Medical Genomics and Epigenomics Network

Informacje na temat projektu

MEDGENET

Identyfikator umowy o grant: 692298

DOI 10.3030/692298

Projekt został zamknięty

Data podpisania przez KE 2 Grudnia 2015

Data rozpoczęcia 1 Stycznia 2016

Data zakończenia 31 Grudnia 2018

Finansowanie w ramach

• Twinning of research institutions

Koszt całkowity € 1 016 531,25

Wkład UE € 974 529,25

Koordynowany przez

Masarykova univerzita
Czechia

Rezultaty

Documents, reports (31)

Report on outreach activities II.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

1st on-line book of abstracts WP2

On-line book of abstracts from each workshop published on MEDGENET website on annual basis

Report on outreach activities VI.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

Report on WP2 coordination, networking and educational events III.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on WP1 coordination, networking and educational events I.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on outreach activities III.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

2nd on-line book of abstracts WP2

On-line book of abstracts from each workshop published on MEDGENET website on annual basis

1st on-line book of abstracts WP1

On-line book of abstracts from each workshop published on MEDGENET website

Report on WP1 coordination, networking and educational events IV.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project.

E-Newsletter II.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on CEITEC scientific excellence and MEDGENET impact assessment

Report on CEITEC scientific excellence and MEDGENET impact assessment – assessment on the number of high quality publications produced in CEITEC Molecular Medicine Program, impact of these publications, h-index of involved CEITEC researchers , number of outputs with high potential for clinical application, number of submitted collaborative international projects, income from successful projects with academia and industry. The report will be part of the Final project report and will also be available online on the project website

3rd on-line bok of abstracts WP1

On-line book of abstracts from each workshop published on MEDGENET website

Report after introducing the a tool for monitoring evolution of publishing activity
Report on WP1 coordination, networking and educational events VI.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on WP1 coordination, networking and educational events II.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project.

Report on outreach activities IV.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

Report on WP2 coordination, networking and educational events I.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter VI.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter I.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter III.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Network’s public engagement and outreach plan

Network’s public engagement and outreach plan – with the proposal and description of activities and events

Report on WP1 coordination, networking and educational events V.

Report on WP1 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project.

Report on WP2 coordination, networking and educational events II.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

2nd on-line book of abstracts WP1

On-line book of abstracts from each workshop published on MEDGENET website

Database of funding opportunities

Database of funding opportunities available in all 4 countries of MEDGENET partners. The database will provide information about the most suitable funding for each individual scientists and research group and will be accessible on the MEDGENET website

Report on outreach activities V.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

E-Newsletter V.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on WP1 coordination, networking and educational events III.

Report on WP1 coordination, networking and educational events – published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of the Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

E-Newsletter IV.

E-Newsletter – for online communication and distribution of reports, news and updates on the projects, will be available on the MEDGENET website and will be sent by email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Report on outreach activities I.

Report on outreach activities – semi-annual report summarizing events for public with documentation of agenda and photos from venues, published in an e-Newsletter on semi-annual basis

Report on WP2 coordination, networking and educational events IV.

Report on WP2 coordination, networking and educational events will be published on-line in e-newsletter on semi-annual basis presenting details of future and past workshops, lectures, summer schools and lectures of invited speaker organized by MEDGENET. It will include the program and registration link of each event and reminder of newsletter updates will be distributed via email to all members of Steering Committee and Management Board and further circulated between groupleaders and their teams involved in the project

Websites, patent fillings, videos etc. (1)

MEDGENET web page

MEDGENET web page - will give information about project itself, its goals and activities with regular updates

Publikacje

Peer reviewed articles (107)

ToTem: a tool for variant calling pipeline optimization

Autorzy: Nikola Tom, Ondrej Tom, Jitka Malcikova, Sarka Pavlova, Blanka Kubesova, Tobias Rausch, Miroslav Kolarik, Vladimir Benes, Vojtech Bystry, Sarka Pospisilova
Opublikowane w: BMC Bioinformatics, Numer 19/1, 2018, ISSN 1471-2105
Wydawca: BioMed Central
DOI: 10.1186/s12859-018-2227-x

Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements

Autorzy: A Vardi, E Vlachonikola, M Karypidou, E Stalika, V Bikos, K Gemenetzi, C Maramis, A Siorenta, A Anagnostopoulos, S Pospisilova, N Maglaveras, I Chouvarda, K Stamatopoulos, A Hadzidimitriou
Opublikowane w: Leukemia, Numer 31/7, 2016, Strona(/y) 1555-1561, ISSN 0887-6924
Wydawca: Nature Publishing Group
DOI: 10.1038/leu.2016.362

