Mapping the retrotransposon-mediated layer of neuronal gene regulation in the human genome

Project Information

PRIMATE-TE-IMPACT

Grant agreement ID: 716035

DOI

10.3030/716035

Project closed

EC signature date 14 July 2017

Start date 1 August 2017

End date 31 January 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

UNIVERSITEIT VAN AMSTERDAM
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

ZNF91 deletion in human embryonic stem cells leads to ectopic activation of SVA retrotransposons and up-regulation of KRAB zinc finger gene clusters

Author(s): Nina Haring, Judith Roels, Frank M J Jacobs
Published in: Genome REsearch, Issue 2021 Apr; 31(4): 551–563, 2021, Page(s) 551–563, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.265348.120

Long Non-Coding RNAs in Neuronal Aging

Author(s): Diana Pereira Fernandes, Mainá Bitar, Frank Jacobs, Guy Barry
Published in: Non-Coding RNA, Issue 4/2, 2018, Page(s) 12, ISSN 2311-553X
Publisher: MDPI
DOI: 10.3390/ncrna4020012

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

Author(s): Ian T. Fiddes, Gerrald A. Lodewijk, Meghan Mooring, Colleen M. Bosworth, Adam D. Ewing, Gary L. Mantalas, Adam M. Novak, Anouk van den Bout, Alex Bishara, Jimi L. Rosenkrantz, Ryan Lorig-Roach, Andrew R. Field, Maximilian Haeussler, Lotte Russo, Aparna Bhaduri, Tomasz J. Nowakowski, Alex A. Pollen, Max L. Dougherty, Xander Nuttle, Marie-Claude Addor, Simon Zwolinski, Sol Katzman, Arnold Kriegstein
Published in: Cell, Issue 173/6, 2018, Page(s) 1356-1369.e22, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2018.03.051

Widespread correlation of KRAB zinc finger protein binding with brain-developmental gene expression patterns

Author(s): Grace Farmiloe, Gerrald A. Lodewijk, Stijn F. Robben, Elisabeth J. van Bree, Frank M. J. Jacobs
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 375/1795, 2020, Page(s) 20190333, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2019.0333

Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels.

Author(s): Gerrald A Lodewijk; Diana Pereira Fernandes; Iraklis Vretzakis; Jeanne E. Savage; Frank M. J. Jacobs
Published in: Molecular Biology and evolution, 37(9). Oxford University Press, Issue 1, 2020, Page(s) 2531–2548, ISSN 1537-1719
Publisher: Oxford University Press
DOI: 10.1093/molbev/msaa104

A hidden layer of structural variation in transposable elements reveals potential genetic modifiers in human disease-risk loci

Author(s): "Elisabeth J van Bree # 1, Rita L F P Guimarães # 1 2 3, Mischa Lundberg 4, Elena R Blujdea 1, Jimi L Rosenkrantz 1, Fred T G White 1, Josse Poppinga 1, Paula Ferrer-Raventós 1, Anne-Fleur E Schneider 1, Isabella Clayton 1, David Haussler 5, Marcel J T Reinders 6, Henne Holstege 2 3 6 7, Adam D Ewing 4, Colette Moses 1, Frank M J Jacobs 1 7"
Published in: Genome Research, Issue Apr;32(4):656-670, 2021, Page(s) 656-670, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.275515.121