Medical Genomics and Epigenomics Network

Informazioni relative al progetto

MEDGENET

ID dell’accordo di sovvenzione: 692298

DOI 10.3030/692298

Progetto chiuso

Data della firma CE 2 Dicembre 2015

Data di avvio 1 Gennaio 2016

Data di completamento 31 Dicembre 2018

Finanziato da

• Twinning of research institutions

Costo totale € 1 016 531,25

Contributo UE € 974 529,25

Coordinato da

Masarykova univerzita
Czechia

Risultati finali

Documents, reports (31)

Report on outreach activities II.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

1st on-line book of abstracts WP2

On-line book of abstracts from each workshop published on MEDGENET website on annual basis

Report on outreach activities VI.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

Report on WP2 coordination, networking and educational events III.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on WP1 coordination, networking and educational events I.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on outreach activities III.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

2nd on-line book of abstracts WP2

On-line book of abstracts from each workshop published on MEDGENET website on annual basis

1st on-line book of abstracts WP1

On-line book of abstracts from each workshop published on MEDGENET website

Report on WP1 coordination, networking and educational events IV.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project.

E-Newsletter II.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on CEITEC scientific excellence and MEDGENET impact assessment

Report on CEITEC scientific excellence and MEDGENET impact assessment – assessment on the number of high quality publications produced in CEITEC Molecular Medicine Program, impact of these publications, h-index of involved CEITEC researchers , number of outputs with high potential for clinical application, number of submitted collaborative international projects, income from successful projects with academia and industry. The report will be part of the Final project report and will also be available online on the project website

3rd on-line bok of abstracts WP1

On-line book of abstracts from each workshop published on MEDGENET website

Report after introducing the a tool for monitoring evolution of publishing activity
Report on WP1 coordination, networking and educational events VI.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on WP1 coordination, networking and educational events II.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project.

Report on outreach activities IV.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

Report on WP2 coordination, networking and educational events I.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter VI.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter I.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter III.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Network’s public engagement and outreach plan

Network’s public engagement and outreach plan – with the proposal and description of activities and events

Report on WP1 coordination, networking and educational events V.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project.

Report on WP2 coordination, networking and educational events II.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

2nd on-line book of abstracts WP1

On-line book of abstracts from each workshop published on MEDGENET website

Database of funding opportunities

Database of funding opportunities available in all 4 countries of MEDGENET partners. The database will provide information about the most suitable funding for each individual scientists and research group and will be accessible on the MEDGENET website

Report on outreach activities V.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

E-Newsletter V.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on WP1 coordination, networking and educational events III.

Report on WP1 coordination, networking and educational events – published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter IV.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on outreach activities I.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

Report on WP2 coordination, networking and educational events IV.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Websites, patent fillings, videos etc. (1)

MEDGENET web page

MEDGENET web page - will give information about project itself, its goals and activities with regular updates

Pubblicazioni

Peer reviewed articles (107)

ToTem: a tool for variant calling pipeline optimization

Autori: Nikola Tom, Ondrej Tom, Jitka Malcikova, Sarka Pavlova, Blanka Kubesova, Tobias Rausch, Miroslav Kolarik, Vladimir Benes, Vojtech Bystry, Sarka Pospisilova
Pubblicato in: BMC Bioinformatics, Numero 19/1, 2018, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-018-2227-x

Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements

Autori: A Vardi, E Vlachonikola, M Karypidou, E Stalika, V Bikos, K Gemenetzi, C Maramis, A Siorenta, A Anagnostopoulos, S Pospisilova, N Maglaveras, I Chouvarda, K Stamatopoulos, A Hadzidimitriou
Pubblicato in: Leukemia, Numero 31/7, 2016, Pagina/e 1555-1561, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2016.362

A novel <i>ex vivo</i> high-throughput assay reveals antiproliferative effects of idelalisib and ibrutinib in chronic lymphocytic leukemia

Autori: Daniel Primo, Lydia Scarfò, Aliki Xochelli, Mattias Mattsson, Pamela Ranghetti, Ana Belén Espinosa, Alicia Robles, Julian Gorrochategui, Joaquín Martínez-López, Javier de la Serna, Marcos González, Alberto Chaparro Gil, Eduardo Anguita, Sandra Iraheta, Veerendra Munugalavadla, Christophe Quéva, Stacey Tannheimer, Richard Rosenquist, Kostas Stamatopoulos, Joan Ballesteros, Paolo Ghia
Pubblicato in: Oncotarget, Numero 9/40, 2018, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.25419

GLASS: assisted and standardized assessment of gene variations from Sanger sequence trace data

Autori: Karol Pal, Vojtech Bystry, Tomas Reigl, Martin Demko, Adam Krejci, Tasoula Touloumenidou, Evangelia Stalika, Boris Tichy, Paolo Ghia, Kostas Stamatopoulos, Sarka Pospisilova, Jitka Malcikova, Nikos Darzentas
Pubblicato in: Bioinformatics, Numero 33/23, 2017, Pagina/e 3802-3804, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btx423

Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Autori: Aliki Xochelli, Panagiotis Baliakas, Ioannis Kavakiotis, Andreas Agathangelidis, Lesley-Ann Sutton, Eva Minga, Stavroula Ntoufa, Eugen Tausch, Xiao-Jie Yan, Tait Shanafelt, Karla Plevova, Myriam Boudjogra, Davide Rossi, Zadie Davis, Alba Navarro, Yorick Sandberg, Fie Juhl Vojdeman, Lydia Scarfo, Niki Stavroyianni, Andrey Sudarikov, Silvio Veronese, Tatiana Tzenou, Teodora Karan-Djurasevic, Mark Ca
Pubblicato in: Clinical Cancer Research, Numero 23/17, 2017, Pagina/e 5292-5301, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-16-3100

Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia

Autori: Panagiotis Baliakas, Theodoros Moysiadis, Anastasia Hadzidimitriou, Aliki Xochelli, Sabine Jeromin, Andreas Agathangelidis, Mattias Mattsson, Lesley-Ann Sutton, Eva Minga, Lydia Scarfò, Davide Rossi, Zadie Davis, Neus Villamor, Helen Parker, Jana Kotaskova, Evangelia Stalika, Karla Plevova, Larry Mansouri, Diego Cortese, Alba Navarro, Julio Delgado, Marta Larrayoz, Emma Young, Achilles Anagnostop
Pubblicato in: Haematologica, Numero 104/2, 2019, Pagina/e 360-369, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.195032

ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—update on methodological approaches and results interpretation

Autori: J. Malcikova, E. Tausch, D. Rossi, L. A. Sutton, T. Soussi, T. Zenz, A. P. Kater, C. U. Niemann, D. Gonzalez, F. Davi, M. Gonzalez Diaz, C. Moreno, G. Gaidano, K. Stamatopoulos, R. Rosenquist, S. Stilgenbauer, P. Ghia, S. Pospisilova
Pubblicato in: Leukemia, Numero 32/5, 2018, Pagina/e 1070-1080, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-017-0007-7

Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations

Autori: Aliki Xochelli, Vasilis Bikos, Eleftheria Polychronidou, Chrysi Galigalidou, Andreas Agathangelidis, Frédéric Charlotte, Panagiotis Moschonas, Zadie Davis, Monica Colombo, Maria Roumelioti, Lesley-Ann Sutton, Patricia Groenen, Michiel van den Brand, Myriam Boudjoghra, Patricia Algara, Alexandra Traverse-Glehen, Ana Ferrer, Evangelia Stalika, Maria Karypidou, George Kanellis, Christina Kalpadakis
Pubblicato in: The Journal of Pathology, 2018, ISSN 0022-3417
Editore: John Wiley & Sons Inc.
DOI: 10.1002/path.5209

Integrated epigenomic and transcriptomic analysis reveals TP63 as a novel player in clinically aggressive chronic lymphocytic leukemia

Autori: Nikos Papakonstantinou, Stavroula Ntoufa, Maria Tsagiopoulou, Theodoros Moysiadis, Sujata Bhoi, Andigoni Malousi, Fotis Psomopoulos, Larry Mansouri, Stamatia Laidou, Despoina Papazoglou, Maria Gounari, Konstantinos Pasentsis, Karla Plevova, Venera Kuci-Emruli, Marti Duran-Ferrer, Zadie Davis, Sara Ek, Davide Rossi, Gianluca Gaidano, Matthias Ritgen, David Oscier, Niki Stavroyianni, Sarka Pospisilo
Pubblicato in: International Journal of Cancer, 2018, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.31999

Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations

Autori: R Rosenquist, P Ghia, A Hadzidimitriou, L-A Sutton, A Agathangelidis, P Baliakas, N Darzentas, V Giudicelli, M-P Lefranc, A W Langerak, C Belessi, F Davi, K Stamatopoulos
Pubblicato in: Leukemia, Numero 31/7, 2017, Pagina/e 1477-1481, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2017.125

Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it

Autori: Ivona Nečasová, Eliška Janoušková, Tomáš Klumpler, Ctirad Hofr
Pubblicato in: Nucleic Acids Research, Numero 45/21, 2017, Pagina/e 12170-12180, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkx812

Multiple productive IGH rearrangements denote oligoclonality even in immunophenotypically monoclonal CLL

Autori: K Brazdilova, K Plevova, H Skuhrova Francova, H Kockova, M Borsky, V Bikos, J Malcikova, A Oltova, J Kotaskova, B Tichy, Y Brychtova, J Mayer, M Doubek, S Pospisilova
Pubblicato in: Leukemia, Numero 32/1, 2017, Pagina/e 234-236, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2017.274

"ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres"

Autori: V. Navrkalova, E. Young, P. Baliakas, L. Radova, L.-A. Sutton, K. Plevova, L. Mansouri, V. Ljungstrom, S. Ntoufa, Z. Davis, G. Juliusson, K. E. Smedby, C. Belessi, P. Panagiotidis, T. Touloumenidou, F. Davi, A. W. Langerak, P. Ghia, J. C. Strefford, D. Oscier, J. Mayer, K. Stamatopoulos, S. Pospisilova, R. Rosenquist, M. Trbusek
Pubblicato in: Haematologica, Numero 101/9, 2016, Pagina/e e369-e373, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.142968

Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference

Autori: P. Baliakas, A. Puiggros, A. Xochelli, L.-A. Sutton, F. Nguyen-Khac, A. Gardiner, K. Plevova, E. Minga, A. Hadzidimitriou, R. Walewska, H. McCarthy, M. Ortega, R. Collado, T. Gonzalez, I. Granada, E. Luno, J. Kota kova, T. Moysiadis, Z. Davis, N. Stavroyianni, A. Anagnostopoulos, J. C. Strefford, S. Pospisilova, F. Davi, A. Athanasiadou, R. Rosenquist, D. Oscier, B. Espinet, K. Stamatopoulos
Pubblicato in: Haematologica, Numero 101/7, 2016, Pagina/e e299-e302, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.140202

Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond

Autori: R. Rosenquist, A. Rosenwald, M.-Q. Du, G. Gaidano, P. Groenen, A. Wotherspoon, P. Ghia, P. Gaulard, E. Campo, K. Stamatopoulos
Pubblicato in: Haematologica, Numero 101/9, 2016, Pagina/e 1002-1009, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.134510

