An integrated approach to understanding the impact of de novo mutations on the mammalian genome

Project Information

DENOVOMUT

Grant agreement ID: 694212

DOI

10.3030/694212

Project closed

EC signature date 17 May 2016

Start date 1 January 2017

End date 31 July 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 331,00

EU contribution

€ 2 499 331,00

Coordinated by

THE UNIVERSITY OF EDINBURGH
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

De Novo Mutation Rate Variation and Its Determinants in Chlamydomonas

Author(s): Eugenio López-Cortegano; Rory J. Craig; Jobran Chebib; Toby Samuels; Andrew D. Morgan; Susanne A. Kraemer; Katharina B. Böndel; Rob W. Ness; Nick Colegrave; Peter D. Keightley
Published in: López-Cortegano , E , Craig , R J , Chebib , J , Samuels , T , Morgan , A D , Kraemer , S A , Böndel , K B , Ness , R W , Colegrave , N , Keightley , P D & Hendrickson , H (ed.) 2021 , ' De novo mutation rate variation and its determinants in Chlamydomonas ' , Molecular Biology and Evolution , vol. 38 , no. 9 , msab140 , pp. 3709–3723 . https://doi.org/10.1093/molbev/msab140, Issue 1, 2021, ISSN 1537-1719
Publisher: OUP SMBE
DOI: 10.1093/molbev/msab140

Fitness decline under osmotic stress in Caenorhabditis elegans populations subjected to spontaneous mutation accumulation at varying population sizes.

Author(s): Katju, V., Packard, L. B. and Keightley, P. D.
Published in: Evolution, 2018, ISSN 1558-5646
Publisher: Wiley

Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii

Author(s): Katharina B. Böndel, Susanne A. Kraemer, Toby Samuels, Deirdre McClean, Josianne Lachapelle, Rob W. Ness, Nick Colegrave, Peter D. Keightley
Published in: PLOS Biology, Issue 17/6, 2019, Page(s) e3000192, ISSN 1545-7885
Publisher: PLoS
DOI: 10.1371/journal.pbio.3000192

Variation in the Spectrum of New Mutations among Inbred Strains of Mice

Author(s): Eugenio López-Cortegano, Jobran Chebib, Anika Jonas, Anastasia Vock, Sven Künzel, Diethard Tautz, Peter D Keightley
Published in: Molecular Biology and Evolution, Issue 41, 2024, ISSN 0737-4038
Publisher: Oxford University Press
DOI: 10.1093/molbev/msae163

Comparative genomics of Chlamydomonas.

Author(s): Craig, R. J., Hasan, A. R., Ness, R. W. and Keightley, P. D.
Published in: Plant Cell, 2021, ISSN 1040-4651
Publisher: American Society of Plant Biologists

The distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii inferred using frequency changes under experimental evolution

Author(s): Katharina B. Böndel; Toby Samuels; Rory J. Craig; Rob W. Ness; Nick Colegrave; Peter D. Keightley
Published in: PLoS Genetics, Issue 3, 2022, ISSN 1553-7404
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1009840

Rates and spectra of de novo structural mutations in<i>Chlamydomonas reinhardtii</i>

Author(s): Eugenio López-Cortegano; Rory J. Craig; Jobran Chebib; Eniolaye J. Balogun; Peter D. Keightley
Published in: Genome Research, Issue 2, 2021, ISSN 1549-5469
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.276957.122

Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site

Author(s): Jobran Chebib, Benjamin C. Jackson, Eugenio López-Cortegano, Diethard Tautz, Peter D. Keightley
Published in: Heredity, Issue 126, 2022, Page(s) 107-116, ISSN 0018-067X
Publisher: Nature Publishing Group
DOI: 10.1038/s41437-020-00361-1

Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site.

Author(s): Chebib, J., Jackson, B. C., López-Cortegano, E., Tautz, D. and Keightley, P. D.
Published in: Heredity, 2020, ISSN 1365-2540
Publisher: Nature

Understanding the factors that shape patterns of nucleotide diversity in the house mouse genome

Author(s): Tom R. Booker; Peter D. Keightley
Published in: Booker , T R & Keightley , P D 2018 , ' Understanding the factors that shape patterns of nucleotide diversity in the house mouse genome ' , Molecular Biology and Evolution . https://doi.org/10.1093/molbev/msy188, Issue 1, 2018, ISSN 1537-1719
Publisher: OuP
DOI: 10.1101/275610

Patterns of population structure and complex haplotype sharing among field isolates of the green alga Chlamydomonas reinhardtii

Author(s): Rory J. Craig, Katharina B. Böndel, Kazuharu Arakawa, Takashi Nakada, Takuro Ito, Graham Bell, Nick Colegrave, Peter D. Keightley, Rob W. Ness
Published in: Molecular Ecology, Issue 28/17, 2019, Page(s) 3977-3993, ISSN 0962-1083
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/mec.15193

Inferring the Probability of the Derived versus the Ancestral Allelic State at a Polymorphic Site

Author(s): Peter D. Keightley, Benjamin C. Jackson
Published in: Genetics, 2018, Page(s) genetics.301120.2018, ISSN 0016-6731
Publisher: Genetics Society of America
DOI: 10.1534/genetics.118.301120

The Recombination Landscape in Wild House Mice Inferred Using Population Genomic Data

Author(s): Tom R. Booker, Rob W. Ness, Peter D. Keightley
Published in: Genetics, Issue 207/1, 2017, Page(s) 297-309, ISSN 0016-6731
Publisher: Genetics Society of America
DOI: 10.1534/genetics.117.300063

Detecting positive selection in the genome

Author(s): Tom R. Booker, Benjamin C. Jackson, Peter D. Keightley
Published in: BMC Biology, Issue 15/1, 2017, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-017-0434-y

An estimate of fitness reduction from mutation accumulation in a mammal allows assessment of the consequences of relaxed selection

Author(s): Jobran Chebib, Anika Jonas, Eugenio López-Cortegano, Sven Künzel, Diethard Tautz, Peter D. Keightley
Published in: PLOS Biology, Issue 22, 2024, Page(s) e3002795, ISSN 1545-7885
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pbio.3002795

The rate and spectrum of new mutations in mice inferred by long-read sequencing

Author(s): Eugenio López-Cortegano, Jobran Chebib, Anika Jonas, Anastasia Vock, Sven Künzel, Peter D. Keightley, Diethard Tautz
Published in: Genome Research, Issue 35, 2025, Page(s) 43-54, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.279982.124