Prenylated-flavins: Application and Biochemistry

Publikacje

Enzymatic C–H activation of aromatic compounds through CO2 fixation

Autorzy: Godwin A. Aleku, Annica Saaret, Ruth T. Bradshaw-Allen, Sasha R. Derrington, Gabriel R. Titchiner, Irina Gostimskaya, Deepankar Gahloth, David A. Parker, Sam Hay, David Leys
Opublikowane w: Nature Chemical Biology, Numer 16/11, 2020, Strona(/y) 1255-1260, ISSN 1552-4450
Wydawca: Nature Publishing Group
DOI: 10.1038/s41589-020-0603-0

Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production

Autorzy: Annica Saaret, Benoît Villiers, François Stricher, Macha Anissimova, Mélodie Cadillon, Reynard Spiess, Sam Hay, David Leys
Opublikowane w: Nature Communications, 2021, Strona(/y) 12, 5300, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-25598-0

Ferulic Acid Decarboxylase Controls Oxidative Maturation of the Prenylated Flavin Mononucleotide Cofactor

Autorzy: Arune Balaikaite, Malama Chisanga, Karl Fisher, Derren J. Heyes, Reynard Spiess, David Leys
Opublikowane w: ACS Chemical Biology, Numer 15/9, 2020, Strona(/y) 2466-2475, ISSN 1554-8929
Wydawca: American Chemical Society
DOI: 10.1021/acschembio.0c00456

Prenylated flavins: structures and mechanisms

Autorzy: Samuel Bloor; Iaroslav Michurin; Gabriel R. Titchiner; David Leys
Opublikowane w: The FEBS Journal, 2023, Strona(/y) 2232-2245, ISSN 1742-464X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/febs.16371

UbiD domain dynamics underpins aromatic decarboxylation

Autorzy: Stephen A. Marshall, Karl A.P. Payne, Karl Fisher, GR Titchiner, C Levy, S Hay, D Leys
Opublikowane w: Nature Communications, 2021, Strona(/y) 12, 5056, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-25278-z

The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry

Autorzy: Stephen A. Marshall, Karl A. P. Payne, Karl Fisher, Mark D. White, Aisling Ní Cheallaigh, Arune Balaikaite, Stephen E. J. Rigby, David Leys
Opublikowane w: Nature Communications, Numer 10/1, 2019, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-019-10220-1

Enzymatic <i>N</i>-Allylation of Primary and Secondary Amines Using Renewable Cinnamic Acids Enabled by Bacterial Reductive Aminases

Autorzy: Godwin A. Aleku; Gabriel R. Titchiner; George W. Roberts; Sasha R. Derrington; James R. Marshall; Florian Hollfelder; Nicholas J. Turner; David Leys
Opublikowane w: ACS Susainable Chemistry and Engineering, Numer 9, 2022, ISSN 2168-0485
Wydawca: American Chemical Society
DOI: 10.1021/acssuschemeng.2c01180

Stability engineering of ferulic acid decarboxylase unlocks enhanced aromatic acid decarboxylation

Autorzy: George W Roberts, Karl Fisher, Tom Jowitt, David Leys
Opublikowane w: Current Research in Chemical Biology, 2023, ISSN 2666-2469
Wydawca: Elsevier
DOI: 10.1016/j.crchbi.2023.100043

The role of conserved residues in Fdc decarboxylase in prenylated flavin mononucleotide oxidative maturation, cofactor isomerization, and catalysis

Autorzy: Samuel S. Bailey, Karl A. P. Payne, Karl Fisher, Stephen A. Marshall, Matthew J. Cliff, Reynard Spiess, David A. Parker, Stephen E. J. Rigby, David Leys
Opublikowane w: Journal of Biological Chemistry, Numer 293/7, 2018, Strona(/y) 2272-2287, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA117.000881

The UbiX-UbiD system: The biosynthesis and use of prenylated flavin (prFMN)

Autorzy: Stephen A. Marshall, Karl A.P. Payne, David Leys
Opublikowane w: Archives of Biochemistry and Biophysics, Numer 632, 2017, Strona(/y) 209-221, ISSN 0003-9861
Wydawca: Academic Press
DOI: 10.1016/j.abb.2017.07.014

Regioselective para -Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase

Autorzy: Stefan E. Payer, Stephen A. Marshall, Natalie Bärland, Xiang Sheng, Tamara Reiter, Andela Dordic, Georg Steinkellner, Christiane Wuensch, Susann Kaltwasser, Karl Fisher, Stephen E. J. Rigby, Peter Macheroux, Janet Vonck, Karl Gruber, Kurt Faber, Fahmi Himo, David Leys, Tea Pavkov-Keller, Silvia M. Glueck
Opublikowane w: Angewandte Chemie International Edition, Numer 56/44, 2017, Strona(/y) 13893-13897, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201708091

