Towards outstanding research and training in tumour biology at IMM

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

High Resolution Microscopy Workshop
EC Performance Indicators Widening indicator application for the 3-year window time prior to ReTuBi

EC Performance Indicators Widening indicator application for the 3-year window time prior to ReTuBi

Second edition of the High-Resolution Microscopy Workshop

A second edition of the High-Resolution Microscopy Workshop will be organized on M34 due to the successful implementation of the first edition, the successful accomplishment of the objectives and the growing demand from the partnering institutions on participating in these type of practical activity.

Second edition of the Career development and soft skills for young scientists

A second edition of thethe Career development and soft skills for young scientists – From Lisbon to the World Workshop will be organized on M26 due to the successful implementation of the first edition, the successful accomplishment of the objectives and the growing demand from the partnering institutions on participating in these type of practical activity.

Career development and soft skills for young scientists
Brochure and flyer

ReTuBi website and logo

Publicaciones

CHK1 and replicative stress in T-cell leukemia: Can an irreverent tumor suppressor end up playing the oncogene?

Autores: Leonor M. Sarmento, João T. Barata
Publicado en: Advances in Biological Regulation, Edición 60, 2016, Página(s) 115-121, ISSN 2212-4926
Editor: Elsevier BV
DOI: 10.1016/j.jbior.2015.10.007

Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor

Autores: Leila R. Martins, Yasser Perera, Paulo Lúcio, Maria G. Silva, Silvio E. Perea, João T. Barata
Publicado en: Oncotarget, Edición 5/1, 2014, Página(s) 258-263, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.1513

CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress

Autores: L M Sarmento, V Póvoa, R Nascimento, G Real, I Antunes, L R Martins, C Moita, P M Alves, M Abecasis, L F Moita, R M E Parkhouse, J P P Meijerink, J T Barata
Publicado en: Oncogene, Edición 34/23, 2014, Página(s) 2978-2990, ISSN 0950-9232
Editor: Nature Publishing Group
DOI: 10.1038/onc.2014.248

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

Autores: Irene Maria Aspalter, Emma Gordon, Alexandre Dubrac, Anan Ragab, Jarek Narloch, Pedro Vizán, Ilse Geudens, Russell Thomas Collins, Claudio Areias Franco, Cristina Luna Abrahams, Gavin Thurston, Marcus Fruttiger, Ian Rosewell, Anne Eichmann, Holger Gerhardt
Publicado en: Nature Communications, Edición 6, 2015, Página(s) 7264, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms8264

Targeting bone metastases in prostate cancer: improving clinical outcome

Autores: Jean-Jacques Body, Sandra Casimiro, Luís Costa
Publicado en: Nature Reviews Urology, Edición 12/6, 2015, Página(s) 340-356, ISSN 1759-4812
Editor: Nature Publishing Group
DOI: 10.1038/nrurol.2015.90

Computer simulations reveal complex distribution of haemodynamic forces in a mouse retina model of angiogenesis

Autores: M. O. Bernabeu, M. L. Jones, J. H. Nielsen, T. Kruger, R. W. Nash, D. Groen, S. Schmieschek, J. Hetherington, H. Gerhardt, C. A. Franco, P. V. Coveney
Publicado en: Journal of The Royal Society Interface, Edición 11/99, 2014, Página(s) 20140543-20140543, ISSN 1742-5689
Editor: The Royal Society
DOI: 10.1098/rsif.2014.0543

Novel Insights into Breast Cancer Genetic Variance through RNA Sequencing

Autores: Anelia Horvath, Suresh Babu Pakala, Prakriti Mudvari, Sirigiri Divijendra Natha Reddy, Kazufumi Ohshiro, Sandra Casimiro, Ricardo Pires, Suzanne A. W. Fuqua, Masakazu Toi, Luis Costa, Sujit S. Nair, Saraswati Sukumar, Rakesh Kumar
Publicado en: Scientific Reports, Edición 3, 2013, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep02256

LDL-cholesterol signaling induces breast cancer proliferation and invasion

Autores: Catarina Rodrigues dos Santos, Germana Domingues, Inês Matias, João Matos, Isabel Fonseca, José de Almeida, Sérgio Dias
Publicado en: Lipids in Health and Disease, Edición 13/1, 2014, Página(s) 16, ISSN 1476-511X
Editor: BioMed Central
DOI: 10.1186/1476-511X-13-16

SRF selectively controls tip cell invasive behavior in angiogenesis

Autores: C. A. Franco, J. Blanc, A. Parlakian, R. Blanco, I. M. Aspalter, N. Kazakova, N. Diguet, E. Mylonas, J. Gao-Li, A. Vaahtokari, V. Penard-Lacronique, M. Fruttiger, I. Rosewell, M. Mericskay, H. Gerhardt, Z. Li
Publicado en: Development, Edición 140/11, 2013, Página(s) 2321-2333, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.091074

A Unified Nomenclature and Amino Acid Numbering for Human PTEN

Autores: R. Pulido, S. J. Baker, J. T. Barata, A. Carracedo, V. J. Cid, I. D. Chin-Sang, V. Dave, J. den Hertog, P. Devreotes, B. J. Eickholt, C. Eng, F. B. Furnari, M.-M. Georgescu, A. Gericke, B. Hopkins, X. Jiang, S.-R. Lee, M. Losche, P. Malaney, X. Matias-Guiu, M. Molina, P. P. Pandolfi, R. Parsons, P. Pinton, C. Rivas, R. M. Rocha, M. S. Rodriguez, A. H. Ross, M. Serrano, V. Stambolic, B. Stiles, A. Suzuki, S.-S. Tan, N. K. Tonks, L. C. Trotman, N. Wolff, R. Woscholski, H. Wu, N. R. Leslie
Publicado en: Science Signaling, Edición 7/332, 2014, Página(s) pe15-pe15, ISSN 1937-9145
Editor: American Association for the Advancement of Science
DOI: 10.1126/scisignal.2005560

Heterogeneous lineage marker expression in naive embryonic stem cells is mostly due to spontaneous differentiation

Autores: Gautham Nair, Elsa Abranches, Ana M. V. Guedes, Domingos Henrique, Arjun Raj
Publicado en: Scientific Reports, Edición 5, 2015, Página(s) 13339, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep13339

Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia

Autores: A Lonetti, I L Antunes, F Chiarini, E Orsini, F Buontempo, F Ricci, P L Tazzari, P Pagliaro, F Melchionda, A Pession, A Bertaina, F Locatelli, J A McCubrey, J T Barata, A M Martelli
Publicado en: Leukemia, Edición 28/6, 2013, Página(s) 1196-1206, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2013.369

Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency

Autores: E. Abranches, A. M. V. Guedes, M. Moravec, H. Maamar, P. Svoboda, A. Raj, D. Henrique
Publicado en: Development, Edición 141/14, 2014, Página(s) 2770-2779, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.108910

PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events

Autores: R. D. Mendes, L. M. Sarmento, K. Cante-Barrett, L. Zuurbier, J. G. C. A. M. Buijs-Gladdines, V. Povoa, W. K. Smits, M. Abecasis, J. A. Yunes, E. Sonneveld, M. A. Horstmann, R. Pieters, J. T. Barata, J. P. P. Meijerink
Publicado en: Blood, Edición 124/4, 2014, Página(s) 567-578, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2014-03-562751

Fast, Multi-Dimensional and Simultaneous Kymograph-Like Particle Dynamics (SkyPad) Analysis

Autores: Bruno Cadot, Vincent Gache, Edgar R. Gomes
Publicado en: PLoS ONE, Edición 9/2, 2014, Página(s) e89073, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0089073

PTEN and leukemia stem cells

Autores: Rita Fragoso, João T. Barata
Publicado en: Advances in Biological Regulation, Edición 56, 2014, Página(s) 22-29, ISSN 2212-4926
Editor: Elsevier BV
DOI: 10.1016/j.jbior.2014.05.005

Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression

Autores: Claudio A. Franco, Martin L. Jones, Miguel O. Bernabeu, Ilse Geudens, Thomas Mathivet, Andre Rosa, Felicia M. Lopes, Aida P. Lima, Anan Ragab, Russell T. Collins, Li-Kun Phng, Peter V. Coveney, Holger Gerhardt
Publicado en: PLOS Biology, Edición 13/4, 2015, Página(s) e1002125, ISSN 1545-7885
Editor: PLOS
DOI: 10.1371/journal.pbio.1002125

Bone remodeling markers and bone metastases: From cancer research to clinical implications

Autores: Arlindo Ferreira, Irina Alho, Sandra Casimiro, Luís Costa
Publicado en: BoneKEy Reports, Edición 4, 2015, Página(s) 668, ISSN 2047-6396
Editor: Nature Publishing Group
DOI: 10.1038/bonekey.2015.35

Notch Signalling Is Required for the Formation of Structurally Stable Muscle Fibres in Zebrafish

Autores: Susana Pascoal, Joana Esteves de Lima, Jonathan D. Leslie, Simon M. Hughes, Leonor Saúde
Publicado en: PLoS ONE, Edición 8/6, 2013, Página(s) e68021, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0068021

