Crimean-Congo Haemorrhagic Fever Vaccine

Project Information

CCHFVaccine

Grant agreement ID: 732732

DOI

10.3030/732732

Project closed

EC signature date 9 December 2016

Start date 1 January 2017

End date 30 September 2025

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 6 255 909,80

EU contribution

€ 5 979 607,30

Coordinated by

FOLKHALSOMYNDIGHETEN
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Demonstrators, pilots, prototypes (3)

DIVA

DIVA vaccine.

RVF-VLPs

RVFV-VLPs expressing CCHFV proteins.

RNA

RNA vaccine.

Publications

Peer reviewed articles (24)

A DNA-based vaccine protects against Crimean-Congo haemorrhagic fever virus disease in a Cynomolgus macaque model

Author(s): David W. Hawman, Gustaf Ahlén, K. Sofia Appelberg, Kimberly Meade-White, Patrick W. Hanley, Dana Scott, Vanessa Monteil, Stephanie Devignot, Atsushi Okumura, Friedemann Weber, Heinz Feldmann, Matti Sällberg, Ali Mirazimi
Published in: Nature Microbiology, Issue 6, 2024, Page(s) 187-195, ISSN 2058-5276
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41564-020-00815-6

Diagnosis and Pathogenesis of Nairobi Sheep Disease Orthonairovirus Infections in Sheep and Cattle

Author(s): Julia Hartlaub, Benjamin Gutjahr, Christine Fast, Ali Mirazimi, Markus Keller, Martin H. Groschup
Published in: Viruses, Issue 13/7, 2021, Page(s) 1250, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071250

The interplays between Crimean-Congo hemorrhagic fever virus (CCHFV) M segment-encoded accessory proteins and structural proteins promote virus assembly and infectivity

Author(s): Natalia Freitas; Margot Enguehard; Solène Denolly; Camille Levy; Gregory Neveu; Solène Lerolle; Stephanie Devignot; Friedemann Weber; Eric Bergeron; Vincent Legros; François-Loïc Cosset
Published in: PLOS Pathogens, Issue 16, 2020, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1008850

Presence of antibodies to Crimean Congo haemorrhagic fever virus in sheep in Tunisia, North Africa

Author(s): Médiha Khamassi Khbou, Rihab Romdhane, Faten Bouaicha Zaafouri, Mohsen Bouajila, Limam Sassi, Sofia K. Appelberg, Ansgar Schulz, Ali Mirazimi, Martin H. Groschup, Mourad Rekik, M'hammed Benzarti, Mohamed Gharbi
Published in: Veterinary Medicine and Science, Issue 7, 2023, Page(s) 2323-2329, ISSN 2053-1095
Publisher: Wiley
DOI: 10.1002/vms3.597

Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus

Author(s): David W Hawman, Kimberly Meade-White, Shanna Leventhal, Friederike Feldmann, Atsushi Okumura, Brian Smith, Dana Scott, Heinz Feldmann
Published in: eLife, Issue 10, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.63906

Convalescent human plasma candidate reference materials protect against Crimean-Congo haemorrhagic fever virus (CCHFV) challenge in an A129 mouse model

Author(s): Sarah Kempster, Mark Hassall, Victoria Graham, Emma Kennedy, Stephen Findlay-Wilson, Francisco J. Salguero, Binnur Bagci, Nazif Elaldi, Murtaza Oz, Tuba Tasseten, Frank W. Charlton, John N. Barr, Juan Fontana, Chinwe Duru, Ernest Ezeajughi, Paul Matejtschuk, Ulrike Arnold, Yemisi Adedeji, Ali Mirazimi, Roger Hewson, Stuart Dowall, Neil Almond
Published in: Virus Research, Issue 346, 2024, Page(s) 199409, ISSN 0168-1702
Publisher: Elsevier BV
DOI: 10.1016/j.virusres.2024.199409

Systems-level temporal immune-metabolic profile in Crimean-Congo hemorrhagic fever virus infection

Author(s): Anoop T. Ambikana, Nazif Elaldib, Sara Svensson- Akusjärvia, Binnur Bagcic, Ayse Nur Pektasd, Roger Hewsone,f, Gokhan Bagcig, Mehmet Araslih, Sofia Appelbergi, Adil Mardinogluj,k, Vikas Sooda,l, Ákos Végvárim, Rui Benfeitasa, Soham Guptaa, Ilhan Cetinn, Ali Mirazimii,o,p, and Ujjwal Neogia,
Published in: Proceedings of the National Academy of Sciences (PNAS), Issue September 5, 2023, 120 (37), 2023, Page(s) e2304722120, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2304722120

