier BV
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Distinct in vitro sensitivity of p53-mutated and ATM-mutated chronic lymphocytic leukemia cells to ofatumumab and rituximab

Auteurs: Ludmila Sebejova, Marek Borsky, Zuzana Jaskova, David Potesil, Veronika Navrkalova, Jitka Malcikova, Martin Sramek, Michael Doubek, Tomas Loja, Sarka Pospisilova, Jiri Mayer, Martin Trbusek
Publié dans: Experimental Hematology, Numéro 42/10, 2014, Page(s) 867-874.e1, ISSN 0301-472X
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MicroRNAs involved in chemo- and radioresistance of high-grade gliomas

Auteurs: Andrej Besse, Jiri Sana, Pavel Fadrus, Ondrej Slaby
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Éditeur: Springer Verlag
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The BCR–ABL1 T315I mutation and additional genomic aberrations are dominant genetic lesions associated with disease progression in patients with chronic myelogenous leukemia resistant to tyrosine kinase inhibitor therapy

Auteurs: Jitka Malcikova, Filip Razga, Tomas Jurcek, Dana Dvorakova, Daniela Zackova, Martina Toskova, Ludmila Sebejova, Jana Smardova, Alexandra Oltova, Gabriela Vankova, Lenka Jurackova, Martin Trbusek, Sarka Pospisilova, Jiri Mayer, Zdenek Racil
Publié dans: Leukemia & Lymphoma, Numéro 54/9, 2013, Page(s) 2083-2087, ISSN 1042-8194
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Diagnostic and prognostic potential of miR-21, miR-29c, miR-148 and miR-203 in adenocarcinoma and squamous cell carcinoma of esophagus

Auteurs: Renata Hezova, Alena Kovarikova, Josef Srovnal, Milada Zemanova, Tomas Harustiak, Jiri Ehrmann, Marian Hajduch, Marek Svoboda, Milana Sachlova, Ondrej Slaby
Publié dans: Diagnostic Pathology, Numéro 10/1, 2015, ISSN 1746-1596
Éditeur: BioMed Central
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TP53 mutation analysis in chronic lymphocytic leukemia: comparison of different detection methods

Auteurs: Barbara Kantorova, Jitka Malcikova, Jana Smardova, Sarka Pavlova, Martin Trbusek, Nikola Tom, Karla Plevova, Boris Tichy, Sim Truong, Eva Diviskova, Jana Kotaskova, Alexandra Oltova, Nancy Patten, Yvona Brychtova, Michael Doubek, Jiri Mayer, Sarka Pospisilova
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Combination of MiR-378 and MiR-210 Serum Levels Enables Sensitive Detection of Renal Cell Carcinoma

Auteurs: Michal Fedorko, Michal Stanik, Robert Iliev, Martina Redova-Lojova, Tana Machackova, Marek Svoboda, Dalibor Pacik, Jan Dolezel, Ondrej Slaby
Publié dans: International Journal of Molecular Sciences, Numéro 16/10, 2015, Page(s) 23382-23389, ISSN 1422-0067
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Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia

Auteurs: Aliki Xochelli, Andreas Agathangelidis, Ioannis Kavakiotis, Evangelia Minga, Lesley Ann Sutton, Panagiotis Baliakas, Ioanna Chouvarda, Véronique Giudicelli, Ioannis Vlahavas, Nikos Maglaveras, Lisa Bonello, Livio Trentin, Alessandra Tedeschi, Panagiotis Panagiotidis, Christian Geisler, Anton W. Langerak, Sarka Pospisilova, Diane F. Jelinek, David Oscier, Nicholas Chiorazzi, Nikos Darzentas, Fred Davi, Paolo Ghia, Richard Rosenquist, Anastasia Hadzidimitriou, Chrysoula Belessi, Marie-Paule Lefranc, Kostas Stamatopoulos
Publié dans: Immunogenetics, Numéro 67/1, 2015, Page(s) 61-66, ISSN 0093-7711
Éditeur: Springer Verlag
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Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway

Auteurs: L.  merdova, J. Svobodova, M. Kabatkova, J. Kohoutek, D. Bla ek, M. Machala, J. Vondra ek
Publié dans: Carcinogenesis, Numéro 35/11, 2014, Page(s) 2534-2543, ISSN 0143-3334
Éditeur: Oxford University Press
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miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1

Auteurs: M. Mraz, L. Chen, L. Z. Rassenti, E. M. Ghia, H. Li, K. Jepsen, E. N. Smith, K. Messer, K. A. Frazer, T. J. Kipps
Publié dans: Blood, Numéro 124/1, 2014, Page(s) 84-95, ISSN 0006-4971
Éditeur: American Society of Hematology
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ToTem: a tool for variant calling pipeline optimization

Auteurs: Nikola Tom, Ondrej Tom, Jitka Malcikova, Sarka Pavlova, Blanka Kubesova, Tobias Rausch, Miroslav Kolarik, Vladimir Benes, Vojtech Bystry, Sarka Pospisilova
Publié dans: BMC Bioinformatics, Numéro 19/1, 2018, ISSN 1471-2105
Éditeur: BioMed Central
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Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements

Auteurs: A Vardi, E Vlachonikola, M Karypidou, E Stalika, V Bikos, K Gemenetzi, C Maramis, A Siorenta, A Anagnostopoulos, S Pospisilova, N Maglaveras, I Chouvarda, K Stamatopoulos, A Hadzidimitriou
Publié dans: Leukemia, Numéro 31/7, 2016, Page(s) 1555-1561, ISSN 0887-6924
Éditeur: Nature Publishing Group
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A novel <i>ex vivo</i> high-throughput assay reveals antiproliferative effects of idelalisib and ibrutinib in chronic lymphocytic leukemia

Auteurs: Daniel Primo, Lydia Scarfò, Aliki Xochelli, Mattias Mattsson, Pamela Ranghetti, Ana Belén Espinosa, Alicia Robles, Julian Gorrochategui, Joaquín Martínez-López, Javier de la Serna, Marcos González, Alberto Chaparro Gil, Eduardo Anguita, Sandra Iraheta, Veerendra Munugalavadla, Christophe Quéva, Stacey Tannheimer, Richard Rosenquist, Kostas Stamatopoulos, Joan Ballesteros, Paolo Ghia
Publié dans: Oncotarget, Numéro 9/40, 2018, ISSN 1949-2553
Éditeur: Impact Journals
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GLASS: assisted and standardized assessment of gene variations from Sanger sequence trace data

Auteurs: Karol Pal, Vojtech Bystry, Tomas Reigl, Martin Demko, Adam Krejci, Tasoula Touloumenidou, Evangelia Stalika, Boris Tichy, Paolo Ghia, Kostas Stamatopoulos, Sarka Pospisilova, Jitka Malcikova, Nikos Darzentas
Publié dans: Bioinformatics, Numéro 33/23, 2017, Page(s) 3802-3804, ISSN 1367-4803
Éditeur: Oxford University Press
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Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Auteurs: Aliki Xochelli, Panagiotis Baliakas, Ioannis Kavakiotis, Andreas Agathangelidis, Lesley-Ann Sutton, Eva Minga, Stavroula Ntoufa, Eugen Tausch, Xiao-Jie Yan, Tait Shanafelt, Karla Plevova, Myriam Boudjogra, Davide Rossi, Zadie Davis, Alba Navarro, Yorick Sandberg, Fie Juhl Vojdeman, Lydia Scarfo, Niki Stavroyianni, Andrey Sudarikov, Silvio Veronese, Tatiana Tzenou, Teodora Karan-Djurasevic, Mark Ca
Publié dans: Clinical Cancer Research, Numéro 23/17, 2017, Page(s) 5292-5301, ISSN 1078-0432
Éditeur: American Association for Cancer Research
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Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia

Auteurs: Panagiotis Baliakas, Theodoros Moysiadis, Anastasia Hadzidimitriou, Aliki Xochelli, Sabine Jeromin, Andreas Agathangelidis, Mattias Mattsson, Lesley-Ann Sutton, Eva Minga, Lydia Scarfò, Davide Rossi, Zadie Davis, Neus Villamor, Helen Parker, Jana Kotaskova, Evangelia Stalika, Karla Plevova, Larry Mansouri, Diego Cortese, Alba Navarro, Julio Delgado, Marta Larrayoz, Emma Young, Achilles Anagnostop
Publié dans: Haematologica, Numéro 104/2, 2019, Page(s) 360-369, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
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ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—update on methodological approaches and results interpretation

Auteurs: J. Malcikova, E. Tausch, D. Rossi, L. A. Sutton, T. Soussi, T. Zenz, A. P. Kater, C. U. Niemann, D. Gonzalez, F. Davi, M. Gonzalez Diaz, C. Moreno, G. Gaidano, K. Stamatopoulos, R. Rosenquist, S. Stilgenbauer, P. Ghia, S. Pospisilova
Publié dans: Leukemia, Numéro 32/5, 2018, Page(s) 1070-1080, ISSN 0887-6924
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Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations

Auteurs: Aliki Xochelli, Vasilis Bikos, Eleftheria Polychronidou, Chrysi Galigalidou, Andreas Agathangelidis, Frédéric Charlotte, Panagiotis Moschonas, Zadie Davis, Monica Colombo, Maria Roumelioti, Lesley-Ann Sutton, Patricia Groenen, Michiel van den Brand, Myriam Boudjoghra, Patricia Algara, Alexandra Traverse-Glehen, Ana Ferrer, Evangelia Stalika, Maria Karypidou, George Kanellis, Christina Kalpadakis
Publié dans: The Journal of Pathology, 2018, ISSN 0022-3417
Éditeur: John Wiley & Sons Inc.
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Integrated epigenomic and transcriptomic analysis reveals TP63 as a novel player in clinically aggressive chronic lymphocytic leukemia

Auteurs: Nikos Papakonstantinou, Stavroula Ntoufa, Maria Tsagiopoulou, Theodoros Moysiadis, Sujata Bhoi, Andigoni Malousi, Fotis Psomopoulos, Larry Mansouri, Stamatia Laidou, Despoina Papazoglou, Maria Gounari, Konstantinos Pasentsis, Karla Plevova, Venera Kuci-Emruli, Marti Duran-Ferrer, Zadie Davis, Sara Ek, Davide Rossi, Gianluca Gaidano, Matthias Ritgen, David Oscier, Niki Stavroyianni, Sarka Pospisilo
Publié dans: International Journal of Cancer, 2018, ISSN 0020-7136
Éditeur: John Wiley & Sons Inc.
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Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations

Auteurs: R Rosenquist, P Ghia, A Hadzidimitriou, L-A Sutton, A Agathangelidis, P Baliakas, N Darzentas, V Giudicelli, M-P Lefranc, A W Langerak, C Belessi, F Davi, K Stamatopoulos
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Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it

Auteurs: Ivona Nečasová, Eliška Janoušková, Tomáš Klumpler, Ctirad Hofr
Publié dans: Nucleic Acids Research, Numéro 45/21, 2017, Page(s) 12170-12180, ISSN 0305-1048
Éditeur: Oxford University Press
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Multiple productive IGH rearrangements denote oligoclonality even in immunophenotypically monoclonal CLL

Auteurs: K Brazdilova, K Plevova, H Skuhrova Francova, H Kockova, M Borsky, V Bikos, J Malcikova, A Oltova, J Kotaskova, B Tichy, Y Brychtova, J Mayer, M Doubek, S Pospisilova
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Éditeur: Nature Publishing Group
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"ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres"

Auteurs: V. Navrkalova, E. Young, P. Baliakas, L. Radova, L.-A. Sutton, K. Plevova, L. Mansouri, V. Ljungstrom, S. Ntoufa, Z. Davis, G. Juliusson, K. E. Smedby, C. Belessi, P. Panagiotidis, T. Touloumenidou, F. Davi, A. W. Langerak, P. Ghia, J. C. Strefford, D. Oscier, J. Mayer, K. Stamatopoulos, S. Pospisilova, R. Rosenquist, M. Trbusek
Publié dans: Haematologica, Numéro 101/9, 2016, Page(s) e369-e373, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
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Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference

Auteurs: P. Baliakas, A. Puiggros, A. Xochelli, L.-A. Sutton, F. Nguyen-Khac, A. Gardiner, K. Plevova, E. Minga, A. Hadzidimitriou, R. Walewska, H. McCarthy, M. Ortega, R. Collado, T. Gonzalez, I. Granada, E. Luno, J. Kota kova, T. Moysiadis, Z. Davis, N. Stavroyianni, A. Anagnostopoulos, J. C. Strefford, S. Pospisilova, F. Davi, A. Athanasiadou, R. Rosenquist, D. Oscier, B. Espinet, K. Stamatopoulos
Publié dans: Haematologica, Numéro 101/7, 2016, Page(s) e299-e302, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
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Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond

Auteurs: R. Rosenquist, A. Rosenwald, M.-Q. Du, G. Gaidano, P. Groenen, A. Wotherspoon, P. Ghia, P. Gaulard, E. Campo, K. Stamatopoulos
Publié dans: Haematologica, Numéro 101/9, 2016, Page(s) 1002-1009, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
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The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia

Auteurs: Nikos Papakonstantinou, Stavroula Ntoufa, Elisavet Chartomatsidou, Konstantia Kotta, Andreas Agathangelidis, Lefki Giassafaki, Tzeni Karamanli, Panagiota Bele, Theodoros Moysiadis, Panagiotis Baliakas, Lesley Ann Sutton, Niki Stavroyianni, Achilles Anagnostopoulos, Antonios M. Makris, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos
Publié dans: Oncotarget, 2016, ISSN 1949-2553
Éditeur: Impact Journals
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Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors

Auteurs: L.-A. Sutton, E. Young, P. Baliakas, A. Hadzidimitriou, T. Moysiadis, K. Plevova, D. Rossi, J. Kminkova, E. Stalika, L. B. Pedersen, J. Malcikova, A. Agathangelidis, Z. Davis, L. Mansouri, L. Scarfo, M. Boudjoghra, A. Navarro, A. F. Muggen, X.-J. Yan, F. Nguyen-Khac, M. Larrayoz, P. Panagiotidis, N. Chiorazzi, C. U. Niemann, C. Belessi, E. Campo, J. C. Strefford, A. W. Langerak, D. Oscier, G. Gaid
Publié dans: Haematologica, Numéro 101/8, 2016, Page(s) 959-967, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
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Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

Auteurs: P. Baliakas, A. Agathangelidis, A. Hadzidimitriou, L.-A. Sutton, E. Minga, A. Tsanousa, L. Scarfo, Z. Davis, X.-J. Yan, T. Shanafelt, K. Plevova, Y. Sandberg, F. J. Vojdeman, M. Boudjogra, T. Tzenou, M. Chatzouli, C. C. Chu, S. Veronese, A. Gardiner, L. Mansouri, K. E. Smedby, L. B. Pedersen, D. Moreno, K. Van Lom, V. Giudicelli, H. S. Francova, F. Nguyen-Khac, P. Panagiotidis, G. Juliusson, L. Angelis, A. Anagnostopoulos, M.-P. Lefranc, M. Facco, L. Trentin, M. Catherwood, M. Montillo, C. H. Geisler, A. W. Langerak, S. Pospisilova, N. Chiorazzi, D. Oscier, D. F. Jelinek, N. Darzentas, C. Belessi, F. Davi, P. Ghia, R. Rosenquist, K. Stamatopoulos
Publié dans: Blood, Numéro 00064971, 2015, Page(s) 856-859, ISSN 0006-4971
Éditeur: American Society of Hematology
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Recurrent mutations refine prognosis in chronic lymphocytic leukemia