Low Molecular Weight Protein Tyrosine Phosphatase Isoforms Regulate Breast Cancer Cells Migration through a RhoA Dependent Mechanism

Autores: Irina Alho, Luis Costa, Manuel Bicho, Constança Coelho
Publicado en: PLoS ONE, Edición 8/9, 2013, Página(s) e76307, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0076307

miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Autores: Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
Publicado en: Journal of Hematology & Oncology, Edición 6/1, 2013, Página(s) 87, ISSN 1756-8722
Editor: BioMed Central
DOI: 10.1186/1756-8722-6-87

Neuromesodermal progenitors and the making of the spinal cord

Autores: D. Henrique, E. Abranches, L. Verrier, K. G. Storey
Publicado en: Development, Edición 142/17, 2015, Página(s) 2864-2875, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.119768

Kinases, tails and more: Regulation of PTEN function by phosphorylation

Autores: Rita Fragoso, João T. Barata
Publicado en: Methods, Edición 77-78, 2015, Página(s) 75-81, ISSN 1046-2023
Editor: Academic Press
DOI: 10.1016/j.ymeth.2014.10.015

Glycogen Synthase Kinase-3 Inhibition Enhances Translation of Pluripotency-Associated Transcription Factors to Contribute to Maintenance of Mouse Embryonic Stem Cell Self-Renewal

Autores: Yolanda Sanchez-Ripoll, Heather K. Bone, Tom Owen, Ana M. V. Guedes, Elsa Abranches, Benjamin Kumpfmueller, Ruth V. Spriggs, Domingos Henrique, Melanie J. Welham
Publicado en: PLoS ONE, Edición 8/4, 2013, Página(s) e60148, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0060148

Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia

Autores: N C Correia, K Durinck, A P Leite, M Ongenaert, P Rondou, F Speleman, F J Enguita, J T Barata
Publicado en: Leukemia, Edición 27/7, 2013, Página(s) 1603-1606, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2013.63

N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy

Autores: S. Falcone, W. Roman, K. Hnia, V. Gache, N. Didier, J. Laine, F. Aurade, I. Marty, I. Nishino, N. Charlet-Berguerand, N. B. Romero, G. Marazzi, D. Sassoon, J. Laporte, E. R. Gomes
Publicado en: EMBO Molecular Medicine, Edición 6/11, 2014, Página(s) 1455-1475, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201404436

RANKL/RANK/MMP-1 Molecular Triad Contributes to the Metastatic Phenotype of Breast and Prostate Cancer Cells In Vitro

Autores: Sandra Casimiro, Khalid S. Mohammad, Ricardo Pires, Joana Tato-Costa, Irina Alho, Rui Teixeira, António Carvalho, Sofia Ribeiro, Allan Lipton, Theresa A. Guise, Luis Costa
Publicado en: PLoS ONE, Edición 8/5, 2013, Página(s) e63153, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0063153

Lymphotoxin-β receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype

Autores: Mónica T. Fernandes, Marinella N. Ghezzo, André B. Silveira, Ravi K. Kalathur, Vanda Póvoa, Ana R. Ribeiro, Sílvia R. Brandalise, Emmanuel Dejardin, Nuno L. Alves, Jacques Ghysdael, João T. Barata, José Andres Yunes, Nuno R. dos Santos
Publicado en: British Journal of Haematology, Edición 171/5, 2015, Página(s) 736-751, ISSN 0007-1048
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bjh.13760

In Vitro and In Vivo Analysis of RTK Inhibitor Efficacy and Identification of Its Novel Targets in Glioblastomas

Autores: Olga Martinho, Renato Silva-Oliveira, Vera Miranda-Gonçalves, Carlos Clara, José Reynaldo Almeida, André Lopes Carvalho, João Taborda Barata, Rui Manuel Reis
Publicado en: Translational Oncology, Edición 6/2, 2013, Página(s) 187-IN20, ISSN 1936-5233
Editor: Neoplasia Press
DOI: 10.1593/tlo.12400

Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression

Autores: Catarina Rodrigues dos Santos, Isabel Fonseca, Sérgio Dias, JC Mendes de Almeida
Publicado en: BMC Cancer, Edición 14/1, 2014, Página(s) 132, ISSN 1471-2407
Editor: BioMed Central
DOI: 10.1186/1471-2407-14-132

IL-7R : Mr Hyde's twists and turns

Autores: J. T. Barata
Publicado en: Blood, Edición 122/26, 2013, Página(s) 4151-4152, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2013-11-536987

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Autores: A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
Publicado en: Haematologica, Edición 99/6, 2014, Página(s) 1062-1068, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.096438

MTA1 Promotes STAT3 Transcription and Pulmonary Metastasis in Breast Cancer

Autores: S. B. Pakala, S. K. Rayala, R.-A. Wang, K. Ohshiro, P. Mudvari, S. D. N. Reddy, Y. Zheng, R. Pires, S. Casimiro, M. R. Pillai, L. Costa, R. Kumar
Publicado en: Cancer Research, Edición 73/12, 2013, Página(s) 3761-3770, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-12-3998

N-Cadherin Locks Left-Right Asymmetry by Ending the Leftward Movement of Hensen’s Node Cells

Autores: Raquel V. Mendes, Gabriel G. Martins, Ana M. Cristovão, Leonor Saúde
Publicado en: Developmental Cell, Edición 30/3, 2014, Página(s) 353-360, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2014.06.010

Therapy-Induced Cellular Senescence Induces Epithelial-to-Mesenchymal Transition and Increases Invasiveness in Rectal Cancer

Autores: Joana Tato-Costa, Sandra Casimiro, Teresa Pacheco, Ricardo Pires, Afonso Fernandes, Irina Alho, Pedro Pereira, Paulo Costa, Henrique Bicha Castelo, João Ferreira, Luís Costa
Publicado en: Clinical Colorectal Cancer, 2015, ISSN 1533-0028
Editor: Cancer Information Group
DOI: 10.1016/j.clcc.2015.09.003

The role of low-molecular-weight protein tyrosine phosphatase (LMW-PTP ACP1) in oncogenesis

Autores: Irina Alho, Luís Costa, Manuel Bicho, Constança Coelho
Publicado en: Tumor Biology, Edición 34/4, 2013, Página(s) 1979-1989, ISSN 1010-4283
Editor: Springer Verlag
DOI: 10.1007/s13277-013-0784-1

Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking the Nuclear Envelope to the Actin and Microtubule Cytoskeleton

Autores: Manuela D’Alessandro, Karim Hnia, Vincent Gache, Catherine Koch, Christos Gavriilidis, David Rodriguez, Anne-Sophie Nicot, Norma B. Romero, Yannick Schwab, Edgar Gomes, Michel Labouesse, Jocelyn Laporte
Publicado en: Developmental Cell, Edición 35/2, 2015, Página(s) 186-198, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2015.09.018

PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia

Autores: André Bortolini Silveira, Angelo Brunelli Albertoni Laranjeira, Gisele Olinto Libanio Rodrigues, Rodrigues Leal, Bruno António Cardoso, João Taborda Barata, Rosendo Augusto Yunes, Nilson Ivo Tonin Zanchin, Sílvia Regina Brandalise, José Andrés Yunes
Publicado en: Oncotarget, Edición 6/15, 2015, Página(s) 13105-13118, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.3524

The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis

Autores: Katie Bentley, Claudio Areias Franco, Andrew Philippides, Raquel Blanco, Martina Dierkes, Véronique Gebala, Fabio Stanchi, Martin Jones, Irene M. Aspalter, Guiseppe Cagna, Simone Weström, Lena Claesson-Welsh, Dietmar Vestweber, Holger Gerhardt
Publicado en: Nature Cell Biology, Edición 16/4, 2014, Página(s) 309-321, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/ncb2926

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo

Autores: Kristina Preuße, Lena Tveriakhina, Karin Schuster-Gossler, Cláudia Gaspar, Alexandra Isabel Rosa, Domingos Henrique, Achim Gossler, Michael Stauber
Publicado en: PLOS Genetics, Edición 11/6, 2015, Página(s) e1005328, ISSN 1553-7404
Editor: PLOS
DOI: 10.1371/journal.pgen.1005328

Computational fluid dynamics assisted characterization of parafoveal hemodynamics in normal and diabetic eyes using adaptive optics scanning laser ophthalmoscopy

Autores: Yang Lu, Miguel O. Bernabeu, Jan Lammer, Charles C. Cai, Martin L. Jones, Claudio A. Franco, Lloyd Paul Aiello, Jennifer K. Sun
Publicado en: Biomedical Optics Express, Edición 7/12, 2016, Página(s) 4958, ISSN 2156-7085
Editor: The Optical Society
DOI: 10.1364/BOE.7.004958

A system for studying mechanisms of neuromuscular junction development and maintenance

Autores: Valérie Vilmont, Bruno Cadot, Gilles Ouanounou, Edgar R. Gomes
Publicado en: Development, Edición 143/13, 2016, Página(s) 2464-2477, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.130278

The impact of chronic intermittent hypoxia on hematopoiesis and the bone marrow microenvironment

