Skip to main content

Towards outstanding research and training in tumour biology at IMM


High Resolution Microscopy Workshop

High Resolution Microscopy Workshop

EC Performance Indicators Widening indicator application for the 3-year window time prior to ReTuBi

EC Performance Indicators Widening indicator application for the 3-year window time prior to ReTuBi

Second edition of the High-Resolution Microscopy Workshop

A second edition of the High-Resolution Microscopy Workshop will be organized on M34 due to the successful implementation of the first edition, the successful accomplishment of the objectives and the growing demand from the partnering institutions on participating in these type of practical activity.

Second edition of the Career development and soft skills for young scientists

A second edition of thethe Career development and soft skills for young scientists – From Lisbon to the World Workshop will be organized on M26 due to the successful implementation of the first edition, the successful accomplishment of the objectives and the growing demand from the partnering institutions on participating in these type of practical activity.

Career development and soft skills for young scientists

Career development and soft skills for young scientists

Brochure and flyer

Brochure and flyer

Searching for OpenAIRE data...


Computational fluid dynamics assisted characterization of parafoveal hemodynamics in normal and diabetic eyes using adaptive optics scanning laser ophthalmoscopy

Author(s): Yang Lu, Miguel O. Bernabeu, Jan Lammer, Charles C. Cai, Martin L. Jones, Claudio A. Franco, Lloyd Paul Aiello, Jennifer K. Sun
Published in: Biomedical Optics Express, Issue 7/12, 2016, Page(s) 4958, ISSN 2156-7085
DOI: 10.1364/BOE.7.004958

A system for studying mechanisms of neuromuscular junction development and maintenance

Author(s): Valérie Vilmont, Bruno Cadot, Gilles Ouanounou, Edgar R. Gomes
Published in: Development, Issue 143/13, 2016, Page(s) 2464-2477, ISSN 0950-1991
DOI: 10.1242/dev.130278

The impact of chronic intermittent hypoxia on hematopoiesis and the bone marrow microenvironment

Author(s): Inês Alvarez-Martins, Leonor Remédio, Inês Matias, Lucília N. Diogo, Emília C. Monteiro, Sérgio Dias
Published in: Pflügers Archiv - European Journal of Physiology, Issue 468/5, 2016, Page(s) 919-932, ISSN 0031-6768
DOI: 10.1007/s00424-016-1797-6

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

Author(s): Susana L. Silva, Adriana S. Albuquerque, Ana Serra-Caetano, Russell B. Foxall, Ana R. Pires, Paula Matoso, Susana M. Fernandes, João Ferreira, Rémi Cheynier, Rui M. M. Victorino, Iris Caramalho, João T. Barata, Ana E. Sousa
Published in: Oncotarget, Issue 7/11, 2016, Page(s) 12163-12175, ISSN 1949-2553
DOI: 10.18632/oncotarget.7512

FOXO1 couples metabolic activity and growth state in the vascular endothelium

Author(s): Kerstin Wilhelm, Katharina Happel, Guy Eelen, Sandra Schoors, Mark F. Oellerich, Radiance Lim, Barbara Zimmermann, Irene M. Aspalter, Claudio A. Franco, Thomas Boettger, Thomas Braun, Marcus Fruttiger, Klaus Rajewsky, Charles Keller, Jens C. Brüning, Holger Gerhardt, Peter Carmeliet, Michael Potente
Published in: Nature, Issue 529/7585, 2016, Page(s) 216-220, ISSN 0028-0836
DOI: 10.1038/nature16498

Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

Author(s): Ivan Quétier, Jacqueline J.T. Marshall, Bradley Spencer-Dene, Sylvie Lachmann, Adele Casamassima, Claudio Franco, Sarah Escuin, Joseph T. Worrall, Priththivika Baskaran, Vinothini Rajeeve, Michael Howell, Andrew J. Copp, Gordon Stamp, Ian Rosewell, Pedro Cutillas, Holger Gerhardt, Peter J. Parker, Angus J.M. Cameron
Published in: Cell Reports, Issue 14/3, 2016, Page(s) 440-448, ISSN 2211-1247
DOI: 10.1016/j.celrep.2015.12.049

Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity

Author(s): Alice Melão, Maureen Spit, Bruno A. Cardoso, João T. Barata
Published in: Haematologica, Issue 101/11, 2016, Page(s) 1368-1379, ISSN 0390-6078
DOI: 10.3324/haematol.2015.141143

LDL-Cholesterol Increases the Transcytosis of Molecules through Endothelial Monolayers

Author(s): Ana Magalhaes, Inês Matias, Inês Palmela, Maria Alexandra Brito, Sérgio Dias
Published in: PLOS ONE, Issue 11/10, 2016, Page(s) e0163988, ISSN 1932-6203
DOI: 10.1371/journal.pone.0163988

microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia

Author(s): Nádia C. Correia, Alice Melão, Vanda Póvoa, Leonor Sarmento, Marta Gómez de Cedrón, Marcos Malumbres, Francisco J. Enguita, João T. Barata
Published in: Oncotarget, Issue 7/7, 2016, Page(s) 8268-8281, ISSN 1949-2553
DOI: 10.18632/oncotarget.6987

Blood flow boosts BMP signaling to keep vessels in shape

Author(s): Claudio A. Franco, Holger Gerhardt
Published in: The Journal of Cell Biology, Issue 214/7, 2016, Page(s) 793-795, ISSN 0021-9525
DOI: 10.1083/jcb.201609038

Endothelial cell dynamics in vascular remodelling

Author(s): Pedro Barbacena, Joana R. Carvalho, Claudio A. Franco
Published in: Clinical Hemorheology and Microcirculation, Issue 64/4, 2017, Page(s) 557-563, ISSN 1386-0291
DOI: 10.3233/CH-168006

Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice

Author(s): Sandra Trindade, Filipa Rijo-Ferreira, Tânia Carvalho, Daniel Pinto-Neves, Fabien Guegan, Francisco Aresta-Branco, Fabio Bento, Simon A. Young, Andreia Pinto, Jan Van Den Abbeele, Ruy M. Ribeiro, Sérgio Dias, Terry K. Smith, Luisa M. Figueiredo
Published in: Cell Host & Microbe, Issue 19/6, 2016, Page(s) 837-848, ISSN 1931-3128
DOI: 10.1016/j.chom.2016.05.002

Dynein disruption perturbs post-synaptic components and contributes to impaired MuSK clustering at the NMJ: implication in ALS

Author(s): Valérie Vilmont, Bruno Cadot, Elsa Vezin, Fabien Le Grand, Edgar R. Gomes
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
DOI: 10.1038/srep27804

