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The polyA machinery: Elucidating the molecular mechanisms of mRNA polyadenylation, deadenylation and RNA recognition

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Analysis of mRNA deadenylation by multi-protein complexes

Author(s): Michael W. Webster, James A.W. Stowell, Terence T.L. Tang, Lori A. Passmore
Published in: Methods, Issue 126, 2017, Page(s) 95-104, ISSN 1046-2023
DOI: 10.1016/j.ymeth.2017.06.009

Architecture of eukaryotic mRNA 3′-end processing machinery

Author(s): Ana Casañal, Ananthanarayanan Kumar, Chris H. Hill, Ashley D. Easter, Paul Emsley, Gianluca Degliesposti, Yuliya Gordiyenko, Balaji Santhanam, Jana Wolf, Katrin Wiederhold, Gillian L. Dornan, Mark Skehel, Carol V. Robinson, Lori A. Passmore
Published in: Science, Issue 358/6366, 2017, Page(s) 1056-1059, ISSN 0036-8075
DOI: 10.1126/science.aao6535

mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases

Author(s): Michael W. Webster, Ying-Hsin Chen, James A.W. Stowell, Najwa Alhusaini, Thomas Sweet, Brenton R. Graveley, Jeff Coller, Lori A. Passmore
Published in: Molecular Cell, Issue 70/6, 2018, Page(s) 1089-1100.e8, ISSN 1097-2765
DOI: 10.1016/j.molcel.2018.05.033

The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases

Author(s): Terence T. L. Tang, James A. W. Stowell, Chris H. Hill, Lori A. Passmore
Published in: Nature Structural & Molecular Biology, Issue 26/6, 2019, Page(s) 433-442, ISSN 1545-9993
DOI: 10.1038/s41594-019-0227-9

Importance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity In Vivo

Author(s): Wi S. Lai, Deborah J. Stumpo, Melissa L. Wells, Artiom Gruzdev, Stephanie N. Hicks, Cindo O. Nicholson, Zhengfeng Yang, Roberta Faccio, Michael W. Webster, Lori A. Passmore, Perry J. Blackshear
Published in: Molecular and Cellular Biology, Issue 39/13, 2019, ISSN 0270-7306
DOI: 10.1128/mcb.00029-19

Mechanistic insights into mRNA 3′-end processing

Author(s): Ananthanarayanan Kumar, Marcello Clerici, Lena M Muckenfuss, Lori A Passmore, Martin Jinek
Published in: Current Opinion in Structural Biology, Issue 59, 2019, Page(s) 143-150, ISSN 0959-440X
DOI: 10.1016/

Interpretation of medium resolution cryoEM maps of multi-protein complexes

Author(s): Ana Casañal, Shabih Shakeel, Lori A Passmore
Published in: Current Opinion in Structural Biology, Issue 58, 2019, Page(s) 166-174, ISSN 0959-440X
DOI: 10.1016/

The APT complex is involved in non-coding RNA transcription and is distinct from CPF

Author(s): Michael Lidschreiber, Ashley D Easter, Sofia Battaglia, Juan B Rodríguez-Molina, Ana Casañal, Manuel Carminati, Carlo Baejen, Pawel Grzechnik, Kerstin C Maier, Patrick Cramer, Lori A Passmore
Published in: Nucleic Acids Research, 2018, ISSN 0305-1048
DOI: 10.1093/nar/gky845

RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not

Author(s): Michael W Webster, James AW Stowell, Lori A Passmore
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
DOI: 10.7554/elife.40670

Activation of the Endonuclease that Defines mRNA 3′ Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex

Author(s): Chris H. Hill, Vytautė Boreikaitė, Ananthanarayanan Kumar, Ana Casañal, Peter Kubík, Gianluca Degliesposti, Sarah Maslen, Angelica Mariani, Ottilie von Loeffelholz, Mathias Girbig, Mark Skehel, Lori A. Passmore
Published in: Molecular Cell, Issue 73/6, 2019, Page(s) 1217-1231.e11, ISSN 1097-2765
DOI: 10.1016/j.molcel.2018.12.023

Recognition of Poly(A) RNA through Its Intrinsic Helical Structure

Author(s): Terence T.L. Tang, Lori A. Passmore
Published in: Cold Spring Harbor Symposia on Quantitative Biology, Issue 15 April 2020, 2020, Page(s) 039818, ISSN 0091-7451
DOI: 10.1101/sqb.2019.84.039818