Autores: Inês Alvarez-Martins, Leonor Remédio, Inês Matias, Lucília N. Diogo, Emília C. Monteiro, Sérgio Dias
Publicado en: Pflügers Archiv - European Journal of Physiology, Edición 468/5, 2016, Página(s) 919-932, ISSN 0031-6768
Editor: Springer Verlag
DOI: 10.1007/s00424-016-1797-6

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

Autores: Susana L. Silva, Adriana S. Albuquerque, Ana Serra-Caetano, Russell B. Foxall, Ana R. Pires, Paula Matoso, Susana M. Fernandes, João Ferreira, Rémi Cheynier, Rui M. M. Victorino, Iris Caramalho, João T. Barata, Ana E. Sousa
Publicado en: Oncotarget, Edición 7/11, 2016, Página(s) 12163-12175, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.7512

FOXO1 couples metabolic activity and growth state in the vascular endothelium

Autores: Kerstin Wilhelm, Katharina Happel, Guy Eelen, Sandra Schoors, Mark F. Oellerich, Radiance Lim, Barbara Zimmermann, Irene M. Aspalter, Claudio A. Franco, Thomas Boettger, Thomas Braun, Marcus Fruttiger, Klaus Rajewsky, Charles Keller, Jens C. Brüning, Holger Gerhardt, Peter Carmeliet, Michael Potente
Publicado en: Nature, Edición 529/7585, 2016, Página(s) 216-220, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature16498

Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

Autores: Ivan Quétier, Jacqueline J.T. Marshall, Bradley Spencer-Dene, Sylvie Lachmann, Adele Casamassima, Claudio Franco, Sarah Escuin, Joseph T. Worrall, Priththivika Baskaran, Vinothini Rajeeve, Michael Howell, Andrew J. Copp, Gordon Stamp, Ian Rosewell, Pedro Cutillas, Holger Gerhardt, Peter J. Parker, Angus J.M. Cameron
Publicado en: Cell Reports, Edición 14/3, 2016, Página(s) 440-448, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2015.12.049

Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity

Autores: Alice Melão, Maureen Spit, Bruno A. Cardoso, João T. Barata
Publicado en: Haematologica, Edición 101/11, 2016, Página(s) 1368-1379, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.141143

LDL-Cholesterol Increases the Transcytosis of Molecules through Endothelial Monolayers

Autores: Ana Magalhaes, Inês Matias, Inês Palmela, Maria Alexandra Brito, Sérgio Dias
Publicado en: PLOS ONE, Edición 11/10, 2016, Página(s) e0163988, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0163988

microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia

Autores: Nádia C. Correia, Alice Melão, Vanda Póvoa, Leonor Sarmento, Marta Gómez de Cedrón, Marcos Malumbres, Francisco J. Enguita, João T. Barata
Publicado en: Oncotarget, Edición 7/7, 2016, Página(s) 8268-8281, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.6987

Blood flow boosts BMP signaling to keep vessels in shape

Autores: Claudio A. Franco, Holger Gerhardt
Publicado en: The Journal of Cell Biology, Edición 214/7, 2016, Página(s) 793-795, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.201609038

Endothelial cell dynamics in vascular remodelling

Autores: Pedro Barbacena, Joana R. Carvalho, Claudio A. Franco
Publicado en: Clinical Hemorheology and Microcirculation, Edición 64/4, 2017, Página(s) 557-563, ISSN 1386-0291
Editor: IOS Press
DOI: 10.3233/CH-168006

Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice

Autores: Sandra Trindade, Filipa Rijo-Ferreira, Tânia Carvalho, Daniel Pinto-Neves, Fabien Guegan, Francisco Aresta-Branco, Fabio Bento, Simon A. Young, Andreia Pinto, Jan Van Den Abbeele, Ruy M. Ribeiro, Sérgio Dias, Terry K. Smith, Luisa M. Figueiredo
Publicado en: Cell Host & Microbe, Edición 19/6, 2016, Página(s) 837-848, ISSN 1931-3128
Editor: Cell Press
DOI: 10.1016/j.chom.2016.05.002

Dynein disruption perturbs post-synaptic components and contributes to impaired MuSK clustering at the NMJ: implication in ALS

Autores: Valérie Vilmont, Bruno Cadot, Elsa Vezin, Fabien Le Grand, Edgar R. Gomes
Publicado en: Scientific Reports, Edición 6/1, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep27804

Inoculated Cell Density as a Determinant Factor of the Growth Dynamics and Metastatic Efficiency of a Breast Cancer Murine Model

Autores: Ana C. Gregório, Nuno A. Fonseca, Vera Moura, Manuela Lacerda, Paulo Figueiredo, Sérgio Simões, Sérgio Dias, João Nuno Moreira
Publicado en: PLOS ONE, Edición 11/11, 2016, Página(s) e0165817, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0165817

Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling

Autores: Claudio A Franco, Martin L Jones, Miguel O Bernabeu, Anne-Clemence Vion, Pedro Barbacena, Jieqing Fan, Thomas Mathivet, Catarina G Fonseca, Anan Ragab, Terry P Yamaguchi, Peter V Coveney, Richard A Lang, Holger Gerhardt
Publicado en: eLife, Edición 5, 2016, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/eLife.07727

MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia

Autores: Nádia C. Correia, Rita Fragoso, Tânia Carvalho, Francisco J. Enguita, João T. Barata
Publicado en: Scientific Reports, Edición 6/1, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep31894

Organização e implementação de uma consulta de cardio‐oncologia

Autores: Manuela Fiuza, Leonor Ribeiro, Andreia Magalhães, Ana Rita Sousa, Miguel Nobre Menezes, Marília Jorge, Luís Costa, Fausto José Pinto
Publicado en: Revista Portuguesa de Cardiologia, Edición 35/9, 2016, Página(s) 485-494, ISSN 0870-2551
Editor: Sociedade Portuguesa De Cardiologia
DOI: 10.1016/j.repc.2016.04.006

The prognostic role of RANK SNP rs34945627 in breast cancer patients with bone metastases

Autores: Arlindo Ferreira, Irina Alho, Inês Vendrell, Marta Melo, Raquel Brás, Ana Lúcia Costa, Ana Rita Sousa, André Mansinho, Catarina Abreu, Catarina Pulido, Daniela Macedo, Teresa Pacheco, Lurdes Correia, Luis Costa, Sandra Casimiro
Publicado en: Oncotarget, Edición 7/27, 2016, Página(s) 41380-41389, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.9356

N-Telopeptide of Type I Collagen Long-Term Dynamics in Breast Cancer Patients With Bone Metastases: Clinical Outcomes and Influence of Extraskeletal Metastases

Autores: A. R. Ferreira, I. Alho, N. Shan, M. Matias, M. Faria, S. Casimiro, K. Leitzel, S. Ali, A. Lipton, L. Costa
Publicado en: The Oncologist, Edición 21/12, 2016, Página(s) 1418-1426, ISSN 1083-7159
Editor: AlphaMed Press Inc
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Radiolabeled block copolymer micelles for image-guided drug delivery

Autores: Elisabete Ribeiro, Irina Alho, Fernanda Marques, Lurdes Gano, Isabel Correia, João D.G. Correia, Sandra Casimiro, Luís Costa, Isabel Santos, Célia Fernandes
Publicado en: International Journal of Pharmaceutics, Edición 515/1-2, 2016, Página(s) 692-701, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2016.11.004

Dynamic modeling of bone metastasis, microenvironment and therapy

Autores: Rui Moura Coelho, João Miranda Lemos, Irina Alho, Duarte Valério, Arlindo R Ferreira, Luís Costa, Susana Vinga
Publicado en: Journal of Theoretical Biology, Edición 391, 2016, Página(s) 1-12, ISSN 0022-5193
Editor: Academic Press
DOI: 10.1016/j.jtbi.2015.11.024

Variation in type of adjuvant chemotherapy received among patients with stage I breast cancer: A multi-institutional Portuguese cohort study

Autores: Arlindo R. Ferreira, Ana Palha, Lurdes Correia, Pedro Filipe, Vasco Rodrigues, Luís Costa, Ana Miranda, Rosário André, João Fernandes, Joaquim Gouveia, José Luís Passos-Coelho, António Moreira, Margarida Brito, Joana Ribeiro, Otto Metzger-Filho, Nancy U. Lin, Inês Vaz-Luís
Publicado en: The Breast, Edición 29, 2016, Página(s) 68-73, ISSN 0960-9776
Editor: Churchill Livingstone
DOI: 10.1016/j.breast.2016.07.004

Molecular Mechanisms of Bone Metastasis: Which Targets Came from the Bench to the Bedside?