A novel <i>ex vivo</i> high-throughput assay reveals antiproliferative effects of idelalisib and ibrutinib in chronic lymphocytic leukemia

Autorzy: Daniel Primo, Lydia Scarfò, Aliki Xochelli, Mattias Mattsson, Pamela Ranghetti, Ana Belén Espinosa, Alicia Robles, Julian Gorrochategui, Joaquín Martínez-López, Javier de la Serna, Marcos González, Alberto Chaparro Gil, Eduardo Anguita, Sandra Iraheta, Veerendra Munugalavadla, Christophe Quéva, Stacey Tannheimer, Richard Rosenquist, Kostas Stamatopoulos, Joan Ballesteros, Paolo Ghia
Opublikowane w: Oncotarget, Numer 9/40, 2018, ISSN 1949-2553
Wydawca: Impact Journals
DOI: 10.18632/oncotarget.25419

GLASS: assisted and standardized assessment of gene variations from Sanger sequence trace data

Autorzy: Karol Pal, Vojtech Bystry, Tomas Reigl, Martin Demko, Adam Krejci, Tasoula Touloumenidou, Evangelia Stalika, Boris Tichy, Paolo Ghia, Kostas Stamatopoulos, Sarka Pospisilova, Jitka Malcikova, Nikos Darzentas
Opublikowane w: Bioinformatics, Numer 33/23, 2017, Strona(/y) 3802-3804, ISSN 1367-4803
Wydawca: Oxford University Press
DOI: 10.1093/bioinformatics/btx423

Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Autorzy: Aliki Xochelli, Panagiotis Baliakas, Ioannis Kavakiotis, Andreas Agathangelidis, Lesley-Ann Sutton, Eva Minga, Stavroula Ntoufa, Eugen Tausch, Xiao-Jie Yan, Tait Shanafelt, Karla Plevova, Myriam Boudjogra, Davide Rossi, Zadie Davis, Alba Navarro, Yorick Sandberg, Fie Juhl Vojdeman, Lydia Scarfo, Niki Stavroyianni, Andrey Sudarikov, Silvio Veronese, Tatiana Tzenou, Teodora Karan-Djurasevic, Mark Ca
Opublikowane w: Clinical Cancer Research, Numer 23/17, 2017, Strona(/y) 5292-5301, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-16-3100

Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia

Autorzy: Panagiotis Baliakas, Theodoros Moysiadis, Anastasia Hadzidimitriou, Aliki Xochelli, Sabine Jeromin, Andreas Agathangelidis, Mattias Mattsson, Lesley-Ann Sutton, Eva Minga, Lydia Scarfò, Davide Rossi, Zadie Davis, Neus Villamor, Helen Parker, Jana Kotaskova, Evangelia Stalika, Karla Plevova, Larry Mansouri, Diego Cortese, Alba Navarro, Julio Delgado, Marta Larrayoz, Emma Young, Achilles Anagnostop
Opublikowane w: Haematologica, Numer 104/2, 2019, Strona(/y) 360-369, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.195032

ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—update on methodological approaches and results interpretation

Autorzy: J. Malcikova, E. Tausch, D. Rossi, L. A. Sutton, T. Soussi, T. Zenz, A. P. Kater, C. U. Niemann, D. Gonzalez, F. Davi, M. Gonzalez Diaz, C. Moreno, G. Gaidano, K. Stamatopoulos, R. Rosenquist, S. Stilgenbauer, P. Ghia, S. Pospisilova
Opublikowane w: Leukemia, Numer 32/5, 2018, Strona(/y) 1070-1080, ISSN 0887-6924
Wydawca: Nature Publishing Group
DOI: 10.1038/s41375-017-0007-7

Disease-biased and shared characteristics of the immunoglobulin gene repertoires in marginal zone B cell lymphoproliferations

Autorzy: Aliki Xochelli, Vasilis Bikos, Eleftheria Polychronidou, Chrysi Galigalidou, Andreas Agathangelidis, Frédéric Charlotte, Panagiotis Moschonas, Zadie Davis, Monica Colombo, Maria Roumelioti, Lesley-Ann Sutton, Patricia Groenen, Michiel van den Brand, Myriam Boudjoghra, Patricia Algara, Alexandra Traverse-Glehen, Ana Ferrer, Evangelia Stalika, Maria Karypidou, George Kanellis, Christina Kalpadakis
Opublikowane w: The Journal of Pathology, 2018, ISSN 0022-3417
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/path.5209

Integrated epigenomic and transcriptomic analysis reveals TP63 as a novel player in clinically aggressive chronic lymphocytic leukemia