The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia

Autori: Nikos Papakonstantinou, Stavroula Ntoufa, Elisavet Chartomatsidou, Konstantia Kotta, Andreas Agathangelidis, Lefki Giassafaki, Tzeni Karamanli, Panagiota Bele, Theodoros Moysiadis, Panagiotis Baliakas, Lesley Ann Sutton, Niki Stavroyianni, Achilles Anagnostopoulos, Antonios M. Makris, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos
Pubblicato in: Oncotarget, 2016, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.9371

Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors

Autori: L.-A. Sutton, E. Young, P. Baliakas, A. Hadzidimitriou, T. Moysiadis, K. Plevova, D. Rossi, J. Kminkova, E. Stalika, L. B. Pedersen, J. Malcikova, A. Agathangelidis, Z. Davis, L. Mansouri, L. Scarfo, M. Boudjoghra, A. Navarro, A. F. Muggen, X.-J. Yan, F. Nguyen-Khac, M. Larrayoz, P. Panagiotidis, N. Chiorazzi, C. U. Niemann, C. Belessi, E. Campo, J. C. Strefford, A. W. Langerak, D. Oscier, G. Gaid
Pubblicato in: Haematologica, Numero 101/8, 2016, Pagina/e 959-967, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.141812

Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

Autori: P. Baliakas, A. Agathangelidis, A. Hadzidimitriou, L.-A. Sutton, E. Minga, A. Tsanousa, L. Scarfo, Z. Davis, X.-J. Yan, T. Shanafelt, K. Plevova, Y. Sandberg, F. J. Vojdeman, M. Boudjogra, T. Tzenou, M. Chatzouli, C. C. Chu, S. Veronese, A. Gardiner, L. Mansouri, K. E. Smedby, L. B. Pedersen, D. Moreno, K. Van Lom, V. Giudicelli, H. S. Francova, F. Nguyen-Khac, P. Panagiotidis, G. Juliusson, L. Angelis, A. Anagnostopoulos, M.-P. Lefranc, M. Facco, L. Trentin, M. Catherwood, M. Montillo, C. H. Geisler, A. W. Langerak, S. Pospisilova, N. Chiorazzi, D. Oscier, D. F. Jelinek, N. Darzentas, C. Belessi, F. Davi, P. Ghia, R. Rosenquist, K. Stamatopoulos
Pubblicato in: Blood, Numero 00064971, 2015, Pagina/e 856-859, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2014-09-600874

Recurrent mutations refine prognosis in chronic lymphocytic leukemia

Autori: P Baliakas, A Hadzidimitriou, L-A Sutton, D Rossi, E Minga, N Villamor, M Larrayoz, J Kminkova, A Agathangelidis, Z Davis, E Tausch, E Stalika, B Kantorova, L Mansouri, L Scarfò, D Cortese, V Navrkalova, M J J Rose-Zerilli, K E Smedby, G Juliusson, A Anagnostopoulos, A M Makris, A Navarro, J Delgado, D Oscier, C Belessi, S Stilgenbauer, P Ghia, S Pospisilova, G Gaidano, E Campo, J C Strefford, K Stamatopoulos, R Rosenquist
Pubblicato in: Leukemia, Numero 08876924, 2014, Pagina/e 329-336, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2014.196

Prognostic relevance of MYD88 mutations in CLL: the jury is still out

Autori: P. Baliakas, A. Hadzidimitriou, A. Agathangelidis, D. Rossi, L.-A. Sutton, J. Kminkova, L. Scarfo, S. Pospisilova, G. Gaidano, K. Stamatopoulos, P. Ghia, R. Rosenquist
Pubblicato in: Blood, Numero 00064971, 2015, Pagina/e 1043-1044, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2015-05-648634

Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data

Autori: Panagiotis Baliakas, Michalis Iskas, Anne Gardiner, Zadie Davis, Karla Plevova, Florence Nguyen-Khac, Jitka Malcikova, Achilles Anagnostopoulos, Sharron Glide, Sarah Mould, Kristina Stepanovska, Martin Brejcha, Chrysoula Belessi, Frederic Davi, Sarka Pospisilova, Anastasia Athanasiadou, Kostas Stamatopoulos, David Oscier
Pubblicato in: American Journal of Hematology, Numero 03618609, 2014, Pagina/e 249-255, ISSN 0361-8609
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ajh.23618

Human Rap1 modulates TRF2 attraction to telomeric DNA

Autori: E. Janou kova, I. Ne asova, J. Pavlou kova, M. Zimmermann, M. Hluchy, V. Marini, M. Novakova, C. Hofr
Pubblicato in: Nucleic Acids Research, Numero 03051048, 2015, Pagina/e 2691-2700, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkv097

Treatment of chronic lymphocytic leukemia with monoclonal antibodies, where are we heading?

Autori: Michael Doubek, Michal Šmída
Pubblicato in: Expert Review of Hematology, Numero 17474086, 2015, Pagina/e 743-764, ISSN 1747-4086
Editore: Expert Reviews
DOI: 10.1586/17474086.2015.1079123

Molecular systematics of <I>Barbatosphaeria</I> (<I>Sordariomycetes</I>): multigene phylogeny and secondary ITS structure

Autori: M. Réblová, K. Réblová, V. Štěpánek
Pubblicato in: Persoonia - Molecular Phylogeny and Evolution of Fungi, Numero 00315850, 2015, Pagina/e 21-38, ISSN 0031-5850
Editore: National Herbarium Nederland/Leiden Branch
DOI: 10.3767/003158515X687434

MicroRNAs in B-cell lymphomas: how a complex biology gets more complex

Autori: K Musilova, M Mraz
Pubblicato in: Leukemia, Numero 08876924, 2014, Pagina/e 1004-1017, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/leu.2014.351

Clonal evolution in chronic lymphocytic leukemia detected by fluorescence in situ hybridization and conventional cytogenetics after stimulation with CpG oligonucleotides and interleukin-2: A prospective analysis