Autores: Sandra Casimiro, Arlindo Ferreira, André Mansinho, Irina Alho, Luis Costa
Publicado en: International Journal of Molecular Sciences, Edición 17/9, 2016, Página(s) 1415, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms17091415

Health resource utilization associated with skeletal-related events: results from a retrospective European study

Autores: Jean-Jacques Body, João Pereira, Harm Sleeboom, Nikos Maniadakis, Evangelos Terpos, Yves Pascal Acklin, Jindrich Finek, Oliver Gunther, Guy Hechmati, Tony Mossman, Luis Costa, Wojciech Rogowski, Hareth Nahi, Roger von Moos
Publicado en: The European Journal of Health Economics, Edición 17/6, 2016, Página(s) 711-721, ISSN 1618-7598
Editor: Springer Verlag
DOI: 10.1007/s10198-015-0716-7

Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells

Autores: Petra Gimpel, Yin Loon Lee, Radoslaw M. Sobota, Alessandra Calvi, Victoria Koullourou, Rutti Patel, Kamel Mamchaoui, François Nédélec, Sue Shackleton, Jan Schmoranzer, Brian Burke, Bruno Cadot, Edgar R. Gomes
Publicado en: Current Biology, Edición 27/19, 2017, Página(s) 2999-3009.e9, ISSN 0960-9822
Editor: Cell Press
DOI: 10.1016/j.cub.2017.08.031

Myofibril contraction and crosslinking drive nuclear movement to the periphery of skeletal muscle

Autores: William Roman, João P. Martins, Filomena A. Carvalho, Raphael Voituriez, Jasmine V. G. Abella, Nuno C. Santos, Bruno Cadot, Michael Way, Edgar R. Gomes
Publicado en: Nature Cell Biology, Edición 19/10, 2017, Página(s) 1189-1201, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/ncb3605

<em>In Vitro</em> Differentiation of Mature Myofibers for Live Imaging

Autores: Mafalda R. Pimentel, Sestina Falcone, Bruno Cadot, Edgar R. Gomes
Publicado en: Journal of Visualized Experiments, Edición 119, 2017, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/55141

Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia

Autores: Cecilia Evangelisti, Alessandra Cappellini, Mariana Oliveira, Rita Fragoso, João T. Barata, Alice Bertaina, Franco Locatelli, Carolina Simioni, Luca M. Neri, Francesca Chiarini, Annalisa Lonetti, Francesca Buontempo, Ester Orsini, Andrea Pession, Lucia Manzoli, Alberto Maria Martelli, Camilla Evangelisti
Publicado en: Journal of Cellular Physiology, 2017, ISSN 0021-9541
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jcp.26135

From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia

Autores: Mariana L. Oliveira, Padma Akkapeddi, Isabel Alcobia, Afonso R. Almeida, Bruno A. Cardoso, Rita Fragoso, Teresa L. Serafim, João T. Barata
Publicado en: Cellular Signalling, Edición 38, 2017, Página(s) 10-25, ISSN 0898-6568
Editor: Elsevier BV
DOI: 10.1016/j.cellsig.2017.06.011

IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity

Autores: Susana L. Silva, Adriana S. Albuquerque, Paula Matoso, Bénédicte Charmeteau-de-Muylder, Rémi Cheynier, Dário Ligeiro, Miguel Abecasis, Rui Anjos, João T. Barata, Rui M. M. Victorino, Ana E. Sousa
Publicado en: Frontiers in Immunology, Edición 8, 2017, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.00020

Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks

Autores: Claudio A. Franco, Holger Gerhardt
Publicado en: Developmental Cell, Edición 41/6, 2017, Página(s) 574-576, ISSN 1534-5807
Editor: Cell Press
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Radionuclides in oncology clinical practice – review of the literature

Autores: Helena Luna Pais, Irina Alho, Inês Vendrell, André Mansinho, Luís Costa
Publicado en: Dalton Transactions, Edición 46/42, 2017, Página(s) 14475-14487, ISSN 1477-9226
Editor: Royal Society of Chemistry
DOI: 10.1039/C7DT01929G

Bone metastasis risk factors in breast cancer

Autores: Catarina Pulido, Inês Vendrell, Arlindo R Ferreira, Sandra Casimiro, André Mansinho, Irina Alho, Luís Costa
Publicado en: ecancermedicalscience, Edición 11, 2017, ISSN 1754-6605
Editor: Ecancermedicalscience
DOI: 10.3332/ecancer.2017.715

Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer

Autores: Barbara Tavares, Raquel Jacinto, Pedro Sampaio, Sara Pestana, Andreia Pinto, Andreia Vaz, Mónica Roxo-Rosa, Rui Gardner, Telma Lopes, Britta Schilling, Ian Henry, Leonor Saúde, Susana Santos Lopes
Publicado en: eLife, Edición 6, 2017, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/eLife.25165

Improving quality of life in patients with advanced cancer: Targeting metastatic bone pain

Autores: Roger von Moos, Luis Costa, Carla Ida Ripamonti, Daniela Niepel, Daniele Santini
Publicado en: European Journal of Cancer, Edición 71, 2017, Página(s) 80-94, ISSN 0959-8049
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2016.10.021

Gold Nanobeacons for Tracking Gene Silencing in Zebrafish

Autores: Milton Cordeiro, Lara Carvalho, Joana Silva, Leonor Saúde, Alexandra Fernandes, Pedro Baptista
Publicado en: Nanomaterials, Edición 7/1, 2017, Página(s) 10, ISSN 2079-4991
Editor: Nanomaterials
DOI: 10.3390/nano7010010

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium( ii ) catalyst

Autores: Terence T.-L. Kwan, Omar Boutureira, Elizabeth C. Frye, Stephen J. Walsh, Moni K. Gupta, Stephen Wallace, Yuteng Wu, Fengzhi Zhang, Hannah F. Sore, Warren R. J. D. Galloway, Jason W. Chin, Martin Welch, Gonçalo J. L. Bernardes, David R. Spring
Publicado en: Chem. Sci., Edición 8/5, 2017, Página(s) 3871-3878, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/c6sc05313k

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases

Autores: Jean B. Bertoldo, Tiago Rodrigues, Lavinia Dunsmore, Francesco A. Aprile, Marta C. Marques, Leonardo A. Rosado, Omar Boutureira, Thomas B. Steinbrecher, Woody Sherman, Francisco Corzana, Hernán Terenzi, Gonçalo J.L. Bernardes
Publicado en: Chem, Edición 3/4, 2017, Página(s) 665-677, ISSN 2451-9294
Editor: Chem
DOI: 10.1016/j.chempr.2017.07.009

Oxidative Activation of C–S Bonds with an Electropositive Nitrogen Promoter Enables Orthogonal Glycosylation of Alkyl over Phenyl Thioglycosides

Autores: Annabel Kitowski, Ester Jiménez-Moreno, Míriam Salvadó, Jordi Mestre, Sergio Castillón, Gonzalo Jiménez-Osés, Omar Boutureira, Gonçalo J. L. Bernardes
Publicado en: Organic Letters, Edición 19/19, 2017, Página(s) 5490-5493, ISSN 1523-7060
Editor: American Chemical Society
DOI: 10.1021/acs.orglett.7b02886

Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

Autores: Nuria Martínez-Sáez, Shuang Sun, Davide Oldrini, Pietro Sormanni, Omar Boutureira, Filippo Carboni, Ismael Compañón, Michael J. Deery, Michele Vendruscolo, Francisco Corzana, Roberto Adamo, Gonçalo J. L. Bernardes
Publicado en: Angewandte Chemie International Edition, Edición 56/47, 2017, Página(s) 14963-14967, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
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Short (16-mer) locked nucleic acid splice-switching oligonucleotides restore dystrophin production in Duchenne Muscular Dystrophy myotubes

Autores: Vanessa Borges Pires, Ricardo Simões, Kamel Mamchaoui, Célia Carvalho, Maria Carmo-Fonseca
Publicado en: PLOS ONE, Edición 12/7, 2017, Página(s) e0181065, ISSN 1932-6203
Editor: Public Library of Science
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Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation

Autores: Sreerama Chaitanya Sridhara, Sílvia Carvalho, Ana Rita Grosso, Lina Marcela Gallego-Paez, Maria Carmo-Fonseca, Sérgio Fernandes de Almeida
Publicado en: Cell Reports, Edición 18/2, 2017, Página(s) 334-343, ISSN 2211-1247
Editor: Cell Press
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Trends in therapeutic drug conjugates for bacterial diseases: a patent review

Autores: Pedro M. S. D. Cal, Maria J. Matos, Gonçalo J. L. Bernardes
Publicado en: Expert Opinion on Therapeutic Patents, Edición 27/2, 2017, Página(s) 179-189, ISSN 1354-3776
Editor: Ashley Publications Ltd.
DOI: 10.1080/13543776.2017.1259411

Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs

Autores: Margarita Schlackow, Takayuki Nojima, Tomas Gomes, Ashish Dhir, Maria Carmo-Fonseca, Nick J. Proudfoot
Publicado en: Molecular Cell, Edición 65/1, 2017, Página(s) 25-38, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2016.11.029

Site-Selective Modification of Proteins with Oxetanes

Autores: Omar Boutureira, Nuria Martínez-Sáez, Kevin M. Brindle, André A. Neves, Francisco Corzana, Gonçalo J. L. Bernardes
Publicado en: Chemistry - A European Journal, Edición 23/27, 2017, Página(s) 6483-6489, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201700745

Nickel-Catalyzed Azide–Alkyne Cycloaddition To Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water

