Towards outstanding research and training in tumour biology at IMM

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

High Resolution Microscopy Workshop
EC Performance Indicators Widening indicator application for the 3-year window time prior to ReTuBi

EC Performance Indicators Widening indicator application for the 3-year window time prior to ReTuBi

Second edition of the High-Resolution Microscopy Workshop

A second edition of the High-Resolution Microscopy Workshop will be organized on M34 due to the successful implementation of the first edition, the successful accomplishment of the objectives and the growing demand from the partnering institutions on participating in these type of practical activity.

Second edition of the Career development and soft skills for young scientists

A second edition of thethe Career development and soft skills for young scientists – From Lisbon to the World Workshop will be organized on M26 due to the successful implementation of the first edition, the successful accomplishment of the objectives and the growing demand from the partnering institutions on participating in these type of practical activity.

Career development and soft skills for young scientists
Brochure and flyer

ReTuBi website and logo

Pubblicazioni

Computational fluid dynamics assisted characterization of parafoveal hemodynamics in normal and diabetic eyes using adaptive optics scanning laser ophthalmoscopy

Autori: Yang Lu, Miguel O. Bernabeu, Jan Lammer, Charles C. Cai, Martin L. Jones, Claudio A. Franco, Lloyd Paul Aiello, Jennifer K. Sun
Pubblicato in: Biomedical Optics Express, Numero 7/12, 2016, Pagina/e 4958, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/BOE.7.004958

A system for studying mechanisms of neuromuscular junction development and maintenance

Autori: Valérie Vilmont, Bruno Cadot, Gilles Ouanounou, Edgar R. Gomes
Pubblicato in: Development, Numero 143/13, 2016, Pagina/e 2464-2477, ISSN 0950-1991
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dev.130278

The impact of chronic intermittent hypoxia on hematopoiesis and the bone marrow microenvironment

Autori: Inês Alvarez-Martins, Leonor Remédio, Inês Matias, Lucília N. Diogo, Emília C. Monteiro, Sérgio Dias
Pubblicato in: Pflügers Archiv - European Journal of Physiology, Numero 468/5, 2016, Pagina/e 919-932, ISSN 0031-6768
Editore: Springer Verlag
DOI: 10.1007/s00424-016-1797-6

Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

Autori: Susana L. Silva, Adriana S. Albuquerque, Ana Serra-Caetano, Russell B. Foxall, Ana R. Pires, Paula Matoso, Susana M. Fernandes, João Ferreira, Rémi Cheynier, Rui M. M. Victorino, Iris Caramalho, João T. Barata, Ana E. Sousa
Pubblicato in: Oncotarget, Numero 7/11, 2016, Pagina/e 12163-12175, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.7512

FOXO1 couples metabolic activity and growth state in the vascular endothelium

Autori: Kerstin Wilhelm, Katharina Happel, Guy Eelen, Sandra Schoors, Mark F. Oellerich, Radiance Lim, Barbara Zimmermann, Irene M. Aspalter, Claudio A. Franco, Thomas Boettger, Thomas Braun, Marcus Fruttiger, Klaus Rajewsky, Charles Keller, Jens C. Brüning, Holger Gerhardt, Peter Carmeliet, Michael Potente
Pubblicato in: Nature, Numero 529/7585, 2016, Pagina/e 216-220, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/nature16498

Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

Autori: Ivan Quétier, Jacqueline J.T. Marshall, Bradley Spencer-Dene, Sylvie Lachmann, Adele Casamassima, Claudio Franco, Sarah Escuin, Joseph T. Worrall, Priththivika Baskaran, Vinothini Rajeeve, Michael Howell, Andrew J. Copp, Gordon Stamp, Ian Rosewell, Pedro Cutillas, Holger Gerhardt, Peter J. Parker, Angus J.M. Cameron
Pubblicato in: Cell Reports, Numero 14/3, 2016, Pagina/e 440-448, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2015.12.049

Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity

Autori: Alice Melão, Maureen Spit, Bruno A. Cardoso, João T. Barata
Pubblicato in: Haematologica, Numero 101/11, 2016, Pagina/e 1368-1379, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.141143

LDL-Cholesterol Increases the Transcytosis of Molecules through Endothelial Monolayers

Autori: Ana Magalhaes, Inês Matias, Inês Palmela, Maria Alexandra Brito, Sérgio Dias
Pubblicato in: PLOS ONE, Numero 11/10, 2016, Pagina/e e0163988, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0163988

microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia

Autori: Nádia C. Correia, Alice Melão, Vanda Póvoa, Leonor Sarmento, Marta Gómez de Cedrón, Marcos Malumbres, Francisco J. Enguita, João T. Barata
Pubblicato in: Oncotarget, Numero 7/7, 2016, Pagina/e 8268-8281, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.6987

Blood flow boosts BMP signaling to keep vessels in shape

Autori: Claudio A. Franco, Holger Gerhardt
Pubblicato in: The Journal of Cell Biology, Numero 214/7, 2016, Pagina/e 793-795, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.201609038

Endothelial cell dynamics in vascular remodelling

Autori: Pedro Barbacena, Joana R. Carvalho, Claudio A. Franco
Pubblicato in: Clinical Hemorheology and Microcirculation, Numero 64/4, 2017, Pagina/e 557-563, ISSN 1386-0291
Editore: IOS Press
DOI: 10.3233/CH-168006

Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice

Autori: Sandra Trindade, Filipa Rijo-Ferreira, Tânia Carvalho, Daniel Pinto-Neves, Fabien Guegan, Francisco Aresta-Branco, Fabio Bento, Simon A. Young, Andreia Pinto, Jan Van Den Abbeele, Ruy M. Ribeiro, Sérgio Dias, Terry K. Smith, Luisa M. Figueiredo
Pubblicato in: Cell Host & Microbe, Numero 19/6, 2016, Pagina/e 837-848, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2016.05.002

Dynein disruption perturbs post-synaptic components and contributes to impaired MuSK clustering at the NMJ: implication in ALS

Autori: Valérie Vilmont, Bruno Cadot, Elsa Vezin, Fabien Le Grand, Edgar R. Gomes
Pubblicato in: Scientific Reports, Numero 6/1, 2016, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep27804

Inoculated Cell Density as a Determinant Factor of the Growth Dynamics and Metastatic Efficiency of a Breast Cancer Murine Model

Autori: Ana C. Gregório, Nuno A. Fonseca, Vera Moura, Manuela Lacerda, Paulo Figueiredo, Sérgio Simões, Sérgio Dias, João Nuno Moreira
Pubblicato in: PLOS ONE, Numero 11/11, 2016, Pagina/e e0165817, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0165817

Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling

Autori: Claudio A Franco, Martin L Jones, Miguel O Bernabeu, Anne-Clemence Vion, Pedro Barbacena, Jieqing Fan, Thomas Mathivet, Catarina G Fonseca, Anan Ragab, Terry P Yamaguchi, Peter V Coveney, Richard A Lang, Holger Gerhardt
Pubblicato in: eLife, Numero 5, 2016, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.07727

MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia

Autori: Nádia C. Correia, Rita Fragoso, Tânia Carvalho, Francisco J. Enguita, João T. Barata
Pubblicato in: Scientific Reports, Numero 6/1, 2016, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep31894

Organização e implementação de uma consulta de cardio‐oncologia

Autori: Manuela Fiuza, Leonor Ribeiro, Andreia Magalhães, Ana Rita Sousa, Miguel Nobre Menezes, Marília Jorge, Luís Costa, Fausto José Pinto
Pubblicato in: Revista Portuguesa de Cardiologia, Numero 35/9, 2016, Pagina/e 485-494, ISSN 0870-2551
Editore: Sociedade Portuguesa De Cardiologia
DOI: 10.1016/j.repc.2016.04.006