Auteurs: P Baliakas, A Hadzidimitriou, L-A Sutton, D Rossi, E Minga, N Villamor, M Larrayoz, J Kminkova, A Agathangelidis, Z Davis, E Tausch, E Stalika, B Kantorova, L Mansouri, L Scarfò, D Cortese, V Navrkalova, M J J Rose-Zerilli, K E Smedby, G Juliusson, A Anagnostopoulos, A M Makris, A Navarro, J Delgado, D Oscier, C Belessi, S Stilgenbauer, P Ghia, S Pospisilova, G Gaidano, E Campo, J C Strefford, K Stamatopoulos, R Rosenquist
Publié dans: Leukemia, Numéro 08876924, 2014, Page(s) 329-336, ISSN 0887-6924
Éditeur: Nature Publishing Group
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Prognostic relevance of MYD88 mutations in CLL: the jury is still out

Auteurs: P. Baliakas, A. Hadzidimitriou, A. Agathangelidis, D. Rossi, L.-A. Sutton, J. Kminkova, L. Scarfo, S. Pospisilova, G. Gaidano, K. Stamatopoulos, P. Ghia, R. Rosenquist
Publié dans: Blood, Numéro 00064971, 2015, Page(s) 1043-1044, ISSN 0006-4971
Éditeur: American Society of Hematology
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Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data

Auteurs: Panagiotis Baliakas, Michalis Iskas, Anne Gardiner, Zadie Davis, Karla Plevova, Florence Nguyen-Khac, Jitka Malcikova, Achilles Anagnostopoulos, Sharron Glide, Sarah Mould, Kristina Stepanovska, Martin Brejcha, Chrysoula Belessi, Frederic Davi, Sarka Pospisilova, Anastasia Athanasiadou, Kostas Stamatopoulos, David Oscier
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Éditeur: John Wiley & Sons Inc.
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Human Rap1 modulates TRF2 attraction to telomeric DNA

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Treatment of chronic lymphocytic leukemia with monoclonal antibodies, where are we heading?

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Molecular systematics of <I>Barbatosphaeria</I> (<I>Sordariomycetes</I>): multigene phylogeny and secondary ITS structure

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MicroRNAs in B-cell lymphomas: how a complex biology gets more complex

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Clonal evolution in chronic lymphocytic leukemia detected by fluorescence in situ hybridization and conventional cytogenetics after stimulation with CpG oligonucleotides and interleukin-2: A prospective analysis

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MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia

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The role of microRNAs in mitochondria in cancer

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TP53 Mutation Analysis in Clinical Practice: Lessons From Chronic Lymphocytic Leukemia

Auteurs: Jitka Malcikova, Sarka Pavlova, Katerina Stano Kozubik, Sarka Pospisilova
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The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors

Auteurs: Jitka Malcikova, Evangelia Stalika, Zadie Davis, Karla Plevova, Martin Trbusek, Larry Mansouri, Lydia Scarfò, Panagiotis Baliakas, Anne Gardiner, Lesley-Ann Sutton, Hana Skuhrova Francova, Andreas Agathangelidis, Achilles Anagnostopoulos, Ian Tracy, Antonis Makris, Jana Smardova, Paolo Ghia, Chrysoula Belessi, David Gonzalez, Richard Rosenquist, David Oscier, Sarka Pospisilova, Kostas Stamatopoulos
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MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma

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Identification of novel sequence variations in microRNAs in chronic lymphocytic leukemia

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Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients

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The BCR–ABL1 T315I mutation and additional genomic aberrations are dominant genetic lesions associated with disease progression in patients with chronic myelogenous leukemia resistant to tyrosine kinase inhibitor therapy

Auteurs: Jitka Malcikova, Filip Razga, Tomas Jurcek, Dana Dvorakova, Daniela Zackova, Martina Toskova, Ludmila Sebejova, Jana Smardova, Alexandra Oltova, Gabriela Vankova, Lenka Jurackova, Martin Trbusek, Sarka Pospisilova, Jiri Mayer, Zdenek Racil
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MicroRNA-206: a Promising Theranostic Marker

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miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib

Auteurs: Jana Merhautova, Renata Hezova, Alexandr Poprach, Alena Kovarikova, Lenka Radova, Marek Svoboda, Rostislav Vyzula, Regina Demlova, Ondrej Slaby
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Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting

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Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia

Auteurs: J Malcikova, K Stano-Kozubik, B Tichy, B Kantorova, S Pavlova, N Tom, L Radova, J Smardova, F Pardy, M Doubek, Y Brychtova, M Mraz, K Plevova, E Diviskova, A Oltova, J Mayer, S Pospisilova, M Trbusek
Publié dans: Leukemia, Numéro 08876924, 2014, Page(s) 877-885, ISSN 0887-6924
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MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia

Auteurs: B. Cui, L. Chen, S. Zhang, M. Mraz, J.-F. Fecteau, J. Yu, E. M. Ghia, L. Zhang, L. Bao, L. Z. Rassenti, K. Messer, G. A. Calin, C. M. Croce, T. J. Kipps
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The outcome of chronic lymphocytic leukemia patients who relapsed after fludarabine, cyclophosphamide, and rituximab

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TP53 mutation analysis in chronic lymphocytic leukemia: comparison of different detection methods

Auteurs: Barbara Kantorova, Jitka Malcikova, Jana Smardova, Sarka Pavlova, Martin Trbusek, Nikola Tom, Karla Plevova, Boris Tichy, Sim Truong, Eva Diviskova, Jana Kotaskova, Alexandra Oltova, Nancy Patten, Yvona Brychtova, Michael Doubek, Jiri Mayer, Sarka Pospisilova
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Identification of MicroRNAs Regulated by Isothiocyanates and Association of Polymorphisms Inside Their Target Sites with Risk of Sporadic Colorectal Cancer

Auteurs: Ondrej Slaby, Milana Sachlova, Veronika Brezkova, Renata Hezova, Alena Kovarikova, Svatava Bischofová, Sabina Sevcikova, Julie Bienertova-Vasku, Anna Vasku, Marek Svoboda, Rostislav Vyzula
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MicroRNA Profiling of Activated and Tolerogenic Human Dendritic Cells

Auteurs: Zuzana Stumpfova, Renata Hezova, Albano Carlo Meli, Ondrej Slaby, Jaroslav Michalek
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Extension of microRNA expression pattern associated with high-risk neuroblastoma

Auteurs: Julie Bienertova-Vasku, Pavel Mazanek, Renata Hezova, Anna Curdova, Jana Nekvindova, Leos Kren, Jaroslav Sterba, Ondrej Slaby
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B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells

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Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

Auteurs: Larry Mansouri, Lesley-Ann Sutton, Viktor Ljungström, Sina Bondza, Linda Arngården, Sujata Bhoi, Jimmy Larsson, Diego Cortese, Antonia Kalushkova, Karla Plevova, Emma Young, Rebeqa Gunnarsson, Elin Falk-Sörqvist, Peter Lönn, Alice F. Muggen, Xiao-Jie Yan, Birgitta Sander, Gunilla Enblad, Karin E. Smedby, Gunnar Juliusson, Chrysoula Belessi, Johan Rung, Nicholas Chiorazzi, Jonathan C. Strefford, Anton W. Langerak, Sarka Pospisilova, Frederic Davi, Mats Hellström, Helena Jernberg-Wiklund, Paolo Ghia, Ola Söderberg, Kostas Stamatopoulos, Mats Nilsson, Richard Rosenquist
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The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration

Auteurs: M. Kaucka, K. Plevova, S. Pavlova, P. Janovska, A. Mishra, J. Verner, J. Prochazkova, P. Krejci, J. Kotaskova, P. Ovesna, B. Tichy, Y. Brychtova, M. Doubek, A. Kozubik, J. Mayer, S. Pospisilova, V. Bryja
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miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1

Auteurs: M. Mraz, L. Chen, L. Z. Rassenti, E. M. Ghia, H. Li, K. Jepsen, E. N. Smith, K. Messer, K. A. Frazer, T. J. Kipps
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Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones

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RNA secondary structure, an important bioinformatics tool to enhance multiple sequence alignment: a case study (Sordariomycetes, Fungi)

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The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus

Auteurs: Marek Mraz, Katerina Stano Kozubik, Karla Plevova, Katerina Musilova, Boris Tichy, Marek Borsky, Petr Kuglik, Michael Doubek, Yvona Brychtova, Jiri Mayer, Sarka Pospisilova
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Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenström macroglobulinemia

