Prenylated-flavins: Application and Biochemistry

Informazioni relative al progetto

pre-FAB

ID dell’accordo di sovvenzione: 695013

DOI

10.3030/695013

Progetto chiuso

Data della firma CE 18 Aprile 2016

Data di avvio 1 Settembre 2016

Data di completamento 31 Agosto 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 494 328,75

Contributo UE

€ 2 494 328,75

Coordinato da

THE UNIVERSITY OF MANCHESTER
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (21)

Enzymatic C–H activation of aromatic compounds through CO2 fixation

Autori: Godwin A. Aleku, Annica Saaret, Ruth T. Bradshaw-Allen, Sasha R. Derrington, Gabriel R. Titchiner, Irina Gostimskaya, Deepankar Gahloth, David A. Parker, Sam Hay, David Leys
Pubblicato in: Nature Chemical Biology, Numero 16/11, 2020, Pagina/e 1255-1260, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-020-0603-0

Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production

Autori: Annica Saaret, Benoît Villiers, François Stricher, Macha Anissimova, Mélodie Cadillon, Reynard Spiess, Sam Hay, David Leys
Pubblicato in: Nature Communications, 2021, Pagina/e 12, 5300, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-25598-0

Ferulic Acid Decarboxylase Controls Oxidative Maturation of the Prenylated Flavin Mononucleotide Cofactor

Autori: Arune Balaikaite, Malama Chisanga, Karl Fisher, Derren J. Heyes, Reynard Spiess, David Leys
Pubblicato in: ACS Chemical Biology, Numero 15/9, 2020, Pagina/e 2466-2475, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.0c00456

Prenylated flavins: structures and mechanisms

Autori: Samuel Bloor; Iaroslav Michurin; Gabriel R. Titchiner; David Leys
Pubblicato in: The FEBS Journal, 2023, Pagina/e 2232-2245, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.16371

UbiD domain dynamics underpins aromatic decarboxylation

Autori: Stephen A. Marshall, Karl A.P. Payne, Karl Fisher, GR Titchiner, C Levy, S Hay, D Leys
Pubblicato in: Nature Communications, 2021, Pagina/e 12, 5056, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-25278-z

The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry

Autori: Stephen A. Marshall, Karl A. P. Payne, Karl Fisher, Mark D. White, Aisling Ní Cheallaigh, Arune Balaikaite, Stephen E. J. Rigby, David Leys
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-10220-1

Enzymatic <i>N</i>-Allylation of Primary and Secondary Amines Using Renewable Cinnamic Acids Enabled by Bacterial Reductive Aminases

Autori: Godwin A. Aleku; Gabriel R. Titchiner; George W. Roberts; Sasha R. Derrington; James R. Marshall; Florian Hollfelder; Nicholas J. Turner; David Leys
Pubblicato in: ACS Susainable Chemistry and Engineering, Numero 9, 2022, ISSN 2168-0485
Editore: American Chemical Society
DOI: 10.1021/acssuschemeng.2c01180

Stability engineering of ferulic acid decarboxylase unlocks enhanced aromatic acid decarboxylation

Autori: George W Roberts, Karl Fisher, Tom Jowitt, David Leys
Pubblicato in: Current Research in Chemical Biology, 2023, ISSN 2666-2469
Editore: Elsevier
DOI: 10.1016/j.crchbi.2023.100043

The role of conserved residues in Fdc decarboxylase in prenylated flavin mononucleotide oxidative maturation, cofactor isomerization, and catalysis

Autori: Samuel S. Bailey, Karl A. P. Payne, Karl Fisher, Stephen A. Marshall, Matthew J. Cliff, Reynard Spiess, David A. Parker, Stephen E. J. Rigby, David Leys
Pubblicato in: Journal of Biological Chemistry, Numero 293/7, 2018, Pagina/e 2272-2287, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA117.000881

The UbiX-UbiD system: The biosynthesis and use of prenylated flavin (prFMN)

Autori: Stephen A. Marshall, Karl A.P. Payne, David Leys
Pubblicato in: Archives of Biochemistry and Biophysics, Numero 632, 2017, Pagina/e 209-221, ISSN 0003-9861
Editore: Academic Press
DOI: 10.1016/j.abb.2017.07.014

