Prenylated-flavins: Application and Biochemistry

Publicaciones

Enzymatic C–H activation of aromatic compounds through CO2 fixation

Autores: Godwin A. Aleku, Annica Saaret, Ruth T. Bradshaw-Allen, Sasha R. Derrington, Gabriel R. Titchiner, Irina Gostimskaya, Deepankar Gahloth, David A. Parker, Sam Hay, David Leys
Publicado en: Nature Chemical Biology, Edición 16/11, 2020, Página(s) 1255-1260, ISSN 1552-4450
Editor: Nature Publishing Group
DOI: 10.1038/s41589-020-0603-0

Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production

Autores: Annica Saaret, Benoît Villiers, François Stricher, Macha Anissimova, Mélodie Cadillon, Reynard Spiess, Sam Hay, David Leys
Publicado en: Nature Communications, 2021, Página(s) 12, 5300, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-25598-0

Ferulic Acid Decarboxylase Controls Oxidative Maturation of the Prenylated Flavin Mononucleotide Cofactor

Autores: Arune Balaikaite, Malama Chisanga, Karl Fisher, Derren J. Heyes, Reynard Spiess, David Leys
Publicado en: ACS Chemical Biology, Edición 15/9, 2020, Página(s) 2466-2475, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.0c00456

Prenylated flavins: structures and mechanisms

Autores: Samuel Bloor; Iaroslav Michurin; Gabriel R. Titchiner; David Leys
Publicado en: The FEBS Journal, 2023, Página(s) 2232-2245, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.16371

UbiD domain dynamics underpins aromatic decarboxylation

Autores: Stephen A. Marshall, Karl A.P. Payne, Karl Fisher, GR Titchiner, C Levy, S Hay, D Leys
Publicado en: Nature Communications, 2021, Página(s) 12, 5056, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-25278-z

The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry

Autores: Stephen A. Marshall, Karl A. P. Payne, Karl Fisher, Mark D. White, Aisling Ní Cheallaigh, Arune Balaikaite, Stephen E. J. Rigby, David Leys
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-10220-1

Enzymatic <i>N</i>-Allylation of Primary and Secondary Amines Using Renewable Cinnamic Acids Enabled by Bacterial Reductive Aminases

Autores: Godwin A. Aleku; Gabriel R. Titchiner; George W. Roberts; Sasha R. Derrington; James R. Marshall; Florian Hollfelder; Nicholas J. Turner; David Leys
Publicado en: ACS Susainable Chemistry and Engineering, Edición 9, 2022, ISSN 2168-0485
Editor: American Chemical Society
DOI: 10.1021/acssuschemeng.2c01180

Stability engineering of ferulic acid decarboxylase unlocks enhanced aromatic acid decarboxylation

Autores: George W Roberts, Karl Fisher, Tom Jowitt, David Leys
Publicado en: Current Research in Chemical Biology, 2023, ISSN 2666-2469
Editor: Elsevier
DOI: 10.1016/j.crchbi.2023.100043

The role of conserved residues in Fdc decarboxylase in prenylated flavin mononucleotide oxidative maturation, cofactor isomerization, and catalysis

Autores: Samuel S. Bailey, Karl A. P. Payne, Karl Fisher, Stephen A. Marshall, Matthew J. Cliff, Reynard Spiess, David A. Parker, Stephen E. J. Rigby, David Leys
Publicado en: Journal of Biological Chemistry, Edición 293/7, 2018, Página(s) 2272-2287, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA117.000881

The UbiX-UbiD system: The biosynthesis and use of prenylated flavin (prFMN)

Autores: Stephen A. Marshall, Karl A.P. Payne, David Leys
Publicado en: Archives of Biochemistry and Biophysics, Edición 632, 2017, Página(s) 209-221, ISSN 0003-9861
Editor: Academic Press
DOI: 10.1016/j.abb.2017.07.014

Regioselective para -Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase

Autores: Stefan E. Payer, Stephen A. Marshall, Natalie Bärland, Xiang Sheng, Tamara Reiter, Andela Dordic, Georg Steinkellner, Christiane Wuensch, Susann Kaltwasser, Karl Fisher, Stephen E. J. Rigby, Peter Macheroux, Janet Vonck, Karl Gruber, Kurt Faber, Fahmi Himo, David Leys, Tea Pavkov-Keller, Silvia M. Glueck
Publicado en: Angewandte Chemie International Edition, Edición 56/44, 2017, Página(s) 13893-13897, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201708091