Inoculated Cell Density as a Determinant Factor of the Growth Dynamics and Metastatic Efficiency of a Breast Cancer Murine Model

Author(s): Ana C. Gregório, Nuno A. Fonseca, Vera Moura, Manuela Lacerda, Paulo Figueiredo, Sérgio Simões, Sérgio Dias, João Nuno Moreira
Published in: PLOS ONE, Issue 11/11, 2016, Page(s) e0165817, ISSN 1932-6203
DOI: 10.1371/journal.pone.0165817

Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling

Author(s): Claudio A Franco, Martin L Jones, Miguel O Bernabeu, Anne-Clemence Vion, Pedro Barbacena, Jieqing Fan, Thomas Mathivet, Catarina G Fonseca, Anan Ragab, Terry P Yamaguchi, Peter V Coveney, Richard A Lang, Holger Gerhardt
Published in: eLife, Issue 5, 2016, ISSN 2050-084X
DOI: 10.7554/eLife.07727

MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia

Author(s): Nádia C. Correia, Rita Fragoso, Tânia Carvalho, Francisco J. Enguita, João T. Barata
Published in: Scientific Reports, Issue 6/1, 2016, ISSN 2045-2322
DOI: 10.1038/srep31894

Organização e implementação de uma consulta de cardio‐oncologia

Author(s): Manuela Fiuza, Leonor Ribeiro, Andreia Magalhães, Ana Rita Sousa, Miguel Nobre Menezes, Marília Jorge, Luís Costa, Fausto José Pinto
Published in: Revista Portuguesa de Cardiologia, Issue 35/9, 2016, Page(s) 485-494, ISSN 0870-2551
DOI: 10.1016/j.repc.2016.04.006

The prognostic role of RANK SNP rs34945627 in breast cancer patients with bone metastases

Author(s): Arlindo Ferreira, Irina Alho, Inês Vendrell, Marta Melo, Raquel Brás, Ana Lúcia Costa, Ana Rita Sousa, André Mansinho, Catarina Abreu, Catarina Pulido, Daniela Macedo, Teresa Pacheco, Lurdes Correia, Luis Costa, Sandra Casimiro
Published in: Oncotarget, Issue 7/27, 2016, Page(s) 41380-41389, ISSN 1949-2553
DOI: 10.18632/oncotarget.9356

N-Telopeptide of Type I Collagen Long-Term Dynamics in Breast Cancer Patients With Bone Metastases: Clinical Outcomes and Influence of Extraskeletal Metastases

Author(s): A. R. Ferreira, I. Alho, N. Shan, M. Matias, M. Faria, S. Casimiro, K. Leitzel, S. Ali, A. Lipton, L. Costa
Published in: The Oncologist, Issue 21/12, 2016, Page(s) 1418-1426, ISSN 1083-7159
DOI: 10.1634/theoncologist.2015-0527

Radiolabeled block copolymer micelles for image-guided drug delivery

Author(s): Elisabete Ribeiro, Irina Alho, Fernanda Marques, Lurdes Gano, Isabel Correia, João D.G. Correia, Sandra Casimiro, Luís Costa, Isabel Santos, Célia Fernandes
Published in: International Journal of Pharmaceutics, Issue 515/1-2, 2016, Page(s) 692-701, ISSN 0378-5173
DOI: 10.1016/j.ijpharm.2016.11.004

Dynamic modeling of bone metastasis, microenvironment and therapy

Author(s): Rui Moura Coelho, João Miranda Lemos, Irina Alho, Duarte Valério, Arlindo R Ferreira, Luís Costa, Susana Vinga
Published in: Journal of Theoretical Biology, Issue 391, 2016, Page(s) 1-12, ISSN 0022-5193
DOI: 10.1016/j.jtbi.2015.11.024

Variation in type of adjuvant chemotherapy received among patients with stage I breast cancer: A multi-institutional Portuguese cohort study

Author(s): Arlindo R. Ferreira, Ana Palha, Lurdes Correia, Pedro Filipe, Vasco Rodrigues, Luís Costa, Ana Miranda, Rosário André, João Fernandes, Joaquim Gouveia, José Luís Passos-Coelho, António Moreira, Margarida Brito, Joana Ribeiro, Otto Metzger-Filho, Nancy U. Lin, Inês Vaz-Luís
Published in: The Breast, Issue 29, 2016, Page(s) 68-73, ISSN 0960-9776
DOI: 10.1016/j.breast.2016.07.004

Molecular Mechanisms of Bone Metastasis: Which Targets Came from the Bench to the Bedside?

Author(s): Sandra Casimiro, Arlindo Ferreira, André Mansinho, Irina Alho, Luis Costa
Published in: International Journal of Molecular Sciences, Issue 17/9, 2016, Page(s) 1415, ISSN 1422-0067
DOI: 10.3390/ijms17091415

Health resource utilization associated with skeletal-related events: results from a retrospective European study

Author(s): Jean-Jacques Body, João Pereira, Harm Sleeboom, Nikos Maniadakis, Evangelos Terpos, Yves Pascal Acklin, Jindrich Finek, Oliver Gunther, Guy Hechmati, Tony Mossman, Luis Costa, Wojciech Rogowski, Hareth Nahi, Roger von Moos
Published in: The European Journal of Health Economics, Issue 17/6, 2016, Page(s) 711-721, ISSN 1618-7598
DOI: 10.1007/s10198-015-0716-7

Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells

Author(s): Petra Gimpel, Yin Loon Lee, Radoslaw M. Sobota, Alessandra Calvi, Victoria Koullourou, Rutti Patel, Kamel Mamchaoui, François Nédélec, Sue Shackleton, Jan Schmoranzer, Brian Burke, Bruno Cadot, Edgar R. Gomes
Published in: Current Biology, Issue 27/19, 2017, Page(s) 2999-3009.e9, ISSN 0960-9822
DOI: 10.1016/j.cub.2017.08.031

Myofibril contraction and crosslinking drive nuclear movement to the periphery of skeletal muscle

Author(s): William Roman, João P. Martins, Filomena A. Carvalho, Raphael Voituriez, Jasmine V. G. Abella, Nuno C. Santos, Bruno Cadot, Michael Way, Edgar R. Gomes
Published in: Nature Cell Biology, Issue 19/10, 2017, Page(s) 1189-1201, ISSN 1465-7392
DOI: 10.1038/ncb3605

<em>In Vitro</em> Differentiation of Mature Myofibers for Live Imaging

Author(s): Mafalda R. Pimentel, Sestina Falcone, Bruno Cadot, Edgar R. Gomes
Published in: Journal of Visualized Experiments, Issue 119, 2017, ISSN 1940-087X
DOI: 10.3791/55141

Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia

Author(s): Cecilia Evangelisti, Alessandra Cappellini, Mariana Oliveira, Rita Fragoso, João T. Barata, Alice Bertaina, Franco Locatelli, Carolina Simioni, Luca M. Neri, Francesca Chiarini, Annalisa Lonetti, Francesca Buontempo, Ester Orsini, Andrea Pession, Lucia Manzoli, Alberto Maria Martelli, Camilla Evangelisti
Published in: Journal of Cellular Physiology, 2017, ISSN 0021-9541
DOI: 10.1002/jcp.26135

From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia

Author(s): Mariana L. Oliveira, Padma Akkapeddi, Isabel Alcobia, Afonso R. Almeida, Bruno A. Cardoso, Rita Fragoso, Teresa L. Serafim, João T. Barata
Published in: Cellular Signalling, Issue 38, 2017, Page(s) 10-25, ISSN 0898-6568
DOI: 10.1016/j.cellsig.2017.06.011

IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity

Author(s): Susana L. Silva, Adriana S. Albuquerque, Paula Matoso, Bénédicte Charmeteau-de-Muylder, Rémi Cheynier, Dário Ligeiro, Miguel Abecasis, Rui Anjos, João T. Barata, Rui M. M. Victorino, Ana E. Sousa
Published in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
DOI: 10.3389/fimmu.2017.00020

Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks

Author(s): Claudio A. Franco, Holger Gerhardt
Published in: Developmental Cell, Issue 41/6, 2017, Page(s) 574-576, ISSN 1534-5807
DOI: 10.1016/j.devcel.2017.06.008

Radionuclides in oncology clinical practice – review of the literature

Author(s): Helena Luna Pais, Irina Alho, Inês Vendrell, André Mansinho, Luís Costa
Published in: Dalton Transactions, Issue 46/42, 2017, Page(s) 14475-14487, ISSN 1477-9226
DOI: 10.1039/C7DT01929G

Bone metastasis risk factors in breast cancer

Author(s): Catarina Pulido, Inês Vendrell, Arlindo R Ferreira, Sandra Casimiro, André Mansinho, Irina Alho, Luís Costa
Published in: ecancermedicalscience, Issue 11, 2017, ISSN 1754-6605
DOI: 10.3332/ecancer.2017.715

Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer

Author(s): Barbara Tavares, Raquel Jacinto, Pedro Sampaio, Sara Pestana, Andreia Pinto, Andreia Vaz, Mónica Roxo-Rosa, Rui Gardner, Telma Lopes, Britta Schilling, Ian Henry, Leonor Saúde, Susana Santos Lopes
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
DOI: 10.7554/eLife.25165

Improving quality of life in patients with advanced cancer: Targeting metastatic bone pain

Author(s): Roger von Moos, Luis Costa, Carla Ida Ripamonti, Daniela Niepel, Daniele Santini
Published in: European Journal of Cancer, Issue 71, 2017, Page(s) 80-94, ISSN 0959-8049
DOI: 10.1016/j.ejca.2016.10.021

Gold Nanobeacons for Tracking Gene Silencing in Zebrafish

Author(s): Milton Cordeiro, Lara Carvalho, Joana Silva, Leonor Saúde, Alexandra Fernandes, Pedro Baptista
Published in: Nanomaterials, Issue 7/1, 2017, Page(s) 10, ISSN 2079-4991
DOI: 10.3390/nano7010010

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium( ii ) catalyst

Author(s): Terence T.-L. Kwan, Omar Boutureira, Elizabeth C. Frye, Stephen J. Walsh, Moni K. Gupta, Stephen Wallace, Yuteng Wu, Fengzhi Zhang, Hannah F. Sore, Warren R. J. D. Galloway, Jason W. Chin, Martin Welch, Gonçalo J. L. Bernardes, David R. Spring
Published in: Chem. Sci., Issue 8/5, 2017, Page(s) 3871-3878, ISSN 2041-6520
DOI: 10.1039/c6sc05313k

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases

Author(s): Jean B. Bertoldo, Tiago Rodrigues, Lavinia Dunsmore, Francesco A. Aprile, Marta C. Marques, Leonardo A. Rosado, Omar Boutureira, Thomas B. Steinbrecher, Woody Sherman, Francisco Corzana, Hernán Terenzi, Gonçalo J.L. Bernardes
Published in: Chem, Issue 3/4, 2017, Page(s) 665-677, ISSN 2451-9294
DOI: 10.1016/j.chempr.2017.07.009

Oxidative Activation of C–S Bonds with an Electropositive Nitrogen Promoter Enables Orthogonal Glycosylation of Alkyl over Phenyl Thioglycosides

Author(s): Annabel Kitowski, Ester Jiménez-Moreno, Míriam Salvadó, Jordi Mestre, Sergio Castillón, Gonzalo Jiménez-Osés, Omar Boutureira, Gonçalo J. L. Bernardes
Published in: Organic Letters, Issue 19/19, 2017, Page(s) 5490-5493, ISSN 1523-7060
DOI: 10.1021/acs.orglett.7b02886

Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

Author(s): Nuria Martínez-Sáez, Shuang Sun, Davide Oldrini, Pietro Sormanni, Omar Boutureira, Filippo Carboni, Ismael Compañón, Michael J. Deery, Michele Vendruscolo, Francisco Corzana, Roberto Adamo, Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, Issue 56/47, 2017, Page(s) 14963-14967, ISSN 1433-7851
DOI: 10.1002/anie.201708847

Short (16-mer) locked nucleic acid splice-switching oligonucleotides restore dystrophin production in Duchenne Muscular Dystrophy myotubes

Author(s): Vanessa Borges Pires, Ricardo Simões, Kamel Mamchaoui, Célia Carvalho, Maria Carmo-Fonseca
Published in: PLOS ONE, Issue 12/7, 2017, Page(s) e0181065, ISSN 1932-6203
DOI: 10.1371/journal.pone.0181065

Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation

Author(s): Sreerama Chaitanya Sridhara, Sílvia Carvalho, Ana Rita Grosso, Lina Marcela Gallego-Paez, Maria Carmo-Fonseca, Sérgio Fernandes de Almeida
Published in: Cell Reports, Issue 18/2, 2017, Page(s) 334-343, ISSN 2211-1247
DOI: 10.1016/j.celrep.2016.12.050

Trends in therapeutic drug conjugates for bacterial diseases: a patent review

Author(s): Pedro M. S. D. Cal, Maria J. Matos, Gonçalo J. L. Bernardes
Published in: Expert Opinion on Therapeutic Patents, Issue 27/2, 2017, Page(s) 179-189, ISSN 1354-3776
DOI: 10.1080/13543776.2017.1259411

Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs

Author(s): Margarita Schlackow, Takayuki Nojima, Tomas Gomes, Ashish Dhir, Maria Carmo-Fonseca, Nick J. Proudfoot
Published in: Molecular Cell, Issue 65/1, 2017, Page(s) 25-38, ISSN 1097-2765
DOI: 10.1016/j.molcel.2016.11.029

Site-Selective Modification of Proteins with Oxetanes

Author(s): Omar Boutureira, Nuria Martínez-Sáez, Kevin M. Brindle, André A. Neves, Francisco Corzana, Gonçalo J. L. Bernardes
Published in: Chemistry - A European Journal, Issue 23/27, 2017, Page(s) 6483-6489, ISSN 0947-6539
DOI: 10.1002/chem.201700745

Nickel-Catalyzed Azide–Alkyne Cycloaddition To Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water

Author(s): Woo Gyum Kim, Mi Eun Kang, Jae Bin Lee, Min Ho Jeon, Sungmin Lee, Jungha Lee, Bongseo Choi, Pedro M. S. D. Cal, Sebyung Kang, Jung-Min Kee, Gonçalo J. L. Bernardes, Jan-Uwe Rohde, Wonyoung Choe, Sung You Hong
Published in: Journal of the American Chemical Society, Issue 139/35, 2017, Page(s) 12121-12124, ISSN 0002-7863
DOI: 10.1021/jacs.7b06338

Deep intronic mutations and human disease

Author(s): Rita Vaz-Drago, Noélia Custódio, Maria Carmo-Fonseca
Published in: Human Genetics, Issue 136/9, 2017, Page(s) 1093-1111, ISSN 0340-6717
DOI: 10.1007/s00439-017-1809-4

Whole gene sequencing identifies deep-intronic variants with potential functional impact in patients with hypertrophic cardiomyopathy

Author(s): Rita Mendes de Almeida, Joana Tavares, Sandra Martins, Teresa Carvalho, Francisco J. Enguita, Dulce Brito, Maria Carmo-Fonseca, Luís Rocha Lopes
Published in: PLOS ONE, Issue 12/8, 2017, Page(s) e0182946, ISSN 1932-6203
DOI: 10.1371/journal.pone.0182946

Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils

Author(s): Max J. H. Worthington, Renata L. Kucera, Inês S. Albuquerque, Christopher T. Gibson, Alexander Sibley, Ashley D. Slattery, Jonathan A. Campbell, Salah F. K. Alboaiji, Katherine A. Muller, Jason Young, Nick Adamson, Jason R. Gascooke, Deshetti Jampaiah, Ylias M. Sabri, Suresh K. Bhargava, Samuel J. Ippolito, David A. Lewis, Jamie S. Quinton, Amanda V. Ellis, Alexander Johs, Gonçalo J. L. Bernarde
Published in: Chemistry - A European Journal, Issue 23/64, 2017, Page(s) 16219-16230, ISSN 0947-6539
DOI: 10.1002/chem.201702871

Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells

Author(s): Ester Jiménez-Moreno, Zijian Guo, Bruno L. Oliveira, Inês S. Albuquerque, Annabel Kitowski, Ana Guerreiro, Omar Boutureira, Tiago Rodrigues, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Published in: Angewandte Chemie International Edition, Issue 56/1, 2017, Page(s) 243-247, ISSN 1433-7851
DOI: 10.1002/anie.201609607

A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages

Author(s): Mafalda M. A. Pereira, Inês Mahú, Elsa Seixas, Noelia Martinéz-Sánchez, Nadiya Kubasova, Roksana M Pirzgalska, Paul Cohen, Marcelo O Dietrich, Miguel López, Gonçalo J. L. Bernardes, Ana I. Domingos
Published in: Nature Communications, Issue 8, 2017, Page(s) 14967, ISSN 2041-1723
DOI: 10.1038/ncomms14967

Pharmacological inhibition of the spliceosome subunit SF3b triggers exon junction complex-independent nonsense-mediated decay

Author(s): Teresa Carvalho, Sandra Martins, José Rino, Sérgio Marinho, Maria Carmo-Fonseca
Published in: Journal of Cell Science, Issue 130/9, 2017, Page(s) 1519-1531, ISSN 0021-9533
DOI: 10.1242/jcs.202200

Inverse electron demand Diels–Alder reactions in chemical biology

Author(s): B. L. Oliveira, Z. Guo, G. J. L. Bernardes
Published in: Chem. Soc. Rev., Issue 46/16, 2017, Page(s) 4895-4950, ISSN 0306-0012
DOI: 10.1039/C7CS00184C

Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells

Author(s): Pedro M. S. D. Cal, Florian Sieglitz, Fábio M. F. Santos, Cátia Parente Carvalho, Ana Guerreiro, Jean B. Bertoldo, Uwe Pischel, Pedro M. P. Gois, Gonçalo J. L. Bernardes
Published in: Chem. Commun., Issue 53/2, 2017, Page(s) 368-371, ISSN 1359-7345
DOI: 10.1039/c6cc08671c

Association of Anger Expression-Out with NK Cell Counts in Colorectal Cancer Patients

Author(s): Estela Kakoo-Brioso, Luís Costa, Sílvia Ouakinin
Published in: Acta Médica Portuguesa, Issue 31/3, 2018, Page(s) 152, ISSN 0870-399X
DOI: 10.20344/amp.9573

Microtubule motors involved in nuclear movement during skeletal muscle differentiation

Author(s): V. Gache, E. R. Gomes, B. Cadot
Published in: Molecular Biology of the Cell, Issue 28/7, 2017, Page(s) 865-874, ISSN 1059-1524
DOI: 10.1091/mbc.e16-06-0405

Impact on sexual function of surgical treatment in rectal cancer

Author(s): Pedro Costa, João M. Cardoso, Hugo Louro, Jorge Dias, Luís Costa, Raquel Rodrigues, Paulo Espiridião, Jorge Maciel, Luís Ferraz
Published in: International braz j urol, Issue 44/1, 2018, Page(s) 141-149, ISSN 1677-6119
DOI: 10.1590/s1677-5538.ibju.2017.0318

Local Arrangement of Fibronectin by Myofibroblasts Governs Peripheral Nuclear Positioning in Muscle Cells

Author(s): William Roman, João P. Martins, Edgar R. Gomes
Published in: Developmental Cell, Issue 46/1, 2018, Page(s) 102-111.e6, ISSN 1534-5807
DOI: 10.1016/j.devcel.2018.05.031

Serum YB-1 (Y-box binding protein 1) as a biomarker of bone disease progression in patients with breast cancer and bone metastases