The prognostic role of RANK SNP rs34945627 in breast cancer patients with bone metastases

Autori: Arlindo Ferreira, Irina Alho, Inês Vendrell, Marta Melo, Raquel Brás, Ana Lúcia Costa, Ana Rita Sousa, André Mansinho, Catarina Abreu, Catarina Pulido, Daniela Macedo, Teresa Pacheco, Lurdes Correia, Luis Costa, Sandra Casimiro
Pubblicato in: Oncotarget, Numero 7/27, 2016, Pagina/e 41380-41389, ISSN 1949-2553
Editore: Impact Journals
DOI: 10.18632/oncotarget.9356

N-Telopeptide of Type I Collagen Long-Term Dynamics in Breast Cancer Patients With Bone Metastases: Clinical Outcomes and Influence of Extraskeletal Metastases

Autori: A. R. Ferreira, I. Alho, N. Shan, M. Matias, M. Faria, S. Casimiro, K. Leitzel, S. Ali, A. Lipton, L. Costa
Pubblicato in: The Oncologist, Numero 21/12, 2016, Pagina/e 1418-1426, ISSN 1083-7159
Editore: AlphaMed Press Inc
DOI: 10.1634/theoncologist.2015-0527

Radiolabeled block copolymer micelles for image-guided drug delivery

Autori: Elisabete Ribeiro, Irina Alho, Fernanda Marques, Lurdes Gano, Isabel Correia, João D.G. Correia, Sandra Casimiro, Luís Costa, Isabel Santos, Célia Fernandes
Pubblicato in: International Journal of Pharmaceutics, Numero 515/1-2, 2016, Pagina/e 692-701, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2016.11.004

Dynamic modeling of bone metastasis, microenvironment and therapy

Autori: Rui Moura Coelho, João Miranda Lemos, Irina Alho, Duarte Valério, Arlindo R Ferreira, Luís Costa, Susana Vinga
Pubblicato in: Journal of Theoretical Biology, Numero 391, 2016, Pagina/e 1-12, ISSN 0022-5193
Editore: Academic Press
DOI: 10.1016/j.jtbi.2015.11.024

Variation in type of adjuvant chemotherapy received among patients with stage I breast cancer: A multi-institutional Portuguese cohort study

Autori: Arlindo R. Ferreira, Ana Palha, Lurdes Correia, Pedro Filipe, Vasco Rodrigues, Luís Costa, Ana Miranda, Rosário André, João Fernandes, Joaquim Gouveia, José Luís Passos-Coelho, António Moreira, Margarida Brito, Joana Ribeiro, Otto Metzger-Filho, Nancy U. Lin, Inês Vaz-Luís
Pubblicato in: The Breast, Numero 29, 2016, Pagina/e 68-73, ISSN 0960-9776
Editore: Churchill Livingstone
DOI: 10.1016/j.breast.2016.07.004

Molecular Mechanisms of Bone Metastasis: Which Targets Came from the Bench to the Bedside?

Autori: Sandra Casimiro, Arlindo Ferreira, André Mansinho, Irina Alho, Luis Costa
Pubblicato in: International Journal of Molecular Sciences, Numero 17/9, 2016, Pagina/e 1415, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms17091415

Health resource utilization associated with skeletal-related events: results from a retrospective European study

Autori: Jean-Jacques Body, João Pereira, Harm Sleeboom, Nikos Maniadakis, Evangelos Terpos, Yves Pascal Acklin, Jindrich Finek, Oliver Gunther, Guy Hechmati, Tony Mossman, Luis Costa, Wojciech Rogowski, Hareth Nahi, Roger von Moos
Pubblicato in: The European Journal of Health Economics, Numero 17/6, 2016, Pagina/e 711-721, ISSN 1618-7598
Editore: Springer Verlag
DOI: 10.1007/s10198-015-0716-7

Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells

Autori: Petra Gimpel, Yin Loon Lee, Radoslaw M. Sobota, Alessandra Calvi, Victoria Koullourou, Rutti Patel, Kamel Mamchaoui, François Nédélec, Sue Shackleton, Jan Schmoranzer, Brian Burke, Bruno Cadot, Edgar R. Gomes
Pubblicato in: Current Biology, Numero 27/19, 2017, Pagina/e 2999-3009.e9, ISSN 0960-9822
Editore: Cell Press
DOI: 10.1016/j.cub.2017.08.031

Myofibril contraction and crosslinking drive nuclear movement to the periphery of skeletal muscle

Autori: William Roman, João P. Martins, Filomena A. Carvalho, Raphael Voituriez, Jasmine V. G. Abella, Nuno C. Santos, Bruno Cadot, Michael Way, Edgar R. Gomes
Pubblicato in: Nature Cell Biology, Numero 19/10, 2017, Pagina/e 1189-1201, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/ncb3605

<em>In Vitro</em> Differentiation of Mature Myofibers for Live Imaging

Autori: Mafalda R. Pimentel, Sestina Falcone, Bruno Cadot, Edgar R. Gomes
Pubblicato in: Journal of Visualized Experiments, Numero 119, 2017, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/55141

Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia

Autori: Cecilia Evangelisti, Alessandra Cappellini, Mariana Oliveira, Rita Fragoso, João T. Barata, Alice Bertaina, Franco Locatelli, Carolina Simioni, Luca M. Neri, Francesca Chiarini, Annalisa Lonetti, Francesca Buontempo, Ester Orsini, Andrea Pession, Lucia Manzoli, Alberto Maria Martelli, Camilla Evangelisti
Pubblicato in: Journal of Cellular Physiology, 2017, ISSN 0021-9541
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jcp.26135

From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia

Autori: Mariana L. Oliveira, Padma Akkapeddi, Isabel Alcobia, Afonso R. Almeida, Bruno A. Cardoso, Rita Fragoso, Teresa L. Serafim, João T. Barata
Pubblicato in: Cellular Signalling, Numero 38, 2017, Pagina/e 10-25, ISSN 0898-6568
Editore: Elsevier BV
DOI: 10.1016/j.cellsig.2017.06.011

IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity

Autori: Susana L. Silva, Adriana S. Albuquerque, Paula Matoso, Bénédicte Charmeteau-de-Muylder, Rémi Cheynier, Dário Ligeiro, Miguel Abecasis, Rui Anjos, João T. Barata, Rui M. M. Victorino, Ana E. Sousa
Pubblicato in: Frontiers in Immunology, Numero 8, 2017, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.00020

Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks

Autori: Claudio A. Franco, Holger Gerhardt
Pubblicato in: Developmental Cell, Numero 41/6, 2017, Pagina/e 574-576, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2017.06.008

Radionuclides in oncology clinical practice – review of the literature

Autori: Helena Luna Pais, Irina Alho, Inês Vendrell, André Mansinho, Luís Costa
Pubblicato in: Dalton Transactions, Numero 46/42, 2017, Pagina/e 14475-14487, ISSN 1477-9226
Editore: Royal Society of Chemistry
DOI: 10.1039/C7DT01929G

Bone metastasis risk factors in breast cancer

Autori: Catarina Pulido, Inês Vendrell, Arlindo R Ferreira, Sandra Casimiro, André Mansinho, Irina Alho, Luís Costa
Pubblicato in: ecancermedicalscience, Numero 11, 2017, ISSN 1754-6605
Editore: Ecancermedicalscience
DOI: 10.3332/ecancer.2017.715

Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer

Autori: Barbara Tavares, Raquel Jacinto, Pedro Sampaio, Sara Pestana, Andreia Pinto, Andreia Vaz, Mónica Roxo-Rosa, Rui Gardner, Telma Lopes, Britta Schilling, Ian Henry, Leonor Saúde, Susana Santos Lopes
Pubblicato in: eLife, Numero 6, 2017, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.25165

Improving quality of life in patients with advanced cancer: Targeting metastatic bone pain

