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Single-Molecule And Structural Studies Of ATP-Dependent Chromatin Remodelling

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Publications

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Author(s): Graeme Hewitt, Valerie Borel, Sandra Segura-Bayona, Tohru Takaki, Phil Ruis, Roberto Bellelli, Laura C. Lehmann, Lucia Sommerova, Aleksandra Vancevska, Antonia Tomas-Loba, Kang Zhu, Christopher Cooper, Kasper Fugger, Harshil Patel, Robert Goldstone, Deborah Schneider-Luftman, Ellie Herbert, Gordon Stamp, Rachel Brough, Stephen Pettitt, Christopher J. Lord, Stephen C. West, Ivan Ahel, Dragana Ahel,
Published in: Molecular Cell, 81/4, 2021, Page(s) 767-783.e11, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.12.006

Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch

Author(s): Laura C. Lehmann, Luka Bacic, Graeme Hewitt, Klaus Brackmann, Anton Sabantsev, Guillaume Gaullier, Sofia Pytharopoulou, Gianluca Degliesposti, Hanneke Okkenhaug, Song Tan, Alessandro Costa, J. Mark Skehel, Simon J. Boulton, Sebastian Deindl
Published in: Cell Reports, 33/12, 2020, Page(s) 108529, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108529

Structure-guided approach to site-specific fluorophore labeling of the lac repressor LacI

Author(s): Kalle Kipper, Nadja Eremina, Emil Marklund, Sumera Tubasum, Guanzhong Mao, Laura Christina Lehmann, Johan Elf, Sebastian Deindl
Published in: PLOS ONE, 13/6, 2018, Page(s) e0198416, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0198416

New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites

Author(s): Caroline Ballet, Mário S. P. Correia, Louis P. Conway, Theresa L. Locher, Laura C. Lehmann, Neeraj Garg, Miroslav Vujasinovic, Sebastian Deindl, J.-Matthias Löhr, Daniel Globisch
Published in: Chemical Science, 9/29, 2018, Page(s) 6233-6239, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sc01502c

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

Author(s): Laura C. Lehmann, Graeme Hewitt, Shintaro Aibara, Alexander Leitner, Emil Marklund, Sarah L. Maslen, Varun Maturi, Yang Chen, David van der Spoel, J. Mark Skehel, Aristidis Moustakas, Simon J. Boulton, Sebastian Deindl
Published in: Molecular Cell, 68/5, 2017, Page(s) 847-859.e7, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2017.10.017

Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling

Author(s): Anton Sabantsev, Robert F. Levendosky, Xiaowei Zhuang, Gregory D. Bowman, Sebastian Deindl
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09657-1

The ribosomal protein S1-dependent standby site in tisB mRNA consists of a single-stranded region and a 5′ structure element

Author(s): Cédric Romilly, Sebastian Deindl, E. Gerhart H. Wagner
Published in: Proceedings of the National Academy of Sciences, 116/32, 2019, Page(s) 15901-15906, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1904309116

DNA surface exploration and operator bypassing during target search

Author(s): Emil Marklund, Brad van Oosten, Guanzhong Mao, Elias Amselem, Kalle Kipper, Anton Sabantsev, Andrew Emmerich, Daniel Globisch, Xuan Zheng, Laura C. Lehmann, Otto G. Berg, Magnus Johansson, Johan Elf, Sebastian Deindl
Published in: Nature, 583/7818, 2020, Page(s) 858-861, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2413-7

Recent advances in single-molecule fluorescence microscopy render structural biology dynamic

Author(s): Luka Bacic, Anton Sabantsev, Sebastian Deindl
Published in: Current Opinion in Structural Biology, 65, 2020, Page(s) 61-68, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2020.05.006