Crimean-Congo Haemorrhagic Fever Vaccine

Información del proyecto

CCHFVaccine

Identificador del acuerdo de subvención: 732732

DOI

10.3030/732732

Proyecto cerrado

Fecha de la firma de la CE 9 Diciembre 2016

Fecha de inicio 1 Enero 2017

Fecha de finalización 30 Septiembre 2025

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 6 255 909,80

Aportación de la UE

€ 5 979 607,30

Coordinado por

FOLKHALSOMYNDIGHETEN
Sweden

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Demonstrators, pilots, prototypes (3)

DIVA

DIVA vaccine.

RVF-VLPs

RVFV-VLPs expressing CCHFV proteins.

RNA

RNA vaccine.

Publicaciones

Peer reviewed articles (24)

A DNA-based vaccine protects against Crimean-Congo haemorrhagic fever virus disease in a Cynomolgus macaque model

Autores: David W. Hawman, Gustaf Ahlén, K. Sofia Appelberg, Kimberly Meade-White, Patrick W. Hanley, Dana Scott, Vanessa Monteil, Stephanie Devignot, Atsushi Okumura, Friedemann Weber, Heinz Feldmann, Matti Sällberg, Ali Mirazimi
Publicado en: Nature Microbiology, Edición 6, 2024, Página(s) 187-195, ISSN 2058-5276
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41564-020-00815-6

Diagnosis and Pathogenesis of Nairobi Sheep Disease Orthonairovirus Infections in Sheep and Cattle

Autores: Julia Hartlaub, Benjamin Gutjahr, Christine Fast, Ali Mirazimi, Markus Keller, Martin H. Groschup
Publicado en: Viruses, Edición 13/7, 2021, Página(s) 1250, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071250

The interplays between Crimean-Congo hemorrhagic fever virus (CCHFV) M segment-encoded accessory proteins and structural proteins promote virus assembly and infectivity

Autores: Natalia Freitas; Margot Enguehard; Solène Denolly; Camille Levy; Gregory Neveu; Solène Lerolle; Stephanie Devignot; Friedemann Weber; Eric Bergeron; Vincent Legros; François-Loïc Cosset
Publicado en: PLOS Pathogens, Edición 16, 2020, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1008850

Presence of antibodies to Crimean Congo haemorrhagic fever virus in sheep in Tunisia, North Africa

Autores: Médiha Khamassi Khbou, Rihab Romdhane, Faten Bouaicha Zaafouri, Mohsen Bouajila, Limam Sassi, Sofia K. Appelberg, Ansgar Schulz, Ali Mirazimi, Martin H. Groschup, Mourad Rekik, M'hammed Benzarti, Mohamed Gharbi
Publicado en: Veterinary Medicine and Science, Edición 7, 2023, Página(s) 2323-2329, ISSN 2053-1095
Editor: Wiley
DOI: 10.1002/vms3.597

Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus

Autores: David W Hawman, Kimberly Meade-White, Shanna Leventhal, Friederike Feldmann, Atsushi Okumura, Brian Smith, Dana Scott, Heinz Feldmann
Publicado en: eLife, Edición 10, 2023, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.63906

Convalescent human plasma candidate reference materials protect against Crimean-Congo haemorrhagic fever virus (CCHFV) challenge in an A129 mouse model

Autores: Sarah Kempster, Mark Hassall, Victoria Graham, Emma Kennedy, Stephen Findlay-Wilson, Francisco J. Salguero, Binnur Bagci, Nazif Elaldi, Murtaza Oz, Tuba Tasseten, Frank W. Charlton, John N. Barr, Juan Fontana, Chinwe Duru, Ernest Ezeajughi, Paul Matejtschuk, Ulrike Arnold, Yemisi Adedeji, Ali Mirazimi, Roger Hewson, Stuart Dowall, Neil Almond
Publicado en: Virus Research, Edición 346, 2024, Página(s) 199409, ISSN 0168-1702
Editor: Elsevier BV
DOI: 10.1016/j.virusres.2024.199409

Systems-level temporal immune-metabolic profile in Crimean-Congo hemorrhagic fever virus infection

Autores: Anoop T. Ambikana, Nazif Elaldib, Sara Svensson- Akusjärvia, Binnur Bagcic, Ayse Nur Pektasd, Roger Hewsone,f, Gokhan Bagcig, Mehmet Araslih, Sofia Appelbergi, Adil Mardinogluj,k, Vikas Sooda,l, Ákos Végvárim, Rui Benfeitasa, Soham Guptaa, Ilhan Cetinn, Ali Mirazimii,o,p, and Ujjwal Neogia,
Publicado en: Proceedings of the National Academy of Sciences (PNAS), Edición September 5, 2023, 120 (37), 2023, Página(s) e2304722120, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2304722120