Auteurs: Lenka Kubiczkova Besse, Lenka Sedlarikova, Fedor Kryukov, Jana Nekvindova, Lenka Radova, Martina Almasi, Jana Pelcova, Jiri Minarik, Tomas Pika, Zuzana Pikalova, Vlastimil Scudla, Marta Krejci, Zdenek Adam, Ludek Pour, Roman Hajek, Sabina Sevcikova
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Histone H1 Differentially Inhibits DNA Bending by Reduced and Oxidized HMGB1 Protein

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Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma

Auteurs: Lenka Besse, Lenka Sedlarikova, Fedor Kryukov, Jana Nekvindova, Lenka Radova, Ondrej Slaby, Petr Kuglik, Martina Almasi, Miroslav Penka, Marta Krejci, Zdenek Adam, Ludek Pour, Sabina Sevcikova, Roman Hajek
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ARResT/AssignSubsets: a novel application for robust subclassification of chronic lymphocytic leukemia based on B cell receptor IG stereotypy

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The impact of SF3B1 mutations in CLL on the DNA-damage response

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"Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2"

Auteurs: J C Strefford, L-A Sutton, P Baliakas, A Agathangelidis, J Malčíková, K Plevova, L Scarfó, Z Davis, E Stalika, D Cortese, N Cahill, L B Pedersen, P F di Celle, T Tzenou, C Geisler, P Panagiotidis, A W Langerak, N Chiorazzi, S Pospisilova, D Oscier, F Davi, C Belessi, L Mansouri, P Ghia, K Stamatopoulos, R Rosenquist
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CLCN1 Mutations in Czech Patients with Myotonia Congenita, In Silico Analysis of Novel and Known Mutations in the Human Dimeric Skeletal Muscle Chloride Channel

Auteurs: Daniela Skálová, Jana Zídková, Stanislav Voháňka, Radim Mazanec, Zuzana Mušová, Petr Vondráček, Lenka Mrázová, Josef Kraus, Kamila Réblová, Lenka Fajkusová
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The Significance of Stereotyped B-Cell Receptors in Chronic Lymphocytic Leukemia

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Hepcidin levels in Diamond-Blackfan anemia reflect erythropoietic activity and transfusion dependency

Auteurs: D. Pospisilova, D. Holub, Z. Zidova, L. Sulovska, J. Houda, V. Mihal, I. Hadacova, L. Radova, P. Dzubak, M. Hajduch, V. Divoky, M. Horvathova
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The structure and substrate specificity of human Cdk12/Cyclin K

Auteurs: Christian A. Bösken, Lucas Farnung, Corinna Hintermair, Miriam Merzel Schachter, Karin Vogel-Bachmayr, Dalibor Blazek, Kanchan Anand, Robert P. Fisher, Dirk Eick, Matthias Geyer
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Phylogenetic Reconstruction of the Calosphaeriales and Togniniales Using Five Genes and Predicted RNA Secondary Structures of ITS, and Flabellascus tenuirostris gen. et sp. nov.

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Diagnostic and prognostic potential of miR-21, miR-29c, miR-148 and miR-203 in adenocarcinoma and squamous cell carcinoma of esophagus

Auteurs: Renata Hezova, Alena Kovarikova, Josef Srovnal, Milada Zemanova, Tomas Harustiak, Jiri Ehrmann, Marian Hajduch, Marek Svoboda, Milana Sachlova, Ondrej Slaby
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Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

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MicroRNAs targeting EGFR signalling pathway in colorectal cancer

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Combination of fludarabine, amsacrine, and cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with high-risk acute myeloid leukemia

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Immunogenomic analysis of insect bite hypersensitivity in a model horse population

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Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice

Auteurs: O. Stehlíková, J. Chovancová, B. Tichý, M. Krejčí, Y. Brychtová, A. Panovská, H. Francová Skuhrová, K. Burčková, M. Borský, T. Loja, J. Mayer, Š. Pospíšilová, M. Doubek
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Ofatumumab added to dexamethasone in patients with relapsed or refractory chronic lymphocytic leukemia: Results from a phase II study

Auteurs: Michael Doubek, Yvona Brychtova, Anna Panovska, Ludmila Sebejova, Olga Stehlikova, Jana Chovancova, Jitka Malcikova, Jana Smardova, Karla Plevova, Pavlina Volfova, Martin Trbusek, Marek Mraz, Denisa Bakesova, Jakub Trizuljak, Marketa Hadrabova, Petra Obrtlikova, Josef Karban, Lukas Smolej, Alexandra Oltova, Eva Jelinkova, Sarka Pospisilova, Jiri Mayer
Publié dans: American Journal of Hematology, Numéro 03618609, 2015, Page(s) 417-421, ISSN 0361-8609
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ajh.23964

Contributions of the TEL-patch Amino Acid Cluster on TPP1 to Telomeric DNA Synthesis by Human Telomerase

Auteurs: Andrew B. Dalby, Ctirad Hofr, Thomas R. Cech
Publié dans: Journal of Molecular Biology, Numéro 00222836, 2015, Page(s) 1291-1303, ISSN 0022-2836
Éditeur: Academic Press
DOI: 10.1016/j.jmb.2015.01.008

NOD/SCID IL2Rγ-null mouse xenograft model of human p53-mutated chronic lymphocytic leukemia and ATM-mutated mantle cell lymphoma using permanent cell lines

Auteurs: Jan Verner, Martin Trbusek, Jana Chovancova, Zuzana Jaskova, Mojmir Moulis, Frantisek Folber, Roman Halouzka, Jiri Mayer, Sarka Pospisilova, Michael Doubek
Publié dans: Leukemia & Lymphoma, Numéro 10428194, 2015, Page(s) 3198-3206, ISSN 1042-8194
Éditeur: Taylor & Francis
DOI: 10.3109/10428194.2015.1034701

Fludarabine with cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with poor-risk chronic lymphocytic leukemia

Auteurs: Marta Krejci, Michael Doubek, Yvona Brychtova, Olga Stehlikova, Jana Chovancova, Boris Tichy, Hana Skuhrova Francova, Milan Navratil, Miroslav Tomiska, Ondrej Horky, Sarka Pospisilova, Jiri Mayer
Publié dans: Annals of Hematology, Numéro 09395555, 2013, Page(s) 249-254, ISSN 0939-5555
Éditeur: Springer Verlag
DOI: 10.1007/s00277-012-1579-y

Combination of MiR-378 and MiR-210 Serum Levels Enables Sensitive Detection of Renal Cell Carcinoma

Auteurs: Michal Fedorko, Michal Stanik, Robert Iliev, Martina Redova-Lojova, Tana Machackova, Marek Svoboda, Dalibor Pacik, Jan Dolezel, Ondrej Slaby
Publié dans: International Journal of Molecular Sciences, Numéro 14220067, 2015, Page(s) 23382-23389, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms161023382

Binding of Histone H1 to DNA Is Differentially Modulated by Redox State of HMGB1

Auteurs: Eva Polanská, Šárka Pospíšilová, Michal Štros
Publié dans: PLoS ONE, Numéro 19326203, 2014, Page(s) e89070, ISSN 1932-6203
Éditeur: Public Library of Science
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Novel Evolutionary Lineages Revealed in the Chaetothyriales (Fungi) Based on Multigene Phylogenetic Analyses and Comparison of ITS Secondary Structure

Auteurs: Martina Réblová, Wendy A. Untereiner, Kamila Réblová
Publié dans: PLoS ONE, Numéro 19326203, 2013, Page(s) e63547, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0063547

Distinct in vitro sensitivity of p53-mutated and ATM-mutated chronic lymphocytic leukemia cells to ofatumumab and rituximab

Auteurs: Ludmila Sebejova, Marek Borsky, Zuzana Jaskova, David Potesil, Veronika Navrkalova, Jitka Malcikova, Martin Sramek, Michael Doubek, Tomas Loja, Sarka Pospisilova, Jiri Mayer, Martin Trbusek
Publié dans: Experimental Hematology, Numéro 0301472X, 2014, Page(s) 867-874.e1, ISSN 0301-472X
Éditeur: Elsevier BV
DOI: 10.1016/j.exphem.2014.06.003

ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin

Auteurs: V. Navrkalova, L. Sebejova, J. Zemanova, J. Kminkova, B. Kubesova, J. Malcikova, M. Mraz, J. Smardova, S. Pavlova, M. Doubek, Y. Brychtova, D. Potesil, V. Nemethova, J. Mayer, S. Pospisilova, M. Trbusek
Publié dans: Haematologica, Numéro 03906078, 2013, Page(s) 1124-1131, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2012.081620

Towards error-free profiling of immune repertoires

Auteurs: Mikhail Shugay, Olga V Britanova, Ekaterina M Merzlyak, Maria A Turchaninova, Ilgar Z Mamedov, Timur R Tuganbaev, Dmitriy A Bolotin, Dmitry B Staroverov, Ekaterina V Putintseva, Karla Plevova, Carsten Linnemann, Dmitriy Shagin, Sarka Pospisilova, Sergey Lukyanov, Ton N Schumacher, Dmitriy M Chudakov
Publié dans: Nature Methods, Numéro 15487091, 2014, Page(s) 653-655, ISSN 1548-7091
Éditeur: Nature Publishing Group
DOI: 10.1038/NMETH.2960

Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia

Auteurs: Aliki Xochelli, Andreas Agathangelidis, Ioannis Kavakiotis, Evangelia Minga, Lesley Ann Sutton, Panagiotis Baliakas, Ioanna Chouvarda, Véronique Giudicelli, Ioannis Vlahavas, Nikos Maglaveras, Lisa Bonello, Livio Trentin, Alessandra Tedeschi, Panagiotis Panagiotidis, Christian Geisler, Anton W. Langerak, Sarka Pospisilova, Diane F. Jelinek, David Oscier, Nicholas Chiorazzi, Nikos Darzentas, Fred Davi, Paolo Ghia, Richard Rosenquist, Anastasia Hadzidimitriou, Chrysoula Belessi, Marie-Paule Lefranc, Kostas Stamatopoulos
Publié dans: Immunogenetics, Numéro 00937711, 2015, Page(s) 61-66, ISSN 0093-7711
Éditeur: Springer Verlag
DOI: 10.1007/s00251-014-0812-3

Urine microRNAs as potential noninvasive biomarkers in urologic cancers

Auteurs: Hana Mlcochova, Renata Hezova, Michal Stanik, Ondrej Slaby
Publié dans: Urologic Oncology: Seminars and Original Investigations, Numéro 10781439, 2014, Page(s) 41.e1-41.e9, ISSN 1078-1439
Éditeur: Elsevier BV
DOI: 10.1016/j.urolonc.2013.04.011

MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma

Auteurs: Martina Redova, Alexandr Poprach, Andrej Besse, Robert Iliev, Jana Nekvindova, Radek Lakomy, Lenka Radova, Marek Svoboda, Jan Dolezel, Rostislav Vyzula, Ondrej Slaby
Publié dans: Tumor Biology, Numéro 10104283, 2013, Page(s) 481-491, ISSN 1010-4283
Éditeur: Springer Verlag
DOI: 10.1007/s13277-012-0573-2

Temporal Dynamics of Clonal Evolution in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-34/IGKV2-30 Antigen Receptors: Longitudinal Immunogenetic Evidence

Auteurs: Lesley Sutton, Efterpi Kostareli
Publié dans: Molecular Medicine, Numéro 10761551, 2013, Page(s) 1, ISSN 1076-1551
Éditeur: North Shore - Long Jewish Research Institute
DOI: 10.2119/molmed.2013.00042

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins

Auteurs: Niamh Mannion, Fabiana Arieti, Angela Gallo, Liam Keegan, Mary O'Connell
Publié dans: Biomolecules, Numéro 2218273X, 2015, Page(s) 2338-2362, ISSN 2218-273X
Éditeur: MDPI AG
DOI: 10.3390/biom5042338

IgG-Switched CLL Has a Distinct Immunogenetic Signature from the Common MD Variant: Ontogenetic Implications

Auteurs: A. Vardi, A. Agathangelidis, L.-A. Sutton, M. Chatzouli, L. Scarfo, L. Mansouri, V. Douka, A. Anagnostopoulos, N. Darzentas, R. Rosenquist, P. Ghia, C. Belessi, K. Stamatopoulos
Publié dans: Clinical Cancer Research, Numéro 10780432, 2014, Page(s) 323-330, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-13-1993

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

Auteurs: Jan Machal, Jan Novak, Renata Hezova, Filip Zlamal, Anna Vasku, Ondrej Slaby, Julie Bienertova-Vasku
Publié dans: Genes & Nutrition, Numéro 15558932, 2015, ISSN 1555-8932
Éditeur: New Century Health Publishers
DOI: 10.1007/s12263-015-0488-9

Hypergravity effects on glide arc plasma

Auteurs: Jiří Šperka, Pavel Souček, Jack J. W. A. Van Loon, Alan Dowson, Christian Schwarz, Jutta Krause, Gerrit Kroesen, Vít Kudrle
Publié dans: The European Physical Journal D, Numéro 14346060, 2013, ISSN 1434-6060
Éditeur: Springer Verlag
DOI: 10.1140/epjd/e2013-40408-7

Splenic marginal-zone lymphoma: ontogeny and genetics

Auteurs: Panagiotis Baliakas, Jonathan C. Strefford, Vasilis Bikos, Marina Parry, Kostas Stamatopoulos, David Oscier
Publié dans: Leukemia & Lymphoma, Numéro 10428194, 2014, Page(s) 301-310, ISSN 1042-8194
Éditeur: Taylor & Francis
DOI: 10.3109/10428194.2014.919636

Isosteric and Nonisosteric Base Pairs in RNA Motifs: Molecular Dynamics and Bioinformatics Study of the Sarcin–Ricin Internal Loop

Auteurs: Marek Havrila, Kamila Réblová, Craig L. Zirbel, Neocles B. Leontis, Jiří Šponer
Publié dans: The Journal of Physical Chemistry B, Numéro 15206106, 2013, Page(s) 14302-14319, ISSN 1520-6106
Éditeur: American Chemical Society
DOI: 10.1021/jp408530w

Assessment of TP53 functionality in chronic lymphocytic leukaemia by different assays; an ERIC-wide approach

Auteurs: G. Doreen te Raa, Jitka Malčiková, Marek Mraz, Martin Trbusek, Magali Le Garff-Tavernier, Hélène Merle-Béral, Rudolf Greil, Olaf Merkel, Sarka Pospíšilová, Ke Lin, Andrew R. Pettitt, Tatjana Stankovic, Marinus H. van Oers, Eric Eldering, Stephan Stilgenbauer, Thorsten Zenz, Arnon P. Kater
Publié dans: British Journal of Haematology, Numéro 00071048, 2014, Page(s) 565-569, ISSN 0007-1048
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/bjh.13006

Molecular Evidence for Antigen Drive in the Natural History of Mantle Cell Lymphoma

Auteurs: Aliki Xochelli, Lesley-Ann Sutton, Andreas Agathangelidis, Evangelia Stalika, Maria Karypidou, Fotini Marantidou, Alba Navarro Lopez, Giorgos Papadopoulos, Jana Supikova, Patricia Groenen, Myriam Boudjogra, Christer Sundstrom, Maurilio Ponzoni, Hana Skuhrova Francova, Achilles Anagnostopoulos, Sarka Pospisilova, Theodora Papadaki, Dimitris Tzovaras, Paolo Ghia, Christiane Pott, Frederic Davi, Elias Campo, Richard Rosenquist, Anastasia Hadzidimitriou, Chrysoula Belessi, Kostas Stamatopoulos
Publié dans: The American Journal of Pathology, Numéro 00029440, 2015, Page(s) 1740-1748, ISSN 0002-9440
Éditeur: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2015.02.006