Author(s): A.R. Ferreira, M. Bettencourt, I. Alho, A.L. Costa, A.R. Sousa, A. Mansinho, C. Abreu, C. Pulido, D. Macedo, I. Vendrell, T.R. Pacheco, L. Costa, S. Casimiro
Published in: Journal of Bone Oncology, Issue 6, 2017, Page(s) 16-21, ISSN 2212-1374
DOI: 10.1016/j.jbo.2017.01.002

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

Author(s): Filipa Neto, Alexandra Klaus-Bergmann, Yu Ting Ong, Silvanus Alt, Anne-Clémence Vion, Anna Szymborska, Joana R Carvalho, Irene Hollfinger, Eireen Bartels-Klein, Claudio A Franco, Michael Potente, Holger Gerhardt
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
DOI: 10.7554/eLife.31037

LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

Author(s): Elvira Infante, Alessia Castagnino, Robin Ferrari, Pedro Monteiro, Sonia Agüera-González, Perrine Paul-Gilloteaux, Mélanie J. Domingues, Paolo Maiuri, Matthew Raab, Catherine M. Shanahan, Alexandre Baffet, Matthieu Piel, Edgar R. Gomes, Philippe Chavrier
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-04865-7

Nuclear positioning in skeletal muscle

Author(s): William Roman, Edgar R. Gomes
Published in: Seminars in Cell & Developmental Biology, Issue 82, 2018, Page(s) 51-56, ISSN 1084-9521
DOI: 10.1016/j.semcdb.2017.11.005

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

Author(s): S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata, B Silva-Santos
Published in: Leukemia, Issue 31/7, 2016, Page(s) 1603-1610, ISSN 0887-6924
DOI: 10.1038/leu.2016.363

Dealing with the nucleus during cell migration

Author(s): Francisco J Calero-Cuenca, Cátia S Janota, Edgar R Gomes
Published in: Current Opinion in Cell Biology, Issue 50, 2018, Page(s) 35-41, ISSN 0955-0674
DOI: 10.1016/

Damage and protection cost curves for coastal floods within the 600 largest European cities

Author(s): Boris F. Prahl, Markus Boettle, Luís Costa, Jürgen P. Kropp, Diego Rybski
Published in: Scientific Data, Issue 5, 2018, Page(s) 180034, ISSN 2052-4463
DOI: 10.1038/sdata.2018.34

PolNet: A Tool to Quantify Network-Level Cell Polarity and Blood Flow in Vascular Remodeling

Author(s): Miguel O. Bernabeu, Martin L. Jones, Rupert W. Nash, Anna Pezzarossa, Peter V. Coveney, Holger Gerhardt, Claudio A. Franco
Published in: Biophysical Journal, Issue 114/9, 2018, Page(s) 2052-2058, ISSN 0006-3495
DOI: 10.1016/j.bpj.2018.03.032

N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy

Author(s): S. Falcone, W. Roman, K. Hnia, V. Gache, N. Didier, J. Laine, F. Aurade, I. Marty, I. Nishino, N. Charlet-Berguerand, N. B. Romero, G. Marazzi, D. Sassoon, J. Laporte, E. R. Gomes
Published in: EMBO Molecular Medicine, Issue 6/11, 2014, Page(s) 1455-1475, ISSN 1757-4676
DOI: 10.15252/emmm.201404436

Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking the Nuclear Envelope to the Actin and Microtubule Cytoskeleton

Author(s): Manuela D’Alessandro, Karim Hnia, Vincent Gache, Catherine Koch, Christos Gavriilidis, David Rodriguez, Anne-Sophie Nicot, Norma B. Romero, Yannick Schwab, Edgar Gomes, Michel Labouesse, Jocelyn Laporte
Published in: Developmental Cell, Issue 35/2, 2015, Page(s) 186-198, ISSN 1534-5807
DOI: 10.1016/j.devcel.2015.09.018

The contemporary nucleus: A trip down memory lane

Author(s): Daniel S. Osorio, Edgar R. Gomes
Published in: Biology of the Cell, Issue 105/9, 2013, Page(s) 430-441, ISSN 0248-4900
DOI: 10.1111/boc.201300009

Moving and positioning the nucleus in skeletal muscle – one step at a time

Author(s): Bruno Cadot, Vincent Gache, Edgar R Gomes
Published in: Nucleus, Issue 6/5, 2015, Page(s) 373-381, ISSN 1949-1034
DOI: 10.1080/19491034.2015.1090073

Fast, Multi-Dimensional and Simultaneous Kymograph-Like Particle Dynamics (SkyPad) Analysis

Author(s): Bruno Cadot, Vincent Gache, Edgar R. Gomes
Published in: PLoS ONE, Issue 9/2, 2014, Page(s) e89073, ISSN 1932-6203
DOI: 10.1371/journal.pone.0089073

Computer simulations reveal complex distribution of haemodynamic forces in a mouse retina model of angiogenesis

Author(s): M. O. Bernabeu, M. L. Jones, J. H. Nielsen, T. Kruger, R. W. Nash, D. Groen, S. Schmieschek, J. Hetherington, H. Gerhardt, C. A. Franco, P. V. Coveney
Published in: Journal of The Royal Society Interface, Issue 11/99, 2014, Page(s) 20140543-20140543, ISSN 1742-5689
DOI: 10.1098/rsif.2014.0543

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

Author(s): Irene Maria Aspalter, Emma Gordon, Alexandre Dubrac, Anan Ragab, Jarek Narloch, Pedro Vizán, Ilse Geudens, Russell Thomas Collins, Claudio Areias Franco, Cristina Luna Abrahams, Gavin Thurston, Marcus Fruttiger, Ian Rosewell, Anne Eichmann, Holger Gerhardt
Published in: Nature Communications, Issue 6, 2015, Page(s) 7264, ISSN 2041-1723
DOI: 10.1038/ncomms8264

The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis

Author(s): Katie Bentley, Claudio Areias Franco, Andrew Philippides, Raquel Blanco, Martina Dierkes, Véronique Gebala, Fabio Stanchi, Martin Jones, Irene M. Aspalter, Guiseppe Cagna, Simone Weström, Lena Claesson-Welsh, Dietmar Vestweber, Holger Gerhardt
Published in: Nature Cell Biology, Issue 16/4, 2014, Page(s) 309-321, ISSN 1465-7392
DOI: 10.1038/ncb2926

Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression

Author(s): Claudio A. Franco, Martin L. Jones, Miguel O. Bernabeu, Ilse Geudens, Thomas Mathivet, Andre Rosa, Felicia M. Lopes, Aida P. Lima, Anan Ragab, Russell T. Collins, Li-Kun Phng, Peter V. Coveney, Holger Gerhardt
Published in: PLOS Biology, Issue 13/4, 2015, Page(s) e1002125, ISSN 1545-7885
DOI: 10.1371/journal.pbio.1002125