Autori: Roger von Moos, Luis Costa, Carla Ida Ripamonti, Daniela Niepel, Daniele Santini
Pubblicato in: European Journal of Cancer, Numero 71, 2017, Pagina/e 80-94, ISSN 0959-8049
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2016.10.021

Gold Nanobeacons for Tracking Gene Silencing in Zebrafish

Autori: Milton Cordeiro, Lara Carvalho, Joana Silva, Leonor Saúde, Alexandra Fernandes, Pedro Baptista
Pubblicato in: Nanomaterials, Numero 7/1, 2017, Pagina/e 10, ISSN 2079-4991
Editore: Nanomaterials
DOI: 10.3390/nano7010010

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium( ii ) catalyst

Autori: Terence T.-L. Kwan, Omar Boutureira, Elizabeth C. Frye, Stephen J. Walsh, Moni K. Gupta, Stephen Wallace, Yuteng Wu, Fengzhi Zhang, Hannah F. Sore, Warren R. J. D. Galloway, Jason W. Chin, Martin Welch, Gonçalo J. L. Bernardes, David R. Spring
Pubblicato in: Chem. Sci., Numero 8/5, 2017, Pagina/e 3871-3878, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c6sc05313k

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases

Autori: Jean B. Bertoldo, Tiago Rodrigues, Lavinia Dunsmore, Francesco A. Aprile, Marta C. Marques, Leonardo A. Rosado, Omar Boutureira, Thomas B. Steinbrecher, Woody Sherman, Francisco Corzana, Hernán Terenzi, Gonçalo J.L. Bernardes
Pubblicato in: Chem, Numero 3/4, 2017, Pagina/e 665-677, ISSN 2451-9294
Editore: Chem
DOI: 10.1016/j.chempr.2017.07.009

Oxidative Activation of C–S Bonds with an Electropositive Nitrogen Promoter Enables Orthogonal Glycosylation of Alkyl over Phenyl Thioglycosides

Autori: Annabel Kitowski, Ester Jiménez-Moreno, Míriam Salvadó, Jordi Mestre, Sergio Castillón, Gonzalo Jiménez-Osés, Omar Boutureira, Gonçalo J. L. Bernardes
Pubblicato in: Organic Letters, Numero 19/19, 2017, Pagina/e 5490-5493, ISSN 1523-7060
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.7b02886

Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

Autori: Nuria Martínez-Sáez, Shuang Sun, Davide Oldrini, Pietro Sormanni, Omar Boutureira, Filippo Carboni, Ismael Compañón, Michael J. Deery, Michele Vendruscolo, Francisco Corzana, Roberto Adamo, Gonçalo J. L. Bernardes
Pubblicato in: Angewandte Chemie International Edition, Numero 56/47, 2017, Pagina/e 14963-14967, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201708847

Short (16-mer) locked nucleic acid splice-switching oligonucleotides restore dystrophin production in Duchenne Muscular Dystrophy myotubes

Autori: Vanessa Borges Pires, Ricardo Simões, Kamel Mamchaoui, Célia Carvalho, Maria Carmo-Fonseca
Pubblicato in: PLOS ONE, Numero 12/7, 2017, Pagina/e e0181065, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0181065

Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation

Autori: Sreerama Chaitanya Sridhara, Sílvia Carvalho, Ana Rita Grosso, Lina Marcela Gallego-Paez, Maria Carmo-Fonseca, Sérgio Fernandes de Almeida
Pubblicato in: Cell Reports, Numero 18/2, 2017, Pagina/e 334-343, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.12.050

Trends in therapeutic drug conjugates for bacterial diseases: a patent review

Autori: Pedro M. S. D. Cal, Maria J. Matos, Gonçalo J. L. Bernardes
Pubblicato in: Expert Opinion on Therapeutic Patents, Numero 27/2, 2017, Pagina/e 179-189, ISSN 1354-3776
Editore: Ashley Publications Ltd.
DOI: 10.1080/13543776.2017.1259411

Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs

Autori: Margarita Schlackow, Takayuki Nojima, Tomas Gomes, Ashish Dhir, Maria Carmo-Fonseca, Nick J. Proudfoot
Pubblicato in: Molecular Cell, Numero 65/1, 2017, Pagina/e 25-38, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2016.11.029

Site-Selective Modification of Proteins with Oxetanes

Autori: Omar Boutureira, Nuria Martínez-Sáez, Kevin M. Brindle, André A. Neves, Francisco Corzana, Gonçalo J. L. Bernardes
Pubblicato in: Chemistry - A European Journal, Numero 23/27, 2017, Pagina/e 6483-6489, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201700745

Nickel-Catalyzed Azide–Alkyne Cycloaddition To Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water

Autori: Woo Gyum Kim, Mi Eun Kang, Jae Bin Lee, Min Ho Jeon, Sungmin Lee, Jungha Lee, Bongseo Choi, Pedro M. S. D. Cal, Sebyung Kang, Jung-Min Kee, Gonçalo J. L. Bernardes, Jan-Uwe Rohde, Wonyoung Choe, Sung You Hong
Pubblicato in: Journal of the American Chemical Society, Numero 139/35, 2017, Pagina/e 12121-12124, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b06338

Deep intronic mutations and human disease

Autori: Rita Vaz-Drago, Noélia Custódio, Maria Carmo-Fonseca
Pubblicato in: Human Genetics, Numero 136/9, 2017, Pagina/e 1093-1111, ISSN 0340-6717
Editore: Springer Verlag
DOI: 10.1007/s00439-017-1809-4

Whole gene sequencing identifies deep-intronic variants with potential functional impact in patients with hypertrophic cardiomyopathy

Autori: Rita Mendes de Almeida, Joana Tavares, Sandra Martins, Teresa Carvalho, Francisco J. Enguita, Dulce Brito, Maria Carmo-Fonseca, Luís Rocha Lopes
Pubblicato in: PLOS ONE, Numero 12/8, 2017, Pagina/e e0182946, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0182946

Laying Waste to Mercury: Inexpensive Sorbents Made from Sulfur and Recycled Cooking Oils

Autori: Max J. H. Worthington, Renata L. Kucera, Inês S. Albuquerque, Christopher T. Gibson, Alexander Sibley, Ashley D. Slattery, Jonathan A. Campbell, Salah F. K. Alboaiji, Katherine A. Muller, Jason Young, Nick Adamson, Jason R. Gascooke, Deshetti Jampaiah, Ylias M. Sabri, Suresh K. Bhargava, Samuel J. Ippolito, David A. Lewis, Jamie S. Quinton, Amanda V. Ellis, Alexander Johs, Gonçalo J. L. Bernarde
Pubblicato in: Chemistry - A European Journal, Numero 23/64, 2017, Pagina/e 16219-16230, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201702871

Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells

Autori: Ester Jiménez-Moreno, Zijian Guo, Bruno L. Oliveira, Inês S. Albuquerque, Annabel Kitowski, Ana Guerreiro, Omar Boutureira, Tiago Rodrigues, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Pubblicato in: Angewandte Chemie International Edition, Numero 56/1, 2017, Pagina/e 243-247, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201609607

A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages

Autori: Mafalda M. A. Pereira, Inês Mahú, Elsa Seixas, Noelia Martinéz-Sánchez, Nadiya Kubasova, Roksana M Pirzgalska, Paul Cohen, Marcelo O Dietrich, Miguel López, Gonçalo J. L. Bernardes, Ana I. Domingos
Pubblicato in: Nature Communications, Numero 8, 2017, Pagina/e 14967, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms14967

Pharmacological inhibition of the spliceosome subunit SF3b triggers exon junction complex-independent nonsense-mediated decay