The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex

Auteurs: Lucie Kozakova, Lucie Vondrova, Karel Stejskal, Panagoula Charalabous, Peter Kolesar, Alan R Lehmann, Stjepan Uldrijan, Christopher M Sanderson, Zbynek Zdrahal, Jan J Palecek
Publié dans: Cell Cycle, Numéro 15384101, 2015, Page(s) 920-930, ISSN 1538-4101
Éditeur: Landes Bioscience
DOI: 10.1080/15384101.2014.1000112

Role of S-turn2 in the Structure, Dynamics, and Function of Mitochondrial Ribosomal A-Site. A Bioinformatics and Molecular Dynamics Simulation Study

Auteurs: Joanna Panecka, Marek Havrila, Kamila Réblová, Jiří Šponer, Joanna Trylska
Publié dans: The Journal of Physical Chemistry B, Numéro 15206106, 2014, Page(s) 6687-6701, ISSN 1520-6106
Éditeur: American Chemical Society
DOI: 10.1021/jp5030685

Dynamic changes in microRNA expression profiles reflect progression of Barrett's esophagus to esophageal adenocarcinoma

Auteurs: O. Slaby, J. Srovnal, L. Radova, J. Gregar, J. Juracek, P. Luzna, M. Svoboda, M. Hajduch, J. Ehrmann
Publié dans: Carcinogenesis, Numéro 01433334, 2015, Page(s) 521-527, ISSN 0143-3334
Éditeur: Oxford University Press
DOI: 10.1093/carcin/bgv023

Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma

Auteurs: Andrea Janikova, Andrea Mareckova, Aneta Baumeisterova, Marta Krejci, Jana Supikova, David Salek, Ondrej Horky, Boris Tichy, Ivo Hanke, Sarka Pospisilova, Mojmir Moulis, Jiri Mayer
Publié dans: Leukemia & Lymphoma, Numéro 10428194, 2014, Page(s) 1935-1938, ISSN 1042-8194
Éditeur: Taylor & Francis
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Small nucleolar RNAs functioning and potential roles in cancer

Auteurs: Nithyananda Thorenoor, Ondrej Slaby
Publié dans: Tumor Biology, Numéro 10104283, 2015, Page(s) 41-53, ISSN 1010-4283
Éditeur: Springer Verlag
DOI: 10.1007/s13277-014-2818-8

Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia

Auteurs: Jakub Trizuljak, Josef Srovnal, Karla Plevová, Yvona Brychtová, Lukáš Semerád, Denisa Bakešová, Eva Létalová, Andrea Benedíková, Jiří Mayer, Marián Hajdúch, Šárka Pospíšilová, Michael Doubek
Publié dans: Clinical Lymphoma Myeloma and Leukemia, Numéro 21522669, 2015, Page(s) 439-442, ISSN 2152-2669
Éditeur: Cancer Media Group
DOI: 10.1016/j.clml.2015.02.003

The Epitranscriptome and Innate Immunity

Auteurs: Mary A. O’Connell, Niamh M. Mannion, Liam P. Keegan
Publié dans: PLOS Genetics, Numéro 15537404, 2015, Page(s) e1005687, ISSN 1553-7404
Éditeur: Public Library ScienceUBLIC LIBRARY SCIENCE
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MicroRNAs involved in chemo- and radioresistance of high-grade gliomas

Auteurs: Andrej Besse, Jiri Sana, Pavel Fadrus, Ondrej Slaby
Publié dans: Tumor Biology, Numéro 10104283, 2013, Page(s) 1969-1978, ISSN 1010-4283
Éditeur: Springer Verlag
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MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis

Auteurs: A. Benner, L. Mansouri, D. Rossi, A. Majid, K. Willander, A. Parker, G. Bond, S. Pavlova, H. Nuckel, O. Merkel, P. Ghia, E. Montserrat, M. A. Kaderi, R. Rosenquist, G. Gaidano, M. J. S. Dyer, P. Soderkvist, M. Linderholm, D. Oscier, Z. Tvaruzkova, S. Pospisilova, U. Duhrsen, R. Greil, H. Dohner, S. Stilgenbauer, T. Zenz
Publié dans: Haematologica, Numéro 03906078, 2014, Page(s) 1285-1291, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
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Circulating miRNAs as new blood-based biomarkers for solid cancers

Auteurs: Martina Redova, Jiri Sana, Ondrej Slaby
Publié dans: Future Oncology, Numéro 14796694, 2013, Page(s) 387-402, ISSN 1479-6694
Éditeur: Future Medicine Ltd.
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Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway

Auteurs: L.  merdova, J. Svobodova, M. Kabatkova, J. Kohoutek, D. Bla ek, M. Machala, J. Vondra ek
Publié dans: Carcinogenesis, Numéro 01433334, 2014, Page(s) 2534-2543, ISSN 0143-3334
Éditeur: Oxford University Press
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Hypergravity synthesis of graphitic carbon nanomaterial in glide arc plasma

Auteurs: Jiří Šperka, Pavel Souček, Jack J.W.A. Van Loon, Alan Dowson, Christian Schwarz, Jutta Krause, Yuriy Butenko, Gerrit Kroesen, Vít Kudrle
Publié dans: Materials Research Bulletin, Numéro 00255408, 2014, Page(s) 61-65, ISSN 0025-5408
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Computational study of missense mutations in phenylalanine hydroxylase

Auteurs: Kamila Réblová, Petr Kulhánek, Lenka Fajkusová
Publié dans: Journal of Molecular Modeling, Numéro 16102940, 2015, ISSN 1610-2940
Éditeur: Springer Verlag
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Hyperphenylalaninemia in the Czech Republic: Genotype–phenotype correlations and in silico analysis of novel missense mutations

Auteurs: Kamila Réblová, Zuzana Hrubá, Dagmar Procházková, Renata Pazdírková, Slávka Pouchlá, Lenka Fajkusová
Publié dans: Clinica Chimica Acta, Numéro 00098981, 2013, Page(s) 1-10, ISSN 0009-8981
Éditeur: Elsevier BV
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TaqMan based real time PCR assay targeting EML4-ALK fusion transcripts in NSCLC

Auteurs: Blanka Robesova, Monika Bajerova, Kvetoslava Liskova, Jana Skrickova, Marcela Tomiskova, Sarka Pospisilova, Jiri Mayer, Dana Dvorakova
Publié dans: Lung Cancer, Numéro 01695002, 2014, Page(s) 25-30, ISSN 0169-5002
Éditeur: Elsevier BV
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MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia

Auteurs: Marek Mraz, Thomas J. Kipps
Publié dans: Leukemia & Lymphoma, Numéro 54/8, 2013, Page(s) 1836-1839, ISSN 1042-8194
Éditeur: Taylor & Francis
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Histone H1 Differentially Inhibits DNA Bending by Reduced and Oxidized HMGB1 Protein

Auteurs: Michal Štros, Eva Polanská, Martin Kučírek, Šárka Pospíšilová
Publié dans: PLOS ONE, Numéro 10/9, 2015, Page(s) e0138774, ISSN 1932-6203
Éditeur: Public Library of Science
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CLCN1 Mutations in Czech Patients with Myotonia Congenita, In Silico Analysis of Novel and Known Mutations in the Human Dimeric Skeletal Muscle Chloride Channel

Auteurs: Daniela Skálová, Jana Zídková, Stanislav Voháňka, Radim Mazanec, Zuzana Mušová, Petr Vondráček, Lenka Mrázová, Josef Kraus, Kamila Réblová, Lenka Fajkusová
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Éditeur: Public Library of Science
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Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia

Auteurs: J Malcikova, K Stano-Kozubik, B Tichy, B Kantorova, S Pavlova, N Tom, L Radova, J Smardova, F Pardy, M Doubek, Y Brychtova, M Mraz, K Plevova, E Diviskova, A Oltova, J Mayer, S Pospisilova, M Trbusek
Publié dans: Leukemia, Numéro 29/4, 2014, Page(s) 877-885, ISSN 0887-6924
Éditeur: Nature Publishing Group
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MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia

Auteurs: B. Cui, L. Chen, S. Zhang, M. Mraz, J.-F. Fecteau, J. Yu, E. M. Ghia, L. Zhang, L. Bao, L. Z. Rassenti, K. Messer, G. A. Calin, C. M. Croce, T. J. Kipps
Publié dans: Blood, Numéro 124/4, 2014, Page(s) 546-554, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2014-03-559690

The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex

Auteurs: Lucie Kozakova, Lucie Vondrova, Karel Stejskal, Panagoula Charalabous, Peter Kolesar, Alan R Lehmann, Stjepan Uldrijan, Christopher M Sanderson, Zbynek Zdrahal, Jan J Palecek
Publié dans: Cell Cycle, Numéro 14/6, 2015, Page(s) 920-930, ISSN 1538-4101
Éditeur: Landes Bioscience
DOI: 10.1080/15384101.2014.1000112

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins

Auteurs: Niamh Mannion, Fabiana Arieti, Angela Gallo, Liam Keegan, Mary O'Connell
Publié dans: Biomolecules, Numéro 5/4, 2015, Page(s) 2338-2362, ISSN 2218-273X
Éditeur: MDPI AG
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miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib

Auteurs: Jana Merhautova, Renata Hezova, Alexandr Poprach, Alena Kovarikova, Lenka Radova, Marek Svoboda, Rostislav Vyzula, Regina Demlova, Ondrej Slaby
Publié dans: BioMed Research International, Numéro 2015, 2015, Page(s) 1-5, ISSN 2314-6133
Éditeur: Hindawi Publishing Corporation
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The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors

Auteurs: Jitka Malcikova, Evangelia Stalika, Zadie Davis, Karla Plevova, Martin Trbusek, Larry Mansouri, Lydia Scarfò, Panagiotis Baliakas, Anne Gardiner, Lesley-Ann Sutton, Hana Skuhrova Francova, Andreas Agathangelidis, Achilles Anagnostopoulos, Ian Tracy, Antonis Makris, Jana Smardova, Paolo Ghia, Chrysoula Belessi, David Gonzalez, Richard Rosenquist, David Oscier, Sarka Pospisilova, Kostas Stamatopoulos
Publié dans: British Journal of Haematology, Numéro 166/4, 2014, Page(s) 621-625, ISSN 0007-1048
Éditeur: Blackwell Publishing Inc.
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Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

Auteurs: Larry Mansouri, Lesley-Ann Sutton, Viktor Ljungström, Sina Bondza, Linda Arngården, Sujata Bhoi, Jimmy Larsson, Diego Cortese, Antonia Kalushkova, Karla Plevova, Emma Young, Rebeqa Gunnarsson, Elin Falk-Sörqvist, Peter Lönn, Alice F. Muggen, Xiao-Jie Yan, Birgitta Sander, Gunilla Enblad, Karin E. Smedby, Gunnar Juliusson, Chrysoula Belessi, Johan Rung, Nicholas Chiorazzi, Jonathan C. Strefford, Anton W. Langerak, Sarka Pospisilova, Frederic Davi, Mats Hellström, Helena Jernberg-Wiklund, Paolo Ghia, Ola Söderberg, Kostas Stamatopoulos, Mats Nilsson, Richard Rosenquist
Publié dans: The Journal of Experimental Medicine, Numéro 212/6, 2015, Page(s) 833-843, ISSN 0022-1007
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Recurrent mutations refine prognosis in chronic lymphocytic leukemia

Auteurs: P Baliakas, A Hadzidimitriou, L-A Sutton, D Rossi, E Minga, N Villamor, M Larrayoz, J Kminkova, A Agathangelidis, Z Davis, E Tausch, E Stalika, B Kantorova, L Mansouri, L Scarfò, D Cortese, V Navrkalova, M J J Rose-Zerilli, K E Smedby, G Juliusson, A Anagnostopoulos, A M Makris, A Navarro, J Delgado, D Oscier, C Belessi, S Stilgenbauer, P Ghia, S Pospisilova, G Gaidano, E Campo, J C Strefford, K Stamatopoulos, R Rosenquist
Publié dans: Leukemia, Numéro 29/2, 2014, Page(s) 329-336, ISSN 0887-6924
Éditeur: Nature Publishing Group
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Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1

Auteurs: Vineeta Khare, Alex Lyakhovich, Kyle Dammann, Michaela Lang, Melanie Borgmann, Boris Tichy, Sarka Pospisilova, Gloria Luciani, Christoph Campregher, Rayko Evstatiev, Maren Pflueger, Harald Hundsberger, Christoph Gasche
Publié dans: Biochemical Pharmacology, Numéro 85/2, 2013, Page(s) 234-244, ISSN 0006-2952
Éditeur: Elsevier BV
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TP53 Mutation Analysis in Clinical Practice: Lessons From Chronic Lymphocytic Leukemia

Auteurs: Jitka Malcikova, Sarka Pavlova, Katerina Stano Kozubik, Sarka Pospisilova
Publié dans: Human Mutation, Numéro 35/6, 2014, Page(s) 663-671, ISSN 1059-7794
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DOI: 10.1002/humu.22508

Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients

Auteurs: J. Sana, L. Radova, R. Lakomy, L. Kren, P. Fadrus, M. Smrcka, A. Besse, J. Nekvindova, M. Hermanova, R. Jancalek, M. Svoboda, M. Hajduch, P. Slampa, R. Vyzula, O. Slaby
Publié dans: Carcinogenesis, Numéro 35/12, 2014, Page(s) 2756-2762, ISSN 0143-3334
Éditeur: Oxford University Press
DOI: 10.1093/carcin/bgu212

The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration

Auteurs: M. Kaucka, K. Plevova, S. Pavlova, P. Janovska, A. Mishra, J. Verner, J. Prochazkova, P. Krejci, J. Kotaskova, P. Ovesna, B. Tichy, Y. Brychtova, M. Doubek, A. Kozubik, J. Mayer, S. Pospisilova, V. Bryja
Publié dans: Cancer Research, Numéro 73/5, 2013, Page(s) 1491-1501, ISSN 0008-5472
Éditeur: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-12-1752

Combination of fludarabine, amsacrine, and cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with high-risk acute myeloid leukemia

Auteurs: Marta Krejci, Michael Doubek, Jaroslav Dusek, Yvona Brychtova, Zdenek Racil, Milan Navratil, Miroslav Tomiska, Ondrej Horky, Sarka Pospisilova, Jiri Mayer
Publié dans: Annals of Hematology, Numéro 92/10, 2013, Page(s) 1397-1403, ISSN 0939-5555
Éditeur: Springer Verlag
DOI: 10.1007/s00277-013-1790-5

Hyperphenylalaninemia in the Czech Republic: Genotype–phenotype correlations and in silico analysis of novel missense mutations

Auteurs: Kamila Réblová, Zuzana Hrubá, Dagmar Procházková, Renata Pazdírková, Slávka Pouchlá, Lenka Fajkusová
Publié dans: Clinica Chimica Acta, Numéro 419, 2013, Page(s) 1-10, ISSN 0009-8981
Éditeur: Elsevier BV
DOI: 10.1016/j.cca.2013.01.006

B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells

Auteurs: Vaclav Seda, Marek Mraz
Publié dans: European Journal of Haematology, Numéro 94/3, 2015, Page(s) 193-205, ISSN 0902-4441
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/ejh.12427

Isosteric and Nonisosteric Base Pairs in RNA Motifs: Molecular Dynamics and Bioinformatics Study of the Sarcin–Ricin Internal Loop

Auteurs: Marek Havrila, Kamila Réblová, Craig L. Zirbel, Neocles B. Leontis, Jiří Šponer
Publié dans: The Journal of Physical Chemistry B, Numéro 117/46, 2013, Page(s) 14302-14319, ISSN 1520-6106
Éditeur: American Chemical Society
DOI: 10.1021/jp408530w

Small nucleolar RNAs functioning and potential roles in cancer

Auteurs: Nithyananda Thorenoor, Ondrej Slaby
Publié dans: Tumor Biology, Numéro 36/1, 2015, Page(s) 41-53, ISSN 1010-4283
Éditeur: Springer Verlag
DOI: 10.1007/s13277-014-2818-8

