Genomics of Chromosome Architecture and Dynamics in Single Cells

Project Information

GoCADiSC

Grant agreement ID: 694466

DOI 10.3030/694466

Project closed

EC signature date 20 May 2016

Start date 1 March 2017

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 497 125,00

EU contribution € 2 497 125,00

Coordinated by

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands

Publications

Peer reviewed articles (11)

Local rewiring of genome–nuclear lamina interactions by transcription.

Author(s): Brueckner L, Zhao PA, van Schaik T, Leemans C, Sima J, Peric-Hupkes D, Gilbert DM, van Steensel B
Published in: EMBO Journal, Issue 39, 2020, Page(s) e103159, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2019103159

Systematicanalysis of intrinsic enhancer-promoter compatibility in the mouse genome.

Author(s): Martinez-Ara M, Comoglio F, van Arensbergen J, van Steensel B.
Published in: Mol. Cell, Issue 10972765, 2022, Page(s) 2519-2531, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.04.009

CTCF and cohesin promote focal detachment of DNA from the nuclear lamina

Author(s): van Schaik T, Liu NQ, Manzo SG, Peric-Hupkes D, de Wit E, van Steensel B.
Published in: Genome Biology, Issue 23, 2022, Page(s) 185, ISSN 1465-6906
Publisher: BMC/Springer Nature
DOI: 10.1186/s13059-022-02754-3

Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance

Author(s): Schep R, Brinkman EK, Leemans C, Vergara X, van der Weide RH, Morris B, van Schaik T, Manzo SG, Peric-Hupkes D, van den Berg J, Beijersbergen RL, Medema RH, van Steensel B
Published in: Mol. Cell, Issue 81, 2021, Page(s) 2216-2230, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.03.032

Dynamic chromosomal interactions and control of heterochromatinpositioning by Ki-67.

Author(s): van Schaik T, Manzo SG, Vouzas AE, Liu NQ, Teunissen H, de Wit E, Gilbert DM, van Steensel B.
Published in: EMBO Reports, Issue 1469221X, 2022, Page(s) e55782, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202255782

Kinetics and Fidelity of the Repair of Cas9-Induced Double-Strand DNA Breaks

Author(s): Eva K. Brinkman, Tao Chen, Marcel de Haas, Hanna A. Holland, Waseem Akhtar, Bas van Steensel
Published in: Molecular Cell, Issue 70/5, 2018, Page(s) 801-813.e6, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.04.016

Easy quantification of template-directed CRISPR/Cas9 editing

Author(s): Eva K Brinkman, Arne N Kousholt, Tim Harmsen, Christ Leemans, Tao Chen, Jos Jonkers, Bas van Steensel
Published in: Nucleic Acids Research, Issue 46/10, 2018, Page(s) e58-e58, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky164

High-throughput identification of human SNPs affecting regulatory element activity

Author(s): Joris van Arensbergen, Ludo Pagie, Vincent D. FitzPatrick, Marcel de Haas, Marijke P. Baltissen, Federico Comoglio, Robin H. van der Weide, Hans Teunissen, Urmo Võsa, Lude Franke, Elzo de Wit, Michiel Vermeulen, Harmen J. Bussemaker, Bas van Steensel
Published in: Nature Genetics, Issue 51/7, 2019, Page(s) 1160-1169, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-019-0455-2

The role of transcription in shaping the spatial organization of the genome

Author(s): Bas van Steensel, Eileen E. M. Furlong
Published in: Nature Reviews Molecular Cell Biology, Issue 20/6, 2019, Page(s) 327-337, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-019-0114-6

The large fraction of heterochromatin in Drosophila neurons is bound by both B-type lamin and HP1a

Author(s): Alexey V. Pindyurin, Artem A. Ilyin, Anton V. Ivankin, Mikhail V. Tselebrovsky, Valentina V. Nenasheva, Elena A. Mikhaleva, Ludo Pagie, Bas van Steensel, Yuri Y. Shevelyov
Published in: Epigenetics & Chromatin, Issue 11/1, 2018, ISSN 1756-8935
Publisher: BioMed Central
DOI: 10.1186/s13072-018-0235-8

Promoter-Intrinsic and Local Chromatin Features Determine Gene Repression in LADs

Author(s): Christ Leemans, Marloes C.H. van der Zwalm, Laura Brueckner, Federico Comoglio, Tom van Schaik, Ludo Pagie, Joris van Arensbergen, Bas van Steensel
Published in: Cell, Issue 177/4, 2019, Page(s) 852-864.e14, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.03.009