The nanoparticle-scope : a new integrated instrument for accurate and reproducible physico-chemical characterisation of nanoparticles (npSCOPE)

Leistungen

Nano-material sampling and preparation protocols

Guide describing the preparation handling and storage of the nanomaterial samples

Evaluation report on performance of the npSCOPE instrument in representative test cases for risk assessment

Presentation and evaluation of npSCOPE results obtained in the nanotoxicology test cases including reproducibility based on the roundrobin studies and benchmarking against existing stateoftheart instruments

Description of correlative workflow

A description of the sequence of measurements to be followed to ensure adequate characterisation both for nanotoxicology studies and other applications of the npSCOPE instrument

Evaluation report on performance of the npSCOPE instrument for applications beyond nanotoxicology

Presentation and evaluation of npSCOPE results obtained in test examples in materialsscience nanomedicine and pharmaceutics including reproducibility based on the roundrobin studies and benchmarking against existing stateoftheart instruments

List of validated performance specifications of the npSCOPE instrument

List of performance specifications of the instrument with details about samples and protocols used to determine the various parameters

Global validation report of npSCOPE instrument, including benchmarking against existing state-of-the-art techniques

Report describing the overall performance of the npSCOPE instrument and methodologies the application landscape and roadmaps for its future use

Confirmed specification

List of performance specifications for the npSCOPE instrument and its subsystems including mechanical and electrical interface definitions

Description of cryo-workflow

A description of the sequence of measurements to be followed sample preparation and characterisation workflows to ensure adequate characterisation both for nanotoxicology studies and other applications of the npSCOPE instrument under cryoconditions

Project website

Website for the project is publically accessible with preliminary content

Final version of the software for data processing

A final version of the data analysis software for the automated data processing and reporting within the npSCOPE project is delivered focusing on datasets from the npSCOPE instrument

Veröffentlichungen

Scanning transmission imaging in the helium ion microscope using a microchannel plate with a delay line detector

Autoren: Eduardo Serralta, Nico Klingner, Olivier De Castro, Michael Mousley, Santhana Eswara, Serge Duarte Pinto, Tom Wirtz, Gregor Hlawacek
Veröffentlicht in: Beilstein Journal of Nanotechnology, Ausgabe 11, 2020, Seite(n) 1854-1864, ISSN 2190-4286
Herausgeber: Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
DOI: 10.3762/bjnano.11.167

Critical Assessment of Analytical Methods for the Harmonized and Cost-Efficient Analysis of Microplastics

Autoren: Sebastian Primpke, Silke H. Christiansen, Win Cowger, Hannah De Frond, Ashok Deshpande, Marten Fischer, Erika B. Holland, Michaela Meyns, Bridget A. O'Donnell, Barbara E. Ossmann, Marco Pittroff, George Sarau, Barbara M. Scholz-Böttcher, Kara J. Wiggin
Veröffentlicht in: Applied Spectroscopy, Ausgabe 74/9, 2020, Seite(n) 1012-1047, ISSN 0003-7028
Herausgeber: Society for Applied Spectroscopy
DOI: 10.1177/0003702820921465

Supported Two-Dimensional Materials under Ion Irradiation: The Substrate Governs Defect Production

Autoren: Silvan Kretschmer, Mikhail Maslov, Sadegh Ghaderzadeh, Mahdi Ghorbani-Asl, Gregor Hlawacek, Arkady V. Krasheninnikov
Veröffentlicht in: ACS Applied Materials & Interfaces, Ausgabe 10/36, 2018, Seite(n) 30827-30836, ISSN 1944-8244
Herausgeber: American Chemical Society
DOI: 10.1021/acsami.8b08471

Stationary beam full-field transmission helium ion microscopy using sub-50 keV He + : Projected images and intensity patterns

Autoren: Michael Mousley, Santhana Eswara, Olivier De Castro, Olivier Bouton, Nico Klingner, Christoph T Koch, Gregor Hlawacek, Tom Wirtz
Veröffentlicht in: Beilstein Journal of Nanotechnology, Ausgabe 10, 2019, Seite(n) 1648-1657, ISSN 2190-4286
Herausgeber: Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
DOI: 10.3762/bjnano.10.160

Highest resolution chemical imaging based on Secondary Ion Mass Spectrometry performed on the Helium Ion Microscope