Autores: Woo Gyum Kim, Mi Eun Kang, Jae Bin Lee, Min Ho Jeon, Sungmin Lee, Jungha Lee, Bongseo Choi, Pedro M. S. D. Cal, Sebyung Kang, Jung-Min Kee, Gonçalo J. L. Bernardes, Jan-Uwe Rohde, Wonyoung Choe, Sung You Hong
Publicado en: Journal of the American Chemical Society, Edición 139/35, 2017, Página(s) 12121-12124, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.7b06338

Deep intronic mutations and human disease

Autores: Rita Vaz-Drago, Noélia Custódio, Maria Carmo-Fonseca
Publicado en: Human Genetics, Edición 136/9, 2017, Página(s) 1093-1111, ISSN 0340-6717
Editor: Springer Verlag
DOI: 10.1007/s00439-017-1809-4

Whole gene sequencing identifies deep-intronic variants with potential functional impact in patients with hypertrophic cardiomyopathy

Autores: Rita Mendes de Almeida, Joana Tavares, Sandra Martins, Teresa Carvalho, Francisco J. Enguita, Dulce Brito, Maria Carmo-Fonseca, Luís Rocha Lopes
Publicado en: PLOS ONE, Edición 12/8, 2017, Página(s) e0182946, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0182946

Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils

Autores: Max J. H. Worthington, Renata L. Kucera, Inês S. Albuquerque, Christopher T. Gibson, Alexander Sibley, Ashley D. Slattery, Jonathan A. Campbell, Salah F. K. Alboaiji, Katherine A. Muller, Jason Young, Nick Adamson, Jason R. Gascooke, Deshetti Jampaiah, Ylias M. Sabri, Suresh K. Bhargava, Samuel J. Ippolito, David A. Lewis, Jamie S. Quinton, Amanda V. Ellis, Alexander Johs, Gonçalo J. L. Bernarde
Publicado en: Chemistry - A European Journal, Edición 23/64, 2017, Página(s) 16219-16230, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201702871

Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells

Autores: Ester Jiménez-Moreno, Zijian Guo, Bruno L. Oliveira, Inês S. Albuquerque, Annabel Kitowski, Ana Guerreiro, Omar Boutureira, Tiago Rodrigues, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Publicado en: Angewandte Chemie International Edition, Edición 56/1, 2017, Página(s) 243-247, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
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A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages

Autores: Mafalda M. A. Pereira, Inês Mahú, Elsa Seixas, Noelia Martinéz-Sánchez, Nadiya Kubasova, Roksana M Pirzgalska, Paul Cohen, Marcelo O Dietrich, Miguel López, Gonçalo J. L. Bernardes, Ana I. Domingos
Publicado en: Nature Communications, Edición 8, 2017, Página(s) 14967, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms14967

Pharmacological inhibition of the spliceosome subunit SF3b triggers exon junction complex-independent nonsense-mediated decay

Autores: Teresa Carvalho, Sandra Martins, José Rino, Sérgio Marinho, Maria Carmo-Fonseca
Publicado en: Journal of Cell Science, Edición 130/9, 2017, Página(s) 1519-1531, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
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Inverse electron demand Diels–Alder reactions in chemical biology

Autores: B. L. Oliveira, Z. Guo, G. J. L. Bernardes
Publicado en: Chem. Soc. Rev., Edición 46/16, 2017, Página(s) 4895-4950, ISSN 0306-0012
Editor: Royal Society of Chemistry
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Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells

Autores: Pedro M. S. D. Cal, Florian Sieglitz, Fábio M. F. Santos, Cátia Parente Carvalho, Ana Guerreiro, Jean B. Bertoldo, Uwe Pischel, Pedro M. P. Gois, Gonçalo J. L. Bernardes
Publicado en: Chem. Commun., Edición 53/2, 2017, Página(s) 368-371, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/c6cc08671c

Association of Anger Expression-Out with NK Cell Counts in Colorectal Cancer Patients

Autores: Estela Kakoo-Brioso, Luís Costa, Sílvia Ouakinin
Publicado en: Acta Médica Portuguesa, Edición 31/3, 2018, Página(s) 152, ISSN 0870-399X
Editor: Ordem dos Medicos
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Microtubule motors involved in nuclear movement during skeletal muscle differentiation

Autores: V. Gache, E. R. Gomes, B. Cadot
Publicado en: Molecular Biology of the Cell, Edición 28/7, 2017, Página(s) 865-874, ISSN 1059-1524
Editor: American Society for Cell Biology
DOI: 10.1091/mbc.e16-06-0405

Impact on sexual function of surgical treatment in rectal cancer

Autores: Pedro Costa, João M. Cardoso, Hugo Louro, Jorge Dias, Luís Costa, Raquel Rodrigues, Paulo Espiridião, Jorge Maciel, Luís Ferraz
Publicado en: International braz j urol, Edición 44/1, 2018, Página(s) 141-149, ISSN 1677-6119
Editor: BRAZILIAN SOC UROL
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Local Arrangement of Fibronectin by Myofibroblasts Governs Peripheral Nuclear Positioning in Muscle Cells

Autores: William Roman, João P. Martins, Edgar R. Gomes
Publicado en: Developmental Cell, Edición 46/1, 2018, Página(s) 102-111.e6, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2018.05.031

Serum YB-1 (Y-box binding protein 1) as a biomarker of bone disease progression in patients with breast cancer and bone metastases

Autores: A.R. Ferreira, M. Bettencourt, I. Alho, A.L. Costa, A.R. Sousa, A. Mansinho, C. Abreu, C. Pulido, D. Macedo, I. Vendrell, T.R. Pacheco, L. Costa, S. Casimiro
Publicado en: Journal of Bone Oncology, Edición 6, 2017, Página(s) 16-21, ISSN 2212-1374
Editor: Elsevier GmbH
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YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

Autores: Filipa Neto, Alexandra Klaus-Bergmann, Yu Ting Ong, Silvanus Alt, Anne-Clémence Vion, Anna Szymborska, Joana R Carvalho, Irene Hollfinger, Eireen Bartels-Klein, Claudio A Franco, Michael Potente, Holger Gerhardt
Publicado en: eLife, Edición 7, 2018, ISSN 2050-084X
Editor: eLife Sciences Publications
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LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

Autores: Elvira Infante, Alessia Castagnino, Robin Ferrari, Pedro Monteiro, Sonia Agüera-González, Perrine Paul-Gilloteaux, Mélanie J. Domingues, Paolo Maiuri, Matthew Raab, Catherine M. Shanahan, Alexandre Baffet, Matthieu Piel, Edgar R. Gomes, Philippe Chavrier
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-04865-7

Nuclear positioning in skeletal muscle

Autores: William Roman, Edgar R. Gomes
Publicado en: Seminars in Cell & Developmental Biology, Edición 82, 2018, Página(s) 51-56, ISSN 1084-9521
Editor: Academic Press
DOI: 10.1016/j.semcdb.2017.11.005

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

Autores: S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata, B Silva-Santos
Publicado en: Leukemia, Edición 31/7, 2016, Página(s) 1603-1610, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2016.363

Dealing with the nucleus during cell migration

Autores: Francisco J Calero-Cuenca, Cátia S Janota, Edgar R Gomes
Publicado en: Current Opinion in Cell Biology, Edición 50, 2018, Página(s) 35-41, ISSN 0955-0674
Editor: Elsevier BV
DOI: 10.1016/j.ceb.2018.01.014

Damage and protection cost curves for coastal floods within the 600 largest European cities

Autores: Boris F. Prahl, Markus Boettle, Luís Costa, Jürgen P. Kropp, Diego Rybski
Publicado en: Scientific Data, Edición 5, 2018, Página(s) 180034, ISSN 2052-4463
Editor: NATURE PUBLISHING GROUP
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PolNet: A Tool to Quantify Network-Level Cell Polarity and Blood Flow in Vascular Remodeling

Autores: Miguel O. Bernabeu, Martin L. Jones, Rupert W. Nash, Anna Pezzarossa, Peter V. Coveney, Holger Gerhardt, Claudio A. Franco
Publicado en: Biophysical Journal, Edición 114/9, 2018, Página(s) 2052-2058, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2018.03.032

N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy

Autores: S. Falcone, W. Roman, K. Hnia, V. Gache, N. Didier, J. Laine, F. Aurade, I. Marty, I. Nishino, N. Charlet-Berguerand, N. B. Romero, G. Marazzi, D. Sassoon, J. Laporte, E. R. Gomes
Publicado en: EMBO Molecular Medicine, Edición 17574676, 2014, Página(s) 1455-1475, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
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Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking the Nuclear Envelope to the Actin and Microtubule Cytoskeleton

Autores: Manuela D’Alessandro, Karim Hnia, Vincent Gache, Catherine Koch, Christos Gavriilidis, David Rodriguez, Anne-Sophie Nicot, Norma B. Romero, Yannick Schwab, Edgar Gomes, Michel Labouesse, Jocelyn Laporte
Publicado en: Developmental Cell, Edición 15345807, 2015, Página(s) 186-198, ISSN 1534-5807
Editor: Cell Press
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The contemporary nucleus: A trip down memory lane

Autores: Daniel S. Osorio, Edgar R. Gomes
Publicado en: Biology of the Cell, Edición 02484900, 2013, Página(s) 430-441, ISSN 0248-4900
Editor: Portland Press, Ltd.
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Moving and positioning the nucleus in skeletal muscle – one step at a time

