Description du projet
Système innovant de production végétale
Les micro-organismes associés aux plantes, notamment les bactéries et les champignons, jouent un rôle essentiel dans la santé des végétaux et la synthèse des métabolites secondaires. La compréhension de l’interaction entre les plantes hôtes et les micro-organismes qui leur sont associés est susceptible de contribuer à l’amélioration de la production de composés bioactifs à des fins médicinales et cosmétiques. Financé par le programme Actions Marie Skłodowska-Curie, le projet MICROMETABOLITE vise à étudier l’influence des micro-organismes sur la production de métabolites et à établir de nouveaux systèmes de production de dérivés de naphtoquinone connus pour leurs propriétés anti-inflammatoires et leur rôle dans la régénération des tissus. Le projet permettra également de former de jeunes scientifiques qui seront à l’origine des futures avancées dans le domaine des applications pharmaceutiques et cosméceutiques.
Objectif
Plant-derived natural products or, more specifically, plant secondary metabolites are backbones of today’s pharmaceutical and cosmeceutical industry. Plant-associated microorganisms have been implicated an important role in sustaining plant growth and, through inducing or influencing synthesis pathways, in the production of plant secondary metabolites. MICROMETABOLITE aims at exploring the plant-associated microflora for improving the production of bioactive secondary plant metabolites that are of high value for industrial applications. The network will focus on members of the Boraginaceae plant family including Lithospermum and Alkanna species, which produce the naphtoquinones shikonin and alkannin derivatives (A/S). These plants are used for the production of several pharmaceutical and cosmeceutical preparations that are already on the market or in the final stages of development. Specifically, we will analyse relationships between the content of A/S or other secondary metabolites, the plant genotype, and the plant-associated microflora. Further, we will explore in which ways microorganisms beneficially influence metabolite production, and we will establish novel production systems, enabling that raw materials for industrial applications can be cultivated under Good Agricultural Practices (GAP).
MICROMETABOLITE aspires to create an environment that will foster synergistic cooperation between researchers in relevant, currently hardly inter-linked scientific disciplines and maximize the exploitation of plant biotechnology in accordance with the needs of the European pharmaceutical and cosmetic industries. As the first network in this area, it will train some of the most talented European young scientists (ESRs) to become future leading scientists, technologists and entrepreneurs, who can take on leadership in the required scientific and technological discovery and in the development of next-generation pharmaceutical and cosmeceutical applications.
Champ scientifique
- agricultural sciencesagriculture, forestry, and fisheriesagricultureagronomyplant protection
- natural sciencesbiological sciencesmicrobiologybacteriology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural sciencesbiological sciencesmicrobiologymycology
- agricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulture
Programme(s)
Régime de financement
MSCA-ITN-ETN - European Training NetworksCoordinateur
1210 Wien
Autriche