Autorzy: Nikos Papakonstantinou, Stavroula Ntoufa, Maria Tsagiopoulou, Theodoros Moysiadis, Sujata Bhoi, Andigoni Malousi, Fotis Psomopoulos, Larry Mansouri, Stamatia Laidou, Despoina Papazoglou, Maria Gounari, Konstantinos Pasentsis, Karla Plevova, Venera Kuci-Emruli, Marti Duran-Ferrer, Zadie Davis, Sara Ek, Davide Rossi, Gianluca Gaidano, Matthias Ritgen, David Oscier, Niki Stavroyianni, Sarka Pospisilo
Opublikowane w: International Journal of Cancer, 2018, ISSN 0020-7136
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/ijc.31999

Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations

Autorzy: R Rosenquist, P Ghia, A Hadzidimitriou, L-A Sutton, A Agathangelidis, P Baliakas, N Darzentas, V Giudicelli, M-P Lefranc, A W Langerak, C Belessi, F Davi, K Stamatopoulos
Opublikowane w: Leukemia, Numer 31/7, 2017, Strona(/y) 1477-1481, ISSN 0887-6924
Wydawca: Nature Publishing Group
DOI: 10.1038/leu.2017.125

Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it

Autorzy: Ivona Nečasová, Eliška Janoušková, Tomáš Klumpler, Ctirad Hofr
Opublikowane w: Nucleic Acids Research, Numer 45/21, 2017, Strona(/y) 12170-12180, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkx812

Multiple productive IGH rearrangements denote oligoclonality even in immunophenotypically monoclonal CLL

Autorzy: K Brazdilova, K Plevova, H Skuhrova Francova, H Kockova, M Borsky, V Bikos, J Malcikova, A Oltova, J Kotaskova, B Tichy, Y Brychtova, J Mayer, M Doubek, S Pospisilova
Opublikowane w: Leukemia, Numer 32/1, 2017, Strona(/y) 234-236, ISSN 0887-6924
Wydawca: Nature Publishing Group
DOI: 10.1038/leu.2017.274

"ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres"

Autorzy: V. Navrkalova, E. Young, P. Baliakas, L. Radova, L.-A. Sutton, K. Plevova, L. Mansouri, V. Ljungstrom, S. Ntoufa, Z. Davis, G. Juliusson, K. E. Smedby, C. Belessi, P. Panagiotidis, T. Touloumenidou, F. Davi, A. W. Langerak, P. Ghia, J. C. Strefford, D. Oscier, J. Mayer, K. Stamatopoulos, S. Pospisilova, R. Rosenquist, M. Trbusek
Opublikowane w: Haematologica, Numer 101/9, 2016, Strona(/y) e369-e373, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.142968

Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference

Autorzy: P. Baliakas, A. Puiggros, A. Xochelli, L.-A. Sutton, F. Nguyen-Khac, A. Gardiner, K. Plevova, E. Minga, A. Hadzidimitriou, R. Walewska, H. McCarthy, M. Ortega, R. Collado, T. Gonzalez, I. Granada, E. Luno, J. Kota kova, T. Moysiadis, Z. Davis, N. Stavroyianni, A. Anagnostopoulos, J. C. Strefford, S. Pospisilova, F. Davi, A. Athanasiadou, R. Rosenquist, D. Oscier, B. Espinet, K. Stamatopoulos
Opublikowane w: Haematologica, Numer 101/7, 2016, Strona(/y) e299-e302, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.140202

Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond

Autorzy: R. Rosenquist, A. Rosenwald, M.-Q. Du, G. Gaidano, P. Groenen, A. Wotherspoon, P. Ghia, P. Gaulard, E. Campo, K. Stamatopoulos
Opublikowane w: Haematologica, Numer 101/9, 2016, Strona(/y) 1002-1009, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.134510

The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia

Autorzy: Nikos Papakonstantinou, Stavroula Ntoufa, Elisavet Chartomatsidou, Konstantia Kotta, Andreas Agathangelidis, Lefki Giassafaki, Tzeni Karamanli, Panagiota Bele, Theodoros Moysiadis, Panagiotis Baliakas, Lesley Ann Sutton, Niki Stavroyianni, Achilles Anagnostopoulos, Antonios M. Makris, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos
Opublikowane w: Oncotarget, 2016, ISSN 1949-2553
Wydawca: Impact Journals
DOI: 10.18632/oncotarget.9371

Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors

Autorzy: L.-A. Sutton, E. Young, P. Baliakas, A. Hadzidimitriou, T. Moysiadis, K. Plevova, D. Rossi, J. Kminkova, E. Stalika, L. B. Pedersen, J. Malcikova, A. Agathangelidis, Z. Davis, L. Mansouri, L. Scarfo, M. Boudjoghra, A. Navarro, A. F. Muggen, X.-J. Yan, F. Nguyen-Khac, M. Larrayoz, P. Panagiotidis, N. Chiorazzi, C. U. Niemann, C. Belessi, E. Campo, J. C. Strefford, A. W. Langerak, D. Oscier, G. Gaid
Opublikowane w: Haematologica, Numer 101/8, 2016, Strona(/y) 959-967, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2016.141812

Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

Autorzy: P. Baliakas, A. Agathangelidis, A. Hadzidimitriou, L.-A. Sutton, E. Minga, A. Tsanousa, L. Scarfo, Z. Davis, X.-J. Yan, T. Shanafelt, K. Plevova, Y. Sandberg, F. J. Vojdeman, M. Boudjogra, T. Tzenou, M. Chatzouli, C. C. Chu, S. Veronese, A. Gardiner, L. Mansouri, K. E. Smedby, L. B. Pedersen, D. Moreno, K. Van Lom, V. Giudicelli, H. S. Francova, F. Nguyen-Khac, P. Panagiotidis, G. Juliusson, L. Angelis, A. Anagnostopoulos, M.-P. Lefranc, M. Facco, L. Trentin, M. Catherwood, M. Montillo, C. H. Geisler, A. W. Langerak, S. Pospisilova, N. Chiorazzi, D. Oscier, D. F. Jelinek, N. Darzentas, C. Belessi, F. Davi, P. Ghia, R. Rosenquist, K. Stamatopoulos
Opublikowane w: Blood, Numer 00064971, 2015, Strona(/y) 856-859, ISSN 0006-4971
Wydawca: American Society of Hematology
DOI: 10.1182/blood-2014-09-600874

Recurrent mutations refine prognosis in chronic lymphocytic leukemia

Autorzy: P Baliakas, A Hadzidimitriou, L-A Sutton, D Rossi, E Minga, N Villamor, M Larrayoz, J Kminkova, A Agathangelidis, Z Davis, E Tausch, E Stalika, B Kantorova, L Mansouri, L Scarfò, D Cortese, V Navrkalova, M J J Rose-Zerilli, K E Smedby, G Juliusson, A Anagnostopoulos, A M Makris, A Navarro, J Delgado, D Oscier, C Belessi, S Stilgenbauer, P Ghia, S Pospisilova, G Gaidano, E Campo, J C Strefford, K Stamatopoulos, R Rosenquist
Opublikowane w: Leukemia, Numer 08876924, 2014, Strona(/y) 329-336, ISSN 0887-6924
Wydawca: Nature Publishing Group
DOI: 10.1038/leu.2014.196

Prognostic relevance of MYD88 mutations in CLL: the jury is still out

Autorzy: P. Baliakas, A. Hadzidimitriou, A. Agathangelidis, D. Rossi, L.-A. Sutton, J. Kminkova, L. Scarfo, S. Pospisilova, G. Gaidano, K. Stamatopoulos, P. Ghia, R. Rosenquist
Opublikowane w: Blood, Numer 00064971, 2015, Strona(/y) 1043-1044, ISSN 0006-4971
Wydawca: American Society of Hematology
DOI: 10.1182/blood-2015-05-648634

Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data

Autorzy: Panagiotis Baliakas, Michalis Iskas, Anne Gardiner, Zadie Davis, Karla Plevova, Florence Nguyen-Khac, Jitka Malcikova, Achilles Anagnostopoulos, Sharron Glide, Sarah Mould, Kristina Stepanovska, Martin Brejcha, Chrysoula Belessi, Frederic Davi, Sarka Pospisilova, Anastasia Athanasiadou, Kostas Stamatopoulos, David Oscier
Opublikowane w: American Journal of Hematology, Numer 03618609, 2014, Strona(/y) 249-255, ISSN 0361-8609
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/ajh.23618

Human Rap1 modulates TRF2 attraction to telomeric DNA

Autorzy: E. Janou kova, I. Ne asova, J. Pavlou kova, M. Zimmermann, M. Hluchy, V. Marini, M. Novakova, C. Hofr
Opublikowane w: Nucleic Acids Research, Numer 03051048, 2015, Strona(/y) 2691-2700, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkv097

Treatment of chronic lymphocytic leukemia with monoclonal antibodies, where are we heading?

