Descrizione del progetto
Mitocondri e tumorigenesi
Le cellule tumorali presentano mutazioni negli enzimi metabolici codificati dal DNA nucleare e mitocondriale. Ciò comporta alterazioni nei processi metabolici chiave, soddisfa la maggiore richiesta di energia delle cellule tumorali e ne promuove la sopravvivenza nel microambiente tumorale. Il progetto TRANSMIT, finanziato dal programma di azioni Marie Skłodowska-Curie, si propone di studiare l’adattamento metabolico ed epigenetico delle cellule tumorali, con particolare attenzione ai mitocondri. I ricercatori studieranno diversi tipi di tumori per individuare nuovi possibili biomarcatori e svelare i meccanismi molecolari coinvolti nella riprogrammazione delle cellule tumorali. Nel complesso, TRANSMIT formerà ricercatori in fase iniziale di carriera per collegare la ricerca di base con le strategie terapeutiche e comunicare questi progressi ai pazienti e alle loro famiglie.
Obiettivo
The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical evidences place mitochondria as key actors in cancer metabolic restructuring, not only because these organelles have a crucial role in the energy and biosynthetic intermediates production but also because occurrence of mutations in metabolic enzymes encoded by both nuclear and mitochondrial DNA has been associated to different types of cancer. TRANSMIT aims to dissect the metabolic remodeling in human cancers, placing the focus on the role of mitochondria and bridging basic research to the improvement/development of therapeutic strategies. Further, TRANSMIT fosters the communication of this emerging field to the patients and their families. To these aims, TRANSMIT will create a network of seven different countries, among which world-leading basic science and clinical centers of excellence, several industrial partners with up-to-date omics technologies, as well as non-profit foundations and associations who care for cancer patients. By creating the critical mass of scientific excellence, TRANSMIT will allow to transfer the current knowledge into the wide field of cancer research, translating scientific and technical advances into the education and training of eleven Early Stage Researchers. TRANSMIT will implement training-through-research dedicated to unravel the metabolic features of cancer, as well as to provide a full portfolio of complementary skills through the creation of a network of basic, translational and industrial laboratories, devoted to a multidisciplinary/multisectorial education of young scientists.
Campo scientifico
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-ITN-ETN - European Training NetworksCoordinatore
40126 Bologna
Italia