Descripción del proyecto
Mitocondrias y tumorigénesis
Las células cancerosas presentan mutaciones en las enzimas metabólicas codificadas por el ADN nuclear y mitocondrial. Ello provoca alteraciones en procesos metabólicos básicos, satisface su mayor demanda energética y favorece su supervivencia en el microentorno tumoral. El proyecto TRANSMIT, financiado por las acciones Marie Skłodowska-Curie, tiene por objeto investigar la adaptación metabólica y epigenética de las células cancerosas, prestando especial atención a las mitocondrias. Sus investigadores estudiarán distintos tipos de tumores para identificar posibles biomarcadores novedosos y desvelar los mecanismos moleculares implicados en la reprogramación de las células cancerosas. En conjunto, durante el curso de TRANSMIT se formará a investigadores noveles a fin de que puedan aunar la investigación fundamental con las estrategias terapéuticas y comunicar estos avances a los pacientes y sus familias.
Objetivo
The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical evidences place mitochondria as key actors in cancer metabolic restructuring, not only because these organelles have a crucial role in the energy and biosynthetic intermediates production but also because occurrence of mutations in metabolic enzymes encoded by both nuclear and mitochondrial DNA has been associated to different types of cancer. TRANSMIT aims to dissect the metabolic remodeling in human cancers, placing the focus on the role of mitochondria and bridging basic research to the improvement/development of therapeutic strategies. Further, TRANSMIT fosters the communication of this emerging field to the patients and their families. To these aims, TRANSMIT will create a network of seven different countries, among which world-leading basic science and clinical centers of excellence, several industrial partners with up-to-date omics technologies, as well as non-profit foundations and associations who care for cancer patients. By creating the critical mass of scientific excellence, TRANSMIT will allow to transfer the current knowledge into the wide field of cancer research, translating scientific and technical advances into the education and training of eleven Early Stage Researchers. TRANSMIT will implement training-through-research dedicated to unravel the metabolic features of cancer, as well as to provide a full portfolio of complementary skills through the creation of a network of basic, translational and industrial laboratories, devoted to a multidisciplinary/multisectorial education of young scientists.
Ámbito científico
Programa(s)
Régimen de financiación
MSCA-ITN-ETN - European Training NetworksCoordinador
40126 Bologna
Italia