Autoren: Jean-Nicolas Audinot, Patrick Philipp, Olivier De Castro, Antje Biesemeier, Hung Quang Hoang, Tom Wirtz
Veröffentlicht in: Reports on Progress in Physics, 2021, ISSN 0034-4885
Herausgeber: Institute of Physics Publishing
DOI: 10.1088/1361-6633/ac1e32

Freestanding and Supported MoS 2 Monolayers under Cluster Irradiation: Insights from Molecular Dynamics Simulations

Autoren: Sadegh Ghaderzadeh, Vladimir Ladygin, Mahdi Ghorbani-Asl, Gregor Hlawacek, Marika Schleberger, Arkady V. Krasheninnikov
Veröffentlicht in: ACS Applied Materials & Interfaces, Ausgabe 12/33, 2020, Seite(n) 37454-37463, ISSN 1944-8244
Herausgeber: American Chemical Society
DOI: 10.1021/acsami.0c09255

Correlative Electron Microscopy, High Resolution Ion Imaging and Secondary Ion Mass Spectrometry for High Resolution Nanoanalytics on Biological Tissue

Autoren: Antje Biesemeier, Olivier De Castro, Eduardo Serralta, Jelena Lovric, Santhana Eswara, Jean-Nicolas Audinot, Sébastien Cambier, Tom Wirtz
Veröffentlicht in: Microscopy and Microanalysis, Ausgabe 26/S2, 2020, Seite(n) 818-820, ISSN 1431-9276
Herausgeber: Cambridge University Press
DOI: 10.1017/s1431927620015950

Critical Review of Processing and Classification Techniques for Images and Spectra in Microplastic Research

Autoren: Win Cowger, Andrew Gray, Silke H. Christiansen, Hannah DeFrond, Ashok D. Deshpande, Ludovic Hemabessiere, Eunah Lee, Leonid Mill, Keenan Munno, Barbara E. Ossmann, Marco Pittroff, Chelsea Rochman, George Sarau, Shannon Tarby, Sebastian Primpke
Veröffentlicht in: Applied Spectroscopy, Ausgabe 74/9, 2020, Seite(n) 989-1010, ISSN 0003-7028
Herausgeber: Society for Applied Spectroscopy
DOI: 10.1177/0003702820929064

Magnetic Sector SIMS System with Continuous Focal Plane Detector for Advanced Analytical Capabilities on FIB Instruments

Autoren: Tom Wirtz, Olivier De Castro, Antje Biesemeier, Hung Quang Hoang, Jean-Nicolas Audinot
Veröffentlicht in: Microscopy and Microanalysis, Ausgabe 26/S2, 2020, Seite(n) 1972-1974, ISSN 1431-9276
Herausgeber: Cambridge University Press
DOI: 10.1017/s1431927620019984

Correlative Microscopy and Spectroscopy Workflow for Microplastics

Autoren: George Sarau, Lasse Kling, Barbara E. Oßmann, Ann-Katrin Unger, Frank Vogler, Silke H. Christiansen
Veröffentlicht in: Applied Spectroscopy, Ausgabe 74/9, 2020, Seite(n) 1155-1160, ISSN 0003-7028
Herausgeber: Society for Applied Spectroscopy
DOI: 10.1177/0003702820916250

Channeling effects in gold nanoclusters under He ion irradiation: insights from molecular dynamics simulations

Autoren: Sadegh Ghaderzadeh, Mahdi Ghorbani-Asl, Silvan Kretschmer, Gregor Hlawacek, Arkady V Krasheninnikov
Veröffentlicht in: Nanotechnology, Ausgabe 31/3, 2020, Seite(n) 035302, ISSN 0957-4484
Herausgeber: Institute of Physics Publishing
DOI: 10.1088/1361-6528/ab4847

Advanced Analytical Capabilities on FIB Instruments Using SIMS

Autoren: Tom Wirtz, Olivier De Castro, Antje Biesemeier, Hung Quang Hoang, Jean-Nicolas Audinot
Veröffentlicht in: Microscopy and Microanalysis, Ausgabe 26/S2, 2020, Seite(n) 82-83, ISSN 1431-9276
Herausgeber: Cambridge University Press
DOI: 10.1017/s143192762001332x