Autori: Martin Brejcha, Martina Stoklasová, Yvona Brychtová, Anna Panovská, Kristina Štěpanovská, Gabriela Vaňková, Karla Plevová, Alexandra Oltová, Kateřina Horká, Šárka Pospíšilová, Jiří Mayer, Michael Doubek
Pubblicato in: Leukemia Research, Numero 01452126, 2014, Pagina/e 170-175, ISSN 0145-2126
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.leukres.2013.10.019

Forced aggregation and defined factors allow highly uniform-sized embryoid bodies and functional cardiomyocytes from human embryonic and induced pluripotent stem cells

Autori: Martin Pesl, Ivana Acimovic, Jan Pribyl, Renata Hezova, Aleksandra Vilotic, Jeremy Fauconnier, Jan Vrbsky, Peter Kruzliak, Petr Skladal, Tomas Kara, Vladimir Rotrekl, Alain Lacampagne, Petr Dvorak, Albano C. Meli
Pubblicato in: Heart and Vessels, Numero 09108327, 2014, Pagina/e 834-846, ISSN 0910-8327
Editore: Springer Verlag
DOI: 10.1007/s00380-013-0436-9

MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia

Autori: Marek Mraz, Thomas J. Kipps
Pubblicato in: Leukemia & Lymphoma, Numero 10428194, 2013, Pagina/e 1836-1839, ISSN 1042-8194
Editore: Taylor & Francis
DOI: 10.3109/10428194.2013.796055

Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1

Autori: Vineeta Khare, Alex Lyakhovich, Kyle Dammann, Michaela Lang, Melanie Borgmann, Boris Tichy, Sarka Pospisilova, Gloria Luciani, Christoph Campregher, Rayko Evstatiev, Maren Pflueger, Harald Hundsberger, Christoph Gasche
Pubblicato in: Biochemical Pharmacology, Numero 00062952, 2013, Pagina/e 234-244, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2012.10.026

The role of microRNAs in mitochondria in cancer

Autori: Julie Bienertova-Vasku, Jiri Sana, Ondrej Slaby
Pubblicato in: Cancer Letters, Numero 03043835, 2013, Pagina/e 1-7, ISSN 0304-3835
Editore: Elsevier BV
DOI: 10.1016/j.canlet.2013.05.001

TP53 Mutation Analysis in Clinical Practice: Lessons From Chronic Lymphocytic Leukemia

Autori: Jitka Malcikova, Sarka Pavlova, Katerina Stano Kozubik, Sarka Pospisilova
Pubblicato in: Human Mutation, Numero 10597794, 2014, Pagina/e 663-671, ISSN 1059-7794
Editore: John Wiley & Sons Inc.
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Autori: Jitka Malcikova, Evangelia Stalika, Zadie Davis, Karla Plevova, Martin Trbusek, Larry Mansouri, Lydia Scarfò, Panagiotis Baliakas, Anne Gardiner, Lesley-Ann Sutton, Hana Skuhrova Francova, Andreas Agathangelidis, Achilles Anagnostopoulos, Ian Tracy, Antonis Makris, Jana Smardova, Paolo Ghia, Chrysoula Belessi, David Gonzalez, Richard Rosenquist, David Oscier, Sarka Pospisilova, Kostas Stamatopoulos
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MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma

Autori: Petra Vychytilova-Faltejskova, Igor Kiss, Sona Klusova, Jan Hlavsa, Vladimir Prochazka, Zdenek Kala, Jan Mazanec, Jitka Hausnerova, Leos Kren, Marketa Hermanova, Jiri Lenz, Petr Karasek, Rostislav Vyzula, Ondrej Slaby
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Identification of novel sequence variations in microRNAs in chronic lymphocytic leukemia

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Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients

Autori: J. Sana, L. Radova, R. Lakomy, L. Kren, P. Fadrus, M. Smrcka, A. Besse, J. Nekvindova, M. Hermanova, R. Jancalek, M. Svoboda, M. Hajduch, P. Slampa, R. Vyzula, O. Slaby
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The BCR–ABL1 T315I mutation and additional genomic aberrations are dominant genetic lesions associated with disease progression in patients with chronic myelogenous leukemia resistant to tyrosine kinase inhibitor therapy

Autori: Jitka Malcikova, Filip Razga, Tomas Jurcek, Dana Dvorakova, Daniela Zackova, Martina Toskova, Ludmila Sebejova, Jana Smardova, Alexandra Oltova, Gabriela Vankova, Lenka Jurackova, Martin Trbusek, Sarka Pospisilova, Jiri Mayer, Zdenek Racil
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MicroRNA-206: a Promising Theranostic Marker

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miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib

Autori: Jana Merhautova, Renata Hezova, Alexandr Poprach, Alena Kovarikova, Lenka Radova, Marek Svoboda, Rostislav Vyzula, Regina Demlova, Ondrej Slaby
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Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting

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Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia

Autori: J Malcikova, K Stano-Kozubik, B Tichy, B Kantorova, S Pavlova, N Tom, L Radova, J Smardova, F Pardy, M Doubek, Y Brychtova, M Mraz, K Plevova, E Diviskova, A Oltova, J Mayer, S Pospisilova, M Trbusek
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MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia

Autori: B. Cui, L. Chen, S. Zhang, M. Mraz, J.-F. Fecteau, J. Yu, E. M. Ghia, L. Zhang, L. Bao, L. Z. Rassenti, K. Messer, G. A. Calin, C. M. Croce, T. J. Kipps
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The outcome of chronic lymphocytic leukemia patients who relapsed after fludarabine, cyclophosphamide, and rituximab