Regioselective para -Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase

Autori: Stefan E. Payer, Stephen A. Marshall, Natalie Bärland, Xiang Sheng, Tamara Reiter, Andela Dordic, Georg Steinkellner, Christiane Wuensch, Susann Kaltwasser, Karl Fisher, Stephen E. J. Rigby, Peter Macheroux, Janet Vonck, Karl Gruber, Kurt Faber, Fahmi Himo, David Leys, Tea Pavkov-Keller, Silvia M. Glueck
Pubblicato in: Angewandte Chemie International Edition, Numero 56/44, 2017, Pagina/e 13893-13897, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201708091

Enzymatic Carboxylation of 2-Furoic Acid Yields 2,5-Furandicarboxylic Acid (FDCA)

Autori: Karl A.P. Payne, Stephen A. Marshall, Karl Fisher, Matthew J. Cliff, Diego M. Cannas, Cunyu Yan, Derren J. Heyes, David A. Parker, Igor Larrosa, David Leys
Pubblicato in: ACS Catalysis, Numero 9/4, 2019, Pagina/e 2854-2865, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.8b04862

Flavin metamorphosis: cofactor transformation through prenylation

Autori: David Leys
Pubblicato in: Current Opinion in Chemical Biology, Numero 47, 2018, Pagina/e 117-125, ISSN 1367-5931
Editore: Elsevier BV
DOI: 10.1016/j.cbpa.2018.09.024

Terminal Alkenes from Acrylic Acid Derivatives via Non-Oxidative Enzymatic Decarboxylation by Ferulic Acid Decarboxylases

Autori: Godwin A. Aleku, Christoph Prause, Ruth T. Bradshaw-Allen, Katharina Plasch, Silvia M. Glueck, Samuel S. Bailey, Karl A. P. Payne, David A. Parker, Kurt Faber, David Leys
Pubblicato in: ChemCatChem, Numero 10/17, 2018, Pagina/e 3736-3745, ISSN 1867-3880
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.201800643

Enzymatic control of cycloadduct conformation ensures reversible 1,3-dipolar cycloaddition in a prFMN-dependent decarboxylase

Autori: Samuel S. Bailey, Karl A. P. Payne, Annica Saaret, Stephen A. Marshall, Irina Gostimskaya, Iaroslav Kosov, Karl Fisher, Sam Hay, David Leys
Pubblicato in: Nature Chemistry, Numero 11/11, 2019, Pagina/e 1049-1057, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-019-0324-8

Structural and biochemical characterization of the prenylated flavin mononucleotide-dependent indole-3-carboxylic acid decarboxylase

Autori: Deepankar Gahloth; Karl Fisher; Karl A.P. Payne; Matthew Cliff; Colin Levy; David Leys
Pubblicato in: Journal of Biological Chemistry, Numero 4, 2022, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2022.101771

Structural insights into UbiD reversible decarboxylation

Autori: George W. Roberts; David Leys
Pubblicato in: Current Opinion in Structural Biology, Numero 8, 2022, ISSN 0959-440X
Editore: Elsevier BV
DOI: 10.1016/j.sbi.2022.102432

Synthetic Enzyme‐Catalyzed CO 2 Fixation Reactions

Autori: Godwin A. Aleku, George W. Roberts, Gabriel R. Titchiner, David Leys
Pubblicato in: ChemSusChem, Numero 14/8, 2021, Pagina/e 1781-1804, ISSN 1864-5631
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cssc.202100159

Structure and Mechanism of Pseudomonas aeruginosa PA0254/HudA, a prFMN-Dependent Pyrrole-2-carboxylic Acid Decarboxylase Linked to Virulence

Autori: Karl A. P. Payne, Stephen A. Marshall, Karl Fisher, Stephen E. J. Rigby, Matthew J. Cliff, Reynard Spiess, Diego M. Cannas, Igor Larrosa, Sam Hay, David Leys
Pubblicato in: ACS Catalysis, Numero 11/5, 2021, Pagina/e 2865-2878, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.0c05042

Biocatalytic reduction of α,β-unsaturated carboxylic acids to allylic alcohols

Autori: Godwin A. Aleku, George W. Roberts, David Leys
Pubblicato in: Green Chemistry, Numero 22/12, 2020, Pagina/e 3927-3939, ISSN 1463-9262
Editore: Royal Society of Chemistry
DOI: 10.1039/d0gc00867b

Biosynthesis of Pyrrole-2-carbaldehyde via Enzymatic CO2 Fixation

Autori: Gabriel R. Titchiner; Stephen A. Marshall; Herkus Miscikas; David Leys
Pubblicato in: Catalysts, 2022, Pagina/e 12, 538, ISSN 2073-4344
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/catal12050538