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Magnetic DIagnostic Assay for neurodegenerative diseases

Objetivo

MADIA aims at realizing a versatile and cheap diagnostic device based on magnetoresistive sensors, microfluidic device,
ultra–small Magnetic Nanoparticles (MNPs) and advanced bio-chemical functionalization methods for the early and ultrasensitive.
in vitro detection of biomarkers trustfully associated with 2 incurable neurodegenerative diseases: Alzheimer’s
Disease (AD) and Parkinson Disease (PD). We plan to achieve sensitivities at least three orders of magnitude higher than
best state-of-the-art values flexibility to operate for a wide range of concentrations.
WHY: Neurodegenerative diseases (ND) are debilitating and largely untreatable conditions that are strongly linked with age.
Amongst these disorders, the dementias are responsible for the greatest burden of disease, with Alzheimer’s disease and
related disorders affecting some 7 million people in Europe. The current costs of the order of €130 billion per annum to care
for people with dementia across Europe highlight age-related neurodegenerative disease as one of the largest medical and
societal challenges faced by our society. PD is the second most common neurodegenerative disorder worldwide after AD.
WHAT: The operation principle behind the proposed tool embodies a Magnetic Sensor Assay approach and consists of
recognizing the targeted core and downstream biomarkers obtained from body fluids (such as cerebrospinal fluid - CSF and
blood) through their complexation with nano-magnetic labels (MNPs) followed by a highly sensitive magnetic detection at
micro-scales. The specific recognition of the protein by the magnetic nanoparticles will be achieved and ensured via protein
bonding to functionalizing groups grafted on the surface of the MNP. The complexes MNP-BM will be injected into
microfluidics channels flowing in the close vicinity of magnetic sensors, bringing thus the MNP-BM to distances where the
magnetic field of the MNP will trigger a quantitatively detectable sensor response.

Convocatoria de propuestas

H2020-ICT-2016-1
Consulte otros proyectos de esta convocatoria

Régimen de financiación

RIA - Research and Innovation action

Coordinador

CONSIGLIO NAZIONALE DELLE RICERCHE
Dirección
Piazzale Aldo Moro 7
00185 Roma
Italia
Tipo de actividad
Research Organisations
Aportación de la UE
€ 701 412

Participantes (9)

UNIVERSITY OF BRIGHTON
United Kingdom
Aportación de la UE
€ 530 986,25
Dirección
Lewes Road Mithras House
BN2 4AT Brighton
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
España
Aportación de la UE
€ 358 420
Dirección
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSITAET BIELEFELD
Alemania
Aportación de la UE
€ 400 000
Dirección
Universitaetsstrasse 25
33615 Bielefeld
Tipo de actividad
Higher or Secondary Education Establishments
SERVIZO GALEGO DE SAUDE
España
Aportación de la UE
€ 249 572,50
Dirección
Edificio Administrativo San Lázaro
15703 Santiago De Compostela
Tipo de actividad
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
FONDAZIONE EUROPEAN BRAIN RESEARCHINSTITUTE RITA LEVI
Italia
Aportación de la UE
€ 383 250
Dirección
Via Regina Elena 295
00161 Roma
Tipo de actividad
Research Organisations
SCRIBA NANOTECNOLOGIE SRL
Italia
Aportación de la UE
€ 390 687,50
Dirección
Via Di Corticella 183/8
40128 Bologna
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ORTHOKEY ITALIA SRL
Italia
Aportación de la UE
€ 332 437,50
Dirección
Piazza Nazioni Unite 15
54033 Carrara Ms
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIODEVICE SYSTEMS SRO
Chequia
Aportación de la UE
€ 292 796,25
Dirección
Bulharska 996 20
10100 Praha
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INNOVA SRL
Italia
Aportación de la UE
€ 251 500
Dirección
Via Cicerone, 66
00193 Roma
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)