Crimean-Congo Haemorrhagic Fever Vaccine

Informacje na temat projektu

CCHFVaccine

Identyfikator umowy o grant: 732732

DOI

10.3030/732732

Projekt został zamknięty

Data podpisania przez KE 9 Grudnia 2016

Data rozpoczęcia 1 Stycznia 2017

Data zakończenia 30 Września 2025

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 6 255 909,80

Wkład UE

€ 5 979 607,30

Koordynowany przez

FOLKHALSOMYNDIGHETEN
Sweden

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Demonstrators, pilots, prototypes (3)

DIVA

DIVA vaccine.

RVF-VLPs

RVFV-VLPs expressing CCHFV proteins.

RNA

RNA vaccine.

Publikacje

Peer reviewed articles (24)

A DNA-based vaccine protects against Crimean-Congo haemorrhagic fever virus disease in a Cynomolgus macaque model

Autorzy: David W. Hawman, Gustaf Ahlén, K. Sofia Appelberg, Kimberly Meade-White, Patrick W. Hanley, Dana Scott, Vanessa Monteil, Stephanie Devignot, Atsushi Okumura, Friedemann Weber, Heinz Feldmann, Matti Sällberg, Ali Mirazimi
Opublikowane w: Nature Microbiology, Numer 6, 2024, Strona(/y) 187-195, ISSN 2058-5276
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41564-020-00815-6

Diagnosis and Pathogenesis of Nairobi Sheep Disease Orthonairovirus Infections in Sheep and Cattle

Autorzy: Julia Hartlaub, Benjamin Gutjahr, Christine Fast, Ali Mirazimi, Markus Keller, Martin H. Groschup
Opublikowane w: Viruses, Numer 13/7, 2021, Strona(/y) 1250, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071250

The interplays between Crimean-Congo hemorrhagic fever virus (CCHFV) M segment-encoded accessory proteins and structural proteins promote virus assembly and infectivity

Autorzy: Natalia Freitas; Margot Enguehard; Solène Denolly; Camille Levy; Gregory Neveu; Solène Lerolle; Stephanie Devignot; Friedemann Weber; Eric Bergeron; Vincent Legros; François-Loïc Cosset
Opublikowane w: PLOS Pathogens, Numer 16, 2020, ISSN 1553-7366
Wydawca: Public Library of Science
DOI: 10.1371/journal.ppat.1008850

Presence of antibodies to Crimean Congo haemorrhagic fever virus in sheep in Tunisia, North Africa

Autorzy: Médiha Khamassi Khbou, Rihab Romdhane, Faten Bouaicha Zaafouri, Mohsen Bouajila, Limam Sassi, Sofia K. Appelberg, Ansgar Schulz, Ali Mirazimi, Martin H. Groschup, Mourad Rekik, M'hammed Benzarti, Mohamed Gharbi
Opublikowane w: Veterinary Medicine and Science, Numer 7, 2023, Strona(/y) 2323-2329, ISSN 2053-1095
Wydawca: Wiley
DOI: 10.1002/vms3.597

Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus

Autorzy: David W Hawman, Kimberly Meade-White, Shanna Leventhal, Friederike Feldmann, Atsushi Okumura, Brian Smith, Dana Scott, Heinz Feldmann
Opublikowane w: eLife, Numer 10, 2023, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.63906

Convalescent human plasma candidate reference materials protect against Crimean-Congo haemorrhagic fever virus (CCHFV) challenge in an A129 mouse model

Autorzy: Sarah Kempster, Mark Hassall, Victoria Graham, Emma Kennedy, Stephen Findlay-Wilson, Francisco J. Salguero, Binnur Bagci, Nazif Elaldi, Murtaza Oz, Tuba Tasseten, Frank W. Charlton, John N. Barr, Juan Fontana, Chinwe Duru, Ernest Ezeajughi, Paul Matejtschuk, Ulrike Arnold, Yemisi Adedeji, Ali Mirazimi, Roger Hewson, Stuart Dowall, Neil Almond
Opublikowane w: Virus Research, Numer 346, 2024, Strona(/y) 199409, ISSN 0168-1702
Wydawca: Elsevier BV
DOI: 10.1016/j.virusres.2024.199409

Systems-level temporal immune-metabolic profile in Crimean-Congo hemorrhagic fever virus infection

Autorzy: Anoop T. Ambikana, Nazif Elaldib, Sara Svensson- Akusjärvia, Binnur Bagcic, Ayse Nur Pektasd, Roger Hewsone,f, Gokhan Bagcig, Mehmet Araslih, Sofia Appelbergi, Adil Mardinogluj,k, Vikas Sooda,l, Ákos Végvárim, Rui Benfeitasa, Soham Guptaa, Ilhan Cetinn, Ali Mirazimii,o,p, and Ujjwal Neogia,
Opublikowane w: Proceedings of the National Academy of Sciences (PNAS), Numer September 5, 2023, 120 (37), 2023, Strona(/y) e2304722120, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2304722120