Autores: Bruno Cadot, Vincent Gache, Edgar R Gomes
Publicado en: Nucleus, Edición 19491034, 2015, Página(s) 373-381, ISSN 1949-1034
Editor: Landes Bioscience
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Fast, Multi-Dimensional and Simultaneous Kymograph-Like Particle Dynamics (SkyPad) Analysis

Autores: Bruno Cadot, Vincent Gache, Edgar R. Gomes
Publicado en: PLoS ONE, Edición 19326203, 2014, Página(s) e89073, ISSN 1932-6203
Editor: Public Library of Science
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Computer simulations reveal complex distribution of haemodynamic forces in a mouse retina model of angiogenesis

Autores: M. O. Bernabeu, M. L. Jones, J. H. Nielsen, T. Kruger, R. W. Nash, D. Groen, S. Schmieschek, J. Hetherington, H. Gerhardt, C. A. Franco, P. V. Coveney
Publicado en: Journal of The Royal Society Interface, Edición 17425689, 2014, Página(s) 20140543-20140543, ISSN 1742-5689
Editor: The Royal Society
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Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

Autores: Irene Maria Aspalter, Emma Gordon, Alexandre Dubrac, Anan Ragab, Jarek Narloch, Pedro Vizán, Ilse Geudens, Russell Thomas Collins, Claudio Areias Franco, Cristina Luna Abrahams, Gavin Thurston, Marcus Fruttiger, Ian Rosewell, Anne Eichmann, Holger Gerhardt
Publicado en: Nature Communications, Edición 20411723, 2015, Página(s) 7264, ISSN 2041-1723
Editor: Nature Publishing Group
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The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis

Autores: Katie Bentley, Claudio Areias Franco, Andrew Philippides, Raquel Blanco, Martina Dierkes, Véronique Gebala, Fabio Stanchi, Martin Jones, Irene M. Aspalter, Guiseppe Cagna, Simone Weström, Lena Claesson-Welsh, Dietmar Vestweber, Holger Gerhardt
Publicado en: Nature Cell Biology, Edición 14657392, 2014, Página(s) 309-321, ISSN 1465-7392
Editor: Nature Publishing Group
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Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression

Autores: Claudio A. Franco, Martin L. Jones, Miguel O. Bernabeu, Ilse Geudens, Thomas Mathivet, Andre Rosa, Felicia M. Lopes, Aida P. Lima, Anan Ragab, Russell T. Collins, Li-Kun Phng, Peter V. Coveney, Holger Gerhardt
Publicado en: PLOS Biology, Edición 15457885, 2015, Página(s) e1002125, ISSN 1545-7885
Editor: PLOS
DOI: 10.1371/journal.pbio.1002125

SRF selectively controls tip cell invasive behavior in angiogenesis

Autores: C. A. Franco, J. Blanc, A. Parlakian, R. Blanco, I. M. Aspalter, N. Kazakova, N. Diguet, E. Mylonas, J. Gao-Li, A. Vaahtokari, V. Penard-Lacronique, M. Fruttiger, I. Rosewell, M. Mericskay, H. Gerhardt, Z. Li
Publicado en: Development, Edición 09501991, 2013, Página(s) 2321-2333, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.091074

Generation and Characterization of a Novel Mouse Embryonic Stem Cell Line with a Dynamic Reporter of Nanog Expression

Autores: Elsa Abranches, Evguenia Bekman, Domingos Henrique
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e59928, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0059928

Glycogen Synthase Kinase-3 Inhibition Enhances Translation of Pluripotency-Associated Transcription Factors to Contribute to Maintenance of Mouse Embryonic Stem Cell Self-Renewal

Autores: Yolanda Sanchez-Ripoll, Heather K. Bone, Tom Owen, Ana M. V. Guedes, Elsa Abranches, Benjamin Kumpfmueller, Ruth V. Spriggs, Domingos Henrique, Melanie J. Welham
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e60148, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0060148

Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency

Autores: E. Abranches, A. M. V. Guedes, M. Moravec, H. Maamar, P. Svoboda, A. Raj, D. Henrique
Publicado en: Development, Edición 09501991, 2014, Página(s) 2770-2779, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.108910

Generation of sensory hair cells by genetic programming with a combination of transcription factors

Autores: A. Costa, L. Sanchez-Guardado, S. Juniat, J. E. Gale, N. Daudet, D. Henrique
Publicado en: Development, Edición 09501991, 2015, Página(s) 1948-1959, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.119149

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo

Autores: Kristina Preuße, Lena Tveriakhina, Karin Schuster-Gossler, Cláudia Gaspar, Alexandra Isabel Rosa, Domingos Henrique, Achim Gossler, Michael Stauber
Publicado en: PLOS Genetics, Edición 15537404, 2015, Página(s) e1005328, ISSN 1553-7404
Editor: PLOS
DOI: 10.1371/journal.pgen.1005328

Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells

Autores: Tiago G. Fernandes, Sofia T. Duarte, Mehrnaz Ghazvini, Cláudia Gaspar, Diana C. Santos, Ana R. Porteira, Gonçalo M. C. Rodrigues, Simone Haupt, Diogo M. Rombo, Judith Armstrong, Ana M. Sebastião, Joost Gribnau, Àngels Garcia-Cazorla, Oliver Brüstle, Domingos Henrique, Joaquim M. S. Cabral, Maria Margarida Diogo
Publicado en: Biotechnology Journal, Edición 18606768, 2015, Página(s) 1578-1588, ISSN 1860-6768
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201400751

Heterogeneous lineage marker expression in naive embryonic stem cells is mostly due to spontaneous differentiation

Autores: Gautham Nair, Elsa Abranches, Ana M. V. Guedes, Domingos Henrique, Arjun Raj
Publicado en: Scientific Reports, Edición 20452322, 2015, Página(s) 13339, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep13339

Transcriptome profiling of induced hair cells (iHCs) generated by combined expression of Gfi1, Pou4f3 and Atoh1 during embryonic stem cell differentiation

Autores: Aida Costa, Domingos Henrique
Publicado en: Genomics Data, Edición 22135960, 2015, Página(s) 77-80, ISSN 2213-5960
Editor: Elsevier Inc.
DOI: 10.1016/j.gdata.2015.08.017

Neuromesodermal progenitors and the making of the spinal cord

Autores: D. Henrique, E. Abranches, L. Verrier, K. G. Storey
Publicado en: Development, Edición 09501991, 2015, Página(s) 2864-2875, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.119768

Therapy-Induced Cellular Senescence Induces Epithelial-to-Mesenchymal Transition and Increases Invasiveness in Rectal Cancer

Autores: Joana Tato-Costa, Sandra Casimiro, Teresa Pacheco, Ricardo Pires, Afonso Fernandes, Irina Alho, Pedro Pereira, Paulo Costa, Henrique Bicha Castelo, João Ferreira, Luís Costa
Publicado en: Clinical Colorectal Cancer, Edición 15330028, 2015, ISSN 1533-0028
Editor: Cancer Information Group
DOI: 10.1016/j.clcc.2015.09.003

Targeting bone metastases in prostate cancer: improving clinical outcome

Autores: Jean-Jacques Body, Sandra Casimiro, Luís Costa
Publicado en: Nature Reviews Urology, Edición 17594812, 2015, Página(s) 340-356, ISSN 1759-4812
Editor: Nature Publishing Group
DOI: 10.1038/nrurol.2015.90

Bone remodeling markers and bone metastases: From cancer research to clinical implications

Autores: Arlindo Ferreira, Irina Alho, Sandra Casimiro, Luís Costa
Publicado en: BoneKEy Reports, Edición 20476396, 2015, Página(s) 668, ISSN 2047-6396
Editor: Nature Publishing Group
DOI: 10.1038/bonekey.2015.35

Metadherin expression and lung relapse in patients with colorectal carcinoma

Autores: Sandra Casimiro, Afonso Fernandes, António Gouveia Oliveira, Marco Franco, Ricardo Pires, Mafalda Peres, Margarida Matias, Joana Tato-Costa, Nuno Guerra, Madalena Ramos, Jorge Cruz, Luis Costa
Publicado en: Clinical & Experimental Metastasis, Edición 02620898, 2014, Página(s) 689-696, ISSN 0262-0898
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10585-014-9659-0

RANKL enhances the effect of an antagonist of inhibitor of apoptosis proteins (cIAPs) in RANK-positive breast cancer cells

Autores: S. Casimiro, I. Alho, M. Bettencourt, R. Pires, A. Lipton, L. Costa
Publicado en: Journal of Bone Oncology, Edición 22121374, 2013, Página(s) 116-122, ISSN 2212-1374
Editor: Elsevier GmbH
DOI: 10.1016/j.jbo.2013.07.001

Novel Insights into Breast Cancer Genetic Variance through RNA Sequencing

Autores: Anelia Horvath, Suresh Babu Pakala, Prakriti Mudvari, Sirigiri Divijendra Natha Reddy, Kazufumi Ohshiro, Sandra Casimiro, Ricardo Pires, Suzanne A. W. Fuqua, Masakazu Toi, Luis Costa, Sujit S. Nair, Saraswati Sukumar, Rakesh Kumar
Publicado en: Scientific Reports, Edición 20452322, 2013, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep02256

