Crimean-Congo Haemorrhagic Fever Vaccine

Informations projet

CCHFVaccine

N° de convention de subvention: 732732

DOI 10.3030/732732

Date de signature de la CE 9 Decembre 2016

Date de début 1 Janvier 2017

Date de fin 31 Decembre 2024

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total € 6 255 909,80

Contribution de l’UE € 5 979 607,30

Coordonné par

FOLKHALSOMYNDIGHETEN
Sweden

Livrables

Demonstrators, pilots, prototypes (3)

DIVA

DIVA vaccine.

RVF-VLPs

RVFV-VLPs expressing CCHFV proteins.

RNA

RNA vaccine.

Publications

Peer reviewed articles (16)

Diagnosis and Pathogenesis of Nairobi Sheep Disease Orthonairovirus Infections in Sheep and Cattle

Auteurs: Julia Hartlaub, Benjamin Gutjahr, Christine Fast, Ali Mirazimi, Markus Keller, Martin H. Groschup
Publié dans: Viruses, Numéro 13/7, 2021, Page(s) 1250, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071250

The interplays between Crimean-Congo hemorrhagic fever virus (CCHFV) M segment-encoded accessory proteins and structural proteins promote virus assembly and infectivity

Auteurs: Natalia Freitas; Margot Enguehard; Solène Denolly; Camille Levy; Gregory Neveu; Solène Lerolle; Stephanie Devignot; Friedemann Weber; Eric Bergeron; Vincent Legros; François-Loïc Cosset
Publié dans: PLOS Pathogens, Numéro 16, 2020, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1008850

Systems-level temporal immune-metabolic profile in Crimean-Congo hemorrhagic fever virus infection

Auteurs: Anoop T. Ambikana, Nazif Elaldib, Sara Svensson- Akusjärvia, Binnur Bagcic, Ayse Nur Pektasd, Roger Hewsone,f, Gokhan Bagcig, Mehmet Araslih, Sofia Appelbergi, Adil Mardinogluj,k, Vikas Sooda,l, Ákos Végvárim, Rui Benfeitasa, Soham Guptaa, Ilhan Cetinn, Ali Mirazimii,o,p, and Ujjwal Neogia,
Publié dans: Proceedings of the National Academy of Sciences (PNAS), Numéro September 5, 2023, 120 (37), 2023, Page(s) e2304722120, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2304722120

Nucleoside-Modified mRNA Vaccines Protect IFNAR–/– Mice against Crimean-Congo Hemorrhagic Fever Virus Infection

Auteurs: Sofia Appelberg; Lijo John; Norbert Pardi; Ákos Végvári; Sándor Bereczky; Gustaf Ahlén; Vanessa Monteil; Samir Abdurahman; Flora Mikaeloff; Mitchell Beattie; Ying Tam ; Matti Sällberg; Ujjwal Neogi; Drew Weissman; Ali Mirazimi
Publié dans: Journal of Virology, Numéro 96, 2022, Page(s) e01568-21, ISSN 0022-538X
Éditeur: American Society for Microbiology
DOI: 10.1128/jvi.01568-21

Deciphering Antibody Responses to Orthonairoviruses in Ruminants

Auteurs: Julia Hartlaub, Markus Keller, Martin H. Groschup
Publié dans: Microorganisms, Numéro 9/7, 2021, Page(s) 1493, ISSN 2076-2607
Éditeur: MDPI
DOI: 10.3390/microorganisms9071493

Recombinant Rift Valley fever viruses encoding bluetongue virus (BTV) antigens: Immunity and efficacy studies upon a BTV-4 challenge

Auteurs: Sandra Moreno; Eva Calvo-Pinilla; Stephanie Devignot; Friedemann Weber; Javier Ortego; Alejandro Brun
Publié dans: PLOS Neglected Tropical Diseases, Numéro 14, 2020, ISSN 1935-2727
Éditeur: Public Library of Science
DOI: 10.1371/journal.pntd.0008942

Accelerated DNA vaccine regimen provides protection against Crimean-Congo hemorrhagic fever virus challenge in a macaque model

Auteurs: David W. Hawman; Kimberly Meade-White; Shanna Leventhal; Sofia Appelberg; Gustaf Ahlén; Negin Nikouyan; Chad Clancy; Brian Smith; Patrick Hanley; Jamie Lovaglio; Ali Mirazimi; Matti Sällberg; Heinz Feldmann
Publié dans: Molecular Therapy, Numéro 31, 2022, Page(s) VOLUME 31, ISSUE 2, P387-397, ISSN 1525-0016
Éditeur: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.09.016

Experimental Challenge of Sheep and Cattle with Dugbe Orthonairovirus, a Neglected African Arbovirus Distantly Related to CCHFV