SRF selectively controls tip cell invasive behavior in angiogenesis

Author(s): C. A. Franco, J. Blanc, A. Parlakian, R. Blanco, I. M. Aspalter, N. Kazakova, N. Diguet, E. Mylonas, J. Gao-Li, A. Vaahtokari, V. Penard-Lacronique, M. Fruttiger, I. Rosewell, M. Mericskay, H. Gerhardt, Z. Li
Published in: Development, Issue 140/11, 2013, Page(s) 2321-2333, ISSN 0950-1991
DOI: 10.1242/dev.091074

Generation and Characterization of a Novel Mouse Embryonic Stem Cell Line with a Dynamic Reporter of Nanog Expression

Author(s): Elsa Abranches, Evguenia Bekman, Domingos Henrique
Published in: PLoS ONE, Issue 8/3, 2013, Page(s) e59928, ISSN 1932-6203
DOI: 10.1371/journal.pone.0059928

Glycogen Synthase Kinase-3 Inhibition Enhances Translation of Pluripotency-Associated Transcription Factors to Contribute to Maintenance of Mouse Embryonic Stem Cell Self-Renewal

Author(s): Yolanda Sanchez-Ripoll, Heather K. Bone, Tom Owen, Ana M. V. Guedes, Elsa Abranches, Benjamin Kumpfmueller, Ruth V. Spriggs, Domingos Henrique, Melanie J. Welham
Published in: PLoS ONE, Issue 8/4, 2013, Page(s) e60148, ISSN 1932-6203
DOI: 10.1371/journal.pone.0060148

Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency

Author(s): E. Abranches, A. M. V. Guedes, M. Moravec, H. Maamar, P. Svoboda, A. Raj, D. Henrique
Published in: Development, Issue 141/14, 2014, Page(s) 2770-2779, ISSN 0950-1991
DOI: 10.1242/dev.108910

Generation of sensory hair cells by genetic programming with a combination of transcription factors

Author(s): A. Costa, L. Sanchez-Guardado, S. Juniat, J. E. Gale, N. Daudet, D. Henrique
Published in: Development, Issue 142/11, 2015, Page(s) 1948-1959, ISSN 0950-1991
DOI: 10.1242/dev.119149

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo

Author(s): Kristina Preuße, Lena Tveriakhina, Karin Schuster-Gossler, Cláudia Gaspar, Alexandra Isabel Rosa, Domingos Henrique, Achim Gossler, Michael Stauber
Published in: PLOS Genetics, Issue 11/6, 2015, Page(s) e1005328, ISSN 1553-7404
DOI: 10.1371/journal.pgen.1005328

Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells

Author(s): Tiago G. Fernandes, Sofia T. Duarte, Mehrnaz Ghazvini, Cláudia Gaspar, Diana C. Santos, Ana R. Porteira, Gonçalo M. C. Rodrigues, Simone Haupt, Diogo M. Rombo, Judith Armstrong, Ana M. Sebastião, Joost Gribnau, Àngels Garcia-Cazorla, Oliver Brüstle, Domingos Henrique, Joaquim M. S. Cabral, Maria Margarida Diogo
Published in: Biotechnology Journal, Issue 10/10, 2015, Page(s) 1578-1588, ISSN 1860-6768
DOI: 10.1002/biot.201400751

Heterogeneous lineage marker expression in naive embryonic stem cells is mostly due to spontaneous differentiation

Author(s): Gautham Nair, Elsa Abranches, Ana M. V. Guedes, Domingos Henrique, Arjun Raj
Published in: Scientific Reports, Issue 5, 2015, Page(s) 13339, ISSN 2045-2322
DOI: 10.1038/srep13339

Transcriptome profiling of induced hair cells (iHCs) generated by combined expression of Gfi1, Pou4f3 and Atoh1 during embryonic stem cell differentiation

Author(s): Aida Costa, Domingos Henrique
Published in: Genomics Data, Issue 6, 2015, Page(s) 77-80, ISSN 2213-5960
DOI: 10.1016/j.gdata.2015.08.017

Neuromesodermal progenitors and the making of the spinal cord

Author(s): D. Henrique, E. Abranches, L. Verrier, K. G. Storey
Published in: Development, Issue 142/17, 2015, Page(s) 2864-2875, ISSN 0950-1991
DOI: 10.1242/dev.119768

Therapy-Induced Cellular Senescence Induces Epithelial-to-Mesenchymal Transition and Increases Invasiveness in Rectal Cancer

Author(s): Joana Tato-Costa, Sandra Casimiro, Teresa Pacheco, Ricardo Pires, Afonso Fernandes, Irina Alho, Pedro Pereira, Paulo Costa, Henrique Bicha Castelo, João Ferreira, Luís Costa
Published in: Clinical Colorectal Cancer, 2015, ISSN 1533-0028
DOI: 10.1016/j.clcc.2015.09.003

Targeting bone metastases in prostate cancer: improving clinical outcome

Author(s): Jean-Jacques Body, Sandra Casimiro, Luís Costa
Published in: Nature Reviews Urology, Issue 12/6, 2015, Page(s) 340-356, ISSN 1759-4812
DOI: 10.1038/nrurol.2015.90

Bone remodeling markers and bone metastases: From cancer research to clinical implications

Author(s): Arlindo Ferreira, Irina Alho, Sandra Casimiro, Luís Costa
Published in: BoneKEy Reports, Issue 4, 2015, Page(s) 668, ISSN 2047-6396
DOI: 10.1038/bonekey.2015.35

Metadherin expression and lung relapse in patients with colorectal carcinoma

Author(s): Sandra Casimiro, Afonso Fernandes, António Gouveia Oliveira, Marco Franco, Ricardo Pires, Mafalda Peres, Margarida Matias, Joana Tato-Costa, Nuno Guerra, Madalena Ramos, Jorge Cruz, Luis Costa
Published in: Clinical & Experimental Metastasis, Issue 31/6, 2014, Page(s) 689-696, ISSN 0262-0898
DOI: 10.1007/s10585-014-9659-0

RANKL enhances the effect of an antagonist of inhibitor of apoptosis proteins (cIAPs) in RANK-positive breast cancer cells

Author(s): S. Casimiro, I. Alho, M. Bettencourt, R. Pires, A. Lipton, L. Costa
Published in: Journal of Bone Oncology, Issue 2/3, 2013, Page(s) 116-122, ISSN 2212-1374
DOI: 10.1016/j.jbo.2013.07.001