RANKL/RANK/MMP-1 Molecular Triad Contributes to the Metastatic Phenotype of Breast and Prostate Cancer Cells In Vitro

Autores: Sandra Casimiro, Khalid S. Mohammad, Ricardo Pires, Joana Tato-Costa, Irina Alho, Rui Teixeira, António Carvalho, Sofia Ribeiro, Allan Lipton, Theresa A. Guise, Luis Costa
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e63153, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0063153

MTA1 Promotes STAT3 Transcription and Pulmonary Metastasis in Breast Cancer

Autores: S. B. Pakala, S. K. Rayala, R.-A. Wang, K. Ohshiro, P. Mudvari, S. D. N. Reddy, Y. Zheng, R. Pires, S. Casimiro, M. R. Pillai, L. Costa, R. Kumar
Publicado en: Cancer Research, Edición 00085472, 2013, Página(s) 3761-3770, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-12-3998

The role of low-molecular-weight protein tyrosine phosphatase (LMW-PTP ACP1) in oncogenesis

Autores: Irina Alho, Luís Costa, Manuel Bicho, Constança Coelho
Publicado en: Tumor Biology, Edición 10104283, 2013, Página(s) 1979-1989, ISSN 1010-4283
Editor: Springer Verlag
DOI: 10.1007/s13277-013-0784-1

Treatment of Cancer Pain by Targeting Cytokines

Autores: I. Vendrell, D. Macedo, I. Alho, M. R. Dionísio, L. Costa
Publicado en: Mediators of Inflammation, Edición 09629351, 2015, Página(s) 1-11, ISSN 0962-9351
Editor: Hindawi Publishing Corporation
DOI: 10.1155/2015/984570

Low Molecular Weight Protein Tyrosine Phosphatase Isoforms Regulate Breast Cancer Cells Migration through a RhoA Dependent Mechanism

Autores: Irina Alho, Luis Costa, Manuel Bicho, Constança Coelho
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e76307, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0076307

The Bone Marrow-Mediated Protection of Myeloproliferative Neoplastic Cells to Vorinostat and Ruxolitinib Relies on the Activation of JNK and PI3K Signalling Pathways

Autores: Bruno A. Cardoso, Hélio Belo, João T. Barata, António M. Almeida
Publicado en: PLOS ONE, Edición 19326203, 2015, Página(s) e0143897, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0143897

CHK1 and replicative stress in T-cell leukemia: Can an irreverent tumor suppressor end up playing the oncogene?

Autores: Leonor M. Sarmento, João T. Barata
Publicado en: Advances in Biological Regulation, Edición 22124926, 2016, Página(s) 115-121, ISSN 2212-4926
Editor: Elsevier BV
DOI: 10.1016/j.jbior.2015.10.007

PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia

Autores: André Bortolini Silveira, Angelo Brunelli Albertoni Laranjeira, Gisele Olinto Libanio Rodrigues, Rodrigues Leal, Bruno António Cardoso, João Taborda Barata, Rosendo Augusto Yunes, Nilson Ivo Tonin Zanchin, Sílvia Regina Brandalise, José Andrés Yunes
Publicado en: Oncotarget, Edición 19492553, 2015, Página(s) 13105-13118, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.3524

Lymphotoxin-β receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype

Autores: Mónica T. Fernandes, Marinella N. Ghezzo, André B. Silveira, Ravi K. Kalathur, Vanda Póvoa, Ana R. Ribeiro, Sílvia R. Brandalise, Emmanuel Dejardin, Nuno L. Alves, Jacques Ghysdael, João T. Barata, José Andres Yunes, Nuno R. dos Santos
Publicado en: British Journal of Haematology, Edición 00071048, 2015, Página(s) 736-751, ISSN 0007-1048
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bjh.13760

Kinases, tails and more: Regulation of PTEN function by phosphorylation

Autores: Rita Fragoso, João T. Barata
Publicado en: Methods, Edición 10462023, 2015, Página(s) 75-81, ISSN 1046-2023
Editor: Academic Press
DOI: 10.1016/j.ymeth.2014.10.015

CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress

Autores: L M Sarmento, V Póvoa, R Nascimento, G Real, I Antunes, L R Martins, C Moita, P M Alves, M Abecasis, L F Moita, R M E Parkhouse, J P P Meijerink, J T Barata
Publicado en: Oncogene, Edición 09509232, 2014, Página(s) 2978-2990, ISSN 0950-9232
Editor: Nature Publishing Group
DOI: 10.1038/onc.2014.248

Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics

Autores: Diana Gaspar, João M. Freire, Teresa R. Pacheco, João T. Barata, Miguel A.R.B. Castanho
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Edición 01674889, 2015, Página(s) 308-316, ISSN 0167-4889
Editor: Elsevier BV
DOI: 10.1016/j.bbamcr.2014.11.006

A Unified Nomenclature and Amino Acid Numbering for Human PTEN

Autores: R. Pulido, S. J. Baker, J. T. Barata, A. Carracedo, V. J. Cid, I. D. Chin-Sang, V. Dave, J. den Hertog, P. Devreotes, B. J. Eickholt, C. Eng, F. B. Furnari, M.-M. Georgescu, A. Gericke, B. Hopkins, X. Jiang, S.-R. Lee, M. Losche, P. Malaney, X. Matias-Guiu, M. Molina, P. P. Pandolfi, R. Parsons, P. Pinton, C. Rivas, R. M. Rocha, M. S. Rodriguez, A. H. Ross, M. Serrano, V. Stambolic, B. Stiles, A. Suzuki, S.-S. Tan, N. K. Tonks, L. C. Trotman, N. Wolff, R. Woscholski, H. Wu, N. R. Leslie
Publicado en: Science Signaling, Edición 19379145, 2014, Página(s) pe15-pe15, ISSN 1937-9145
Editor: American Association for the Advancement of Science
DOI: 10.1126/scisignal.2005560

PTEN and leukemia stem cells

Autores: Rita Fragoso, João T. Barata
Publicado en: Advances in Biological Regulation, Edición 22124926, 2014, Página(s) 22-29, ISSN 2212-4926
Editor: Elsevier BV
DOI: 10.1016/j.jbior.2014.05.005

PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events

Autores: R. D. Mendes, L. M. Sarmento, K. Cante-Barrett, L. Zuurbier, J. G. C. A. M. Buijs-Gladdines, V. Povoa, W. K. Smits, M. Abecasis, J. A. Yunes, E. Sonneveld, M. A. Horstmann, R. Pieters, J. T. Barata, J. P. P. Meijerink
Publicado en: Blood, Edición 00064971, 2014, Página(s) 567-578, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2014-03-562751

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

Autores: A. M. Gomes, M. V. D. Soares, P. Ribeiro, J. Caldas, V. Povoa, L. R. Martins, A. Melao, A. Serra-Caetano, A. B. de Sousa, J. F. Lacerda, J. T. Barata
Publicado en: Haematologica, Edición 03906078, 2014, Página(s) 1062-1068, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2013.096438

Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor

Autores: Leila R. Martins, Yasser Perera, Paulo Lúcio, Maria G. Silva, Silvio E. Perea, João T. Barata
Publicado en: Oncotarget, Edición 19492553, 2014, Página(s) 258-263, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.1513

Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia

Autores: A Lonetti, I L Antunes, F Chiarini, E Orsini, F Buontempo, F Ricci, P L Tazzari, P Pagliaro, F Melchionda, A Pession, A Bertaina, F Locatelli, J A McCubrey, J T Barata, A M Martelli
Publicado en: Leukemia, Edición 08876924, 2013, Página(s) 1196-1206, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2013.369

IL-7R : Mr Hyde's twists and turns

Autores: J. T. Barata
Publicado en: Blood, Edición 00064971, 2013, Página(s) 4151-4152, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood-2013-11-536987

Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia

Autores: L R Martins, P Lúcio, A Melão, I Antunes, B A Cardoso, R Stansfield, M T S Bertilaccio, P Ghia, D Drygin, M G Silva, J T Barata
Publicado en: Leukemia, Edición 08876924, 2013, Página(s) 179-182, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2013.232

Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia

Autores: N C Correia, K Durinck, A P Leite, M Ongenaert, P Rondou, F Speleman, F J Enguita, J T Barata
Publicado en: Leukemia, Edición 08876924, 2013, Página(s) 1603-1606, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2013.63

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

Autores: F Buontempo, E Orsini, L R Martins, I Antunes, A Lonetti, F Chiarini, G Tabellini, C Evangelisti, C Evangelisti, F Melchionda, A Pession, A Bertaina, F Locatelli, J A McCubrey, A Cappellini, J T Barata, A M Martelli
Publicado en: Leukemia, Edición 08876924, 2013, Página(s) 543-553, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2013.349

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia

Autores: Daniel Ribeiro, Alice Melão, João T. Barata
Publicado en: Advances in Biological Regulation, Edición 22124926, 2013, Página(s) 211-222, ISSN 2212-4926
Editor: Elsevier BV
DOI: 10.1016/j.jbior.2012.10.005

