Projektbeschreibung
Innovatives System zur Pflanzenerzeugung
Pflanzliche Mikroorganismen, einschließlich Bakterien und Pilze, spielen eine wichtige Rolle für die Pflanzengesundheit und die Synthese von Sekundärmetaboliten. Das Zusammenspiel zwischen Wirtspflanzen und den mit ihnen verbundenen Mikroorganismen zu verstehen, kann dazu beitragen, die Produktion bioaktiver Verbindungen für medizinische und kosmetische Zwecke zu optimieren. Im Rahmen des über die Marie-Skłodowska-Curie-Maßnahmen finanzierten Projekts MICROMETABOLITE soll untersucht werden, wie Mikroorganismen die Produktion von Metaboliten beeinflussen. Zudem sollen neuartige Produktionssysteme für Naphtochinonderivate geschaffen werden, die für ihre entzündungshemmenden Eigenschaften und ihre Rolle bei der Geweberegeneration bekannt sind. Das Projektteam wird auch junge Forschende ausbilden, die in Zukunft Fortschritte bei pharmazeutischen und kosmetischen Anwendungen erzielen werden.
Ziel
Plant-derived natural products or, more specifically, plant secondary metabolites are backbones of today’s pharmaceutical and cosmeceutical industry. Plant-associated microorganisms have been implicated an important role in sustaining plant growth and, through inducing or influencing synthesis pathways, in the production of plant secondary metabolites. MICROMETABOLITE aims at exploring the plant-associated microflora for improving the production of bioactive secondary plant metabolites that are of high value for industrial applications. The network will focus on members of the Boraginaceae plant family including Lithospermum and Alkanna species, which produce the naphtoquinones shikonin and alkannin derivatives (A/S). These plants are used for the production of several pharmaceutical and cosmeceutical preparations that are already on the market or in the final stages of development. Specifically, we will analyse relationships between the content of A/S or other secondary metabolites, the plant genotype, and the plant-associated microflora. Further, we will explore in which ways microorganisms beneficially influence metabolite production, and we will establish novel production systems, enabling that raw materials for industrial applications can be cultivated under Good Agricultural Practices (GAP).
MICROMETABOLITE aspires to create an environment that will foster synergistic cooperation between researchers in relevant, currently hardly inter-linked scientific disciplines and maximize the exploitation of plant biotechnology in accordance with the needs of the European pharmaceutical and cosmetic industries. As the first network in this area, it will train some of the most talented European young scientists (ESRs) to become future leading scientists, technologists and entrepreneurs, who can take on leadership in the required scientific and technological discovery and in the development of next-generation pharmaceutical and cosmeceutical applications.
Wissenschaftliches Gebiet
- agricultural sciencesagriculture, forestry, and fisheriesagricultureagronomyplant protection
- natural sciencesbiological sciencesmicrobiologybacteriology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural sciencesbiological sciencesmicrobiologymycology
- agricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulture
Programm/Programme
Thema/Themen
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenFinanzierungsplan
MSCA-ITN-ETN - European Training NetworksKoordinator
1210 Wien
Österreich