Autori: Anna Panovská, Lukáš Smolej, Daniel Lysák, Yvona Brychtová, Martin Šimkovič, Monika Motyčková, Pavel Vodárek, Michaela Lindtnerová, Martin Trbušek, Jitka Malčíková, Šárka Pospíšilová, Jiří Mayer, Michael Doubek
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TP53 mutation analysis in chronic lymphocytic leukemia: comparison of different detection methods

Autori: Barbara Kantorova, Jitka Malcikova, Jana Smardova, Sarka Pavlova, Martin Trbusek, Nikola Tom, Karla Plevova, Boris Tichy, Sim Truong, Eva Diviskova, Jana Kotaskova, Alexandra Oltova, Nancy Patten, Yvona Brychtova, Michael Doubek, Jiri Mayer, Sarka Pospisilova
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Identification of MicroRNAs Regulated by Isothiocyanates and Association of Polymorphisms Inside Their Target Sites with Risk of Sporadic Colorectal Cancer

Autori: Ondrej Slaby, Milana Sachlova, Veronika Brezkova, Renata Hezova, Alena Kovarikova, Svatava Bischofová, Sabina Sevcikova, Julie Bienertova-Vasku, Anna Vasku, Marek Svoboda, Rostislav Vyzula
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MicroRNA Profiling of Activated and Tolerogenic Human Dendritic Cells

Autori: Zuzana Stumpfova, Renata Hezova, Albano Carlo Meli, Ondrej Slaby, Jaroslav Michalek
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Extension of microRNA expression pattern associated with high-risk neuroblastoma

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B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells

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Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia

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The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration

Autori: M. Kaucka, K. Plevova, S. Pavlova, P. Janovska, A. Mishra, J. Verner, J. Prochazkova, P. Krejci, J. Kotaskova, P. Ovesna, B. Tichy, Y. Brychtova, M. Doubek, A. Kozubik, J. Mayer, S. Pospisilova, V. Bryja
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miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1

Autori: M. Mraz, L. Chen, L. Z. Rassenti, E. M. Ghia, H. Li, K. Jepsen, E. N. Smith, K. Messer, K. A. Frazer, T. J. Kipps
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Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones

Autori: K. Plevova, H. S. Francova, K. Burckova, Y. Brychtova, M. Doubek, S. Pavlova, J. Malcikova, J. Mayer, B. Tichy, S. Pospisilova
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RNA secondary structure, an important bioinformatics tool to enhance multiple sequence alignment: a case study (Sordariomycetes, Fungi)

Autori: Martina Réblová, Kamila Réblová
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The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus

Autori: Marek Mraz, Katerina Stano Kozubik, Karla Plevova, Katerina Musilova, Boris Tichy, Marek Borsky, Petr Kuglik, Michael Doubek, Yvona Brychtova, Jiri Mayer, Sarka Pospisilova
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Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenström macroglobulinemia

Autori: Lenka Kubiczkova Besse, Lenka Sedlarikova, Fedor Kryukov, Jana Nekvindova, Lenka Radova, Martina Almasi, Jana Pelcova, Jiri Minarik, Tomas Pika, Zuzana Pikalova, Vlastimil Scudla, Marta Krejci, Zdenek Adam, Ludek Pour, Roman Hajek, Sabina Sevcikova
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Histone H1 Differentially Inhibits DNA Bending by Reduced and Oxidized HMGB1 Protein

Autori: Michal Štros, Eva Polanská, Martin Kučírek, Šárka Pospíšilová
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Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma

Autori: Lenka Besse, Lenka Sedlarikova, Fedor Kryukov, Jana Nekvindova, Lenka Radova, Ondrej Slaby, Petr Kuglik, Martina Almasi, Miroslav Penka, Marta Krejci, Zdenek Adam, Ludek Pour, Sabina Sevcikova, Roman Hajek
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ARResT/AssignSubsets: a novel application for robust subclassification of chronic lymphocytic leukemia based on B cell receptor IG stereotypy

Autori: Vojtech Bystry, Andreas Agathangelidis, Vasilis Bikos, Lesley Ann Sutton, Panagiotis Baliakas, Anastasia Hadzidimitriou, Kostas Stamatopoulos, Nikos Darzentas
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"Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2"

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CLCN1 Mutations in Czech Patients with Myotonia Congenita, In Silico Analysis of Novel and Known Mutations in the Human Dimeric Skeletal Muscle Chloride Channel

Autori: Daniela Skálová, Jana Zídková, Stanislav Voháňka, Radim Mazanec, Zuzana Mušová, Petr Vondráček, Lenka Mrázová, Josef Kraus, Kamila Réblová, Lenka Fajkusová
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The Significance of Stereotyped B-Cell Receptors in Chronic Lymphocytic Leukemia

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Hepcidin levels in Diamond-Blackfan anemia reflect erythropoietic activity and transfusion dependency

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The structure and substrate specificity of human Cdk12/Cyclin K

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Phylogenetic Reconstruction of the Calosphaeriales and Togniniales Using Five Genes and Predicted RNA Secondary Structures of ITS, and Flabellascus tenuirostris gen. et sp. nov.