Autorzy: Michael Doubek, Michal Šmída
Opublikowane w: Expert Review of Hematology, Numer 17474086, 2015, Strona(/y) 743-764, ISSN 1747-4086
Wydawca: Expert Reviews
DOI: 10.1586/17474086.2015.1079123

Molecular systematics of <I>Barbatosphaeria</I> (<I>Sordariomycetes</I>): multigene phylogeny and secondary ITS structure

Autorzy: M. Réblová, K. Réblová, V. Štěpánek
Opublikowane w: Persoonia - Molecular Phylogeny and Evolution of Fungi, Numer 00315850, 2015, Strona(/y) 21-38, ISSN 0031-5850
Wydawca: National Herbarium Nederland/Leiden Branch
DOI: 10.3767/003158515X687434

MicroRNAs in B-cell lymphomas: how a complex biology gets more complex

Autorzy: K Musilova, M Mraz
Opublikowane w: Leukemia, Numer 08876924, 2014, Strona(/y) 1004-1017, ISSN 0887-6924
Wydawca: Nature Publishing Group
DOI: 10.1038/leu.2014.351

Clonal evolution in chronic lymphocytic leukemia detected by fluorescence in situ hybridization and conventional cytogenetics after stimulation with CpG oligonucleotides and interleukin-2: A prospective analysis

Autorzy: Martin Brejcha, Martina Stoklasová, Yvona Brychtová, Anna Panovská, Kristina Štěpanovská, Gabriela Vaňková, Karla Plevová, Alexandra Oltová, Kateřina Horká, Šárka Pospíšilová, Jiří Mayer, Michael Doubek
Opublikowane w: Leukemia Research, Numer 01452126, 2014, Strona(/y) 170-175, ISSN 0145-2126
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.leukres.2013.10.019

Forced aggregation and defined factors allow highly uniform-sized embryoid bodies and functional cardiomyocytes from human embryonic and induced pluripotent stem cells

Autorzy: Martin Pesl, Ivana Acimovic, Jan Pribyl, Renata Hezova, Aleksandra Vilotic, Jeremy Fauconnier, Jan Vrbsky, Peter Kruzliak, Petr Skladal, Tomas Kara, Vladimir Rotrekl, Alain Lacampagne, Petr Dvorak, Albano C. Meli
Opublikowane w: Heart and Vessels, Numer 09108327, 2014, Strona(/y) 834-846, ISSN 0910-8327
Wydawca: Springer Verlag
DOI: 10.1007/s00380-013-0436-9

MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia

Autorzy: Marek Mraz, Thomas J. Kipps
Opublikowane w: Leukemia & Lymphoma, Numer 10428194, 2013, Strona(/y) 1836-1839, ISSN 1042-8194
Wydawca: Taylor & Francis
DOI: 10.3109/10428194.2013.796055

Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1

Autorzy: Vineeta Khare, Alex Lyakhovich, Kyle Dammann, Michaela Lang, Melanie Borgmann, Boris Tichy, Sarka Pospisilova, Gloria Luciani, Christoph Campregher, Rayko Evstatiev, Maren Pflueger, Harald Hundsberger, Christoph Gasche
Opublikowane w: Biochemical Pharmacology, Numer 00062952, 2013, Strona(/y) 234-244, ISSN 0006-2952
Wydawca: Elsevier BV
DOI: 10.1016/j.bcp.2012.10.026

The role of microRNAs in mitochondria in cancer

Autorzy: Julie Bienertova-Vasku, Jiri Sana, Ondrej Slaby
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Distinct in vitro sensitivity of p53-mutated and ATM-mutated chronic lymphocytic leukemia cells to ofatumumab and rituximab

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Opublikowane w: Experimental Hematology, Numer 0301472X, 2014, Strona(/y) 867-874.e1, ISSN 0301-472X
Wydawca: Elsevier BV
DOI: 10.1016/j.exphem.2014.06.003

ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin

Autorzy: V. Navrkalova, L. Sebejova, J. Zemanova, J. Kminkova, B. Kubesova, J. Malcikova, M. Mraz, J. Smardova, S. Pavlova, M. Doubek, Y. Brychtova, D. Potesil, V. Nemethova, J. Mayer, S. Pospisilova, M. Trbusek
Opublikowane w: Haematologica, Numer 03906078, 2013, Strona(/y) 1124-1131, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2012.081620

Towards error-free profiling of immune repertoires

Autorzy: Mikhail Shugay, Olga V Britanova, Ekaterina M Merzlyak, Maria A Turchaninova, Ilgar Z Mamedov, Timur R Tuganbaev, Dmitriy A Bolotin, Dmitry B Staroverov, Ekaterina V Putintseva, Karla Plevova, Carsten Linnemann, Dmitriy Shagin, Sarka Pospisilova, Sergey Lukyanov, Ton N Schumacher, Dmitriy M Chudakov
Opublikowane w: Nature Methods, Numer 15487091, 2014, Strona(/y) 653-655, ISSN 1548-7091
Wydawca: Nature Publishing Group
DOI: 10.1038/NMETH.2960

Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia

Autorzy: Aliki Xochelli, Andreas Agathangelidis, Ioannis Kavakiotis, Evangelia Minga, Lesley Ann Sutton, Panagiotis Baliakas, Ioanna Chouvarda, Véronique Giudicelli, Ioannis Vlahavas, Nikos Maglaveras, Lisa Bonello, Livio Trentin, Alessandra Tedeschi, Panagiotis Panagiotidis, Christian Geisler, Anton W. Langerak, Sarka Pospisilova, Diane F. Jelinek, David Oscier, Nicholas Chiorazzi, Nikos Darzentas, Fred Davi, Paolo Ghia, Richard Rosenquist, Anastasia Hadzidimitriou, Chrysoula Belessi, Marie-Paule Lefranc, Kostas Stamatopoulos
Opublikowane w: Immunogenetics, Numer 00937711, 2015, Strona(/y) 61-66, ISSN 0093-7711
Wydawca: Springer Verlag
DOI: 10.1007/s00251-014-0812-3

Urine microRNAs as potential noninvasive biomarkers in urologic cancers

Autorzy: Hana Mlcochova, Renata Hezova, Michal Stanik, Ondrej Slaby
Opublikowane w: Urologic Oncology: Seminars and Original Investigations, Numer 10781439, 2014, Strona(/y) 41.e1-41.e9, ISSN 1078-1439
Wydawca: Elsevier BV
DOI: 10.1016/j.urolonc.2013.04.011

MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma

Autorzy: Martina Redova, Alexandr Poprach, Andrej Besse, Robert Iliev, Jana Nekvindova, Radek Lakomy, Lenka Radova, Marek Svoboda, Jan Dolezel, Rostislav Vyzula, Ondrej Slaby
Opublikowane w: Tumor Biology, Numer 10104283, 2013, Strona(/y) 481-491, ISSN 1010-4283
Wydawca: Springer Verlag
DOI: 10.1007/s13277-012-0573-2

Temporal Dynamics of Clonal Evolution in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-34/IGKV2-30 Antigen Receptors: Longitudinal Immunogenetic Evidence

Autorzy: Lesley Sutton, Efterpi Kostareli
Opublikowane w: Molecular Medicine, Numer 10761551, 2013, Strona(/y) 1, ISSN 1076-1551
Wydawca: North Shore - Long Jewish Research Institute
DOI: 10.2119/molmed.2013.00042

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins

Autorzy: Niamh Mannion, Fabiana Arieti, Angela Gallo, Liam Keegan, Mary O'Connell
Opublikowane w: Biomolecules, Numer 2218273X, 2015, Strona(/y) 2338-2362, ISSN 2218-273X
Wydawca: MDPI AG
DOI: 10.3390/biom5042338

IgG-Switched CLL Has a Distinct Immunogenetic Signature from the Common MD Variant: Ontogenetic Implications

Autorzy: A. Vardi, A. Agathangelidis, L.-A. Sutton, M. Chatzouli, L. Scarfo, L. Mansouri, V. Douka, A. Anagnostopoulos, N. Darzentas, R. Rosenquist, P. Ghia, C. Belessi, K. Stamatopoulos
Opublikowane w: Clinical Cancer Research, Numer 10780432, 2014, Strona(/y) 323-330, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.CCR-13-1993

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

Autorzy: Jan Machal, Jan Novak, Renata Hezova, Filip Zlamal, Anna Vasku, Ondrej Slaby, Julie Bienertova-Vasku
Opublikowane w: Genes & Nutrition, Numer 15558932, 2015, ISSN 1555-8932
Wydawca: New Century Health Publishers
DOI: 10.1007/s12263-015-0488-9

Hypergravity effects on glide arc plasma

Autorzy: Jiří Šperka, Pavel Souček, Jack J. W. A. Van Loon, Alan Dowson, Christian Schwarz, Jutta Krause, Gerrit Kroesen, Vít Kudrle
Opublikowane w: The European Physical Journal D, Numer 14346060, 2013, ISSN 1434-6060
Wydawca: Springer Verlag
DOI: 10.1140/epjd/e2013-40408-7

Splenic marginal-zone lymphoma: ontogeny and genetics

Autorzy: Panagiotis Baliakas, Jonathan C. Strefford, Vasilis Bikos, Marina Parry, Kostas Stamatopoulos, David Oscier
Opublikowane w: Leukemia & Lymphoma, Numer 10428194, 2014, Strona(/y) 301-310, ISSN 1042-8194
Wydawca: Taylor & Francis
DOI: 10.3109/10428194.2014.919636

Isosteric and Nonisosteric Base Pairs in RNA Motifs: Molecular Dynamics and Bioinformatics Study of the Sarcin–Ricin Internal Loop