Nucleoside-Modified mRNA Vaccines Protect IFNAR–/– Mice against Crimean-Congo Hemorrhagic Fever Virus Infection

Autorzy: Sofia Appelberg; Lijo John; Norbert Pardi; Ákos Végvári; Sándor Bereczky; Gustaf Ahlén; Vanessa Monteil; Samir Abdurahman; Flora Mikaeloff; Mitchell Beattie; Ying Tam ; Matti Sällberg; Ujjwal Neogi; Drew Weissman; Ali Mirazimi
Opublikowane w: Journal of Virology, Numer 96, 2022, Strona(/y) e01568-21, ISSN 0022-538X
Wydawca: American Society for Microbiology
DOI: 10.1128/jvi.01568-21

Deciphering Antibody Responses to Orthonairoviruses in Ruminants

Autorzy: Julia Hartlaub, Markus Keller, Martin H. Groschup
Opublikowane w: Microorganisms, Numer 9/7, 2021, Strona(/y) 1493, ISSN 2076-2607
Wydawca: MDPI
DOI: 10.3390/microorganisms9071493

Recombinant Rift Valley fever viruses encoding bluetongue virus (BTV) antigens: Immunity and efficacy studies upon a BTV-4 challenge

Autorzy: Sandra Moreno; Eva Calvo-Pinilla; Stephanie Devignot; Friedemann Weber; Javier Ortego; Alejandro Brun
Opublikowane w: PLOS Neglected Tropical Diseases, Numer 14, 2020, ISSN 1935-2727
Wydawca: Public Library of Science
DOI: 10.1371/journal.pntd.0008942

Accelerated DNA vaccine regimen provides protection against Crimean-Congo hemorrhagic fever virus challenge in a macaque model

Autorzy: David W. Hawman; Kimberly Meade-White; Shanna Leventhal; Sofia Appelberg; Gustaf Ahlén; Negin Nikouyan; Chad Clancy; Brian Smith; Patrick Hanley; Jamie Lovaglio; Ali Mirazimi; Matti Sällberg; Heinz Feldmann
Opublikowane w: Molecular Therapy, Numer 31, 2022, Strona(/y) VOLUME 31, ISSUE 2, P387-397, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.09.016

Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge

Autorzy: Marko Zivcec, David Safronetz, Dana P. Scott, Shelly Robertson, Heinz Feldmann
Opublikowane w: PLOS Neglected Tropical Diseases, Numer 12, 2022, Strona(/y) e0006628, ISSN 1935-2735
Wydawca: Public Library of Science (PLoS)
DOI: 10.1371/journal.pntd.0006628

Experimental Challenge of Sheep and Cattle with Dugbe Orthonairovirus, a Neglected African Arbovirus Distantly Related to CCHFV

Autorzy: Julia Hartlaub, Felicitas von Arnim, Christine Fast, Ali Mirazimi, Markus Keller, Martin H. Groschup
Opublikowane w: Viruses, Numer 13/3, 2021, Strona(/y) 372, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13030372

Comparison of Crimean-Congo Hemorrhagic Fever Virus and Aigai Virus in Life Cycle Modeling Systems Reveals a Difference in L Protein Activity

Autorzy: Matthew J. Pickin; Stéphanie Devignot; Friedemann Weber; Martin H. Groschup
Opublikowane w: Journal of Virology, Numer 96, 2022, Strona(/y) e00599-22, ISSN 0022-538X
Wydawca: American Society for Microbiology
DOI: 10.1128/jvi.00599-22

Sheep and Cattle Are Not Susceptible to Experimental Inoculation with Hazara Orthonairovirus, a Tick-Borne Arbovirus Closely Related to CCHFV

Autorzy: Julia Hartlaub, Felicitas von Arnim, Christine Fast, Maryna Somova, Ali Mirazimi, Martin H. Groschup, Markus Keller
Opublikowane w: Microorganisms, Numer 8/12, 2020, Strona(/y) 1927, ISSN 2076-2607
Wydawca: US National Library of Medicine National Institutes of Health
DOI: 10.3390/microorganisms8121927

Epitope-mapping of the glycoprotein from Crimean-Congo hemorrhagic fever virus using a microarray approach

Autorzy: Amanda Fritzen, Christian Risinger, Gulay Korukluoglu, Iva Christova, Arina Corli Hitzeroth, Natalie Viljoen, Felicity Jane Burt, Ali Mirazimi, Ola Blixt
Opublikowane w: PLOS Neglected Tropical Diseases, Numer 12/7, 2018, Strona(/y) e0006598, ISSN 1935-2735
Wydawca: NIAID
DOI: 10.1371/journal.pntd.0006598

Second International Conference on Crimean-Congo Hemorrhagic Fever

Autorzy: Jessica R. Spengler, Dennis A. Bente, Mike Bray, Felicity Burt, Roger Hewson, Gülay Korukluoglu, Ali Mirazimi, Friedemann Weber, Anna Papa
Opublikowane w: Antiviral Research, Numer 150, 2018, Strona(/y) 137-147, ISSN 0166-3542
Wydawca: Elsevier BV
DOI: 10.1016/j.antiviral.2017.11.019

Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice

Autorzy: Jorma Hinkula, Stéphanie Devignot, Sara Åkerström, Helen Karlberg, Eva Wattrang, Sándor Bereczky, Mehrdad Mousavi-Jazi, Christian Risinger, Gunnel Lindegren, Caroline Vernersson, Janusz Paweska, Petrus Jansen van Vuren, Ola Blixt, Alejandro Brun, Friedemann Weber, Ali Mirazimi
Opublikowane w: Journal of Virology, Numer 91/10, 2017, ISSN 0022-538X
Wydawca: American Society for Microbiology
DOI: 10.1128/JVI.02076-16

Structure and function of the Toscana virus cap-snatching endonuclease

Autorzy: Rhian Jones, Sana Lessoued, Kristina Meier, Stéphanie Devignot, Sergio Barata-García, Maria Mate, Gabriel Bragagnolo, Friedemann Weber, Maria Rosenthal, Juan Reguera
Opublikowane w: Nucleic Acids Research, Numer 47, 2021, Strona(/y) 10914-10930, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkz838

Cross-Reaction or Co-Infection? Serological Discrimination of Antibodies Directed against Dugbe and Crimean-Congo Hemorrhagic Fever Orthonairovirus in Nigerian Cattle

Autorzy: Julia Hartlaub, Oluwafemi B. Daodu, Balal Sadeghi, Markus Keller, James Olopade, Daniel Oluwayelu, Martin H. Groschup
Opublikowane w: Viruses, Numer 13/7, 2021, Strona(/y) 1398, ISSN 1999-4915
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071398

Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks

Autorzy: Barbara Bartolini, Cesare EM Gruber, Marion Koopmans, Tatjana Avšič, Sylvia Bino, Iva Christova, Roland Grunow, Roger Hewson, Gulay Korukluoglu, Cinthia Menel Lemos, Ali Mirazimi, Anna Papa, Maria Paz Sanchez-Seco, Aisha V. Sauer, Hervè Zeller, Carla Nisii, Maria Rosaria Capobianchi, Giuseppe Ippolito, Chantal B. Reusken, Antonino Di Caro
Opublikowane w: Eurosurveillance, Numer 24, 2024, ISSN 1560-7917
Wydawca: European Centre for Disease Control and Prevention (ECDC)
DOI: 10.2807/1560-7917.es.2019.24.5.1800093

Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target

Autorzy: Ujjwal Neogi; Nazif Elaldi; Sofia Appelberg; Anoop Ambikan; Emma Kennedy; Stuart Dowall; Binnur K Bagci; Soham Gupta; Jimmy E Rodriguez; Sara Svensson-Akusjärvi; Vanessa Monteil; Akos Vegvari; Rui Benfeitas; Akhil Banerjea; Friedemann Weber; Roger Hewson; Ali Mirazimi
Opublikowane w: eLife, Numer 11, 2022, Strona(/y) e76071, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.76071

ISG15 overexpression compensates the defect of Crimean-Congo hemorrhagic fever virus polymerase bearing a protease-inactive ovarian tumor domain

Autorzy: Stephanie Devignot; Thilo Kromer; Ali Mirazimi; Friedemann Weber
Opublikowane w: PLOS Neglected Tropical Diseases, Numer 14, 2020, Strona(/y) 1-24, ISSN 1935-2727
Wydawca: Public Library of Science
DOI: 10.1371/journal.pntd.0008610

Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells

Autorzy: Vanessa M. Monteil, Shane C. Wright, Matheus Dyczynski, Max J. Kellner, Sofia Appelberg, Sebastian W. Platzer, Ahmed Ibrahim, Hyesoo Kwon, Ioannis Pittarokoilis, Mattia Mirandola, Georg Michlits, Stephanie Devignot, Elizabeth Elder, Samir Abdurahman, Sándor Bereczky, Binnur Bagci, Sonia Youhanna, Teodor Aastrup, Volker M. Lauschke, Cristiano Salata, Nazif Elaldi, Friedemann Weber, Nuria Monserrat
Opublikowane w: Nature Microbiology, Numer 9, 2024, Strona(/y) 1499-1512, ISSN 2058-5276
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41564-024-01672-3

Thesis and dissertations (1)

Mejora y evaluación de vacunas basadas en vectores víricos frente a orbivirus y bunyavirus transmitidos por vectores

Autorzy: Moreno Fernández, Sandra
Opublikowane w: reponame:E-Prints Complutense. Archivo Institucional de la UCM, Numer 2, 2021
Wydawca: Universidad Complutense de Madrid

Book chapters (1)

Vector-Borne Infections in Bulgaria

Autorzy: Iva Christova
Opublikowane w: Vectors and Vector-Borne Zoonotic Diseases, 2022
Wydawca: IntechOpen
DOI: 10.5772/intechopen.81916