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Diagnostic and prognostic potential of miR-21, miR-29c, miR-148 and miR-203 in adenocarcinoma and squamous cell carcinoma of esophagus

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Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

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MicroRNAs targeting EGFR signalling pathway in colorectal cancer

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Combination of fludarabine, amsacrine, and cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with high-risk acute myeloid leukemia

Autori: Marta Krejci, Michael Doubek, Jaroslav Dusek, Yvona Brychtova, Zdenek Racil, Milan Navratil, Miroslav Tomiska, Ondrej Horky, Sarka Pospisilova, Jiri Mayer
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Immunogenomic analysis of insect bite hypersensitivity in a model horse population

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Detecting minimal residual disease in patients with chronic lymphocytic leukemia using 8-color flow cytometry protocol in routine hematological practice

Autori: O. Stehlíková, J. Chovancová, B. Tichý, M. Krejčí, Y. Brychtová, A. Panovská, H. Francová Skuhrová, K. Burčková, M. Borský, T. Loja, J. Mayer, Š. Pospíšilová, M. Doubek
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Ofatumumab added to dexamethasone in patients with relapsed or refractory chronic lymphocytic leukemia: Results from a phase II study

Autori: Michael Doubek, Yvona Brychtova, Anna Panovska, Ludmila Sebejova, Olga Stehlikova, Jana Chovancova, Jitka Malcikova, Jana Smardova, Karla Plevova, Pavlina Volfova, Martin Trbusek, Marek Mraz, Denisa Bakesova, Jakub Trizuljak, Marketa Hadrabova, Petra Obrtlikova, Josef Karban, Lukas Smolej, Alexandra Oltova, Eva Jelinkova, Sarka Pospisilova, Jiri Mayer
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Contributions of the TEL-patch Amino Acid Cluster on TPP1 to Telomeric DNA Synthesis by Human Telomerase

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NOD/SCID IL2Rγ-null mouse xenograft model of human p53-mutated chronic lymphocytic leukemia and ATM-mutated mantle cell lymphoma using permanent cell lines

Autori: Jan Verner, Martin Trbusek, Jana Chovancova, Zuzana Jaskova, Mojmir Moulis, Frantisek Folber, Roman Halouzka, Jiri Mayer, Sarka Pospisilova, Michael Doubek
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Fludarabine with cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with poor-risk chronic lymphocytic leukemia

Autori: Marta Krejci, Michael Doubek, Yvona Brychtova, Olga Stehlikova, Jana Chovancova, Boris Tichy, Hana Skuhrova Francova, Milan Navratil, Miroslav Tomiska, Ondrej Horky, Sarka Pospisilova, Jiri Mayer
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Combination of MiR-378 and MiR-210 Serum Levels Enables Sensitive Detection of Renal Cell Carcinoma

Autori: Michal Fedorko, Michal Stanik, Robert Iliev, Martina Redova-Lojova, Tana Machackova, Marek Svoboda, Dalibor Pacik, Jan Dolezel, Ondrej Slaby
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Binding of Histone H1 to DNA Is Differentially Modulated by Redox State of HMGB1

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Novel Evolutionary Lineages Revealed in the Chaetothyriales (Fungi) Based on Multigene Phylogenetic Analyses and Comparison of ITS Secondary Structure

Autori: Martina Réblová, Wendy A. Untereiner, Kamila Réblová
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Distinct in vitro sensitivity of p53-mutated and ATM-mutated chronic lymphocytic leukemia cells to ofatumumab and rituximab

Autori: Ludmila Sebejova, Marek Borsky, Zuzana Jaskova, David Potesil, Veronika Navrkalova, Jitka Malcikova, Martin Sramek, Michael Doubek, Tomas Loja, Sarka Pospisilova, Jiri Mayer, Martin Trbusek
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ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin

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Towards error-free profiling of immune repertoires

Autori: Mikhail Shugay, Olga V Britanova, Ekaterina M Merzlyak, Maria A Turchaninova, Ilgar Z Mamedov, Timur R Tuganbaev, Dmitriy A Bolotin, Dmitry B Staroverov, Ekaterina V Putintseva, Karla Plevova, Carsten Linnemann, Dmitriy Shagin, Sarka Pospisilova, Sergey Lukyanov, Ton N Schumacher, Dmitriy M Chudakov
Pubblicato in: Nature Methods, Numero 15487091, 2014, Pagina/e 653-655, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/NMETH.2960

Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia

Autori: Aliki Xochelli, Andreas Agathangelidis, Ioannis Kavakiotis, Evangelia Minga, Lesley Ann Sutton, Panagiotis Baliakas, Ioanna Chouvarda, Véronique Giudicelli, Ioannis Vlahavas, Nikos Maglaveras, Lisa Bonello, Livio Trentin, Alessandra Tedeschi, Panagiotis Panagiotidis, Christian Geisler, Anton W. Langerak, Sarka Pospisilova, Diane F. Jelinek, David Oscier, Nicholas Chiorazzi, Nikos Darzentas, Fred Davi, Paolo Ghia, Richard Rosenquist, Anastasia Hadzidimitriou, Chrysoula Belessi, Marie-Paule Lefranc, Kostas Stamatopoulos
Pubblicato in: Immunogenetics, Numero 00937711, 2015, Pagina/e 61-66, ISSN 0093-7711
Editore: Springer Verlag
DOI: 10.1007/s00251-014-0812-3

Urine microRNAs as potential noninvasive biomarkers in urologic cancers

Autori: Hana Mlcochova, Renata Hezova, Michal Stanik, Ondrej Slaby
Pubblicato in: Urologic Oncology: Seminars and Original Investigations, Numero 10781439, 2014, Pagina/e 41.e1-41.e9, ISSN 1078-1439
Editore: Elsevier BV
DOI: 10.1016/j.urolonc.2013.04.011

MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma

Autori: Martina Redova, Alexandr Poprach, Andrej Besse, Robert Iliev, Jana Nekvindova, Radek Lakomy, Lenka Radova, Marek Svoboda, Jan Dolezel, Rostislav Vyzula, Ondrej Slaby
Pubblicato in: Tumor Biology, Numero 10104283, 2013, Pagina/e 481-491, ISSN 1010-4283
Editore: Springer Verlag
DOI: 10.1007/s13277-012-0573-2

Temporal Dynamics of Clonal Evolution in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-34/IGKV2-30 Antigen Receptors: Longitudinal Immunogenetic Evidence

Autori: Lesley Sutton, Efterpi Kostareli
Pubblicato in: Molecular Medicine, Numero 10761551, 2013, Pagina/e 1, ISSN 1076-1551
Editore: North Shore - Long Jewish Research Institute
DOI: 10.2119/molmed.2013.00042

