An integrated approach to understanding the impact of de novo mutations on the mammalian genome

Información del proyecto

DENOVOMUT

Identificador del acuerdo de subvención: 694212

DOI

10.3030/694212

Proyecto cerrado

Fecha de la firma de la CE 17 Mayo 2016

Fecha de inicio 1 Enero 2017

Fecha de finalización 31 Julio 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 499 331,00

Aportación de la UE

€ 2 499 331,00

Coordinado por

THE UNIVERSITY OF EDINBURGH
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (16)

De Novo Mutation Rate Variation and Its Determinants in Chlamydomonas

Autores: Eugenio López-Cortegano; Rory J. Craig; Jobran Chebib; Toby Samuels; Andrew D. Morgan; Susanne A. Kraemer; Katharina B. Böndel; Rob W. Ness; Nick Colegrave; Peter D. Keightley
Publicado en: López-Cortegano , E , Craig , R J , Chebib , J , Samuels , T , Morgan , A D , Kraemer , S A , Böndel , K B , Ness , R W , Colegrave , N , Keightley , P D & Hendrickson , H (ed.) 2021 , ' De novo mutation rate variation and its determinants in Chlamydomonas ' , Molecular Biology and Evolution , vol. 38 , no. 9 , msab140 , pp. 3709–3723 . https://doi.org/10.1093/molbev/msab140, Edición 1, 2021, ISSN 1537-1719
Editor: OUP SMBE
DOI: 10.1093/molbev/msab140

Fitness decline under osmotic stress in Caenorhabditis elegans populations subjected to spontaneous mutation accumulation at varying population sizes.

Autores: Katju, V., Packard, L. B. and Keightley, P. D.
Publicado en: Evolution, 2018, ISSN 1558-5646
Editor: Wiley

Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii

Autores: Katharina B. Böndel, Susanne A. Kraemer, Toby Samuels, Deirdre McClean, Josianne Lachapelle, Rob W. Ness, Nick Colegrave, Peter D. Keightley
Publicado en: PLOS Biology, Edición 17/6, 2019, Página(s) e3000192, ISSN 1545-7885
Editor: PLoS
DOI: 10.1371/journal.pbio.3000192

Variation in the Spectrum of New Mutations among Inbred Strains of Mice

Autores: Eugenio López-Cortegano, Jobran Chebib, Anika Jonas, Anastasia Vock, Sven Künzel, Diethard Tautz, Peter D Keightley
Publicado en: Molecular Biology and Evolution, Edición 41, 2024, ISSN 0737-4038
Editor: Oxford University Press
DOI: 10.1093/molbev/msae163

Comparative genomics of Chlamydomonas.

Autores: Craig, R. J., Hasan, A. R., Ness, R. W. and Keightley, P. D.
Publicado en: Plant Cell, 2021, ISSN 1040-4651
Editor: American Society of Plant Biologists

The distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii inferred using frequency changes under experimental evolution

Autores: Katharina B. Böndel; Toby Samuels; Rory J. Craig; Rob W. Ness; Nick Colegrave; Peter D. Keightley
Publicado en: PLoS Genetics, Edición 3, 2022, ISSN 1553-7404
Editor: Public Library of Science
DOI: 10.1371/journal.pgen.1009840

Rates and spectra of de novo structural mutations in<i>Chlamydomonas reinhardtii</i>

Autores: Eugenio López-Cortegano; Rory J. Craig; Jobran Chebib; Eniolaye J. Balogun; Peter D. Keightley
Publicado en: Genome Research, Edición 2, 2021, ISSN 1549-5469
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.276957.122

Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site

Autores: Jobran Chebib, Benjamin C. Jackson, Eugenio López-Cortegano, Diethard Tautz, Peter D. Keightley
Publicado en: Heredity, Edición 126, 2022, Página(s) 107-116, ISSN 0018-067X
Editor: Nature Publishing Group
DOI: 10.1038/s41437-020-00361-1

Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site.

Autores: Chebib, J., Jackson, B. C., López-Cortegano, E., Tautz, D. and Keightley, P. D.
Publicado en: Heredity, 2020, ISSN 1365-2540
Editor: Nature

Understanding the factors that shape patterns of nucleotide diversity in the house mouse genome

Autores: Tom R. Booker; Peter D. Keightley
Publicado en: Booker , T R & Keightley , P D 2018 , ' Understanding the factors that shape patterns of nucleotide diversity in the house mouse genome ' , Molecular Biology and Evolution . https://doi.org/10.1093/molbev/msy188, Edición 1, 2018, ISSN 1537-1719
Editor: OuP
DOI: 10.1101/275610

Patterns of population structure and complex haplotype sharing among field isolates of the green alga Chlamydomonas reinhardtii

Autores: Rory J. Craig, Katharina B. Böndel, Kazuharu Arakawa, Takashi Nakada, Takuro Ito, Graham Bell, Nick Colegrave, Peter D. Keightley, Rob W. Ness
Publicado en: Molecular Ecology, Edición 28/17, 2019, Página(s) 3977-3993, ISSN 0962-1083
Editor: Blackwell Publishing Inc.
DOI: 10.1111/mec.15193

Inferring the Probability of the Derived versus the Ancestral Allelic State at a Polymorphic Site

Autores: Peter D. Keightley, Benjamin C. Jackson
Publicado en: Genetics, 2018, Página(s) genetics.301120.2018, ISSN 0016-6731
Editor: Genetics Society of America
DOI: 10.1534/genetics.118.301120

The Recombination Landscape in Wild House Mice Inferred Using Population Genomic Data

Autores: Tom R. Booker, Rob W. Ness, Peter D. Keightley
Publicado en: Genetics, Edición 207/1, 2017, Página(s) 297-309, ISSN 0016-6731
Editor: Genetics Society of America
DOI: 10.1534/genetics.117.300063

Detecting positive selection in the genome

Autores: Tom R. Booker, Benjamin C. Jackson, Peter D. Keightley
Publicado en: BMC Biology, Edición 15/1, 2017, ISSN 1741-7007
Editor: BioMed Central
DOI: 10.1186/s12915-017-0434-y

An estimate of fitness reduction from mutation accumulation in a mammal allows assessment of the consequences of relaxed selection

Autores: Jobran Chebib, Anika Jonas, Eugenio López-Cortegano, Sven Künzel, Diethard Tautz, Peter D. Keightley
Publicado en: PLOS Biology, Edición 22, 2024, Página(s) e3002795, ISSN 1545-7885
Editor: Public Library of Science (PLoS)
DOI: 10.1371/journal.pbio.3002795

The rate and spectrum of new mutations in mice inferred by long-read sequencing

Autores: Eugenio López-Cortegano, Jobran Chebib, Anika Jonas, Anastasia Vock, Sven Künzel, Peter D. Keightley, Diethard Tautz
Publicado en: Genome Research, Edición 35, 2025, Página(s) 43-54, ISSN 1088-9051
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.279982.124