N-Cadherin Locks Left-Right Asymmetry by Ending the Leftward Movement of Hensen’s Node Cells

Autores: Raquel V. Mendes, Gabriel G. Martins, Ana M. Cristovão, Leonor Saúde
Publicado en: Developmental Cell, Edición 15345807, 2014, Página(s) 353-360, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2014.06.010

Notch Signalling Is Required for the Formation of Structurally Stable Muscle Fibres in Zebrafish

Autores: Susana Pascoal, Joana Esteves de Lima, Jonathan D. Leslie, Simon M. Hughes, Leonor Saúde
Publicado en: PLoS ONE, Edición 19326203, 2013, Página(s) e68021, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0068021

miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Autores: Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
Publicado en: Journal of Hematology & Oncology, Edición 17568722, 2013, Página(s) 87, ISSN 1756-8722
Editor: BioMed Central
DOI: 10.1186/1756-8722-6-87

Bone Marrow-Derived CD11b+Jagged2+ Cells Promote Epithelial-to-Mesenchymal Transition and Metastasization in Colorectal Cancer

Autores: F. Caiado, T. Carvalho, I. Rosa, L. Remedio, A. Costa, J. Matos, B. Heissig, H. Yagita, K. Hattori, J. P. da Silva, P. Fidalgo, A. D. Pereira, S. Dias
Publicado en: Cancer Research, Edición 00085472, 2013, Página(s) 4233-4246, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-13-0085

Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression

Autores: Catarina Rodrigues dos Santos, Isabel Fonseca, Sérgio Dias, JC Mendes de Almeida
Publicado en: BMC Cancer, Edición 14712407, 2014, Página(s) 132, ISSN 1471-2407
Editor: BioMed Central
DOI: 10.1186/1471-2407-14-132

LDL-cholesterol signaling induces breast cancer proliferation and invasion

Autores: Catarina Rodrigues dos Santos, Germana Domingues, Inês Matias, João Matos, Isabel Fonseca, José de Almeida, Sérgio Dias
Publicado en: Lipids in Health and Disease, Edición 1476511X, 2014, Página(s) 16, ISSN 1476-511X
Editor: BioMed Central
DOI: 10.1186/1476-511X-13-16

In Vitro and In Vivo Analysis of RTK Inhibitor Efficacy and Identification of Its Novel Targets in Glioblastomas

Autores: Olga Martinho, Renato Silva-Oliveira, Vera Miranda-Gonçalves, Carlos Clara, José Reynaldo Almeida, André Lopes Carvalho, João Taborda Barata, Rui Manuel Reis
Publicado en: Translational Oncology, Edición 19365233, 2013, Página(s) 187-IN20, ISSN 1936-5233
Editor: Neoplasia Press
DOI: 10.1593/tlo.12400

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia

Autores: Daniel Ribeiro, Alice Melão, João T. Barata
Publicado en: Advances in Biological Regulation, Edición 53/2, 2013, Página(s) 211-222, ISSN 2212-4926
Editor: Elsevier BV
DOI: 10.1016/j.jbior.2012.10.005

Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics

Autores: Diana Gaspar, João M. Freire, Teresa R. Pacheco, João T. Barata, Miguel A.R.B. Castanho
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Edición 1853/2, 2015, Página(s) 308-316, ISSN 0167-4889
Editor: Elsevier BV
DOI: 10.1016/j.bbamcr.2014.11.006

Transcriptome profiling of induced hair cells (iHCs) generated by combined expression of Gfi1, Pou4f3 and Atoh1 during embryonic stem cell differentiation

Autores: Aida Costa, Domingos Henrique
Publicado en: Genomics Data, Edición 6, 2015, Página(s) 77-80, ISSN 2213-5960
Editor: Elsevier Inc.
DOI: 10.1016/j.gdata.2015.08.017

Generation of sensory hair cells by genetic programming with a combination of transcription factors

Autores: A. Costa, L. Sanchez-Guardado, S. Juniat, J. E. Gale, N. Daudet, D. Henrique
Publicado en: Development, Edición 142/11, 2015, Página(s) 1948-1959, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.119149

The contemporary nucleus: A trip down memory lane

Autores: Daniel S. Osorio, Edgar R. Gomes
Publicado en: Biology of the Cell, Edición 105/9, 2013, Página(s) 430-441, ISSN 0248-4900
Editor: Portland Press, Ltd.
DOI: 10.1111/boc.201300009

Treatment of Cancer Pain by Targeting Cytokines

Autores: I. Vendrell, D. Macedo, I. Alho, M. R. Dionísio, L. Costa
Publicado en: Mediators of Inflammation, Edición 2015, 2015, Página(s) 1-11, ISSN 0962-9351
Editor: Hindawi Publishing Corporation
DOI: 10.1155/2015/984570

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

Autores: F Buontempo, E Orsini, L R Martins, I Antunes, A Lonetti, F Chiarini, G Tabellini, C Evangelisti, C Evangelisti, F Melchionda, A Pession, A Bertaina, F Locatelli, J A McCubrey, A Cappellini, J T Barata, A M Martelli
Publicado en: Leukemia, Edición 28/3, 2013, Página(s) 543-553, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2013.349

RANKL enhances the effect of an antagonist of inhibitor of apoptosis proteins (cIAPs) in RANK-positive breast cancer cells

Autores: S. Casimiro, I. Alho, M. Bettencourt, R. Pires, A. Lipton, L. Costa
Publicado en: Journal of Bone Oncology, Edición 2/3, 2013, Página(s) 116-122, ISSN 2212-1374
Editor: Elsevier GmbH
DOI: 10.1016/j.jbo.2013.07.001

The Bone Marrow-Mediated Protection of Myeloproliferative Neoplastic Cells to Vorinostat and Ruxolitinib Relies on the Activation of JNK and PI3K Signalling Pathways

Autores: Bruno A. Cardoso, Hélio Belo, João T. Barata, António M. Almeida
Publicado en: PLOS ONE, Edición 10/12, 2015, Página(s) e0143897, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0143897

Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells

Autores: Tiago G. Fernandes, Sofia T. Duarte, Mehrnaz Ghazvini, Cláudia Gaspar, Diana C. Santos, Ana R. Porteira, Gonçalo M. C. Rodrigues, Simone Haupt, Diogo M. Rombo, Judith Armstrong, Ana M. Sebastião, Joost Gribnau, Àngels Garcia-Cazorla, Oliver Brüstle, Domingos Henrique, Joaquim M. S. Cabral, Maria Margarida Diogo
Publicado en: Biotechnology Journal, Edición 10/10, 2015, Página(s) 1578-1588, ISSN 1860-6768
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201400751

Moving and positioning the nucleus in skeletal muscle – one step at a time

Autores: Bruno Cadot, Vincent Gache, Edgar R Gomes
Publicado en: Nucleus, Edición 6/5, 2015, Página(s) 373-381, ISSN 1949-1034
Editor: Landes Bioscience
DOI: 10.1080/19491034.2015.1090073

Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia

Autores: L R Martins, P Lúcio, A Melão, I Antunes, B A Cardoso, R Stansfield, M T S Bertilaccio, P Ghia, D Drygin, M G Silva, J T Barata
Publicado en: Leukemia, Edición 28/1, 2013, Página(s) 179-182, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/leu.2013.232

Generation and Characterization of a Novel Mouse Embryonic Stem Cell Line with a Dynamic Reporter of Nanog Expression

Autores: Elsa Abranches, Evguenia Bekman, Domingos Henrique
Publicado en: PLoS ONE, Edición 8/3, 2013, Página(s) e59928, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0059928

Bone Marrow-Derived CD11b+Jagged2+ Cells Promote Epithelial-to-Mesenchymal Transition and Metastasization in Colorectal Cancer

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Publicado en: Cancer Research, Edición 73/14, 2013, Página(s) 4233-4246, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-13-0085

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Editor: Kluwer Academic Publishers
DOI: 10.1007/s10585-014-9659-0

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Publicado en: Cancer Biology and the Nuclear Envelope, 2014, Página(s) 505-520, ISBN 978-1-4899-8032-8
Editor: Springer New York
DOI: 10.1007/978-1-4899-8032-8_23

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Publicado en: Encyclopedia of Cell Biology, 2016, Página(s) 677-682, ISBN 9780123947963
Editor: Elsevier
DOI: 10.1016/B978-0-12-394447-4.20065-5

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Publicado en: Embryonic Stem Cell Protocols, 2016, Página(s) 87-100, ISBN 978-1-4939-2954-2
Editor: Springer New York
DOI: 10.1007/7651_2015_255

Connecting the Nucleus to the Cytoskeleton for Nuclear Positioning and Cell Migration

Skeletal Muscle

Autores: B. Cadot, E.R. Gomes
Publicado en: Encyclopedia of Cell Biology, 2016, Página(s) 677-682, ISBN 9780123947963
Editor: Elsevier
DOI: 10.1016/B978-0-12-394447-4.20065-5

Imaging Pluripotency: Time-Lapse Analysis of Mouse Embryonic Stem Cells

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