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins

Autori: Niamh Mannion, Fabiana Arieti, Angela Gallo, Liam Keegan, Mary O'Connell
Pubblicato in: Biomolecules, Numero 2218273X, 2015, Pagina/e 2338-2362, ISSN 2218-273X
Editore: MDPI AG
DOI: 10.3390/biom5042338

IgG-Switched CLL Has a Distinct Immunogenetic Signature from the Common MD Variant: Ontogenetic Implications

Autori: A. Vardi, A. Agathangelidis, L.-A. Sutton, M. Chatzouli, L. Scarfo, L. Mansouri, V. Douka, A. Anagnostopoulos, N. Darzentas, R. Rosenquist, P. Ghia, C. Belessi, K. Stamatopoulos
Pubblicato in: Clinical Cancer Research, Numero 10780432, 2014, Pagina/e 323-330, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-13-1993

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

Autori: Jan Machal, Jan Novak, Renata Hezova, Filip Zlamal, Anna Vasku, Ondrej Slaby, Julie Bienertova-Vasku
Pubblicato in: Genes & Nutrition, Numero 15558932, 2015, ISSN 1555-8932
Editore: New Century Health Publishers
DOI: 10.1007/s12263-015-0488-9

Hypergravity effects on glide arc plasma

Autori: Jiří Šperka, Pavel Souček, Jack J. W. A. Van Loon, Alan Dowson, Christian Schwarz, Jutta Krause, Gerrit Kroesen, Vít Kudrle
Pubblicato in: The European Physical Journal D, Numero 14346060, 2013, ISSN 1434-6060
Editore: Springer Verlag
DOI: 10.1140/epjd/e2013-40408-7

Splenic marginal-zone lymphoma: ontogeny and genetics

Autori: Panagiotis Baliakas, Jonathan C. Strefford, Vasilis Bikos, Marina Parry, Kostas Stamatopoulos, David Oscier
Pubblicato in: Leukemia & Lymphoma, Numero 10428194, 2014, Pagina/e 301-310, ISSN 1042-8194
Editore: Taylor & Francis
DOI: 10.3109/10428194.2014.919636

Isosteric and Nonisosteric Base Pairs in RNA Motifs: Molecular Dynamics and Bioinformatics Study of the Sarcin–Ricin Internal Loop

Autori: Marek Havrila, Kamila Réblová, Craig L. Zirbel, Neocles B. Leontis, Jiří Šponer
Pubblicato in: The Journal of Physical Chemistry B, Numero 15206106, 2013, Pagina/e 14302-14319, ISSN 1520-6106
Editore: American Chemical Society
DOI: 10.1021/jp408530w

Assessment of TP53 functionality in chronic lymphocytic leukaemia by different assays; an ERIC-wide approach

Autori: G. Doreen te Raa, Jitka Malčiková, Marek Mraz, Martin Trbusek, Magali Le Garff-Tavernier, Hélène Merle-Béral, Rudolf Greil, Olaf Merkel, Sarka Pospíšilová, Ke Lin, Andrew R. Pettitt, Tatjana Stankovic, Marinus H. van Oers, Eric Eldering, Stephan Stilgenbauer, Thorsten Zenz, Arnon P. Kater
Pubblicato in: British Journal of Haematology, Numero 00071048, 2014, Pagina/e 565-569, ISSN 0007-1048
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bjh.13006

Molecular Evidence for Antigen Drive in the Natural History of Mantle Cell Lymphoma

Autori: Aliki Xochelli, Lesley-Ann Sutton, Andreas Agathangelidis, Evangelia Stalika, Maria Karypidou, Fotini Marantidou, Alba Navarro Lopez, Giorgos Papadopoulos, Jana Supikova, Patricia Groenen, Myriam Boudjogra, Christer Sundstrom, Maurilio Ponzoni, Hana Skuhrova Francova, Achilles Anagnostopoulos, Sarka Pospisilova, Theodora Papadaki, Dimitris Tzovaras, Paolo Ghia, Christiane Pott, Frederic Davi, Elias Campo, Richard Rosenquist, Anastasia Hadzidimitriou, Chrysoula Belessi, Kostas Stamatopoulos
Pubblicato in: The American Journal of Pathology, Numero 00029440, 2015, Pagina/e 1740-1748, ISSN 0002-9440
Editore: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2015.02.006

The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex

Autori: Lucie Kozakova, Lucie Vondrova, Karel Stejskal, Panagoula Charalabous, Peter Kolesar, Alan R Lehmann, Stjepan Uldrijan, Christopher M Sanderson, Zbynek Zdrahal, Jan J Palecek
Pubblicato in: Cell Cycle, Numero 15384101, 2015, Pagina/e 920-930, ISSN 1538-4101
Editore: Landes Bioscience
DOI: 10.1080/15384101.2014.1000112

Role of S-turn2 in the Structure, Dynamics, and Function of Mitochondrial Ribosomal A-Site. A Bioinformatics and Molecular Dynamics Simulation Study

Autori: Joanna Panecka, Marek Havrila, Kamila Réblová, Jiří Šponer, Joanna Trylska
Pubblicato in: The Journal of Physical Chemistry B, Numero 15206106, 2014, Pagina/e 6687-6701, ISSN 1520-6106
Editore: American Chemical Society
DOI: 10.1021/jp5030685

Dynamic changes in microRNA expression profiles reflect progression of Barrett's esophagus to esophageal adenocarcinoma

Autori: O. Slaby, J. Srovnal, L. Radova, J. Gregar, J. Juracek, P. Luzna, M. Svoboda, M. Hajduch, J. Ehrmann
Pubblicato in: Carcinogenesis, Numero 01433334, 2015, Pagina/e 521-527, ISSN 0143-3334
Editore: Oxford University Press
DOI: 10.1093/carcin/bgv023

Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma

Autori: Andrea Janikova, Andrea Mareckova, Aneta Baumeisterova, Marta Krejci, Jana Supikova, David Salek, Ondrej Horky, Boris Tichy, Ivo Hanke, Sarka Pospisilova, Mojmir Moulis, Jiri Mayer
Pubblicato in: Leukemia & Lymphoma, Numero 10428194, 2014, Pagina/e 1935-1938, ISSN 1042-8194
Editore: Taylor & Francis
DOI: 10.3109/10428194.2013.858150

Small nucleolar RNAs functioning and potential roles in cancer

Autori: Nithyananda Thorenoor, Ondrej Slaby
Pubblicato in: Tumor Biology, Numero 10104283, 2015, Pagina/e 41-53, ISSN 1010-4283
Editore: Springer Verlag
DOI: 10.1007/s13277-014-2818-8

Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia

Autori: Jakub Trizuljak, Josef Srovnal, Karla Plevová, Yvona Brychtová, Lukáš Semerád, Denisa Bakešová, Eva Létalová, Andrea Benedíková, Jiří Mayer, Marián Hajdúch, Šárka Pospíšilová, Michael Doubek
Pubblicato in: Clinical Lymphoma Myeloma and Leukemia, Numero 21522669, 2015, Pagina/e 439-442, ISSN 2152-2669
Editore: Cancer Media Group
DOI: 10.1016/j.clml.2015.02.003

The Epitranscriptome and Innate Immunity

Autori: Mary A. O’Connell, Niamh M. Mannion, Liam P. Keegan
Pubblicato in: PLOS Genetics, Numero 15537404, 2015, Pagina/e e1005687, ISSN 1553-7404
Editore: Public Library ScienceUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1005687

MicroRNAs involved in chemo- and radioresistance of high-grade gliomas

Autori: Andrej Besse, Jiri Sana, Pavel Fadrus, Ondrej Slaby
Pubblicato in: Tumor Biology, Numero 10104283, 2013, Pagina/e 1969-1978, ISSN 1010-4283
Editore: Springer Verlag
DOI: 10.1007/s13277-013-0772-5

MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis

Autori: A. Benner, L. Mansouri, D. Rossi, A. Majid, K. Willander, A. Parker, G. Bond, S. Pavlova, H. Nuckel, O. Merkel, P. Ghia, E. Montserrat, M. A. Kaderi, R. Rosenquist, G. Gaidano, M. J. S. Dyer, P. Soderkvist, M. Linderholm, D. Oscier, Z. Tvaruzkova, S. Pospisilova, U. Duhrsen, R. Greil, H. Dohner, S. Stilgenbauer, T. Zenz
Pubblicato in: Haematologica, Numero 03906078, 2014, Pagina/e 1285-1291, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.101170

Circulating miRNAs as new blood-based biomarkers for solid cancers

Autori: Martina Redova, Jiri Sana, Ondrej Slaby
Pubblicato in: Future Oncology, Numero 14796694, 2013, Pagina/e 387-402, ISSN 1479-6694
Editore: Future Medicine Ltd.
DOI: 10.2217/FON.12.192

Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway

Autori: L.  merdova, J. Svobodova, M. Kabatkova, J. Kohoutek, D. Bla ek, M. Machala, J. Vondra ek
Pubblicato in: Carcinogenesis, Numero 01433334, 2014, Pagina/e 2534-2543, ISSN 0143-3334
Editore: Oxford University Press
DOI: 10.1093/carcin/bgu190

Hypergravity synthesis of graphitic carbon nanomaterial in glide arc plasma

Autori: Jiří Šperka, Pavel Souček, Jack J.W.A. Van Loon, Alan Dowson, Christian Schwarz, Jutta Krause, Yuriy Butenko, Gerrit Kroesen, Vít Kudrle
Pubblicato in: Materials Research Bulletin, Numero 00255408, 2014, Pagina/e 61-65, ISSN 0025-5408
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.materresbull.2014.03.013

Computational study of missense mutations in phenylalanine hydroxylase

Autori: Kamila Réblová, Petr Kulhánek, Lenka Fajkusová
Pubblicato in: Journal of Molecular Modeling, Numero 16102940, 2015, ISSN 1610-2940
Editore: Springer Verlag
DOI: 10.1007/s00894-015-2620-6

Hyperphenylalaninemia in the Czech Republic: Genotype–phenotype correlations and in silico analysis of novel missense mutations

Autori: Kamila Réblová, Zuzana Hrubá, Dagmar Procházková, Renata Pazdírková, Slávka Pouchlá, Lenka Fajkusová
Pubblicato in: Clinica Chimica Acta, Numero 00098981, 2013, Pagina/e 1-10, ISSN 0009-8981
Editore: Elsevier BV
DOI: 10.1016/j.cca.2013.01.006

TaqMan based real time PCR assay targeting EML4-ALK fusion transcripts in NSCLC

Autori: Blanka Robesova, Monika Bajerova, Kvetoslava Liskova, Jana Skrickova, Marcela Tomiskova, Sarka Pospisilova, Jiri Mayer, Dana Dvorakova
Pubblicato in: Lung Cancer, Numero 01695002, 2014, Pagina/e 25-30, ISSN 0169-5002
Editore: Elsevier BV
DOI: 10.1016/j.lungcan.2014.04.002

Book chapters (1)

TP53 Aberrations in Chronic Lymphocytic Leukemia

Autori: Martin Trbusek, Jitka Malcikova
Pubblicato in: Advances in Chronic Lymphocytic Leukemia, 2013, Pagina/e 109-131, ISBN 978-1-4614-8051-8
Editore: Springer New York
DOI: 10.1007/978-1-4614-8051-8_5