Enzymatic Carboxylation of 2-Furoic Acid Yields 2,5-Furandicarboxylic Acid (FDCA)

Autores: Karl A.P. Payne, Stephen A. Marshall, Karl Fisher, Matthew J. Cliff, Diego M. Cannas, Cunyu Yan, Derren J. Heyes, David A. Parker, Igor Larrosa, David Leys
Publicado en: ACS Catalysis, Edición 9/4, 2019, Página(s) 2854-2865, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.8b04862

Flavin metamorphosis: cofactor transformation through prenylation

Autores: David Leys
Publicado en: Current Opinion in Chemical Biology, Edición 47, 2018, Página(s) 117-125, ISSN 1367-5931
Editor: Elsevier BV
DOI: 10.1016/j.cbpa.2018.09.024

Terminal Alkenes from Acrylic Acid Derivatives via Non-Oxidative Enzymatic Decarboxylation by Ferulic Acid Decarboxylases

Autores: Godwin A. Aleku, Christoph Prause, Ruth T. Bradshaw-Allen, Katharina Plasch, Silvia M. Glueck, Samuel S. Bailey, Karl A. P. Payne, David A. Parker, Kurt Faber, David Leys
Publicado en: ChemCatChem, Edición 10/17, 2018, Página(s) 3736-3745, ISSN 1867-3880
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.201800643

Enzymatic control of cycloadduct conformation ensures reversible 1,3-dipolar cycloaddition in a prFMN-dependent decarboxylase

Autores: Samuel S. Bailey, Karl A. P. Payne, Annica Saaret, Stephen A. Marshall, Irina Gostimskaya, Iaroslav Kosov, Karl Fisher, Sam Hay, David Leys
Publicado en: Nature Chemistry, Edición 11/11, 2019, Página(s) 1049-1057, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-019-0324-8

Structural and biochemical characterization of the prenylated flavin mononucleotide-dependent indole-3-carboxylic acid decarboxylase

Autores: Deepankar Gahloth; Karl Fisher; Karl A.P. Payne; Matthew Cliff; Colin Levy; David Leys
Publicado en: Journal of Biological Chemistry, Edición 4, 2022, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.101771

Structural insights into UbiD reversible decarboxylation

Autores: George W. Roberts; David Leys
Publicado en: Current Opinion in Structural Biology, Edición 8, 2022, ISSN 0959-440X
Editor: Elsevier BV
DOI: 10.1016/j.sbi.2022.102432

Synthetic Enzyme‐Catalyzed CO 2 Fixation Reactions

Autores: Godwin A. Aleku, George W. Roberts, Gabriel R. Titchiner, David Leys
Publicado en: ChemSusChem, Edición 14/8, 2021, Página(s) 1781-1804, ISSN 1864-5631
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202100159

Structure and Mechanism of Pseudomonas aeruginosa PA0254/HudA, a prFMN-Dependent Pyrrole-2-carboxylic Acid Decarboxylase Linked to Virulence

Autores: Karl A. P. Payne, Stephen A. Marshall, Karl Fisher, Stephen E. J. Rigby, Matthew J. Cliff, Reynard Spiess, Diego M. Cannas, Igor Larrosa, Sam Hay, David Leys
Publicado en: ACS Catalysis, Edición 11/5, 2021, Página(s) 2865-2878, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.0c05042

Biocatalytic reduction of α,β-unsaturated carboxylic acids to allylic alcohols

Autores: Godwin A. Aleku, George W. Roberts, David Leys
Publicado en: Green Chemistry, Edición 22/12, 2020, Página(s) 3927-3939, ISSN 1463-9262
Editor: Royal Society of Chemistry
DOI: 10.1039/d0gc00867b

Biosynthesis of Pyrrole-2-carbaldehyde via Enzymatic CO2 Fixation

Autores: Gabriel R. Titchiner; Stephen A. Marshall; Herkus Miscikas; David Leys
Publicado en: Catalysts, 2022, Página(s) 12, 538, ISSN 2073-4344
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/catal12050538

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