Nucleoside-Modified mRNA Vaccines Protect IFNAR–/– Mice against Crimean-Congo Hemorrhagic Fever Virus Infection

Autores: Sofia Appelberg; Lijo John; Norbert Pardi; Ákos Végvári; Sándor Bereczky; Gustaf Ahlén; Vanessa Monteil; Samir Abdurahman; Flora Mikaeloff; Mitchell Beattie; Ying Tam ; Matti Sällberg; Ujjwal Neogi; Drew Weissman; Ali Mirazimi
Publicado en: Journal of Virology, Edición 96, 2022, Página(s) e01568-21, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/jvi.01568-21

Deciphering Antibody Responses to Orthonairoviruses in Ruminants

Autores: Julia Hartlaub, Markus Keller, Martin H. Groschup
Publicado en: Microorganisms, Edición 9/7, 2021, Página(s) 1493, ISSN 2076-2607
Editor: MDPI
DOI: 10.3390/microorganisms9071493

Recombinant Rift Valley fever viruses encoding bluetongue virus (BTV) antigens: Immunity and efficacy studies upon a BTV-4 challenge

Autores: Sandra Moreno; Eva Calvo-Pinilla; Stephanie Devignot; Friedemann Weber; Javier Ortego; Alejandro Brun
Publicado en: PLOS Neglected Tropical Diseases, Edición 14, 2020, ISSN 1935-2727
Editor: Public Library of Science
DOI: 10.1371/journal.pntd.0008942

Accelerated DNA vaccine regimen provides protection against Crimean-Congo hemorrhagic fever virus challenge in a macaque model

Autores: David W. Hawman; Kimberly Meade-White; Shanna Leventhal; Sofia Appelberg; Gustaf Ahlén; Negin Nikouyan; Chad Clancy; Brian Smith; Patrick Hanley; Jamie Lovaglio; Ali Mirazimi; Matti Sällberg; Heinz Feldmann
Publicado en: Molecular Therapy, Edición 31, 2022, Página(s) VOLUME 31, ISSUE 2, P387-397, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.09.016

Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge

Autores: Marko Zivcec, David Safronetz, Dana P. Scott, Shelly Robertson, Heinz Feldmann
Publicado en: PLOS Neglected Tropical Diseases, Edición 12, 2022, Página(s) e0006628, ISSN 1935-2735
Editor: Public Library of Science (PLoS)
DOI: 10.1371/journal.pntd.0006628

Experimental Challenge of Sheep and Cattle with Dugbe Orthonairovirus, a Neglected African Arbovirus Distantly Related to CCHFV

Autores: Julia Hartlaub, Felicitas von Arnim, Christine Fast, Ali Mirazimi, Markus Keller, Martin H. Groschup
Publicado en: Viruses, Edición 13/3, 2021, Página(s) 372, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13030372

Comparison of Crimean-Congo Hemorrhagic Fever Virus and Aigai Virus in Life Cycle Modeling Systems Reveals a Difference in L Protein Activity

Autores: Matthew J. Pickin; Stéphanie Devignot; Friedemann Weber; Martin H. Groschup
Publicado en: Journal of Virology, Edición 96, 2022, Página(s) e00599-22, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/jvi.00599-22

Sheep and Cattle Are Not Susceptible to Experimental Inoculation with Hazara Orthonairovirus, a Tick-Borne Arbovirus Closely Related to CCHFV

Autores: Julia Hartlaub, Felicitas von Arnim, Christine Fast, Maryna Somova, Ali Mirazimi, Martin H. Groschup, Markus Keller
Publicado en: Microorganisms, Edición 8/12, 2020, Página(s) 1927, ISSN 2076-2607
Editor: US National Library of Medicine National Institutes of Health
DOI: 10.3390/microorganisms8121927

Epitope-mapping of the glycoprotein from Crimean-Congo hemorrhagic fever virus using a microarray approach

Autores: Amanda Fritzen, Christian Risinger, Gulay Korukluoglu, Iva Christova, Arina Corli Hitzeroth, Natalie Viljoen, Felicity Jane Burt, Ali Mirazimi, Ola Blixt
Publicado en: PLOS Neglected Tropical Diseases, Edición 12/7, 2018, Página(s) e0006598, ISSN 1935-2735
Editor: NIAID
DOI: 10.1371/journal.pntd.0006598

Second International Conference on Crimean-Congo Hemorrhagic Fever

Autores: Jessica R. Spengler, Dennis A. Bente, Mike Bray, Felicity Burt, Roger Hewson, Gülay Korukluoglu, Ali Mirazimi, Friedemann Weber, Anna Papa
Publicado en: Antiviral Research, Edición 150, 2018, Página(s) 137-147, ISSN 0166-3542
Editor: Elsevier BV
DOI: 10.1016/j.antiviral.2017.11.019

Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice

Autores: Jorma Hinkula, Stéphanie Devignot, Sara Åkerström, Helen Karlberg, Eva Wattrang, Sándor Bereczky, Mehrdad Mousavi-Jazi, Christian Risinger, Gunnel Lindegren, Caroline Vernersson, Janusz Paweska, Petrus Jansen van Vuren, Ola Blixt, Alejandro Brun, Friedemann Weber, Ali Mirazimi
Publicado en: Journal of Virology, Edición 91/10, 2017, ISSN 0022-538X
Editor: American Society for Microbiology
DOI: 10.1128/JVI.02076-16

Structure and function of the Toscana virus cap-snatching endonuclease

Autores: Rhian Jones, Sana Lessoued, Kristina Meier, Stéphanie Devignot, Sergio Barata-García, Maria Mate, Gabriel Bragagnolo, Friedemann Weber, Maria Rosenthal, Juan Reguera
Publicado en: Nucleic Acids Research, Edición 47, 2021, Página(s) 10914-10930, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkz838

Cross-Reaction or Co-Infection? Serological Discrimination of Antibodies Directed against Dugbe and Crimean-Congo Hemorrhagic Fever Orthonairovirus in Nigerian Cattle

Autores: Julia Hartlaub, Oluwafemi B. Daodu, Balal Sadeghi, Markus Keller, James Olopade, Daniel Oluwayelu, Martin H. Groschup
Publicado en: Viruses, Edición 13/7, 2021, Página(s) 1398, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13071398

Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks

Autores: Barbara Bartolini, Cesare EM Gruber, Marion Koopmans, Tatjana Avšič, Sylvia Bino, Iva Christova, Roland Grunow, Roger Hewson, Gulay Korukluoglu, Cinthia Menel Lemos, Ali Mirazimi, Anna Papa, Maria Paz Sanchez-Seco, Aisha V. Sauer, Hervè Zeller, Carla Nisii, Maria Rosaria Capobianchi, Giuseppe Ippolito, Chantal B. Reusken, Antonino Di Caro
Publicado en: Eurosurveillance, Edición 24, 2024, ISSN 1560-7917
Editor: European Centre for Disease Control and Prevention (ECDC)
DOI: 10.2807/1560-7917.es.2019.24.5.1800093

Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target

Autores: Ujjwal Neogi; Nazif Elaldi; Sofia Appelberg; Anoop Ambikan; Emma Kennedy; Stuart Dowall; Binnur K Bagci; Soham Gupta; Jimmy E Rodriguez; Sara Svensson-Akusjärvi; Vanessa Monteil; Akos Vegvari; Rui Benfeitas; Akhil Banerjea; Friedemann Weber; Roger Hewson; Ali Mirazimi
Publicado en: eLife, Edición 11, 2022, Página(s) e76071, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.76071

ISG15 overexpression compensates the defect of Crimean-Congo hemorrhagic fever virus polymerase bearing a protease-inactive ovarian tumor domain

Autores: Stephanie Devignot; Thilo Kromer; Ali Mirazimi; Friedemann Weber
Publicado en: PLOS Neglected Tropical Diseases, Edición 14, 2020, Página(s) 1-24, ISSN 1935-2727
Editor: Public Library of Science
DOI: 10.1371/journal.pntd.0008610

Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells

Autores: Vanessa M. Monteil, Shane C. Wright, Matheus Dyczynski, Max J. Kellner, Sofia Appelberg, Sebastian W. Platzer, Ahmed Ibrahim, Hyesoo Kwon, Ioannis Pittarokoilis, Mattia Mirandola, Georg Michlits, Stephanie Devignot, Elizabeth Elder, Samir Abdurahman, Sándor Bereczky, Binnur Bagci, Sonia Youhanna, Teodor Aastrup, Volker M. Lauschke, Cristiano Salata, Nazif Elaldi, Friedemann Weber, Nuria Monserrat
Publicado en: Nature Microbiology, Edición 9, 2024, Página(s) 1499-1512, ISSN 2058-5276
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41564-024-01672-3

Thesis and dissertations (1)

Mejora y evaluación de vacunas basadas en vectores víricos frente a orbivirus y bunyavirus transmitidos por vectores

Autores: Moreno Fernández, Sandra
Publicado en: reponame:E-Prints Complutense. Archivo Institucional de la UCM, Edición 2, 2021
Editor: Universidad Complutense de Madrid

Book chapters (1)

Vector-Borne Infections in Bulgaria

Autores: Iva Christova
Publicado en: Vectors and Vector-Borne Zoonotic Diseases, 2022
Editor: IntechOpen
DOI: 10.5772/intechopen.81916