Imaging and Analytics on the Helium Ion Microscope

Autoren: Tom Wirtz, Olivier De Castro, Jean-Nicolas Audinot, Patrick Philipp
Veröffentlicht in: Annual Review of Analytical Chemistry, Ausgabe 12/1, 2019, Seite(n) 523-543, ISSN 1936-1327
Herausgeber: Annual Reviews, Inc.
DOI: 10.1146/annurev-anchem-061318-115457

In vitro exposure of a 3D-tetraculture representative for the alveolar barrier at the air-liquid interface to silver particles and nanowires

Autoren: Ionel Fizeșan, Sébastien Cambier, Elisa Moschini, Aline Chary, Inge Nelissen, Johanna Ziebel, Jean-Nicolas Audinot, Tom Wirtz, Marcin Kruszewski, Anca Pop, Béla Kiss, Tommaso Serchi, Felicia Loghin, Arno C. Gutleb
Veröffentlicht in: Particle and Fibre Toxicology, Ausgabe 16/1, 2019, ISSN 1743-8977
Herausgeber: BioMed Central
DOI: 10.1186/s12989-019-0297-1

Synthetic Image Rendering Solves Annotation Problem in Deep Learning Nanoparticle Segmentation

Autoren: Leonid Mill, David Wolff, Nele Gerrits, Patrick Philipp, Lasse Kling, Florian Vollnhals, Andrew Ignatenko, Christian Jaremenko, Yixing Huang, Olivier De Castro, Jean‐Nicolas Audinot, Inge Nelissen, Tom Wirtz, Andreas Maier, Silke Christiansen
Veröffentlicht in: Small Methods, Ausgabe 5/7, 2021, Seite(n) 2100223, ISSN 2366-9608
Herausgeber: Wiley-VCH GmbH
DOI: 10.1002/smtd.202100223

In situ Correlative Helium Ion Microscopy and Secondary Ion Mass Spectrometry for High-Resolution Nano-Analytics in Life Sciences

Autoren: Jelena Lovric, Jean-Nicolas Audinot, Tom Wirtz
Veröffentlicht in: Microscopy and Microanalysis, Ausgabe 25/S2, 2019, Seite(n) 1026-1027, ISSN 1431-9276
Herausgeber: Cambridge University Press
DOI: 10.1017/s1431927619005865

Structural and chemical evolution of Au-silica core–shell nanoparticles during 20 keV helium ion irradiation: a comparison between experiment and simulation

Autoren: M. Mousley, W. Möller, P. Philipp, G. Hlawacek, T. Wirtz, S. Eswara
Veröffentlicht in: Scientific Reports, Ausgabe 10/1, 2020, Seite(n) 12058, ISSN 2045-2322
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41598-020-68955-7

npSCOPE: A New Instrument Combining SIMS Imaging, SE Imaging and Transmission Ion Microscopy for High Resolution In-situ Correlative Investigations

Autoren: Olivier De Castro, Antje Biesemeier, Eduardo Serralta, Nico Klingner, Gregor Hlawacek, Peter Gnauck, Serge Duarte Pinto, Falk Lucas, Cecilia Bebeacua, Tom Wirtz
Veröffentlicht in: Microscopy and Microanalysis, Ausgabe 26/S2, 2020, Seite(n) 1976-1977, ISSN 1431-9276
Herausgeber: Cambridge University Press
DOI: 10.1017/s1431927620019996

Novel diagnostic and therapeutic techniques reveal changed metabolic profiles in recurrent focal segmental glomerulosclerosis

Autoren: Janina Müller-Deile, George Sarau, Ahmed M. Kotb, Christian Jaremenko, Ulrike E. Rolle-Kampczyk, Christoph Daniel, Stefan Kalkhof, Silke H. Christiansen, Mario Schiffer
Veröffentlicht in: Scientific Reports, Ausgabe 11/1, 2021, Seite(n) 1, ISSN 2045-2322
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41598-021-83883-w

Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice

Autoren: Christine Coméra, Christel Cartier, Eric Gaultier, Olivier Catrice, Quentin Panouille, Sarah El Hamdi, Kristof Tirez, Inge Nelissen, Vassilia Théodorou, Eric Houdeau
Veröffentlicht in: Particle and Fibre Toxicology, Ausgabe 17/1, 2020, Seite(n) 26, ISSN 1743-8977
Herausgeber: BioMed Central
DOI: 10.1186/s12989-020-00357-z

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