Autori: Teresa Carvalho, Sandra Martins, José Rino, Sérgio Marinho, Maria Carmo-Fonseca
Pubblicato in: Journal of Cell Science, Numero 130/9, 2017, Pagina/e 1519-1531, ISSN 0021-9533
Editore: The Company of Biologists Ltd.
DOI: 10.1242/jcs.202200

Inverse electron demand Diels–Alder reactions in chemical biology

Autori: B. L. Oliveira, Z. Guo, G. J. L. Bernardes
Pubblicato in: Chem. Soc. Rev., Numero 46/16, 2017, Pagina/e 4895-4950, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/C7CS00184C

Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells

Autori: Pedro M. S. D. Cal, Florian Sieglitz, Fábio M. F. Santos, Cátia Parente Carvalho, Ana Guerreiro, Jean B. Bertoldo, Uwe Pischel, Pedro M. P. Gois, Gonçalo J. L. Bernardes
Pubblicato in: Chem. Commun., Numero 53/2, 2017, Pagina/e 368-371, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c6cc08671c

Association of Anger Expression-Out with NK Cell Counts in Colorectal Cancer Patients

Autori: Estela Kakoo-Brioso, Luís Costa, Sílvia Ouakinin
Pubblicato in: Acta Médica Portuguesa, Numero 31/3, 2018, Pagina/e 152, ISSN 0870-399X
Editore: Ordem dos Medicos
DOI: 10.20344/amp.9573

Microtubule motors involved in nuclear movement during skeletal muscle differentiation

Autori: V. Gache, E. R. Gomes, B. Cadot
Pubblicato in: Molecular Biology of the Cell, Numero 28/7, 2017, Pagina/e 865-874, ISSN 1059-1524
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Local Arrangement of Fibronectin by Myofibroblasts Governs Peripheral Nuclear Positioning in Muscle Cells

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YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

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LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

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Nuclear positioning in skeletal muscle

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Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

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Dealing with the nucleus during cell migration

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Damage and protection cost curves for coastal floods within the 600 largest European cities

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The contemporary nucleus: A trip down memory lane

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The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis

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Therapy-Induced Cellular Senescence Induces Epithelial-to-Mesenchymal Transition and Increases Invasiveness in Rectal Cancer

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Targeting bone metastases in prostate cancer: improving clinical outcome

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Bone remodeling markers and bone metastases: From cancer research to clinical implications

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Metadherin expression and lung relapse in patients with colorectal carcinoma

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RANKL enhances the effect of an antagonist of inhibitor of apoptosis proteins (cIAPs) in RANK-positive breast cancer cells

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Novel Insights into Breast Cancer Genetic Variance through RNA Sequencing

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RANKL/RANK/MMP-1 Molecular Triad Contributes to the Metastatic Phenotype of Breast and Prostate Cancer Cells In Vitro

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MTA1 Promotes STAT3 Transcription and Pulmonary Metastasis in Breast Cancer

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The role of low-molecular-weight protein tyrosine phosphatase (LMW-PTP ACP1) in oncogenesis

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Treatment of Cancer Pain by Targeting Cytokines

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Low Molecular Weight Protein Tyrosine Phosphatase Isoforms Regulate Breast Cancer Cells Migration through a RhoA Dependent Mechanism

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The Bone Marrow-Mediated Protection of Myeloproliferative Neoplastic Cells to Vorinostat and Ruxolitinib Relies on the Activation of JNK and PI3K Signalling Pathways

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CHK1 and replicative stress in T-cell leukemia: Can an irreverent tumor suppressor end up playing the oncogene?