Novel Insights into Breast Cancer Genetic Variance through RNA Sequencing

Author(s): Anelia Horvath, Suresh Babu Pakala, Prakriti Mudvari, Sirigiri Divijendra Natha Reddy, Kazufumi Ohshiro, Sandra Casimiro, Ricardo Pires, Suzanne A. W. Fuqua, Masakazu Toi, Luis Costa, Sujit S. Nair, Saraswati Sukumar, Rakesh Kumar
Published in: Scientific Reports, Issue 3, 2013, ISSN 2045-2322
DOI: 10.1038/srep02256

RANKL/RANK/MMP-1 Molecular Triad Contributes to the Metastatic Phenotype of Breast and Prostate Cancer Cells In Vitro

Author(s): Sandra Casimiro, Khalid S. Mohammad, Ricardo Pires, Joana Tato-Costa, Irina Alho, Rui Teixeira, António Carvalho, Sofia Ribeiro, Allan Lipton, Theresa A. Guise, Luis Costa
Published in: PLoS ONE, Issue 8/5, 2013, Page(s) e63153, ISSN 1932-6203
DOI: 10.1371/journal.pone.0063153

MTA1 Promotes STAT3 Transcription and Pulmonary Metastasis in Breast Cancer

Author(s): S. B. Pakala, S. K. Rayala, R.-A. Wang, K. Ohshiro, P. Mudvari, S. D. N. Reddy, Y. Zheng, R. Pires, S. Casimiro, M. R. Pillai, L. Costa, R. Kumar
Published in: Cancer Research, Issue 73/12, 2013, Page(s) 3761-3770, ISSN 0008-5472
DOI: 10.1158/0008-5472.CAN-12-3998

The role of low-molecular-weight protein tyrosine phosphatase (LMW-PTP ACP1) in oncogenesis

Author(s): Irina Alho, Luís Costa, Manuel Bicho, Constança Coelho
Published in: Tumor Biology, Issue 34/4, 2013, Page(s) 1979-1989, ISSN 1010-4283
DOI: 10.1007/s13277-013-0784-1

Treatment of Cancer Pain by Targeting Cytokines

Author(s): I. Vendrell, D. Macedo, I. Alho, M. R. Dionísio, L. Costa
Published in: Mediators of Inflammation, Issue 2015, 2015, Page(s) 1-11, ISSN 0962-9351
DOI: 10.1155/2015/984570

Low Molecular Weight Protein Tyrosine Phosphatase Isoforms Regulate Breast Cancer Cells Migration through a RhoA Dependent Mechanism

Author(s): Irina Alho, Luis Costa, Manuel Bicho, Constança Coelho
Published in: PLoS ONE, Issue 8/9, 2013, Page(s) e76307, ISSN 1932-6203
DOI: 10.1371/journal.pone.0076307

The Bone Marrow-Mediated Protection of Myeloproliferative Neoplastic Cells to Vorinostat and Ruxolitinib Relies on the Activation of JNK and PI3K Signalling Pathways

Author(s): Bruno A. Cardoso, Hélio Belo, João T. Barata, António M. Almeida
Published in: PLOS ONE, Issue 10/12, 2015, Page(s) e0143897, ISSN 1932-6203
DOI: 10.1371/journal.pone.0143897

CHK1 and replicative stress in T-cell leukemia: Can an irreverent tumor suppressor end up playing the oncogene?

Author(s): Leonor M. Sarmento, João T. Barata
Published in: Advances in Biological Regulation, Issue 60, 2016, Page(s) 115-121, ISSN 2212-4926
DOI: 10.1016/j.jbior.2015.10.007

PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia

Author(s): André Bortolini Silveira, Angelo Brunelli Albertoni Laranjeira, Gisele Olinto Libanio Rodrigues, Rodrigues Leal, Bruno António Cardoso, João Taborda Barata, Rosendo Augusto Yunes, Nilson Ivo Tonin Zanchin, Sílvia Regina Brandalise, José Andrés Yunes
Published in: Oncotarget, Issue 6/15, 2015, Page(s) 13105-13118, ISSN 1949-2553
DOI: 10.18632/oncotarget.3524

Lymphotoxin-β receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype

Author(s): Mónica T. Fernandes, Marinella N. Ghezzo, André B. Silveira, Ravi K. Kalathur, Vanda Póvoa, Ana R. Ribeiro, Sílvia R. Brandalise, Emmanuel Dejardin, Nuno L. Alves, Jacques Ghysdael, João T. Barata, José Andres Yunes, Nuno R. dos Santos
Published in: British Journal of Haematology, Issue 171/5, 2015, Page(s) 736-751, ISSN 0007-1048
DOI: 10.1111/bjh.13760

Kinases, tails and more: Regulation of PTEN function by phosphorylation

Author(s): Rita Fragoso, João T. Barata
Published in: Methods, Issue 77-78, 2015, Page(s) 75-81, ISSN 1046-2023
DOI: 10.1016/j.ymeth.2014.10.015

CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress

Author(s): L M Sarmento, V Póvoa, R Nascimento, G Real, I Antunes, L R Martins, C Moita, P M Alves, M Abecasis, L F Moita, R M E Parkhouse, J P P Meijerink, J T Barata
Published in: Oncogene, Issue 34/23, 2014, Page(s) 2978-2990, ISSN 0950-9232
DOI: 10.1038/onc.2014.248

Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics

Author(s): Diana Gaspar, João M. Freire, Teresa R. Pacheco, João T. Barata, Miguel A.R.B. Castanho
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Issue 1853/2, 2015, Page(s) 308-316, ISSN 0167-4889
DOI: 10.1016/j.bbamcr.2014.11.006

A Unified Nomenclature and Amino Acid Numbering for Human PTEN

Author(s): R. Pulido, S. J. Baker, J. T. Barata, A. Carracedo, V. J. Cid, I. D. Chin-Sang, V. Dave, J. den Hertog, P. Devreotes, B. J. Eickholt, C. Eng, F. B. Furnari, M.-M. Georgescu, A. Gericke, B. Hopkins, X. Jiang, S.-R. Lee, M. Losche, P. Malaney, X. Matias-Guiu, M. Molina, P. P. Pandolfi, R. Parsons, P. Pinton, C. Rivas, R. M. Rocha, M. S. Rodriguez, A. H. Ross, M. Serrano, V. Stambolic, B. Stiles, A.
Published in: Science Signaling, Issue 7/332, 2014, Page(s) pe15-pe15, ISSN 1937-9145
DOI: 10.1126/scisignal.2005560

PTEN and leukemia stem cells

Author(s): Rita Fragoso, João T. Barata
Published in: Advances in Biological Regulation, Issue 56, 2014, Page(s) 22-29, ISSN 2212-4926
DOI: 10.1016/j.jbior.2014.05.005

PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events

Author(s): R. D. Mendes, L. M. Sarmento, K. Cante-Barrett, L. Zuurbier, J. G. C. A. M. Buijs-Gladdines, V. Povoa, W. K. Smits, M. Abecasis, J. A. Yunes, E. Sonneveld, M. A. Horstmann, R. Pieters, J. T. Barata, J. P. P. Meijerink
Published in: Blood, Issue 124/4, 2014, Page(s) 567-578, ISSN 0006-4971
DOI: 10.1182/blood-2014-03-562751

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Author(s): A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
Published in: Haematologica, Issue 99/6, 2014, Page(s) 1062-1068, ISSN 0390-6078
DOI: 10.3324/haematol.2013.096438

Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor

Author(s): Leila R. Martins, Yasser Perera, Paulo Lúcio, Maria G. Silva, Silvio E. Perea, João T. Barata
Published in: Oncotarget, Issue 5/1, 2014, Page(s) 258-263, ISSN 1949-2553
DOI: 10.18632/oncotarget.1513

Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia

Author(s): A Lonetti, I L Antunes, F Chiarini, E Orsini, F Buontempo, F Ricci, P L Tazzari, P Pagliaro, F Melchionda, A Pession, A Bertaina, F Locatelli, J A McCubrey, J T Barata, A M Martelli
Published in: Leukemia, Issue 28/6, 2013, Page(s) 1196-1206, ISSN 0887-6924
DOI: 10.1038/leu.2013.369

IL-7R : Mr Hyde's twists and turns

Author(s): J. T. Barata
Published in: Blood, Issue 122/26, 2013, Page(s) 4151-4152, ISSN 0006-4971
DOI: 10.1182/blood-2013-11-536987

Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia

Author(s): L R Martins, P Lúcio, A Melão, I Antunes, B A Cardoso, R Stansfield, M T S Bertilaccio, P Ghia, D Drygin, M G Silva, J T Barata
Published in: Leukemia, Issue 28/1, 2013, Page(s) 179-182, ISSN 0887-6924
DOI: 10.1038/leu.2013.232

Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia

Author(s): N C Correia, K Durinck, A P Leite, M Ongenaert, P Rondou, F Speleman, F J Enguita, J T Barata
Published in: Leukemia, Issue 27/7, 2013, Page(s) 1603-1606, ISSN 0887-6924
DOI: 10.1038/leu.2013.63

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

Author(s): F Buontempo, E Orsini, L R Martins, I Antunes, A Lonetti, F Chiarini, G Tabellini, C Evangelisti, C Evangelisti, F Melchionda, A Pession, A Bertaina, F Locatelli, J A McCubrey, A Cappellini, J T Barata, A M Martelli
Published in: Leukemia, Issue 28/3, 2013, Page(s) 543-553, ISSN 0887-6924
DOI: 10.1038/leu.2013.349

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia

Author(s): Daniel Ribeiro, Alice Melão, João T. Barata
Published in: Advances in Biological Regulation, Issue 53/2, 2013, Page(s) 211-222, ISSN 2212-4926
DOI: 10.1016/j.jbior.2012.10.005

N-Cadherin Locks Left-Right Asymmetry by Ending the Leftward Movement of Hensen’s Node Cells

Author(s): Raquel V. Mendes, Gabriel G. Martins, Ana M. Cristovão, Leonor Saúde
Published in: Developmental Cell, Issue 30/3, 2014, Page(s) 353-360, ISSN 1534-5807
DOI: 10.1016/j.devcel.2014.06.010

Notch Signalling Is Required for the Formation of Structurally Stable Muscle Fibres in Zebrafish

Author(s): Susana Pascoal, Joana Esteves de Lima, Jonathan D. Leslie, Simon M. Hughes, Leonor Saúde
Published in: PLoS ONE, Issue 8/6, 2013, Page(s) e68021, ISSN 1932-6203
DOI: 10.1371/journal.pone.0068021

miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Author(s): Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
Published in: Journal of Hematology & Oncology, Issue 6/1, 2013, Page(s) 87, ISSN 1756-8722
DOI: 10.1186/1756-8722-6-87

Bone Marrow-Derived CD11b+Jagged2+ Cells Promote Epithelial-to-Mesenchymal Transition and Metastasization in Colorectal Cancer

Author(s): F. Caiado, T. Carvalho, I. Rosa, L. Remedio, A. Costa, J. Matos, B. Heissig, H. Yagita, K. Hattori, J. P. da Silva, P. Fidalgo, A. D. Pereira, S. Dias
Published in: Cancer Research, Issue 73/14, 2013, Page(s) 4233-4246, ISSN 0008-5472
DOI: 10.1158/0008-5472.CAN-13-0085

Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression

Author(s): Catarina Rodrigues dos Santos, Isabel Fonseca, Sérgio Dias, JC Mendes de Almeida
Published in: BMC Cancer, Issue 14/1, 2014, Page(s) 132, ISSN 1471-2407
DOI: 10.1186/1471-2407-14-132

LDL-cholesterol signaling induces breast cancer proliferation and invasion

Author(s): Catarina Rodrigues dos Santos, Germana Domingues, Inês Matias, João Matos, Isabel Fonseca, José de Almeida, Sérgio Dias
Published in: Lipids in Health and Disease, Issue 13/1, 2014, Page(s) 16, ISSN 1476-511X
DOI: 10.1186/1476-511X-13-16

In Vitro and In Vivo Analysis of RTK Inhibitor Efficacy and Identification of Its Novel Targets in Glioblastomas

Author(s): Olga Martinho, Renato Silva-Oliveira, Vera Miranda-Gonçalves, Carlos Clara, José Reynaldo Almeida, André Lopes Carvalho, João Taborda Barata, Rui Manuel Reis
Published in: Translational Oncology, Issue 6/2, 2013, Page(s) 187-IN20, ISSN 1936-5233
DOI: 10.1593/tlo.12400

Connecting the Nucleus to the Cytoskeleton for Nuclear Positioning and Cell Migration

Author(s): Daniel S. Osorio, Edgar R. Gomes
Published in: Cancer Biology and the Nuclear Envelope, 2014, Page(s) 505-520
DOI: 10.1007/978-1-4899-8032-8_23

Skeletal Muscle

Author(s): B. Cadot, E.R. Gomes
Published in: Encyclopedia of Cell Biology, 2016, Page(s) 677-682
DOI: 10.1016/B978-0-12-394447-4.20065-5

Imaging Pluripotency: Time-Lapse Analysis of Mouse Embryonic Stem Cells

Author(s): Anna Pezzarossa, Ana M. V. Guedes, Domingos Henrique, Elsa Abranches
Published in: Embryonic Stem Cell Protocols, 2016, Page(s) 87-100
DOI: 10.1007/7651_2015_255