High-valent protein-coordinated catalytic metal sites: Geometric and Electronic ARchitecture

Informazioni relative al progetto

HIGH-GEAR

ID dell’accordo di sovvenzione: 724394

DOI

10.3030/724394

Progetto chiuso

Data della firma CE 30 Gennaio 2017

Data di avvio 1 Giugno 2017

Data di completamento 31 Maggio 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 968 375,00

Contributo UE

€ 1 968 375,00

Coordinato da

STOCKHOLMS UNIVERSITET
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (14)

Key Structural Motifs Balance Metal Binding and Oxidative Reactivity in a Heterobimetallic Mn/Fe Protein.

Autori: Effie C. Kisgeropoulos, Julia J. Griese, Zachary R. Smith, Rui M. M. Branca, Camille R. Schneider, Martin Högbom, Hannah S. Shafaat
Pubblicato in: Journal of the American Chemical Society, Numero 142/11, 2020, Pagina/e 5338–5354, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c00333

High-Resolution XFEL Structure of the Soluble Methane Monooxygenase Hydroxylase Complex with its Regulatory Component at Ambient Temperature in Two Oxidation States.

Autori: Vivek Srinivas, Rahul Banerjee, Hugo Lebrette, Jason C. Jones, Oskar Aurelius, In-Sik Kim, Cindy C. Pham, Sheraz Gul, K.D. Sutherlin, Asmit Bhowmick, Juliane John, Esra Bozkurt, Thomas Fransson, Pierre Aller, Agata Butryn, Isabel Bogacz, Philipp Stefan Simon, Stephen Keable, Alexander Britz, Kensuke Tono, Kyung Sook Kim, Sang-Youn Park, Sang-Jae Lee, Jaehyun Park, Roberto Alonso-Mori, Franklin D.
Pubblicato in: Journal of the American Chemical Society, Numero 142/33, 2020, Pagina/e 14249–14266, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c05613

Redox-controlled reorganization and flavin strain within the ribonucleotide reductase R2b-NrdI complex monitored by serial femtosecond crystallography

Autori: John J, Aurelius O, Srinivas V, Saura P, Kim IS, Bhowmick A, Simon PS, Dasgupta M, Pham C, Gul S, Sutherlin KD, Aller P, Butryn A, Orville AM, Cheah MH, Owada S, Tono K, Fuller FD, Batyuk A, Brewster AS, Sauter NK, Yachandra VK, Yano J, Kaila VRI, Kern J, Lebrette H, Högbom M
Pubblicato in: eLife, Numero 2022 Sep 9;11, 2022, Pagina/e e79226, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.79226

Ether cross-link formation in the R2-like ligand-binding oxidase

Autori: Julia J. Griese, Rui M. M. Branca, Vivek Srinivas, Martin Högbom
Pubblicato in: JBIC Journal of Biological Inorganic Chemistry, Numero 23/6, 2018, Pagina/e 879-886, ISSN 0949-8257
Editore: Springer Verlag
DOI: 10.1007/s00775-018-1583-3

Metal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens

Autori: Vivek Srinivas, Hugo Lebrette, Daniel Lundin, Yuri Kutin, Margareta Sahlin, Michael Lerche, Jürgen Eirich, Rui M. M. Branca, Nicholas Cox, Britt-Marie Sjöberg, Martin Högbom
Pubblicato in: Nature, Numero 563/7731, 2018, Pagina/e 416-420, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-018-0653-6

Driving Protein Conformational Changes with Light: Photoinduced Structural Rearrangement in a Heterobimetallic Oxidase

Autori: Pearson T. Maugeri, Julia J. Griese, Rui M. Branca, Effie K. Miller, Zachary R. Smith, Jürgen Eirich, Martin Högbom, Hannah S. Shafaat
Pubblicato in: Journal of the American Chemical Society, Numero 140/4, 2018, Pagina/e 1471-1480, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.7b11966

Chemical flexibility of heterobimetallic Mn/Fe cofactors: R2lox and R2c proteins

Autori: Yury Kutin, Ramona Kositzki, Rui M. M. Branca, Vivek Srinivas, Daniel Lundin, Michael Haumann, Martin Högbom, Nicholas Cox, Julia J. Griese
Pubblicato in: Journal of Biological Chemistry, Numero 294/48, 2019, Pagina/e 18372-18386, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.010570

Assembly of a heterodinuclear Mn/Fe cofactor is coupled to tyrosine–valine ether cross-link formation in the R2-like ligand-binding oxidase

Autori: Julia J. Griese, Ramona Kositzki, Michael Haumann, Martin Högbom
Pubblicato in: JBIC Journal of Biological Inorganic Chemistry, Numero 24/2, 2019, Pagina/e 211-221, ISSN 0949-8257
Editore: Springer Verlag
DOI: 10.1007/s00775-019-01639-4

Location-specific quantification of protein-bound metal ions by X-ray anomalous dispersion: Q-XAD

Autori: Julia J. Griese, Martin Högbom
Pubblicato in: Acta Crystallographica Section D Structural Biology, Numero 75/8, 2019, Pagina/e 764-771, ISSN 2059-7983
Editore: International Union of Crystallography
DOI: 10.1107/s2059798319009926

Solving a new R2lox protein structure by microcrystal electron diffraction

Autori: Hongyi Xu, Hugo Lebrette, Max T. B. Clabbers, Jingjing Zhao, Julia J. Griese, Xiaodong Zou, Martin Högbom
Pubblicato in: Science Advances, Numero 5/8, 2019, Pagina/e eaax4621, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.aax4621

Redox-induced structural changes in the di-iron and di-manganese forms of Bacillus anthracis ribonucleotide reductase subunit NrdF suggest a mechanism for gating of radical access

Autori: Kristīne Grāve, Wietske Lambert, Gustav Berggren, Julia J. Griese, Matthew D. Bennett, Derek T. Logan, Martin Högbom
Pubblicato in: JBIC Journal of Biological Inorganic Chemistry, Numero 24/6, 2019, Pagina/e 849-861, ISSN 0949-8257
Editore: Springer Verlag
DOI: 10.1007/s00775-019-01703-z

Fate of oxygen species from O2 activation at dimetal cofactors in an oxidase enzyme revealed by 57Fe nuclear resonance X-ray scattering and quantum chemistry

Autori: Stefan Mebs, Vivek Srinivas, Ramona Kositzki, Julia J. Griese, Martin Högbom, Michael Haumann
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Bioenergetics, Numero 1860/12, 2019, Pagina/e 148060, ISSN 0005-2728
Editore: Elsevier BV
DOI: 10.1016/j.bbabio.2019.148060

The Bacillus anthracis class Ib ribonucleotide reductase subunit NrdF intrinsically selects manganese over iron

Autori: Kristīne Grāve, Julia J. Griese, Gustav Berggren, Matthew D. Bennett, Martin Högbom
Pubblicato in: JBIC Journal of Biological Inorganic Chemistry, Numero 25/4, 2020, Pagina/e 571-582, ISSN 0949-8257
Editore: Springer Verlag
DOI: 10.1007/s00775-020-01782-3

Comparative structural analysis provides new insights into the function of R2-like ligand-binding oxidase

Autori: Martin Högbom; Hugo Lebrette; Annika Johansson; Riccardo Diamanti; Julia J. Griese; Vivek Srinivas; Anders Nordström
Pubblicato in: FEBS Letters, Numero Jun;596(12), 2022, Pagina/e 1600-1610, ISSN 0014-5793
Editore: Elsevier BV
DOI: 10.1002/1873-3468.14319