Single-Molecule And Structural Studies Of ATP-Dependent Chromatin Remodelling

Project Information

ChromatinRemodelling

Grant agreement ID: 714068

DOI 10.3030/714068

Project closed

EC signature date 19 October 2016

Start date 1 March 2017

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 498 954,00

EU contribution € 1 498 954,00

Coordinated by

UPPSALA UNIVERSITET
Sweden

Publications

Peer reviewed articles (12)

Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

Author(s): Luka Bacic; Guillaume Gaullier; Anton Sabantsev; Laura C. Lehmann; Klaus Brackmann; Despoina Dimakou; Mario Halic; Graeme Hewitt; Simon J. Boulton; Sebastian Deindl
Published in: eLife, Issue 2, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.71420

Spatiotemporally controlled generation of NTPs for single-molecule studies

Author(s): Anton Sabantsev, Guanzhong Mao, Javier Aguirre Rivera, Mikhail Panfilov, Anatolii Arseniev, Oanh Ho, Mikhail Khodorkovskiy & Sebastian Deindl
Published in: Nature Chemical Biology, Issue 15524469, 2022, ISSN 1552-4469
Publisher: Nature
DOI: 10.1038/s41589-022-01100-9

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Author(s): Graeme Hewitt, Valerie Borel, Sandra Segura-Bayona, Tohru Takaki, Phil Ruis, Roberto Bellelli, Laura C. Lehmann, Lucia Sommerova, Aleksandra Vancevska, Antonia Tomas-Loba, Kang Zhu, Christopher Cooper, Kasper Fugger, Harshil Patel, Robert Goldstone, Deborah Schneider-Luftman, Ellie Herbert, Gordon Stamp, Rachel Brough, Stephen Pettitt, Christopher J. Lord, Stephen C. West, Ivan Ahel, Dragana Ahel,
Published in: Molecular Cell, Issue 81/4, 2021, Page(s) 767-783.e11, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.12.006

Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch

Author(s): Laura C. Lehmann, Luka Bacic, Graeme Hewitt, Klaus Brackmann, Anton Sabantsev, Guillaume Gaullier, Sofia Pytharopoulou, Gianluca Degliesposti, Hanneke Okkenhaug, Song Tan, Alessandro Costa, J. Mark Skehel, Simon J. Boulton, Sebastian Deindl
Published in: Cell Reports, Issue 33/12, 2020, Page(s) 108529, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108529

Structure-guided approach to site-specific fluorophore labeling of the lac repressor LacI

Author(s): Kalle Kipper, Nadja Eremina, Emil Marklund, Sumera Tubasum, Guanzhong Mao, Laura Christina Lehmann, Johan Elf, Sebastian Deindl
Published in: PLOS ONE, Issue 13/6, 2018, Page(s) e0198416, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0198416

New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites

Author(s): Caroline Ballet, Mário S. P. Correia, Louis P. Conway, Theresa L. Locher, Laura C. Lehmann, Neeraj Garg, Miroslav Vujasinovic, Sebastian Deindl, J.-Matthias Löhr, Daniel Globisch
Published in: Chemical Science, Issue 9/29, 2018, Page(s) 6233-6239, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sc01502c

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

Author(s): Laura C. Lehmann, Graeme Hewitt, Shintaro Aibara, Alexander Leitner, Emil Marklund, Sarah L. Maslen, Varun Maturi, Yang Chen, David van der Spoel, J. Mark Skehel, Aristidis Moustakas, Simon J. Boulton, Sebastian Deindl
Published in: Molecular Cell, Issue 68/5, 2017, Page(s) 847-859.e7, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2017.10.017

Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling

Author(s): Anton Sabantsev, Robert F. Levendosky, Xiaowei Zhuang, Gregory D. Bowman, Sebastian Deindl
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09657-1

The ribosomal protein S1-dependent standby site in tisB mRNA consists of a single-stranded region and a 5′ structure element

Author(s): Cédric Romilly, Sebastian Deindl, E. Gerhart H. Wagner
Published in: Proceedings of the National Academy of Sciences, Issue 116/32, 2019, Page(s) 15901-15906, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1904309116

Sequence specificity in DNA binding is mainly governed by association

Author(s): E. Marklund, G. Mao, J. Yan, S. Zikrin, E. Abdurakhmanov, S. Deindl, J. Elf
Published in: Science, Issue Vol 375, Issue 6579, 2022, Page(s) 442-445, ISSN 1095-9203
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abg7427

DNA surface exploration and operator bypassing during target search

Author(s): Emil Marklund, Brad van Oosten, Guanzhong Mao, Elias Amselem, Kalle Kipper, Anton Sabantsev, Andrew Emmerich, Daniel Globisch, Xuan Zheng, Laura C. Lehmann, Otto G. Berg, Magnus Johansson, Johan Elf, Sebastian Deindl
Published in: Nature, Issue 583/7818, 2020, Page(s) 858-861, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2413-7

Recent advances in single-molecule fluorescence microscopy render structural biology dynamic

Author(s): Luka Bacic, Anton Sabantsev, Sebastian Deindl
Published in: Current Opinion in Structural Biology, Issue 65, 2020, Page(s) 61-68, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2020.05.006

Non-peer reviewed articles (1)

Remodeling the genome with DNA twists

Author(s): GREGORY D. BOWMAN AND SEBASTIAN DEINDL
Published in: Science, Issue 10959203, 2019, Page(s) 35-36, ISSN 1095-9203
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aay4317