Binding of Histone H1 to DNA Is Differentially Modulated by Redox State of HMGB1

Auteurs: Eva Polanská, Šárka Pospíšilová, Michal Štros
Publié dans: PLoS ONE, Numéro 9/2, 2014, Page(s) e89070, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0089070

RNA secondary structure, an important bioinformatics tool to enhance multiple sequence alignment: a case study (Sordariomycetes, Fungi)

Auteurs: Martina Réblová, Kamila Réblová
Publié dans: Mycological Progress, Numéro 12/2, 2013, Page(s) 305-319, ISSN 1617-416X
Éditeur: IHW-Verl
DOI: 10.1007/s11557-012-0836-8

Circulating miRNAs as new blood-based biomarkers for solid cancers

Auteurs: Martina Redova, Jiri Sana, Ondrej Slaby
Publié dans: Future Oncology, Numéro 9/3, 2013, Page(s) 387-402, ISSN 1479-6694
Éditeur: Future Medicine Ltd.
DOI: 10.2217/FON.12.192

Hypergravity effects on glide arc plasma

Auteurs: Jiří Šperka, Pavel Souček, Jack J. W. A. Van Loon, Alan Dowson, Christian Schwarz, Jutta Krause, Gerrit Kroesen, Vít Kudrle
Publié dans: The European Physical Journal D, Numéro 67/12, 2013, ISSN 1434-6060
Éditeur: Springer Verlag
DOI: 10.1140/epjd/e2013-40408-7

Ofatumumab added to dexamethasone in patients with relapsed or refractory chronic lymphocytic leukemia: Results from a phase II study

Auteurs: Michael Doubek, Yvona Brychtova, Anna Panovska, Ludmila Sebejova, Olga Stehlikova, Jana Chovancova, Jitka Malcikova, Jana Smardova, Karla Plevova, Pavlina Volfova, Martin Trbusek, Marek Mraz, Denisa Bakesova, Jakub Trizuljak, Marketa Hadrabova, Petra Obrtlikova, Josef Karban, Lukas Smolej, Alexandra Oltova, Eva Jelinkova, Sarka Pospisilova, Jiri Mayer
Publié dans: American Journal of Hematology, Numéro 90/5, 2015, Page(s) 417-421, ISSN 0361-8609
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ajh.23964

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

Auteurs: K. M. Ekumi, H. Paculova, T. Lenasi, V. Pospichalova, C. A. Bosken, J. Rybarikova, V. Bryja, M. Geyer, D. Blazek, M. Barboric
Publié dans: Nucleic Acids Research, Numéro 43/5, 2015, Page(s) 2575-2589, ISSN 0305-1048
Éditeur: Oxford University Press
DOI: 10.1093/nar/gkv101

Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma

Auteurs: Lenka Besse, Lenka Sedlarikova, Fedor Kryukov, Jana Nekvindova, Lenka Radova, Ondrej Slaby, Petr Kuglik, Martina Almasi, Miroslav Penka, Marta Krejci, Zdenek Adam, Ludek Pour, Sabina Sevcikova, Roman Hajek
Publié dans: PLOS ONE, Numéro 10/9, 2015, Page(s) e0137294, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0137294

MicroRNAs targeting EGFR signalling pathway in colorectal cancer

Auteurs: Jitka Mlcochova, Petra Faltejskova, Radim Nemecek, Marek Svoboda, Ondrej Slaby
Publié dans: Journal of Cancer Research and Clinical Oncology, Numéro 139/10, 2013, Page(s) 1615-1624, ISSN 0171-5216
Éditeur: Springer Verlag
DOI: 10.1007/s00432-013-1470-9

Molecular Evidence for Antigen Drive in the Natural History of Mantle Cell Lymphoma

Auteurs: Aliki Xochelli, Lesley-Ann Sutton, Andreas Agathangelidis, Evangelia Stalika, Maria Karypidou, Fotini Marantidou, Alba Navarro Lopez, Giorgos Papadopoulos, Jana Supikova, Patricia Groenen, Myriam Boudjogra, Christer Sundstrom, Maurilio Ponzoni, Hana Skuhrova Francova, Achilles Anagnostopoulos, Sarka Pospisilova, Theodora Papadaki, Dimitris Tzovaras, Paolo Ghia, Christiane Pott, Frederic Davi, Elias Campo, Richard Rosenquist, Anastasia Hadzidimitriou, Chrysoula Belessi, Kostas Stamatopoulos
Publié dans: The American Journal of Pathology, Numéro 185/6, 2015, Page(s) 1740-1748, ISSN 0002-9440
Éditeur: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2015.02.006

Computational study of missense mutations in phenylalanine hydroxylase

Auteurs: Kamila Réblová, Petr Kulhánek, Lenka Fajkusová
Publié dans: Journal of Molecular Modeling, Numéro 21/4, 2015, ISSN 1610-2940
Éditeur: Springer Verlag
DOI: 10.1007/s00894-015-2620-6

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

Auteurs: Jan Machal, Jan Novak, Renata Hezova, Filip Zlamal, Anna Vasku, Ondrej Slaby, Julie Bienertova-Vasku
Publié dans: Genes & Nutrition, Numéro 10/5, 2015, ISSN 1555-8932
Éditeur: New Century Health Publishers
DOI: 10.1007/s12263-015-0488-9

NOD/SCID IL2Rγ-null mouse xenograft model of human p53-mutated chronic lymphocytic leukemia and ATM-mutated mantle cell lymphoma using permanent cell lines

Auteurs: Jan Verner, Martin Trbusek, Jana Chovancova, Zuzana Jaskova, Mojmir Moulis, Frantisek Folber, Roman Halouzka, Jiri Mayer, Sarka Pospisilova, Michael Doubek
Publié dans: Leukemia & Lymphoma, Numéro 56/11, 2015, Page(s) 3198-3206, ISSN 1042-8194
Éditeur: Taylor & Francis
DOI: 10.3109/10428194.2015.1034701

Fludarabine with cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with poor-risk chronic lymphocytic leukemia

Auteurs: Marta Krejci, Michael Doubek, Yvona Brychtova, Olga Stehlikova, Jana Chovancova, Boris Tichy, Hana Skuhrova Francova, Milan Navratil, Miroslav Tomiska, Ondrej Horky, Sarka Pospisilova, Jiri Mayer
Publié dans: Annals of Hematology, Numéro 92/2, 2013, Page(s) 249-254, ISSN 0939-5555
Éditeur: Springer Verlag
DOI: 10.1007/s00277-012-1579-y

MicroRNAs in B-cell lymphomas: how a complex biology gets more complex

Auteurs: K Musilova, M Mraz
Publié dans: Leukemia, Numéro 29/5, 2014, Page(s) 1004-1017, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/leu.2014.351

Dynamic changes in microRNA expression profiles reflect progression of Barrett's esophagus to esophageal adenocarcinoma

Auteurs: O. Slaby, J. Srovnal, L. Radova, J. Gregar, J. Juracek, P. Luzna, M. Svoboda, M. Hajduch, J. Ehrmann
Publié dans: Carcinogenesis, Numéro 36/5, 2015, Page(s) 521-527, ISSN 0143-3334
Éditeur: Oxford University Press
DOI: 10.1093/carcin/bgv023

Book chapters (2)

TP53 Aberrations in Chronic Lymphocytic Leukemia

Auteurs: Martin Trbusek, Jitka Malcikova
Publié dans: Advances in Chronic Lymphocytic Leukemia, Numéro 792, 2013, Page(s) 109-131, ISBN 978-1-4614-8051-8
Éditeur: Springer New York
DOI: 10.1007/978-1-4614-8051-8_5

TP53 Aberrations in Chronic Lymphocytic Leukemia

Auteurs: Martin Trbusek, Jitka Malcikova
Publié dans: Advances in Chronic Lymphocytic Leukemia, 2013, Page(s) 109-131, ISBN 978-1-4614-8051-8
Éditeur: Springer New York
DOI: 10.1007/978-1-4614-8051-8_5