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Genomics of Chromosome Architecture and Dynamics in Single Cells

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Publications

Local rewiring of genome–nuclear lamina interactions by transcription.

Author(s): Brueckner L, Zhao PA, van Schaik T, Leemans C, Sima J, Peric-Hupkes D, Gilbert DM, van Steensel B
Published in: EMBO Journal, 39, 2020, Page(s) e103159, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2019103159

Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance

Author(s): Schep R, Brinkman EK, Leemans C, Vergara X, van der Weide RH, Morris B, van Schaik T, Manzo SG, Peric-Hupkes D, van den Berg J, Beijersbergen RL, Medema RH, van Steensel B
Published in: Mol. Cell, 81, 2021, Page(s) 2216-2230, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.03.032

Kinetics and Fidelity of the Repair of Cas9-Induced Double-Strand DNA Breaks

Author(s): Eva K. Brinkman, Tao Chen, Marcel de Haas, Hanna A. Holland, Waseem Akhtar, Bas van Steensel
Published in: Molecular Cell, 70/5, 2018, Page(s) 801-813.e6, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.04.016

Easy quantification of template-directed CRISPR/Cas9 editing

Author(s): Eva K Brinkman, Arne N Kousholt, Tim Harmsen, Christ Leemans, Tao Chen, Jos Jonkers, Bas van Steensel
Published in: Nucleic Acids Research, 46/10, 2018, Page(s) e58-e58, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky164

High-throughput identification of human SNPs affecting regulatory element activity

Author(s): Joris van Arensbergen, Ludo Pagie, Vincent D. FitzPatrick, Marcel de Haas, Marijke P. Baltissen, Federico Comoglio, Robin H. van der Weide, Hans Teunissen, Urmo Võsa, Lude Franke, Elzo de Wit, Michiel Vermeulen, Harmen J. Bussemaker, Bas van Steensel
Published in: Nature Genetics, 51/7, 2019, Page(s) 1160-1169, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0455-2

The role of transcription in shaping the spatial organization of the genome

Author(s): Bas van Steensel, Eileen E. M. Furlong
Published in: Nature Reviews Molecular Cell Biology, 20/6, 2019, Page(s) 327-337, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-019-0114-6

The large fraction of heterochromatin in Drosophila neurons is bound by both B-type lamin and HP1a

Author(s): Alexey V. Pindyurin, Artem A. Ilyin, Anton V. Ivankin, Mikhail V. Tselebrovsky, Valentina V. Nenasheva, Elena A. Mikhaleva, Ludo Pagie, Bas van Steensel, Yuri Y. Shevelyov
Published in: Epigenetics & Chromatin, 11/1, 2018, ISSN 1756-8935
Publisher: BioMed Central
DOI: 10.1186/s13072-018-0235-8

Promoter-Intrinsic and Local Chromatin Features Determine Gene Repression in LADs

Author(s): Christ Leemans, Marloes C.H. van der Zwalm, Laura Brueckner, Federico Comoglio, Tom van Schaik, Ludo Pagie, Joris van Arensbergen, Bas van Steensel
Published in: Cell, 177/4, 2019, Page(s) 852-864.e14, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.03.009