Enzymatic Carboxylation of 2-Furoic Acid Yields 2,5-Furandicarboxylic Acid (FDCA)

Autorzy: Karl A.P. Payne, Stephen A. Marshall, Karl Fisher, Matthew J. Cliff, Diego M. Cannas, Cunyu Yan, Derren J. Heyes, David A. Parker, Igor Larrosa, David Leys
Opublikowane w: ACS Catalysis, Numer 9/4, 2019, Strona(/y) 2854-2865, ISSN 2155-5435
Wydawca: American Chemical Society
DOI: 10.1021/acscatal.8b04862

Flavin metamorphosis: cofactor transformation through prenylation

Autorzy: David Leys
Opublikowane w: Current Opinion in Chemical Biology, Numer 47, 2018, Strona(/y) 117-125, ISSN 1367-5931
Wydawca: Elsevier BV
DOI: 10.1016/j.cbpa.2018.09.024

Terminal Alkenes from Acrylic Acid Derivatives via Non-Oxidative Enzymatic Decarboxylation by Ferulic Acid Decarboxylases

Autorzy: Godwin A. Aleku, Christoph Prause, Ruth T. Bradshaw-Allen, Katharina Plasch, Silvia M. Glueck, Samuel S. Bailey, Karl A. P. Payne, David A. Parker, Kurt Faber, David Leys
Opublikowane w: ChemCatChem, Numer 10/17, 2018, Strona(/y) 3736-3745, ISSN 1867-3880
Wydawca: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.201800643

Enzymatic control of cycloadduct conformation ensures reversible 1,3-dipolar cycloaddition in a prFMN-dependent decarboxylase

Autorzy: Samuel S. Bailey, Karl A. P. Payne, Annica Saaret, Stephen A. Marshall, Irina Gostimskaya, Iaroslav Kosov, Karl Fisher, Sam Hay, David Leys
Opublikowane w: Nature Chemistry, Numer 11/11, 2019, Strona(/y) 1049-1057, ISSN 1755-4330
Wydawca: Nature Publishing Group
DOI: 10.1038/s41557-019-0324-8

Structural and biochemical characterization of the prenylated flavin mononucleotide-dependent indole-3-carboxylic acid decarboxylase

Autorzy: Deepankar Gahloth; Karl Fisher; Karl A.P. Payne; Matthew Cliff; Colin Levy; David Leys
Opublikowane w: Journal of Biological Chemistry, Numer 4, 2022, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.101771

Structural insights into UbiD reversible decarboxylation

Autorzy: George W. Roberts; David Leys
Opublikowane w: Current Opinion in Structural Biology, Numer 8, 2022, ISSN 0959-440X
Wydawca: Elsevier BV
DOI: 10.1016/j.sbi.2022.102432

Synthetic Enzyme‐Catalyzed CO 2 Fixation Reactions

Autorzy: Godwin A. Aleku, George W. Roberts, Gabriel R. Titchiner, David Leys
Opublikowane w: ChemSusChem, Numer 14/8, 2021, Strona(/y) 1781-1804, ISSN 1864-5631
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202100159

Structure and Mechanism of Pseudomonas aeruginosa PA0254/HudA, a prFMN-Dependent Pyrrole-2-carboxylic Acid Decarboxylase Linked to Virulence

Autorzy: Karl A. P. Payne, Stephen A. Marshall, Karl Fisher, Stephen E. J. Rigby, Matthew J. Cliff, Reynard Spiess, Diego M. Cannas, Igor Larrosa, Sam Hay, David Leys
Opublikowane w: ACS Catalysis, Numer 11/5, 2021, Strona(/y) 2865-2878, ISSN 2155-5435
Wydawca: American Chemical Society
DOI: 10.1021/acscatal.0c05042

Biocatalytic reduction of α,β-unsaturated carboxylic acids to allylic alcohols

Autorzy: Godwin A. Aleku, George W. Roberts, David Leys
Opublikowane w: Green Chemistry, Numer 22/12, 2020, Strona(/y) 3927-3939, ISSN 1463-9262
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0gc00867b

Biosynthesis of Pyrrole-2-carbaldehyde via Enzymatic CO2 Fixation

Autorzy: Gabriel R. Titchiner; Stephen A. Marshall; Herkus Miscikas; David Leys
Opublikowane w: Catalysts, 2022, Strona(/y) 12, 538, ISSN 2073-4344
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/catal12050538

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