Auteurs: Julia Hartlaub, Felicitas von Arnim, Christine Fast, Ali Mirazimi, Markus Keller, Martin H. Groschup
Publié dans: Viruses, Numéro 13/3, 2021, Page(s) 372, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13030372

Comparison of Crimean-Congo Hemorrhagic Fever Virus and Aigai Virus in Life Cycle Modeling Systems Reveals a Difference in L Protein Activity

Auteurs: Matthew J. Pickin; Stéphanie Devignot; Friedemann Weber; Martin H. Groschup
Publié dans: Journal of Virology, Numéro 96, 2022, Page(s) e00599-22, ISSN 0022-538X
Éditeur: American Society for Microbiology
DOI: 10.1128/jvi.00599-22

Sheep and Cattle Are Not Susceptible to Experimental Inoculation with Hazara Orthonairovirus, a Tick-Borne Arbovirus Closely Related to CCHFV

Auteurs: Julia Hartlaub, Felicitas von Arnim, Christine Fast, Maryna Somova, Ali Mirazimi, Martin H. Groschup, Markus Keller
Publié dans: Microorganisms, Numéro 8/12, 2020, Page(s) 1927, ISSN 2076-2607
Éditeur: US National Library of Medicine National Institutes of Health
DOI: 10.3390/microorganisms8121927

Epitope-mapping of the glycoprotein from Crimean-Congo hemorrhagic fever virus using a microarray approach

Auteurs: Amanda Fritzen, Christian Risinger, Gulay Korukluoglu, Iva Christova, Arina Corli Hitzeroth, Natalie Viljoen, Felicity Jane Burt, Ali Mirazimi, Ola Blixt
Publié dans: PLOS Neglected Tropical Diseases, Numéro 12/7, 2018, Page(s) e0006598, ISSN 1935-2735
Éditeur: NIAID
DOI: 10.1371/journal.pntd.0006598

Second International Conference on Crimean-Congo Hemorrhagic Fever

Auteurs: Jessica R. Spengler, Dennis A. Bente, Mike Bray, Felicity Burt, Roger Hewson, Gülay Korukluoglu, Ali Mirazimi, Friedemann Weber, Anna Papa
Publié dans: Antiviral Research, Numéro 150, 2018, Page(s) 137-147, ISSN 0166-3542
Éditeur: Elsevier BV
DOI: 10.1016/j.antiviral.2017.11.019

Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice

Auteurs: Jorma Hinkula, Stéphanie Devignot, Sara Åkerström, Helen Karlberg, Eva Wattrang, Sándor Bereczky, Mehrdad Mousavi-Jazi, Christian Risinger, Gunnel Lindegren, Caroline Vernersson, Janusz Paweska, Petrus Jansen van Vuren, Ola Blixt, Alejandro Brun, Friedemann Weber, Ali Mirazimi
Publié dans: Journal of Virology, Numéro 91/10, 2017, ISSN 0022-538X
Éditeur: American Society for Microbiology
DOI: 10.1128/JVI.02076-16

Cross-Reaction or Co-Infection? Serological Discrimination of Antibodies Directed against Dugbe and Crimean-Congo Hemorrhagic Fever Orthonairovirus in Nigerian Cattle

Auteurs: Julia Hartlaub, Oluwafemi B. Daodu, Balal Sadeghi, Markus Keller, James Olopade, Daniel Oluwayelu, Martin H. Groschup
Publié dans: Viruses, Numéro 13/7, 2021, Page(s) 1398, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071398

Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target

Auteurs: Ujjwal Neogi; Nazif Elaldi; Sofia Appelberg; Anoop Ambikan; Emma Kennedy; Stuart Dowall; Binnur K Bagci; Soham Gupta; Jimmy E Rodriguez; Sara Svensson-Akusjärvi; Vanessa Monteil; Akos Vegvari; Rui Benfeitas; Akhil Banerjea; Friedemann Weber; Roger Hewson; Ali Mirazimi
Publié dans: eLife, Numéro 11, 2022, Page(s) e76071, ISSN 2050-084X
Éditeur: eLife Sciences Publications
DOI: 10.7554/elife.76071

ISG15 overexpression compensates the defect of Crimean-Congo hemorrhagic fever virus polymerase bearing a protease-inactive ovarian tumor domain

Auteurs: Stephanie Devignot; Thilo Kromer; Ali Mirazimi; Friedemann Weber
Publié dans: PLOS Neglected Tropical Diseases, Numéro 14, 2020, Page(s) 1-24, ISSN 1935-2727
Éditeur: Public Library of Science
DOI: 10.1371/journal.pntd.0008610