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“MICROMETABOLITE” – Research Training Network on the Microbial Enhancement of Bioactive Secondary Metabolite Production in Plants

Objective

Plant-derived natural products or, more specifically, plant secondary metabolites are backbones of today’s pharmaceutical and cosmeceutical industry. Plant-associated microorganisms have been implicated an important role in sustaining plant growth and, through inducing or influencing synthesis pathways, in the production of plant secondary metabolites. MICROMETABOLITE aims at exploring the plant-associated microflora for improving the production of bioactive secondary plant metabolites that are of high value for industrial applications. The network will focus on members of the Boraginaceae plant family including Lithospermum and Alkanna species, which produce the naphtoquinones shikonin and alkannin derivatives (A/S). These plants are used for the production of several pharmaceutical and cosmeceutical preparations that are already on the market or in the final stages of development. Specifically, we will analyse relationships between the content of A/S or other secondary metabolites, the plant genotype, and the plant-associated microflora. Further, we will explore in which ways microorganisms beneficially influence metabolite production, and we will establish novel production systems, enabling that raw materials for industrial applications can be cultivated under Good Agricultural Practices (GAP).
MICROMETABOLITE aspires to create an environment that will foster synergistic cooperation between researchers in relevant, currently hardly inter-linked scientific disciplines and maximize the exploitation of plant biotechnology in accordance with the needs of the European pharmaceutical and cosmetic industries. As the first network in this area, it will train some of the most talented European young scientists (ESRs) to become future leading scientists, technologists and entrepreneurs, who can take on leadership in the required scientific and technological discovery and in the development of next-generation pharmaceutical and cosmeceutical applications.

Call for proposal

H2020-MSCA-ITN-2016
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Address
Giefinggasse 4
1210 Wien
Austria
Activity type
Research Organisations
EU contribution
€ 511 868,16

Participants (5)

UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
EU contribution
€ 501 120
Address
Place De L Universite 1
1348 Louvain La Neuve
Activity type
Higher or Secondary Education Establishments
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 484 773,84
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
INSTITUT FUR PFLANZENKULTUR EK
Germany
EU contribution
€ 249 216,48
Address
Solkau 2
29465 Schnega
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
EU contribution
€ 484 773,84
Address
Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT GENT
Belgium
EU contribution
€ 501 120
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments