Descripción del proyecto
Innovador sistema de producción vegetal
Los microorganismos asociados a las plantas, incluidas las bacterias y los hongos, desempeñan un papel fundamental en la sanidad vegetal y la síntesis de metabolitos secundarios. Comprender la interacción entre las plantas hospedadoras y sus microorganismos asociados puede ayudar a mejorar la producción de compuestos bioactivos con fines medicinales y cosméticos. El equipo del proyecto MICROMETABOLITE, financiado por las acciones Marie Skłodowska-Curie, pretende investigar cómo influyen los microorganismos en la producción de metabolitos y establecer nuevos sistemas de producción de derivados de naftoquinona conocidos por sus propiedades antiinflamatorias y su papel en la regeneración de tejidos. En el proyecto también se formará a jóvenes científicos para que lideren futuros avances en aplicaciones farmacéuticas y cosmecéuticas.
Objetivo
Plant-derived natural products or, more specifically, plant secondary metabolites are backbones of today’s pharmaceutical and cosmeceutical industry. Plant-associated microorganisms have been implicated an important role in sustaining plant growth and, through inducing or influencing synthesis pathways, in the production of plant secondary metabolites. MICROMETABOLITE aims at exploring the plant-associated microflora for improving the production of bioactive secondary plant metabolites that are of high value for industrial applications. The network will focus on members of the Boraginaceae plant family including Lithospermum and Alkanna species, which produce the naphtoquinones shikonin and alkannin derivatives (A/S). These plants are used for the production of several pharmaceutical and cosmeceutical preparations that are already on the market or in the final stages of development. Specifically, we will analyse relationships between the content of A/S or other secondary metabolites, the plant genotype, and the plant-associated microflora. Further, we will explore in which ways microorganisms beneficially influence metabolite production, and we will establish novel production systems, enabling that raw materials for industrial applications can be cultivated under Good Agricultural Practices (GAP).
MICROMETABOLITE aspires to create an environment that will foster synergistic cooperation between researchers in relevant, currently hardly inter-linked scientific disciplines and maximize the exploitation of plant biotechnology in accordance with the needs of the European pharmaceutical and cosmetic industries. As the first network in this area, it will train some of the most talented European young scientists (ESRs) to become future leading scientists, technologists and entrepreneurs, who can take on leadership in the required scientific and technological discovery and in the development of next-generation pharmaceutical and cosmeceutical applications.
Ámbito científico
- agricultural sciencesagriculture, forestry, and fisheriesagricultureagronomyplant protection
- natural sciencesbiological sciencesmicrobiologybacteriology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural sciencesbiological sciencesmicrobiologymycology
- agricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulture
Programa(s)
Régimen de financiación
MSCA-ITN-ETN - European Training NetworksCoordinador
1210 Wien
Austria