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PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia

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Lymphotoxin-β receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype

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Kinases, tails and more: Regulation of PTEN function by phosphorylation

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CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress

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Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics

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PTEN and leukemia stem cells

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PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events

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IL-7R : Mr Hyde's twists and turns

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Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia

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Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia

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IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia

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Editore: Elsevier BV
DOI: 10.1016/j.jbior.2012.10.005

N-Cadherin Locks Left-Right Asymmetry by Ending the Leftward Movement of Hensen’s Node Cells

Autori: Raquel V. Mendes, Gabriel G. Martins, Ana M. Cristovão, Leonor Saúde
Pubblicato in: Developmental Cell, Numero 15345807, 2014, Pagina/e 353-360, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2014.06.010

Notch Signalling Is Required for the Formation of Structurally Stable Muscle Fibres in Zebrafish

Autori: Susana Pascoal, Joana Esteves de Lima, Jonathan D. Leslie, Simon M. Hughes, Leonor Saúde
Pubblicato in: PLoS ONE, Numero 19326203, 2013, Pagina/e e68021, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0068021

miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

Autori: Ana Costa, Joana Afonso, Catarina Osório, Ana L Gomes, Francisco Caiado, Joana Valente, Sandra I Aguiar, Francisco Pinto, Mário Ramirez, Sérgio Dias
Pubblicato in: Journal of Hematology & Oncology, Numero 17568722, 2013, Pagina/e 87, ISSN 1756-8722
Editore: BioMed Central
DOI: 10.1186/1756-8722-6-87

Bone Marrow-Derived CD11b+Jagged2+ Cells Promote Epithelial-to-Mesenchymal Transition and Metastasization in Colorectal Cancer

Autori: F. Caiado, T. Carvalho, I. Rosa, L. Remedio, A. Costa, J. Matos, B. Heissig, H. Yagita, K. Hattori, J. P. da Silva, P. Fidalgo, A. D. Pereira, S. Dias
Pubblicato in: Cancer Research, Numero 00085472, 2013, Pagina/e 4233-4246, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-13-0085

Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression

Autori: Catarina Rodrigues dos Santos, Isabel Fonseca, Sérgio Dias, JC Mendes de Almeida
Pubblicato in: BMC Cancer, Numero 14712407, 2014, Pagina/e 132, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/1471-2407-14-132

LDL-cholesterol signaling induces breast cancer proliferation and invasion

Autori: Catarina Rodrigues dos Santos, Germana Domingues, Inês Matias, João Matos, Isabel Fonseca, José de Almeida, Sérgio Dias
Pubblicato in: Lipids in Health and Disease, Numero 1476511X, 2014, Pagina/e 16, ISSN 1476-511X
Editore: BioMed Central
DOI: 10.1186/1476-511X-13-16

In Vitro and In Vivo Analysis of RTK Inhibitor Efficacy and Identification of Its Novel Targets in Glioblastomas

Autori: Olga Martinho, Renato Silva-Oliveira, Vera Miranda-Gonçalves, Carlos Clara, José Reynaldo Almeida, André Lopes Carvalho, João Taborda Barata, Rui Manuel Reis
Pubblicato in: Translational Oncology, Numero 19365233, 2013, Pagina/e 187-IN20, ISSN 1936-5233
Editore: Neoplasia Press
DOI: 10.1593/tlo.12400

Connecting the Nucleus to the Cytoskeleton for Nuclear Positioning and Cell Migration

Autori: Daniel S. Osorio, Edgar R. Gomes
Pubblicato in: Cancer Biology and the Nuclear Envelope, 2014, Pagina/e 505-520, ISBN 978-1-4899-8032-8
Editore: Springer New York
DOI: 10.1007/978-1-4899-8032-8_23

Skeletal Muscle

Autori: B. Cadot, E.R. Gomes
Pubblicato in: Encyclopedia of Cell Biology, 2016, Pagina/e 677-682, ISBN 9780123947963
Editore: Elsevier
DOI: 10.1016/B978-0-12-394447-4.20065-5

Imaging Pluripotency: Time-Lapse Analysis of Mouse Embryonic Stem Cells

Autori: Anna Pezzarossa, Ana M. V. Guedes, Domingos Henrique, Elsa Abranches
Pubblicato in: Embryonic Stem Cell Protocols, 2016, Pagina/e 87-100, ISBN 978-1-4939-2954-2
Editore: Springer New York
DOI: 10.1007/7651_2015_255

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