Nucleoside-Modified mRNA Vaccines Protect IFNAR–/– Mice against Crimean-Congo Hemorrhagic Fever Virus Infection

Author(s): Sofia Appelberg; Lijo John; Norbert Pardi; Ákos Végvári; Sándor Bereczky; Gustaf Ahlén; Vanessa Monteil; Samir Abdurahman; Flora Mikaeloff; Mitchell Beattie; Ying Tam ; Matti Sällberg; Ujjwal Neogi; Drew Weissman; Ali Mirazimi
Published in: Journal of Virology, Issue 96, 2022, Page(s) e01568-21, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/jvi.01568-21

Deciphering Antibody Responses to Orthonairoviruses in Ruminants

Author(s): Julia Hartlaub, Markus Keller, Martin H. Groschup
Published in: Microorganisms, Issue 9/7, 2021, Page(s) 1493, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms9071493

Recombinant Rift Valley fever viruses encoding bluetongue virus (BTV) antigens: Immunity and efficacy studies upon a BTV-4 challenge

Author(s): Sandra Moreno; Eva Calvo-Pinilla; Stephanie Devignot; Friedemann Weber; Javier Ortego; Alejandro Brun
Published in: PLOS Neglected Tropical Diseases, Issue 14, 2020, ISSN 1935-2727
Publisher: Public Library of Science
DOI: 10.1371/journal.pntd.0008942

Accelerated DNA vaccine regimen provides protection against Crimean-Congo hemorrhagic fever virus challenge in a macaque model

Author(s): David W. Hawman; Kimberly Meade-White; Shanna Leventhal; Sofia Appelberg; Gustaf Ahlén; Negin Nikouyan; Chad Clancy; Brian Smith; Patrick Hanley; Jamie Lovaglio; Ali Mirazimi; Matti Sällberg; Heinz Feldmann
Published in: Molecular Therapy, Issue 31, 2022, Page(s) VOLUME 31, ISSUE 2, P387-397, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.09.016

Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge

Author(s): Marko Zivcec, David Safronetz, Dana P. Scott, Shelly Robertson, Heinz Feldmann
Published in: PLOS Neglected Tropical Diseases, Issue 12, 2022, Page(s) e0006628, ISSN 1935-2735
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pntd.0006628

Experimental Challenge of Sheep and Cattle with Dugbe Orthonairovirus, a Neglected African Arbovirus Distantly Related to CCHFV

Author(s): Julia Hartlaub, Felicitas von Arnim, Christine Fast, Ali Mirazimi, Markus Keller, Martin H. Groschup
Published in: Viruses, Issue 13/3, 2021, Page(s) 372, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13030372

Comparison of Crimean-Congo Hemorrhagic Fever Virus and Aigai Virus in Life Cycle Modeling Systems Reveals a Difference in L Protein Activity

Author(s): Matthew J. Pickin; Stéphanie Devignot; Friedemann Weber; Martin H. Groschup
Published in: Journal of Virology, Issue 96, 2022, Page(s) e00599-22, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/jvi.00599-22

Sheep and Cattle Are Not Susceptible to Experimental Inoculation with Hazara Orthonairovirus, a Tick-Borne Arbovirus Closely Related to CCHFV

Author(s): Julia Hartlaub, Felicitas von Arnim, Christine Fast, Maryna Somova, Ali Mirazimi, Martin H. Groschup, Markus Keller
Published in: Microorganisms, Issue 8/12, 2020, Page(s) 1927, ISSN 2076-2607
Publisher: US National Library of Medicine National Institutes of Health
DOI: 10.3390/microorganisms8121927

Epitope-mapping of the glycoprotein from Crimean-Congo hemorrhagic fever virus using a microarray approach

Author(s): Amanda Fritzen, Christian Risinger, Gulay Korukluoglu, Iva Christova, Arina Corli Hitzeroth, Natalie Viljoen, Felicity Jane Burt, Ali Mirazimi, Ola Blixt
Published in: PLOS Neglected Tropical Diseases, Issue 12/7, 2018, Page(s) e0006598, ISSN 1935-2735
Publisher: NIAID
DOI: 10.1371/journal.pntd.0006598

Second International Conference on Crimean-Congo Hemorrhagic Fever

Author(s): Jessica R. Spengler, Dennis A. Bente, Mike Bray, Felicity Burt, Roger Hewson, Gülay Korukluoglu, Ali Mirazimi, Friedemann Weber, Anna Papa
Published in: Antiviral Research, Issue 150, 2018, Page(s) 137-147, ISSN 0166-3542
Publisher: Elsevier BV
DOI: 10.1016/j.antiviral.2017.11.019

Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice

Author(s): Jorma Hinkula, Stéphanie Devignot, Sara Åkerström, Helen Karlberg, Eva Wattrang, Sándor Bereczky, Mehrdad Mousavi-Jazi, Christian Risinger, Gunnel Lindegren, Caroline Vernersson, Janusz Paweska, Petrus Jansen van Vuren, Ola Blixt, Alejandro Brun, Friedemann Weber, Ali Mirazimi
Published in: Journal of Virology, Issue 91/10, 2017, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/JVI.02076-16

Structure and function of the Toscana virus cap-snatching endonuclease

Author(s): Rhian Jones, Sana Lessoued, Kristina Meier, Stéphanie Devignot, Sergio Barata-García, Maria Mate, Gabriel Bragagnolo, Friedemann Weber, Maria Rosenthal, Juan Reguera
Published in: Nucleic Acids Research, Issue 47, 2021, Page(s) 10914-10930, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz838

Cross-Reaction or Co-Infection? Serological Discrimination of Antibodies Directed against Dugbe and Crimean-Congo Hemorrhagic Fever Orthonairovirus in Nigerian Cattle

Author(s): Julia Hartlaub, Oluwafemi B. Daodu, Balal Sadeghi, Markus Keller, James Olopade, Daniel Oluwayelu, Martin H. Groschup
Published in: Viruses, Issue 13/7, 2021, Page(s) 1398, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071398

Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks

Author(s): Barbara Bartolini, Cesare EM Gruber, Marion Koopmans, Tatjana Avšič, Sylvia Bino, Iva Christova, Roland Grunow, Roger Hewson, Gulay Korukluoglu, Cinthia Menel Lemos, Ali Mirazimi, Anna Papa, Maria Paz Sanchez-Seco, Aisha V. Sauer, Hervè Zeller, Carla Nisii, Maria Rosaria Capobianchi, Giuseppe Ippolito, Chantal B. Reusken, Antonino Di Caro
Published in: Eurosurveillance, Issue 24, 2024, ISSN 1560-7917
Publisher: European Centre for Disease Control and Prevention (ECDC)
DOI: 10.2807/1560-7917.es.2019.24.5.1800093

Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target

Author(s): Ujjwal Neogi; Nazif Elaldi; Sofia Appelberg; Anoop Ambikan; Emma Kennedy; Stuart Dowall; Binnur K Bagci; Soham Gupta; Jimmy E Rodriguez; Sara Svensson-Akusjärvi; Vanessa Monteil; Akos Vegvari; Rui Benfeitas; Akhil Banerjea; Friedemann Weber; Roger Hewson; Ali Mirazimi
Published in: eLife, Issue 11, 2022, Page(s) e76071, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.76071

ISG15 overexpression compensates the defect of Crimean-Congo hemorrhagic fever virus polymerase bearing a protease-inactive ovarian tumor domain

Author(s): Stephanie Devignot; Thilo Kromer; Ali Mirazimi; Friedemann Weber
Published in: PLOS Neglected Tropical Diseases, Issue 14, 2020, Page(s) 1-24, ISSN 1935-2727
Publisher: Public Library of Science
DOI: 10.1371/journal.pntd.0008610

Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells

Author(s): Vanessa M. Monteil, Shane C. Wright, Matheus Dyczynski, Max J. Kellner, Sofia Appelberg, Sebastian W. Platzer, Ahmed Ibrahim, Hyesoo Kwon, Ioannis Pittarokoilis, Mattia Mirandola, Georg Michlits, Stephanie Devignot, Elizabeth Elder, Samir Abdurahman, Sándor Bereczky, Binnur Bagci, Sonia Youhanna, Teodor Aastrup, Volker M. Lauschke, Cristiano Salata, Nazif Elaldi, Friedemann Weber, Nuria Monserrat
Published in: Nature Microbiology, Issue 9, 2024, Page(s) 1499-1512, ISSN 2058-5276
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41564-024-01672-3

Thesis and dissertations (1)

Mejora y evaluación de vacunas basadas en vectores víricos frente a orbivirus y bunyavirus transmitidos por vectores

Author(s): Moreno Fernández, Sandra
Published in: reponame:E-Prints Complutense. Archivo Institucional de la UCM, Issue 2, 2021
Publisher: Universidad Complutense de Madrid

Book chapters (1)

Vector-Borne Infections in Bulgaria

Author(s): Iva Christova
Published in: Vectors and Vector-Borne Zoonotic Diseases, 2022
Publisher: IntechOpen
DOI: 10.5772/intechopen.81916