Autorzy: Marek Havrila, Kamila Réblová, Craig L. Zirbel, Neocles B. Leontis, Jiří Šponer
Opublikowane w: The Journal of Physical Chemistry B, Numer 15206106, 2013, Strona(/y) 14302-14319, ISSN 1520-6106
Wydawca: American Chemical Society
DOI: 10.1021/jp408530w

Assessment of TP53 functionality in chronic lymphocytic leukaemia by different assays; an ERIC-wide approach

Autorzy: G. Doreen te Raa, Jitka Malčiková, Marek Mraz, Martin Trbusek, Magali Le Garff-Tavernier, Hélène Merle-Béral, Rudolf Greil, Olaf Merkel, Sarka Pospíšilová, Ke Lin, Andrew R. Pettitt, Tatjana Stankovic, Marinus H. van Oers, Eric Eldering, Stephan Stilgenbauer, Thorsten Zenz, Arnon P. Kater
Opublikowane w: British Journal of Haematology, Numer 00071048, 2014, Strona(/y) 565-569, ISSN 0007-1048
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/bjh.13006

Molecular Evidence for Antigen Drive in the Natural History of Mantle Cell Lymphoma

Autorzy: Aliki Xochelli, Lesley-Ann Sutton, Andreas Agathangelidis, Evangelia Stalika, Maria Karypidou, Fotini Marantidou, Alba Navarro Lopez, Giorgos Papadopoulos, Jana Supikova, Patricia Groenen, Myriam Boudjogra, Christer Sundstrom, Maurilio Ponzoni, Hana Skuhrova Francova, Achilles Anagnostopoulos, Sarka Pospisilova, Theodora Papadaki, Dimitris Tzovaras, Paolo Ghia, Christiane Pott, Frederic Davi, Elias Campo, Richard Rosenquist, Anastasia Hadzidimitriou, Chrysoula Belessi, Kostas Stamatopoulos
Opublikowane w: The American Journal of Pathology, Numer 00029440, 2015, Strona(/y) 1740-1748, ISSN 0002-9440
Wydawca: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2015.02.006

The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex

Autorzy: Lucie Kozakova, Lucie Vondrova, Karel Stejskal, Panagoula Charalabous, Peter Kolesar, Alan R Lehmann, Stjepan Uldrijan, Christopher M Sanderson, Zbynek Zdrahal, Jan J Palecek
Opublikowane w: Cell Cycle, Numer 15384101, 2015, Strona(/y) 920-930, ISSN 1538-4101
Wydawca: Landes Bioscience
DOI: 10.1080/15384101.2014.1000112

Role of S-turn2 in the Structure, Dynamics, and Function of Mitochondrial Ribosomal A-Site. A Bioinformatics and Molecular Dynamics Simulation Study

Autorzy: Joanna Panecka, Marek Havrila, Kamila Réblová, Jiří Šponer, Joanna Trylska
Opublikowane w: The Journal of Physical Chemistry B, Numer 15206106, 2014, Strona(/y) 6687-6701, ISSN 1520-6106
Wydawca: American Chemical Society
DOI: 10.1021/jp5030685

Dynamic changes in microRNA expression profiles reflect progression of Barrett's esophagus to esophageal adenocarcinoma

Autorzy: O. Slaby, J. Srovnal, L. Radova, J. Gregar, J. Juracek, P. Luzna, M. Svoboda, M. Hajduch, J. Ehrmann
Opublikowane w: Carcinogenesis, Numer 01433334, 2015, Strona(/y) 521-527, ISSN 0143-3334
Wydawca: Oxford University Press
DOI: 10.1093/carcin/bgv023

Transmission of t(11;14)-positive cells by allogeneic stem cell transplant: 10-year journey to mantle cell lymphoma

Autorzy: Andrea Janikova, Andrea Mareckova, Aneta Baumeisterova, Marta Krejci, Jana Supikova, David Salek, Ondrej Horky, Boris Tichy, Ivo Hanke, Sarka Pospisilova, Mojmir Moulis, Jiri Mayer
Opublikowane w: Leukemia & Lymphoma, Numer 10428194, 2014, Strona(/y) 1935-1938, ISSN 1042-8194
Wydawca: Taylor & Francis
DOI: 10.3109/10428194.2013.858150

Small nucleolar RNAs functioning and potential roles in cancer

Autorzy: Nithyananda Thorenoor, Ondrej Slaby
Opublikowane w: Tumor Biology, Numer 10104283, 2015, Strona(/y) 41-53, ISSN 1010-4283
Wydawca: Springer Verlag
DOI: 10.1007/s13277-014-2818-8

Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia

Autorzy: Jakub Trizuljak, Josef Srovnal, Karla Plevová, Yvona Brychtová, Lukáš Semerád, Denisa Bakešová, Eva Létalová, Andrea Benedíková, Jiří Mayer, Marián Hajdúch, Šárka Pospíšilová, Michael Doubek
Opublikowane w: Clinical Lymphoma Myeloma and Leukemia, Numer 21522669, 2015, Strona(/y) 439-442, ISSN 2152-2669
Wydawca: Cancer Media Group
DOI: 10.1016/j.clml.2015.02.003

The Epitranscriptome and Innate Immunity

Autorzy: Mary A. O’Connell, Niamh M. Mannion, Liam P. Keegan
Opublikowane w: PLOS Genetics, Numer 15537404, 2015, Strona(/y) e1005687, ISSN 1553-7404
Wydawca: Public Library ScienceUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1005687

MicroRNAs involved in chemo- and radioresistance of high-grade gliomas

Autorzy: Andrej Besse, Jiri Sana, Pavel Fadrus, Ondrej Slaby
Opublikowane w: Tumor Biology, Numer 10104283, 2013, Strona(/y) 1969-1978, ISSN 1010-4283
Wydawca: Springer Verlag
DOI: 10.1007/s13277-013-0772-5

MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis

Autorzy: A. Benner, L. Mansouri, D. Rossi, A. Majid, K. Willander, A. Parker, G. Bond, S. Pavlova, H. Nuckel, O. Merkel, P. Ghia, E. Montserrat, M. A. Kaderi, R. Rosenquist, G. Gaidano, M. J. S. Dyer, P. Soderkvist, M. Linderholm, D. Oscier, Z. Tvaruzkova, S. Pospisilova, U. Duhrsen, R. Greil, H. Dohner, S. Stilgenbauer, T. Zenz
Opublikowane w: Haematologica, Numer 03906078, 2014, Strona(/y) 1285-1291, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.101170

Circulating miRNAs as new blood-based biomarkers for solid cancers

Autorzy: Martina Redova, Jiri Sana, Ondrej Slaby
Opublikowane w: Future Oncology, Numer 14796694, 2013, Strona(/y) 387-402, ISSN 1479-6694
Wydawca: Future Medicine Ltd.
DOI: 10.2217/FON.12.192

Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway

Autorzy: L.  merdova, J. Svobodova, M. Kabatkova, J. Kohoutek, D. Bla ek, M. Machala, J. Vondra ek
Opublikowane w: Carcinogenesis, Numer 01433334, 2014, Strona(/y) 2534-2543, ISSN 0143-3334
Wydawca: Oxford University Press
DOI: 10.1093/carcin/bgu190

Hypergravity synthesis of graphitic carbon nanomaterial in glide arc plasma

Autorzy: Jiří Šperka, Pavel Souček, Jack J.W.A. Van Loon, Alan Dowson, Christian Schwarz, Jutta Krause, Yuriy Butenko, Gerrit Kroesen, Vít Kudrle
Opublikowane w: Materials Research Bulletin, Numer 00255408, 2014, Strona(/y) 61-65, ISSN 0025-5408
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.materresbull.2014.03.013

Computational study of missense mutations in phenylalanine hydroxylase

Autorzy: Kamila Réblová, Petr Kulhánek, Lenka Fajkusová
Opublikowane w: Journal of Molecular Modeling, Numer 16102940, 2015, ISSN 1610-2940
Wydawca: Springer Verlag
DOI: 10.1007/s00894-015-2620-6

Hyperphenylalaninemia in the Czech Republic: Genotype–phenotype correlations and in silico analysis of novel missense mutations

Autorzy: Kamila Réblová, Zuzana Hrubá, Dagmar Procházková, Renata Pazdírková, Slávka Pouchlá, Lenka Fajkusová
Opublikowane w: Clinica Chimica Acta, Numer 00098981, 2013, Strona(/y) 1-10, ISSN 0009-8981
Wydawca: Elsevier BV
DOI: 10.1016/j.cca.2013.01.006

TaqMan based real time PCR assay targeting EML4-ALK fusion transcripts in NSCLC

Autorzy: Blanka Robesova, Monika Bajerova, Kvetoslava Liskova, Jana Skrickova, Marcela Tomiskova, Sarka Pospisilova, Jiri Mayer, Dana Dvorakova
Opublikowane w: Lung Cancer, Numer 01695002, 2014, Strona(/y) 25-30, ISSN 0169-5002
Wydawca: Elsevier BV
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Book chapters (1)

TP53 Aberrations in Chronic Lymphocytic Leukemia

Autorzy: Martin Trbusek, Jitka Malcikova
Opublikowane w: Advances in Chronic Lymphocytic Leukemia, 2013, Strona(/y) 109-131, ISBN 978-1-4614-8051-8
Wydawca: Springer New York
DOI: 10.1007/978-1-4614-8051-8_5