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“MICROMETABOLITE” – Research Training Network on the Microbial Enhancement of Bioactive Secondary Metabolite Production in Plants

Descrizione del progetto

Un innovativo sistema di produzione vegetale

I microrganismi associati alle piante, tra cui batteri e funghi, svolgono un ruolo fondamentale per la salute vegetale e la sintesi dei metaboliti secondari. La comprensione dell’interazione esistente tra le piante ospiti e i microrganismi ad esse associati può contribuire a migliorare la produzione di composti bioattivi per finalità di sviluppo di farmaci e cosmetici. Finanziato dal programma di azioni Marie Skłodowska-Curie, il progetto MICROMETABOLITE si prefigge di studiare le modalità con cui i microrganismi influenzano la produzione di metaboliti e di istituire nuovi sistemi di produzione per i derivati del naftochinone, noti per le loro proprietà antinfiammatorie e il proprio ruolo attivo nella rigenerazione dei tessuti. Il progetto formerà inoltre giovani scienziati per fornire loro le competenze necessarie a guidare i futuri progressi nelle applicazioni farmaceutiche e cosmeceutiche.

Obiettivo

Plant-derived natural products or, more specifically, plant secondary metabolites are backbones of today’s pharmaceutical and cosmeceutical industry. Plant-associated microorganisms have been implicated an important role in sustaining plant growth and, through inducing or influencing synthesis pathways, in the production of plant secondary metabolites. MICROMETABOLITE aims at exploring the plant-associated microflora for improving the production of bioactive secondary plant metabolites that are of high value for industrial applications. The network will focus on members of the Boraginaceae plant family including Lithospermum and Alkanna species, which produce the naphtoquinones shikonin and alkannin derivatives (A/S). These plants are used for the production of several pharmaceutical and cosmeceutical preparations that are already on the market or in the final stages of development. Specifically, we will analyse relationships between the content of A/S or other secondary metabolites, the plant genotype, and the plant-associated microflora. Further, we will explore in which ways microorganisms beneficially influence metabolite production, and we will establish novel production systems, enabling that raw materials for industrial applications can be cultivated under Good Agricultural Practices (GAP).
MICROMETABOLITE aspires to create an environment that will foster synergistic cooperation between researchers in relevant, currently hardly inter-linked scientific disciplines and maximize the exploitation of plant biotechnology in accordance with the needs of the European pharmaceutical and cosmetic industries. As the first network in this area, it will train some of the most talented European young scientists (ESRs) to become future leading scientists, technologists and entrepreneurs, who can take on leadership in the required scientific and technological discovery and in the development of next-generation pharmaceutical and cosmeceutical applications.

Coordinatore

AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Contribution nette de l'UE
€ 511 868,16
Indirizzo
GIEFINGGASSE 4
1210 Wien
Austria

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Regione
Ostösterreich Wien Wien
Tipo di attività
Research Organisations
Collegamenti
Costo totale
€ 511 868,16

Partecipanti (5)